KEGG   PATHWAY: oml04144
Entry
oml04144                    Pathway                                
Name
Endocytosis - Oryzias melastigma (Indian medaka)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
oml04144  Endocytosis
oml04144

Other DBs
GO: 0006897
Organism
Oryzias melastigma (Indian medaka) [GN:oml]
Gene
112157682  arf6a; ADP-ribosylation factor 6a [KO:K07941]
112146706  arf6b; ADP-ribosylation factor 6b [KO:K07941]
112147669  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X2 [KO:K00889] [EC:2.7.1.68]
112148384  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
112162658  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3 [KO:K00889] [EC:2.7.1.68]
112162738  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
112143876  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
112150492  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
112142145  putative PIP5K1A and PSMD4-like protein [KO:K00889] [EC:2.7.1.68]
112142405  pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
112152484  pld1b; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
112146779  pld1a; phospholipase D1a isoform X1 [KO:K01115] [EC:3.1.4.4]
112162872  dnm1a; dynamin-1a isoform X1 [KO:K01528] [EC:3.6.5.5]
112147106  dnm3b; dynamin-3 [KO:K01528] [EC:3.6.5.5]
112160045  dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
112145516  dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
112146673  dnm2a; dynamin-3 isoform X2 [KO:K23484] [EC:3.6.5.5]
112137390  clta; clathrin light chain A isoform X1 [KO:K04644]
112153115  cltb; clathrin light chain B isoform X1 [KO:K04645]
112148239  cltcl1; clathrin heavy chain 1 isoform X1 [KO:K04646]
112139527  cltca; clathrin, heavy chain a (Hc) isoform X1 [KO:K04646]
112153358  clathrin heavy chain 1 isoform X1 [KO:K04646]
112145974  ap2a1; AP-2 complex subunit alpha-1 [KO:K11824]
112160370  AP-2 complex subunit alpha-2 [KO:K11824]
112142550  ap2b1; AP-2 complex subunit beta isoform X1 [KO:K11825]
112147352  AP-2 complex subunit mu-A isoform X1 [KO:K11826]
112149435  ap2s1; AP-2 complex subunit sigma [KO:K11827]
112148996  ehd2b; EH domain-containing protein 2b isoform X1 [KO:K12469]
112149846  EH domain-containing protein 2 [KO:K12469]
112139043  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
112155588  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112162680  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112162776  zfyve16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
112150484  zfyve9b; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
112152005  zfyve9a; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
112148478  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
112160873  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
112151523  tfr1b; transferrin receptor 1b isoform X4 [KO:K06503]
112147141  transferrin receptor protein 1 [KO:K06503]
112147305  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
112151354  melanoma receptor tyrosine-protein kinase [KO:K04361] [EC:2.7.10.1]
112137012  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
112161613  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
112136376  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca [KO:K05093] [EC:2.7.10.1]
112139739  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
112142653  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
112160640  igf1rb; LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
112152311  igf1ra; insulin-like growth factor 1a receptor isoform X2 [KO:K05087] [EC:2.7.10.1]
112142874  E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
112149910  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
112140505  cblb; E3 ubiquitin-protein ligase CBL-B-B [KO:K22517] [EC:2.3.2.27]
112143591  cblc; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
112151195  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
112139945  endophilin-A1 [KO:K11247]
112160674  endophilin-A3 isoform X1 [KO:K11247]
112147606  endophilin-A2 isoform X1 [KO:K11247]
112157004  sh3gl2a; SH3 domain containing GRB2 like 2a, endophilin A1 isoform X1 [KO:K11247]
112136958  sh3gl1b; SH3-domain GRB2-like 1b [KO:K11247]
112140488  endophilin-B1 [KO:K11248]
112151432  sh3glb1a; endophilin-B1a [KO:K11248]
112140334  endophilin-B2 isoform X1 [KO:K21269]
112137772  endophilin-B2 isoform X1 [KO:K21269]
112154993  myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
112144267  amph; amphiphysin isoform X1 [KO:K12562]
112156767  bin1b; myc box-dependent-interacting protein 1b isoform X1 [KO:K12562]
112143214  epn1; epsin-1 isoform X1 [KO:K12471]
112136541  zgc:194578; epsin-1 isoform X2 [KO:K12471]
112146239  epn2; epsin-2 isoform X1 [KO:K12471]
112146774  epn3a; epsin-3 isoform X1 [KO:K12471]
112147568  eps15l1b; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
112150093  eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
