KEGG   PATHWAY: mthb05010
Entry
mthb05010                   Pathway                                
Name
Alzheimer disease - Macaca thibetana thibetana (Pere David's macaque)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
mthb05010  Alzheimer disease
mthb05010

Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:mthb]
Gene
126958467  disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
126933776  disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
126950748  amyloid-beta precursor protein isoform X1 [KO:K04520]
126945007  NEDD8-activating enzyme E1 regulatory subunit isoform X1 [KO:K04532]
126935040  amyloid beta precursor protein binding family B member 1 isoform X1 [KO:K04529]
126930446  glyceraldehyde-3-phosphate dehydrogenase isoform X1 [KO:K00134] [EC:1.2.1.12]
126932591  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
126936330  beta-secretase 1 [KO:K04521] [EC:3.4.23.46]
126950688  beta-secretase 2 isoform X1 [KO:K07747] [EC:3.4.23.45]
126935555  reticulon-3 isoform X1 [KO:K20723]
126934143  reticulon-4 isoform X1 [KO:K20720]
126941941  gamma-secretase subunit PEN-2 [KO:K06170]
126959532  presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
126935884  presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
126935696  nicastrin [KO:K06171]
126932275  gamma-secretase subunit APH-1A [KO:K06172]
126957992  gamma-secretase subunit APH-1B [KO:K06172]
126962846  insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
126947517  neprilysin [KO:K01389] [EC:3.4.24.11]
126938919  microtubule-associated protein tau isoform X1 [KO:K04380]
126953300  LOW QUALITY PROTEIN: microtubule-associated protein tau-like [KO:K04380]
126947324  NADH-ubiquinone oxidoreductase chain 5-like [KO:K03883] [EC:7.1.1.2]
126935373  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
126930135  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
126941129  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
126950655  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
126932207  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
126946139  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
126941467  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
126957346  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
126950258  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
126942379  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
126942872  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
126943346  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
126944267  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
126956821  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
126930414  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
126962403  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126956036  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126949986  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
126963966  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126945886  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126958389  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126960684  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126949375  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
126938104  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
126949807  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
126960621  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
126953759  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
126963639  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 isoform X1 [KO:K03950]
126942854  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
126937961  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
126931739  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
126932556  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
126937587  acyl carrier protein, mitochondrial-like [KO:K03955]
126944402  acyl carrier protein, mitochondrial [KO:K03955]
126951198  acyl carrier protein, mitochondrial-like [KO:K03955]
126942837  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
126932729  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
126930310  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
126942362  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
126959705  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
126948765  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
126949662  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
126932125  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
126934097  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
126958757  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
126934260  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
126949249  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
126939064  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
126935141  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
126948391  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
126937431  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
126942449  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
126963088  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
126944751  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
126939420  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
126950876  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
126934694  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
126961397  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
126944752  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
126930302  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial-like [KO:K11351]
126945660  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
126932178  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
126935729  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
126935957  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like [KO:K03935] [EC:7.1.1.2]
126936392  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
126945830  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial-like [KO:K03936] [EC:7.1.1.2]
126956863  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
126938277  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
126963401  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
126960994  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 isoform X1 [KO:K03938]
126961122  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
126957428  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
126942790  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
126935402  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
126954622  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
126935701  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
126956207  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
126957442  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
126955714  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
126961462  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
126936808  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
126962850  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
126956192  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
126950253  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
