KEGG   PATHWAY: cmk04010
Entry
cmk04010                    Pathway                                
Name
MAPK signaling pathway - Callorhinchus milii (elephant shark)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
cmk04010  MAPK signaling pathway
cmk04010

Other DBs
GO: 0000165
Organism
Callorhinchus milii (elephant shark) [GN:cmk]
Gene
103172863  LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
103180424  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
103179419  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
103185068  voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
103184804  probable voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
103175750  LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
103187106  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
103190861  voltage-dependent L-type calcium channel subunit alpha-1S-like isoform X1 [KO:K04857]
103177010  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
103176814  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a [KO:K04859]
103176769  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
103181799  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
103190066  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
103176297  voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
103173178  voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
103180441  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
103175615  voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
103189401  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
103175616  voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
103175617  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
103174709  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X2 [KO:K04345] [EC:2.7.11.11]
103189096  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
103175619  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103186617  prkcba; protein kinase C, beta a [KO:K19662] [EC:2.7.11.13]
103185131  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
103189133  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
103177620  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
103185841  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
103186967  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103187759  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
103177901  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
103189271  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
103182680  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
103175195  RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
103190331  RAS guanyl-releasing protein 1 [KO:K04350]
103181767  rasgrp3; LOW QUALITY PROTEIN: ras guanyl-releasing protein 3 [KO:K12362]
103182258  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
103183357  nf1a; neurofibromin [KO:K08052]
103182667  rasa1b; ras GTPase-activating protein 1 [KO:K04352]
103179638  rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
103182425  rap1a; ras-related protein Rap-1A [KO:K04353]
103186117  ras-related protein Rap-1b [KO:K07836]
103180890  egf; pro-epidermal growth factor [KO:K04357]
103190258  tgfa; protransforming growth factor alpha [KO:K08774]
103177684  proepiregulin [KO:K09784]
103177685  proheparin-binding EGF-like growth factor isoform X1 [KO:K09782]
103184127  fgf1; fibroblast growth factor 1 [KO:K18496]
103188323  fgf2; fibroblast growth factor 2 [KO:K18497]
103178838  fgf16; fibroblast growth factor 16 [KO:K04358]
103177849  fibroblast growth factor 10 [KO:K04358]
103175102  fgf3; fibroblast growth factor 3 [KO:K04358]
103177314  fibroblast growth factor 18 [KO:K04358]
103175016  fgf4; fibroblast growth factor 4 [KO:K04358]
103178186  fgf20a; fibroblast growth factor 20a [KO:K04358]
103186971  fgf7; fibroblast growth factor 7 precursor [KO:K04358]
103180906  fgf5; fibroblast growth factor 5 [KO:K04358]
103182076  fgf22; fibroblast growth factor 22 [KO:K04358]
103183275  fibroblast growth factor 9 [KO:K04358]
103182483  fibroblast growth factor 6 [KO:K04358]
103185575  fibroblast growth factor 4A [KO:K04358]
103187266  fgf24; fibroblast growth factor 24 [KO:K04358]
103185197  fgf9; fibroblast growth factor 4A [KO:K04358]
103175015  fgf19; fibroblast growth factor 19 [KO:K22603]
103185576  fibroblast growth factor 19 [KO:K22428]
103174983  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
103185566  ntf3; neurotrophin-3 [KO:K04356]
103189452  ntf4; neurotrophin-4 precursor [KO:K12457]
103186003  ins; insulin [KO:K04526]
103179868  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
103186041  insulin-like growth factor II isoform X2 [KO:K13769]
103190280  insulin-like growth factor II isoform X1 [KO:K13769]
103178687  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
103175503  platelet-derived growth factor subunit A [KO:K04359]
103173461  platelet-derived growth factor subunit A-like [KO:K17386]
103182267  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
103185765  pdgfd; platelet-derived growth factor D isoform X2 [KO:K05450]
103179846  kitlga; kit ligand a isoform X1 [KO:K05461]
103179198  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
103190808  vascular endothelial growth factor A [KO:K16859]
103177593  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
103180215  vegfc; vascular endothelial growth factor C [KO:K05449]
103184142  vascular endothelial growth factor C-like [KO:K05449]
103177006  hepatocyte growth factor [KO:K05460]
103184590  angiopoietin-1 [KO:K05465]
103178993  angpt2a; angiopoietin-2a [KO:K05466]
103187308  angpt2b; angiopoietin-2b isoform X1 [KO:K05466]
103178407  efna5b; ephrin-A5b isoform X3 [KO:K05462]
103181940  ephrin-A5 isoform X1 [KO:K05462]
103191264  glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
103184512  neurturin [KO:K25414]
103174789  artemin [KO:K25415]
103181270  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
103183785  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
103190236  receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
103182941  receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
103190693  LOW QUALITY PROTEIN: fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
103185425  fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
103181516  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
103183821  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103173289  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103187358  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
103181967  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
103188389  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
103178167  pdgfra; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103188232  platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103188221  macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
103178222  kita; mast/stem cell growth factor receptor kita [KO:K05091] [EC:2.7.10.1]
103183285  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
103178759  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
103183246  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
103188224  LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
103178168  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
103179355  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103178069  tek; tyrosine-protein kinase receptor Tie-2 [KO:K05121] [EC:2.7.10.1]
103187639  epha2b; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
103182663  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
103175438  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
103179222  LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
103175274  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
103189080  GTPase HRas [KO:K02833]
121852244  GTPase HRas-like [KO:K02833]
103190146  GTPase HRas-like [KO:K07827]
103188873  GTPase KRas isoform X1 [KO:K07827]
121852185  GTPase KRas-like [KO:K07827]
103189723  nras; GTPase NRas [KO:K07828]
103174912  rras2; ras-related protein R-Ras2 [KO:K07830]
103180429  ras-related protein M-Ras isoform X1 [KO:K07831]
103181856  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
103185022  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
103186399  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103183530  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103177672  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
103188576  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103174601  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3 [KO:K04372] [EC:2.7.11.1]
103181915  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
103177736  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
103177513  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
103179194  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X3 [KO:K04373] [EC:2.7.11.1]
103179538  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