112136793  eps15l1a; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
112147086  uncharacterized protein LOC112147086 [KO:K12472]
112142888  spartin [KO:K19366]
112143049  spartin isoform X1 [KO:K19366]
112149662  spartb; spartin b isoform X1 [KO:K19366]
112160718  nedd4a; E3 ubiquitin-protein ligase NEDD4a isoform X1 [KO:K10591] [EC:2.3.2.26]
112162993  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
112154812  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
112161172  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
112159813  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
112144968  itcha; itchy E3 ubiquitin protein ligase a isoform X1 [KO:K05632] [EC:2.3.2.26]
112158896  itchb; itchy E3 ubiquitin protein ligase b [KO:K05632] [EC:2.3.2.26]
112137440  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
112145976  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
112146480  smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
112151160  NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
112157423  ldlrb; low-density lipoprotein receptor [KO:K12473]
112146091  ldlra; low density lipoprotein receptor a [KO:K12473]
112147837  ldlrap1b; low density lipoprotein receptor adapter protein 1b isoform X1 [KO:K12474]
112156206  si:dkey-19b23.8; uncharacterized protein si:dkey-19b23.8 [KO:K12474]
112136333  ldlrap1a; low density lipoprotein receptor adapter protein 1a isoform X1 [KO:K12474]
112158392  si:dkey-71h2.2; low density lipoprotein receptor adapter protein 1 isoform X2 [KO:K12474]
112162866  dab2; disabled homolog 2 isoform X1 [KO:K12475]
112143153  C-C chemokine receptor type 5-like [KO:K04180]
112155304  C-X-C chemokine receptor type 2 [KO:K05050]
112155186  cxcr2; C-X-C chemokine receptor type 2 [KO:K05050]
112160110  C-X-C chemokine receptor type 2 isoform X1 [KO:K05050]
112147558  C-X-C chemokine receptor type 4 isoform X2 [KO:K04189]
112154780  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
112154953  rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
112149333  grk7b; rhodopsin kinase grk7-b [KO:K00909] [EC:2.7.11.14]
112144202  rhodopsin kinase grk7a [KO:K00909] [EC:2.7.11.14]
112160365  grk1a; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
112163042  grk3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
112141415  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
112148836  grk5l; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
112162856  G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
112139372  grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
112142851  arrestin red cell [KO:K04439]
112149476  arrb1; beta-arrestin-1 [KO:K04439]
112155778  waslb; WASP like actin nucleation promoting factor b [KO:K23612]
112144574  si:dkey-197j19.6; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
112161632  actin-related protein 2-B [KO:K17260]
112156140  zgc:101810; actin-related protein 2 [KO:K17260]
112156854  actin-related protein 3 [KO:K18584]
112151215  actin-related protein 3B [KO:K18584]
112138020  actin-related protein 3 [KO:K18584]
112158338  zgc:86896; actin-related protein 2/3 complex subunit 1A-A [KO:K05757]
112137501  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
112137612  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
112160156  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
112163164  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
112139879  actin-related protein 2/3 complex subunit 4 [KO:K05755]
112145743  arpc4l; actin related protein 2/3 complex, subunit 4, like isoform X1 [KO:K05755]
112144201  actin-related protein 2/3 complex subunit 5-A [KO:K05754]
112150702  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
112161561  wipf1b; WAS/WASL-interacting protein family member 1 [KO:K19475]
112138097  wipf3; WAS/WASL-interacting protein family member 3 [KO:K19475]
112138116  wipf2a; WAS/WASL-interacting protein family member 2 [KO:K19475]
112149440  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
112143863  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
112158791  hspa1b; heat shock 70 kDa protein 1B [KO:K03283]
112139003  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
112139445  heat shock 70 kDa protein 1 [KO:K03283]
112139447  heat shock 70 kDa protein 1 [KO:K03283]
112150339  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
112152064  washc4; WASH complex subunit 4 [KO:K18465]
112143892  washc5; WASH complex subunit 5 [KO:K18464]
112161642  washc2c; WASH complex subunit 2 isoform X1 [KO:K18462]
112152136  wash1; WASH complex subunit 1 isoform X1 [KO:K18461]
112156187  washc3; WASH complex subunit 3 [KO:K18463]
112145358  F-actin-capping protein subunit alpha-1 [KO:K10364]
112158938  capza1b; F-actin-capping protein subunit alpha-1b [KO:K10364]
112139210  F-actin-capping protein subunit alpha-2 [KO:K10364]
112145017  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