126961220  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
126935807  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
126930673  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
126943623  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
126960981  cytochrome c1, heme protein, mitochondrial isoform X1 [KO:K00413]
126948676  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
126944495  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
126954785  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
126961549  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
126937178  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
126934429  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
126960839  cytochrome b-c1 complex subunit 7 [KO:K00417]
126954793  cytochrome b-c1 complex subunit 8-like [KO:K00418]
126956035  cytochrome b-c1 complex subunit 8 [KO:K00418]
126963991  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
126942883  cytochrome b-c1 complex subunit 10 [KO:K00420]
126944333  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
126964308  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
126934981  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
126959142  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
126960028  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
126936073  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
126956094  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
126934339  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
126944266  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
126946802  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
126943264  cytochrome c oxidase subunit 6B2 [KO:K02267]
126939820  cytochrome c oxidase subunit 6B1-like [KO:K02267]
126941943  cytochrome c oxidase subunit 6B1 [KO:K02267]
126954498  cytochrome c oxidase subunit 6C [KO:K02268]
126961151  cytochrome c oxidase subunit 6C [KO:K02268]
126946168  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
126934205  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
126946829  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
126951565  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
126952142  cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270]
126942121  cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270]
126955253  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
126946324  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
126942189  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
126930116  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126943807  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126956722  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126938620  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126957169  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126957397  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
126958011  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126933618  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
126946671  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126958869  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126952688  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126960733  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126959711  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
126935615  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
126941410  ATP synthase subunit alpha, mitochondrial [KO:K02132]
126930379  ATP synthase subunit beta, mitochondrial isoform X1 [KO:K02133] [EC:7.1.2.2]
126962920  ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
126942994  ATP synthase subunit delta, mitochondrial isoform X1 [KO:K02134]
126929356  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
126930054  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
126955326  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
126951623  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
126954576  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
126942840  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
126930915  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
126931179  ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
126963773  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
126932708  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
126964152  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
126939892  ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
126940287  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
126959053  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
126949063  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
126954618  ATP synthase subunit d, mitochondrial-like [KO:K02138]
126939263  ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
126934985  ATP synthase subunit d, mitochondrial-like [KO:K02138]
126933171  ATP synthase subunit O, mitochondrial-like [KO:K02137]
126950727  ATP synthase subunit O, mitochondrial [KO:K02137]
126950759  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
126946552  3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
126955734  peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
126946601  LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase D-like [KO:K05864] [EC:5.2.1.8]
126956005  voltage-dependent anion-selective channel protein 1 [KO:K05862]
126962446  voltage-dependent anion-selective channel protein 2 [KO:K15040]
126960768  voltage-dependent anion-selective channel protein 3 [KO:K15041]
126955617  ADP/ATP translocase 4 isoform X1 [KO:K05863]
126955724  ADP/ATP translocase 1 [KO:K05863]
126946121  ADP/ATP translocase 2 [KO:K05863]
126946856  ADP/ATP translocase 3 [KO:K05863]
126947143  ADP/ATP translocase 3 [KO:K05863]
126962461  peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
126961448  lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
126943443  apolipoprotein E [KO:K04524]
126930356  prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
126963192  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
126930443  tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
126935972  FAS-associated death domain protein [KO:K02373]
126932110  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
126929772  BH3-interacting domain death agonist [KO:K04726]
126961592  calmodulin-1-like [KO:K02183]
126962311  calmodulin-like protein 5 [KO:K02183]
126962328  calmodulin-like protein 3 [KO:K02183]
126943484  calmodulin-3 isoform X1 [KO:K02183]
126958173  LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
126951481  calmodulin-1-like [KO:K02183]
126934255  calmodulin-2 [KO:K02183]
126952282  calmodulin-like protein 6 [KO:K02183]
126959699  calmodulin-1 isoform X1 [KO:K02183]
126954988  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
126962430  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
126961264  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
126937786  calcineurin subunit B type 2 [KO:K06268]
126934067  calcineurin subunit B type 1 isoform X1 [KO:K06268]
126935617  bcl2-associated agonist of cell death [KO:K02158]
126949081  cytochrome c-like [KO:K08738]
126961774  cytochrome c-like [KO:K08738]
126936610  cytochrome c-like [KO:K08738]
126937973  cytochrome c-like [KO:K08738]
