Entry
Name
Salmonella infection - Mastomys coucha (southern multimammate mouse)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
BRITE hierarchy
Pathway map
Ortholog table
Organism
Mastomys coucha (southern multimammate mouse) [GN:
mcoc ]
Gene
116076679 Plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282 ]
116072784 Vps11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179 ]
116090929 Vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180 ]
116090719 Vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
116068397 Vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182 ]
116082714 Vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184 ]
116073054 Dync2h1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414 ]
116098555 Dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415 ]
116090294 Dync1i2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415 ]
116070010 Dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416 ]
116072330 Dync1li1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416 ]
116080822 Dync2li1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417 ]
116068083 Dynlrb2; dynein light chain roadblock-type 2 isoform X1 [KO:K10419 ]
116073731 Fyco1; FYVE and coiled-coil domain-containing protein 1 [KO:K21954 ]
116096964 Plekhm2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348 ]
116094832 LOW QUALITY PROTEIN: Golgi resident protein GCP60-like [KO:K23935 ]
116074319 Gcc2; GRIP and coiled-coil domain-containing protein 2 isoform X1 [KO:K20282 ]
116103535 Ahnak; neuroblast differentiation-associated protein AHNAK isoform X1 [KO:K23934 ]
116082718 Elmo1; engulfment and cell motility protein 1 isoform X1 [KO:K12366 ]
116091392 Elmo2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
116070897 Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351 ]
116069083 Myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754 ]
116103001 Mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758 ]
116070033 Fhod1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938 ]
116096877 Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
116102295 Cyfip1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749 ]
116068767 Wasf3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083 ]
116091625 Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
116095058 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
116097037 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
116073929 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
116079916 Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
116102839 Pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923 ] [EC:2.7.1.154 ]
116099223 Pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923 ] [EC:2.7.1.154 ]
116099744 Pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
116098639 Wasl; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612 ]
116073400 Tirap; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403 ]
116073051 Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
116076094 Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
116097745 Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
116086620 Tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793 ]
116093825 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
116098952 Nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727 ]
116099614 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
116070032 Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
116072766 baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060 ]
116072810 baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060 ]
116095017 Tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
116084931 tumor necrosis factor receptor superfamily member 10B-like [KO:K04722 ]
116078316 Nlrp3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800 ]
116080207 Nlrc4; NLR family CARD domain-containing protein 4 isoform X1 [KO:K12805 ]
116103048 apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
Compound
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Bernal-Bayard J, Ramos-Morales F
Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
Journal
Reference
Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
Journal
Reference
Authors
Wemyss MA, Pearson JS
Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
Journal
Reference
Authors
Bierschenk D, Boucher D, Schroder K
Title
Salmonella-induced inflammasome activation in humans.
Journal
Reference
Authors
Pinaud L, Sansonetti PJ, Phalipon A
Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal
Reference
Authors
LaRock DL, Chaudhary A, Miller SI
Title
Salmonellae interactions with host processes.
Journal
Reference
Authors
Ramsden AE, Holden DW, Mota LJ
Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Journal
Reference
Authors
van der Heijden J, Finlay BB
Title
Type III effector-mediated processes in Salmonella infection.
Journal
Reference
Authors
Galan JE
Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
Journal
Reference
Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title
Salmonella takes control: effector-driven manipulation of the host.
Journal
Reference
Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Journal
Reference
Authors
Patel JC, Galan JE
Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Journal
Reference
Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Journal
Reference
Authors
Fu Y, Galan JE
Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
Journal
Related pathway
mcoc04621 NOD-like receptor signaling pathway
KO pathway
LinkDB
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