112159151  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
112161016  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
112149167  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
112151822  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
112142656  snx12; sorting nexin-12 isoform X1 [KO:K17918]
112158533  snx3; sorting nexin-3 [KO:K17918]
112160772  usp8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
112136372  STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
112140944  ras-related protein Rab-7a-like [KO:K07897]
118598730  si:dkey-13a21.4; ras-related protein rab7 [KO:K07897]
112144682  ras-related protein Rab-7a [KO:K07897]
112158866  rab7a; ras-related protein Rab-7a [KO:K07897]
112146346  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
112155350  stam2; signal transducing adapter molecule 2 [KO:K04705]
112151790  tsg101a; tumor susceptibility 101a [KO:K12183]
112147885  mvb12bb; multivesicular body subunit 12Bb [KO:K12186]
112163121  mvb12ba; multivesicular body subunit 12Ba isoform X1 [KO:K12186]
112137566  mvb12a; multivesicular body subunit 12A [KO:K12186]
112160371  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
112141269  vps37d; vacuolar protein sorting-associated protein 37D [KO:K12185]
112148050  vps37ba; VPS37B subunit of ESCRT-I a [KO:K12185]
112137247  vps37a; vacuolar protein sorting-associated protein 37A [KO:K12185]
112137583  vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185]
112154130  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
112142360  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
112154673  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
112141861  charged multivesicular body protein 6 [KO:K12195]
112146985  charged multivesicular body protein 6 [KO:K12195]
112145623  charged multivesicular body protein 4b [KO:K12194]
112158807  chmp4ba; charged multivesicular body protein 4c [KO:K12194]
112152808  charged multivesicular body protein 4b [KO:K12194]
112151226  chmp4c; charged multivesicular body protein 4c [KO:K24782]
112143734  chmp3; charged multivesicular body protein 3 [KO:K12193]
112154592  chmp2a; charged multivesicular body protein 2a [KO:K12191]
112155352  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
112148855  chmp7; charged multivesicular body protein 7 [KO:K15053]
112147589  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
112136919  vacuolar protein sorting-associated protein 4B [KO:K12196]
112152805  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
112158005  vta1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
112140159  charged multivesicular body protein 1a-like [KO:K12197]
112142596  chmp1b; charged multivesicular body protein 1b [KO:K12197]
112152807  charged multivesicular body protein 1a [KO:K12197]
112147540  chmp5a; charged multivesicular body protein 5 [KO:K12198]
112151024  chmp5b; charged multivesicular body protein 5 [KO:K12198]
112161076  ist1; IST1 homolog isoform X1 [KO:K19476]
112136986  programmed cell death 6-interacting protein isoform X1 [KO:K12200]
112160373  spg21; maspardin [KO:K19367]
112141005  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
112161303  sorting nexin-1 [KO:K17917]
112151720  sorting nexin-1 isoform X1 [KO:K17917]
112153454  sorting nexin-2 isoform X1 [KO:K17917]
112161580  snx5; sorting nexin-5 [KO:K17920]
112148766  snx6; sorting nexin-6 isoform X1 [KO:K17920]
112145589  si:dkey-28n18.9; sorting nexin-6 [KO:K17920]
112144970  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
112158705  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
112151792  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
112137100  uncharacterized protein LOC112137100 [KO:K05069]
112146641  il2rb; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
112138762  cytokine receptor common subunit gamma isoform X2 [KO:K05070]
112140870  rho-related GTP-binding protein RhoA-C [KO:K04513]
112144861  transforming protein RhoA isoform X1 [KO:K04513]
112159206  transforming protein RhoA [KO:K04513]
112159207  transforming protein RhoA [KO:K04513]
112159660  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
112139742  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
112140061  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
112140148  major histocompatibility complex class I-related gene protein [KO:K06751]
112140149  major histocompatibility complex class I-related gene protein [KO:K06751]
112140150  major histocompatibility complex class I-related gene protein isoform X1 [KO:K06751]
112161787  major histocompatibility complex class I-related gene protein isoform X1 [KO:K06751]
112161849  zinc-alpha-2-glycoprotein-like isoform X2 [KO:K06751]
112161855  major histocompatibility complex class I-related gene protein isoform X2 [KO:K06751]
112161861  major histocompatibility complex class I-related gene protein [KO:K06751]