126944405  cytochrome c-like [KO:K08738]
126932751  cytochrome c-like [KO:K08738]
126951393  cytochrome c [KO:K08738]
126947125  cytochrome c-like [KO:K08738]
126941401  cytochrome c-like [KO:K08738]
126952962  cytochrome c-like [KO:K08738]
126942126  cytochrome c-like [KO:K08738]
126931282  apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
126929188  LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
126954341  caspase-3 [KO:K02187] [EC:3.4.22.56]
126935320  muscarinic acetylcholine receptor M1 [KO:K04129]
126942792  muscarinic acetylcholine receptor M3 [KO:K04131]
126958839  muscarinic acetylcholine receptor M5 [KO:K04133]
126934742  metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
126937577  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
126964414  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
126959796  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
126964415  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
126935554  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
126936897  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
126944576  glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
126930739  glutamate receptor ionotropic, NMDA 2B [KO:K05210]
126939160  glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
126943541  glutamate receptor ionotropic, NMDA 2D [KO:K05212]
126930225  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
126948779  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
126945535  voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
126939641  voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
126957899  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
126962518  calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
126944456  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
126929669  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126958870  ryanodine receptor 3 [KO:K04963]
126947659  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
126930046  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
126952707  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
126931431  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
126944432  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
126939937  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
126963975  LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
126930406  DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
126939534  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
126933911  eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
126936973  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
126952847  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
126942652  dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
126954697  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
126963142  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
126956917  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
126958657  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
126963745  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
126959174  proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
126950177  proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
126960062  proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
126940977  proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
126929078  proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
126930104  proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
126936605  proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
126950077  LOW QUALITY PROTEIN: proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
126959922  proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
126939764  proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
126937216  proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
126938564  proteasome subunit beta type-3 isoform X1 [KO:K02735] [EC:3.4.25.1]
126959288  proteasome subunit beta type-3-like [KO:K02735] [EC:3.4.25.1]
126960876  proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
126958306  proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
126952482  proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
126932440  proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
126949873  26S proteasome regulatory subunit 7 [KO:K03061]
126949685  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4-like [KO:K03062]
126959662  26S proteasome regulatory subunit 4 [KO:K03062]
126942045  26S proteasome regulatory subunit 6B [KO:K03063]
126958521  26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
126936384  26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
126939552  26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
126948430  26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
126932353  26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
126938459  26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
126930686  26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
126938351  26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
126938990  26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
126948827  26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
126944080  26S proteasome non-ATPase regulatory subunit 7 isoform X1 [KO:K03038]
126936318  26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
126932170  26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
126932948  26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
126942058  26S proteasome non-ATPase regulatory subunit 8 isoform X1 [KO:K03031]
126929075  proteasomal ubiquitin receptor ADRM1 [KO:K06691]
126949968  26S proteasome complex subunit SEM1 isoform X1 [KO:K10881]
126935004  caspase-12 [KO:K04741] [EC:3.4.22.-]
126930595  nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
126935563  calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
126937478  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
126938999  cyclin-dependent kinase 5 activator 1 [KO:K11716]
126942722  zinc transporter ZIP3 [KO:K14709]
126945603  zinc transporter ZIP1-like [KO:K14709]
126958367  zinc transporter ZIP2 [KO:K14709]
126934257  zinc transporter ZIP1 isoform X1 [KO:K14709]
126961607  zinc transporter ZIP4 [KO:K14710]
126931209  zinc transporter ZIP5 [KO:K14711]
126941040  zinc transporter ZIP6 isoform X1 [KO:K14712]
126952757  zinc transporter SLC39A7 [KO:K14713]
126955397  LOW QUALITY PROTEIN: metal cation symporter ZIP8 [KO:K14714]
126958778  zinc transporter ZIP9 isoform X1 [KO:K14715]
126932965  zinc transporter ZIP10 isoform X1 [KO:K14716]
126939914  zinc transporter ZIP11 isoform X1 [KO:K14717]
126963235  zinc transporter ZIP12 isoform X1 [KO:K14718]
126936386  zinc transporter ZIP13 isoform X1 [KO:K14719]
126961265  metal cation symporter ZIP14 isoform X1 [KO:K14720]
126931038  natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
126951617  cyclin-dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
126949239  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
126962014  caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
126954327  dickkopf-related protein 2 [KO:K02165]
126963253  dickkopf-related protein 1 [KO:K02165]
126960789  dickkopf-related protein 4 [KO:K02165]
126930178  proto-oncogene Wnt-1 [KO:K03209]
126930501  protein Wnt-2b [KO:K00182]