103189775  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
103190471  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
103176639  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
103182535  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
103185113  transcriptional regulator Myc-2 [KO:K04377]
103181709  serum response factor isoform X2 [KO:K04378]
103189966  fos; proto-oncogene c-Fos [KO:K04379]
103179558  stathmin-like isoform X1 [KO:K04381]
103179557  stathmin-like [KO:K04381]
103179984  cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
103189875  cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
103187802  interleukin-1 beta [KO:K04519]
103185816  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
103172493  LOW QUALITY PROTEIN: interleukin-1 receptor type 1 [KO:K04386]
103187976  interleukin-1 receptor accessory protein [KO:K04723]
103181552  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
103176334  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103188937  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103180014  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
103180016  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
103180013  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
103180778  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103178707  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103191021  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103191023  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103175476  rac3a; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103181348  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103185931  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
103187405  caspase-3 [KO:K02187] [EC:3.4.22.56]
103190313  caspase-3 [KO:K02187] [EC:3.4.22.56]
103183006  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103184612  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
103172174  death domain-associated protein 6 isoform X1 [KO:K02308]
103189851  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
103176741  interleukin-1 receptor-associated kinase-like 2 [KO:K04730] [EC:2.7.11.1]
103186122  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103186026  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
121852210  LOW QUALITY PROTEIN: TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
103181960  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
103182857  growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
103189132  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
103172117  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103179281  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
103179226  map4k3b; mitogen-activated protein kinase kinase kinase kinase 3 isoform X2 [KO:K04406] [EC:2.7.11.1]
103172499  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
103172733  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103190959  serine/threonine-protein kinase 3/4 [KO:K04411]
103179698  stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
103186428  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
103177870  map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
103189809  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
103189852  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
103187711  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
103178584  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
103190243  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
103179260  map3k21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
103190676  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
103190572  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 isoform X4 [KO:K04422] [EC:2.7.11.25]
103176455  map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
103187330  mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103178324  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103178276  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
103175928  map3k4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
103182170  taok3a; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
103183335  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
103175698  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X3 [KO:K04430] [EC:2.7.12.2]
121851675  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
103185143  map2k6; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
103175734  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103175051  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
103173202  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
103186050  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
103174463  crk; adapter molecule crk [KO:K04438]
103185595  beta-arrestin-1 [KO:K04439]
103176199  S-arrestin-like [KO:K04439]
103180867  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103185857  mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
103183732  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103177012  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103177013  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103176608  zgc:171775; STKc_p38 domain-containing protein isoform X1 [KO:K04441] [EC:2.7.11.24]
103179134  mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
103179136  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103184054  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
103182495  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
103176715  MAP kinase-activated protein kinase 2 [KO:K04444] [EC:2.7.11.1]
103177970  ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
103189665  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
103181515  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
103183227  nfatc1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
103176110  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103185297  jun; transcription factor AP-1 [KO:K04448]
103182041  jund; transcription factor jun-D [KO:K04449]
103176469  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
103189067  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
103175219  max; protein max isoform X1 [KO:K04453]
103178364  mef2cb; myocyte-specific enhancer factor 2C isoform X3 [KO:K04454]
103181987  mef2b; myocyte-specific enhancer factor 2B [KO:K04454]
103180610  LOW QUALITY PROTEIN: heat shock protein beta-1 [KO:K04455]
103182174  si:dkey-1k23.3; heat shock protein beta-1 [KO:K04455]
103175285  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103181750  RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
103174353  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103185375  ppm1aa; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
121852520  LOW QUALITY PROTEIN: protein phosphatase 1A-like [KO:K04457] [EC:3.1.3.16]
103179095  receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
103185322  receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
103190804  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
103191520  dual specificity protein phosphatase 8-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103177659  dusp4; dual specificity protein phosphatase 4 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103186018  LOW QUALITY PROTEIN: dual specificity protein phosphatase 8-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103185223  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103179332  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103188785  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103187819  dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103179844  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
103186142  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
103172589  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
103180804  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
103172185  protein phosphatase 1A [KO:K04461] [EC:3.1.3.16]
103179539  heat shock cognate 71 kDa protein-like [KO:K03283]
103171601  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
103190892  heat shock 70 kDa protein 1B-like [KO:K03283]
103180319  heat shock cognate 71 kDa protein [KO:K03283]
103180320  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
103180852  mecom; histone-lysine N-methyltransferase MECOM [KO:K04462] [EC:2.1.1.367]
103189582  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X2 [KO:K04463] [EC:2.7.12.2]
103181859  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103183358  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
103177625  nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103182230  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Reference
PMID:23085193
  Authors
Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
cmk04070  Phosphatidylinositol signaling system
cmk04110  Cell cycle
cmk04115  p53 signaling pathway
cmk04210  Apoptosis
cmk04310  Wnt signaling pathway
KO pathway
ko04010   
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