112161877  major histocompatibility complex class I-related gene protein-like [KO:K06751]
112161885  major histocompatibility complex class I-related gene protein [KO:K06751]
112161890  major histocompatibility complex class I-related gene protein [KO:K06751]
112162437  H-2 class I histocompatibility antigen, L-D alpha chain isoform X1 [KO:K06751]
112162561  H-2 class I histocompatibility antigen, alpha chain [KO:K06751]
112162562  H-2 class I histocompatibility antigen, alpha chain isoform X1 [KO:K06751]
112162565  class I histocompatibility antigen, F10 alpha chain isoform X1 [KO:K06751]
112162566  class I histocompatibility antigen, F10 alpha chain [KO:K06751]
112162569  H-2 class I histocompatibility antigen, Q7 alpha chain [KO:K06751]
112143896  class I histocompatibility antigen, F10 alpha chain [KO:K06751]
118597892  major histocompatibility complex class I-related gene protein-like [KO:K06751]
112138316  major histocompatibility complex class I-related gene protein-like [KO:K06751]
112162438  class I histocompatibility antigen, F10 alpha chain isoform X1 [KO:K06751]
112162568  H-2 class I histocompatibility antigen, L-D alpha chain-like [KO:K06751]
112162571  H-2 class I histocompatibility antigen, alpha chain-like isoform X1 [KO:K06751]
112138328  major histocompatibility complex class I-related gene protein-like [KO:K06751]
112161846  major histocompatibility complex class I-related gene protein isoform X1 [KO:K06751]
112162570  HLA class I histocompatibility antigen, B alpha chain [KO:K06751]
112144752  major histocompatibility complex class I-related gene protein [KO:K06751]
112144753  major histocompatibility complex class I-related gene protein [KO:K06751]
112144757  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
112138608  class I histocompatibility antigen, F10 alpha chain [KO:K06751]
112138609  H-2 class I histocompatibility antigen, alpha chain [KO:K06751]
112138610  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X2 [KO:K06751]
112139674  uncharacterized protein LOC112139674 [KO:K06751]
112149905  folr; folate receptor [KO:K13649]
112146967  rtbdn; retbindin [KO:K13649]
112139177  cav1; caveolin-1 [KO:K06278]
112145542  caveolin-2-like [KO:K12958]
112144785  zgc:172270; caveolin-2 [KO:K12958]
112159748  zgc:158296; caveolin-3 [KO:K12958]
112139170  cav2; caveolin-2 [KO:K12958]
112145315  cav3; caveolin-3 [KO:K12959]
112157898  ehd3; EH domain-containing protein 3 [KO:K12476]
112146313  ehd4; EH domain-containing protein 4 [KO:K12477]
112152206  eea1; early endosome antigen 1 [KO:K12478]
112162956  rab5aa; RAB5A, member RAS oncogene family, a [KO:K07887]
112136549  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
112137972  rab5b; ras-related protein Rab-5B isoform X1 [KO:K07888]
112146764  rab5c; ras-related protein Rab-5C [KO:K07889]
112140970  rabep1; rab GTPase-binding effector protein 1 isoform X2 [KO:K12480]
112159295  rabenosyn-5 [KO:K12481]
112161117  rab4a; ras-related protein Rab-4A [KO:K07879]
112160494  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
112153112  rufy1; RUN and FYVE domain-containing protein 1 [KO:K12482]
112153200  ehd1a; EH domain-containing protein 1a [KO:K12483]
112162670  vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
112154652  sorting nexin-4 [KO:K17919]
112155478  snx4; sorting nexin-4 isoform X1 [KO:K17919]
112144550  rab22a; ras-related protein Rab-22A [KO:K07891]
112151855  rab31; ras-related protein Rab-31 [KO:K07891]
112158047  rab10; ras-related protein Rab-10 [KO:K07903]
112147397  rab8a; ras-related protein Rab-8A isoform X1 [KO:K07901]
112150656  ras-related protein Rab-8A [KO:K07901]
112148618  rab35b; ras-related protein Rab-35b isoform X2 [KO:K07876]
112146319  si:dkey-16l2.16; ras-related protein Rab-35 [KO:K07876]
112140296  ras-related protein Rab-11A [KO:K07904]
112136661  rab11al; RAB11a, member RAS oncogene family, like [KO:K07904]
112147186  ras-related protein Rab-11B [KO:K07905]
112150496  ras-related protein Rab-11B [KO:K07905]
112150497  ras-related protein Rab-11B [KO:K07905]
112153622  uncharacterized protein LOC112153622 isoform X1 [KO:K12484]
112140778  calponin homology domain-containing protein DDB_G0272472 [KO:K12484]
112148210  rab11fip1a; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
112161784  rab11 family-interacting protein 2 [KO:K12484]
112136197  trichohyalin [KO:K12484]
112144987  rab11fip5a; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
112140594  zfyve27; protrudin [KO:K19368]
112139873  kinesin heavy chain isoform X3 [KO:K10396]
112156676  kinesin heavy chain isoform X1 [KO:K10396]
112151005  kinesin-1 heavy chain [KO:K10396]
112151007  kinesin-1 heavy chain [KO:K10396]
112144740  kif5ab; kinesin heavy chain isoform X1 [KO:K10396]
112158991  kif5aa; kinesin family member 5Aa [KO:K10396]
112154584  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
112141970  rab11 family-interacting protein 4A [KO:K12485]