126951195  protein Wnt-2 [KO:K00182]
126936033  protein Wnt-3a [KO:K00312]
126938314  proto-oncogene Wnt-3 [KO:K00312]
126956796  protein Wnt-4 [KO:K00408]
126930247  protein Wnt-5b [KO:K00444]
126947624  protein Wnt-5a isoform X1 [KO:K00444]
126933008  protein Wnt-6 isoform X1 [KO:K00445]
126949140  protein Wnt-7a [KO:K00572]
126963624  protein Wnt-7b isoform X1 [KO:K00572]
126963076  protein Wnt-8b [KO:K00714]
126957556  protein Wnt-8a [KO:K00714]
126938932  protein Wnt-9b isoform X1 [KO:K01064]
126935947  protein Wnt-9a isoform X1 [KO:K01064]
126930177  protein Wnt-10b [KO:K01357]
126933003  protein Wnt-10a [KO:K01357]
126935098  protein Wnt-11 isoform X1 [KO:K01384]
126950813  protein Wnt-16 [KO:K01558]
126932182  frizzled-7 [KO:K02432]
126949919  frizzled-1 [KO:K02432]
126938678  frizzled-2 [KO:K02235]
126961767  frizzled-3 isoform X1 [KO:K02329]
126934903  frizzled-4 isoform X1 [KO:K02354]
126962319  LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
126933089  frizzled-5 [KO:K02375]
126960879  frizzled-6 isoform X1 [KO:K02376]
126930546  frizzled-10 [KO:K02842]
126950358  frizzled-9 [KO:K02842]
126930738  low-density lipoprotein receptor-related protein 6 [KO:K03068]
126935940  low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
126963728  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
126939681  segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
126951679  segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
126948407  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
126962089  proto-oncogene FRAT1 [KO:K03069]
126962094  GSK-3-binding protein FRAT2 [KO:K03096]
126943871  casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
126964242  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
126953128  casein kinase II subunit beta [KO:K03115]
126944825  axin-1 isoform X1 [KO:K02157]
126938336  axin-2 isoform X1 [KO:K04385]
126942456  LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
126956213  adenomatous polyposis coli protein isoform X1 [KO:K02085]
126948505  catenin beta-1 isoform X1 [KO:K02105]
126956791  casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
126940310  casein kinase I [KO:K08957] [EC:2.7.11.1]
126930365  kinesin heavy chain [KO:K10396]
126963379  kinesin-1 heavy chain isoform X1 [KO:K10396]
126932906  kinesin heavy chain [KO:K10396]
126943454  kinesin light chain 3 isoform X1 [KO:K10407]
126952395  kinesin light chain 4 isoform X1 [KO:K10407]
126959414  kinesin light chain 1 isoform X1 [KO:K10407]
126935351  kinesin light chain 2 [KO:K10407]
126962351  tubulin alpha chain-like 3 [KO:K07374]
126930834  tubulin alpha-1B chain [KO:K07374]
126930835  tubulin alpha-1A chain isoform X1 [KO:K07374]
126930836  tubulin alpha-1C chain [KO:K07374]
126932997  tubulin alpha-4A chain isoform X1 [KO:K07374]
126947927  tubulin alpha-3E chain [KO:K07374]
126929646  tubulin alpha-3 chain [KO:K07374]
126929647  tubulin alpha-8 chain [KO:K07374]
126942625  tubulin beta-4A chain [KO:K07375]
126961754  tubulin beta-8 chain [KO:K07375]
126936994  tubulin beta-4B chain [KO:K07375]
126956508  tubulin beta-8 chain-like [KO:K07375]
126941215  tubulin beta-6 chain isoform X1 [KO:K07375]
126947941  tubulin beta-8 chain-like [KO:K07375]
126952529  tubulin beta-2A chain isoform X1 [KO:K07375]
126953079  tubulin beta chain isoform X1 [KO:K07375]
126929351  tubulin beta-1 chain [KO:K07375]
126944112  uncharacterized protein LOC126944112 [KO:K07375]
126953221  advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
126935869  GTPase HRas isoform X1 [KO:K02833]
126931572  GTPase KRas [KO:K07827]
126930824  GTPase NRas [KO:K07828]
126945567  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
126949633  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
126949054  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
126957976  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
126942673  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
126945851  NADPH oxidase 1 [KO:K08008]
126946357  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
126934745  NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
126935358  transcription factor p65 isoform X1 [KO:K04735]
126955390  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
126938749  nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
126950108  prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
126953141  tumor necrosis factor isoform X1 [KO:K03156]
126950025  interleukin-6 isoform X1 [KO:K05405]
126933365  interleukin-1 alpha isoform X1 [KO:K04383]
126933366  interleukin-1 beta [KO:K04519]
126929640  macrophage colony-stimulating factor 1 [KO:K05453]
126954709  alpha-synuclein isoform X1 [KO:K04528]
126933547  interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
126963067  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
126960750  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
126945470  NF-kappa-B essential modulator isoform X1 [KO:K07210]
126935873  insulin isoform X1 [KO:K04526]
126942469  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
126932885  insulin receptor substrate 1 [KO:K16172]
126940155  insulin receptor substrate 2 [KO:K07187]
126945702  insulin receptor substrate 4 [KO:K17446]
126961422  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
126956531  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
126942202  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
126947557  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126952893  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
126948170  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
126943096  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126959416  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126942032  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126952739  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
126930540  serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
126939023  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
126931061  autophagy-related protein 101 [KO:K19730]
126935748  autophagy-related protein 13 isoform X1 [KO:K08331]
126961411  RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
126935738  activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
126942963  beclin-2 [KO:K08334]
126938472  beclin-1 isoform X1 [KO:K08334]
126947014  phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
126959336  beclin 1-associated autophagy-related key regulator [KO:K17889]
126962156  nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
126941247  phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
126959628  autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
126935549  autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
126938352  WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
126950483  WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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pathway
mthb00190  Oxidative phosphorylation
mthb03050  Proteasome
mthb04020  Calcium signaling pathway
mthb04140  Autophagy - animal
mthb04141  Protein processing in endoplasmic reticulum
mthb04210  Apoptosis
mthb04310  Wnt signaling pathway
mthb04910  Insulin signaling pathway
mthb04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
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