112157215  rab11fip4b; rab11 family-interacting protein 4B isoform X1 [KO:K12485]
112146399  rab11fip4a; rab11 family-interacting protein 4A [KO:K12485]
112151185  partitioning defective 3 homolog isoform X1 [KO:K04237]
112151407  partitioning defective 3 homolog isoform X1 [KO:K04237]
112159141  pard6b; partitioning defective 6 homolog beta [KO:K06093]
112152883  pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
112160207  pard6gb; par-6 family cell polarity regulator gamma b [KO:K06093]
112141323  prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
112147460  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
112143725  cdc42l; cell division cycle 42, like [KO:K04393]
112144774  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
112137131  cell division control protein 42 homolog [KO:K04393]
112159133  cell division control protein 42 homolog isoform X1 [KO:K04393]
112139281  cell division control protein 42 homolog [KO:K04393]
112161512  stromal membrane-associated protein 1 isoform X1 [KO:K12486]
112162440  smap2; stromal membrane-associated protein 2 [KO:K12486]
112137290  stromal membrane-associated protein 1 [KO:K12486]
112149078  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
112148747  git2a; ARF GTPase-activating protein GIT2a isoform X4 [KO:K12487]
112163091  git2b; ARF GTPase-activating protein GIT2b isoform X5 [KO:K12487]
112139996  unm_sa1614; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
112144973  asap2a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2a isoform X1 [KO:K12488]
112151265  asap1b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
112138402  asap2b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2b [KO:K12488]
112147080  asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
112155828  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
112149685  zgc:162872; BAR_ACAPs and ArfGap_ACAP domain-containing protein [KO:K12489]
112150227  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
112144724  acap3b; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
112159488  acap3a; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
112149178  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X3 [KO:K18439]
112155880  zmp:0000000660; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
112137042  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [KO:K18440]
112153181  arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
112147159  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
112156744  agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
112145190  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K17848]
112159479  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
112145721  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
112140281  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 [KO:K12493]
112157798  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
112153989  PH and SEC7 domain-containing protein 1 [KO:K12494]
112161982  psda; PH and SEC7 domain-containing protein 1 isoform X1 [KO:K12494]
112136173  PH and SEC7 domain-containing protein 3 isoform X2 [KO:K12494]
112153338  psd2; PH and SEC7 domain-containing protein 2 [KO:K12494]
112139593  IQ motif and SEC7 domain-containing protein 2-like [KO:K12495]
112158869  IQ motif and SEC7 domain-containing protein 2 [KO:K12495]
112145379  iqsec1b; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
112158990  IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
112159131  iqsec2b; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
112152465  iqsec3b; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
112152660  iqsec3a; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
112153857  cytohesin-3 [KO:K18441]
112154439  cyth1b; cytohesin-1b isoform X1 [KO:K18441]
112143278  si:dkey-283b15.4; cytohesin-2 [KO:K18441]
112137120  cytohesin-4 [KO:K18441]
112145909  cytohesin-4 [KO:K18441]
112146299  cyth1a; cytohesin-1a isoform X1 [KO:K18441]
112146449  cytohesin-3 [KO:K18441]
112151183  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X2 [KO:K18442]
112159137  arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
112161657  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
112147275  arf1; ADP-ribosylation factor 1 [KO:K07937]
112154183  ADP-ribosylation factor 1 [KO:K07937]
112146600  arf2a; ADP-ribosylation factor 2a [KO:K07937]
112144946  ADP-ribosylation factor 3 [KO:K07938]
112159550  arf3a; ADP-ribosylation factor 3a [KO:K07938]
112157079  ADP-ribosylation factor 4 [KO:K07939]
112151729  ADP-ribosylation factor 4 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
oml04060  Cytokine-cytokine receptor interaction
oml04070  Phosphatidylinositol signaling system
oml04130  SNARE interactions in vesicular transport
oml04142  Lysosome
oml04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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