KEGG   PATHWAY: opi04024
Entry
opi04024                    Pathway                                
Name
cAMP signaling pathway - Ochotona princeps (American pika)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
opi04024  cAMP signaling pathway
opi04024

Other DBs
GO: 0019933
Organism
Ochotona princeps (American pika) [GN:opi]
Gene
101520874  VIP peptides isoform X1 [KO:K05264]
101530121  CRH; corticoliberin [KO:K05256]
101518768  glycoprotein hormones alpha chain [KO:K08522]
101519006  CGA; glycoprotein hormones alpha chain [KO:K08522]
101527343  lutropin subunit beta [KO:K08521]
101529037  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
101527959  TSHB; thyrotropin subunit beta [KO:K05251]
101521946  POMC; pro-opiomelanocortin [KO:K05228]
101522840  GCG; pro-glucagon [KO:K05259]
105942139  gastric inhibitory polypeptide [KO:K05258]
101527214  FSHB; follitropin subunit beta [KO:K05250]
101524664  NPPA; natriuretic peptides A [KO:K12334]
101532434  ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262]
101519586  ADRB1; beta-1 adrenergic receptor [KO:K04141]
101520586  ADRB2; beta-2 adrenergic receptor [KO:K04142]
101528562  DRD1; D(1A) dopamine receptor [KO:K04144]
101535903  DRD5; LOW QUALITY PROTEIN: D(1B) dopamine receptor [KO:K05840]
101533431  ADORA2A; adenosine receptor A2a [KO:K04266]
101520829  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
101516289  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
101529940  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
101530523  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
101527025  VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X1 [KO:K04590]
101519963  CRHR1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
101532200  CRHR2; corticotropin-releasing factor receptor 2 isoform X2 [KO:K04579]
101527912  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
101519121  TSHR; thyrotropin receptor [KO:K04249]
101533321  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
101525366  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
101519647  GIPR; gastric inhibitory polypeptide receptor [KO:K04580]
101516666  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
101527661  FSHR; follicle-stimulating hormone receptor [KO:K04247]
101521077  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
101526074  neuroendocrine secretory protein 55-like [KO:K04632]
101526700  EDN1; endothelin-1 [KO:K16366]
101536603  EDN2; endothelin-2 [KO:K16367]
101530533  EDN3; endothelin-3 [KO:K05227]
101532252  SST; somatostatin [KO:K05237]
101520247  NPY; pro-neuropeptide Y [KO:K05232]
101531797  GHRL; appetite-regulating hormone [KO:K05254]
101529945  OXT; oxytocin-neurophysin 1 [KO:K05243]
101529679  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
101531032  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
101519249  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
101528037  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
101525547  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
101526608  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101532237  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101521060  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
101526850  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
101534117  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
101532500  ADORA1; adenosine receptor A1 [KO:K04265]
101520268  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
101532882  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
101519511  SSTR1; somatostatin receptor type 1 [KO:K04217]
101518573  SSTR2; somatostatin receptor type 2 [KO:K04218]
101516787  SSTR5; somatostatin receptor type 5 [KO:K04221]
101535722  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
101535493  HCAR2; hydroxycarboxylic acid receptor 2 [KO:K08402]
101532650  FFAR2; free fatty acid receptor 2 [KO:K04328]
101518503  SUCNR1; succinate receptor 1 [KO:K10042]
101535590  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
101526303  OXTR; oxytocin receptor [KO:K04229]
101522971  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
101525340  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
101516368  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101531957  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
101533323  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101528674  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101529277  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101527552  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
101526286  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101528764  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
101519430  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101523667  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101517485  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101523050  adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
101534526  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
101520630  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
101522897  CNGA3; cyclic nucleotide-gated cation channel alpha-3 [KO:K04950]
101528418  CNGA4; cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
101525264  CNGB1; cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
101522169  CNGB3; LOW QUALITY PROTEIN: cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
101522293  CALM2; calmodulin-2 isoform X1 [KO:K02183]
101516106  CALM1; calmodulin-1 isoform X1 [KO:K02183]
101519171  CALML4; calmodulin-like protein 4 [KO:K02183]
101529054  CALML5; calmodulin-like protein 5 [KO:K02183]
101529298  CALML3; calmodulin-like protein 3 [KO:K02183]
101516467  CALM3; calmodulin-3 [KO:K02183]
101519593  calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
101528216  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X11 [KO:K04515] [EC:2.7.11.17]
101524356  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
101535936  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101525109  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
101526387  BVES; blood vessel epicardial substance [KO:K21108]
101527031  POPDC2; popeye domain-containing protein 2 [KO:K26206]
101525249  POPDC3; popeye domain-containing protein 3 [KO:K26207]
101518516  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
105942383  HCN2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
101533128  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
101517777  ABCC4; multidrug resistance-associated protein 4 isoform X1 [KO:K05673]
101523807  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
101534512  RAPGEF4; rap guanine nucleotide exchange factor 4 [KO:K04351]
101522344  RRAS; ras-related protein R-Ras [KO:K07829]
101521899  RRAS2; ras-related protein R-Ras2 [KO:K07830]
101523215  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101521179  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
101521854  PLCE1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
101531453  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101524844  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101518695  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
101516340  RAP1A; ras-related protein Rap-1A [KO:K04353]
101518056  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
101526247  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
101530917  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
101531375  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
101523885  VAV1; proto-oncogene vav [KO:K05730]
101532428  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101527518  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
101531979  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101529472  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101527484  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
101529450  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
101525255  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
101535305  transforming protein RhoA-like isoform X1 [KO:K04513]
101527677  AFDN; afadin [KO:K05702]
101519449  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101533851  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
101533024  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101532354  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101517982  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101528030  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101533296  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101519021  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101525801  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101526188  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
101534290  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101533612  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105942099  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
101529486  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101530701  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101525427  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101534210  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101525119  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
101516221  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101526425  PPP1R1B; protein phosphatase 1 regulatory subunit 1B [KO:K15494]
101525073  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101522201  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101533284  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101532574  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101532689  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101531761  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
101533371  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
101532921  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101523446  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101534608  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
101517073  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
101518802  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
101528222  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
101526067  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
101521685  JUN; transcription factor AP-1 [KO:K04448]
101521862  GLI3; transcriptional activator GLI3 [KO:K06230]
101523921  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
101521576  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
101522560  hedgehog-interacting protein [KO:K06231]
101536420  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101531611  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101530066  RELA; transcription factor p65 [KO:K04735]
101519303  SOX9; transcription factor SOX-9 isoform X1 [KO:K18435]
101519639  AMH; muellerian-inhibiting factor [KO:K04665]
101526820  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
101528083  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X2 [KO:K00232] [EC:1.3.3.6]
101519244  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
101518851  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101527899  F2R; proteinase-activated receptor 1 [KO:K03914]
101534340  BAD; bcl2-associated agonist of cell death [KO:K02158]
101528437  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
101530829  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
101533973  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101529033  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
101535284  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
101533210  TNNI3; troponin I, cardiac muscle [KO:K12044]
101531850  PLN; cardiac phospholamban [KO:K05852]
101534898  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
101528226  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
101534415  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101526944  RYR2; ryanodine receptor 2 [KO:K04962]
101526017  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X2 [KO:K05208]
101527561  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
101523627  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101536780  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
101535807  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101518204  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
101534582  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
101529951  GRIA1; glutamate receptor 1 isoform X2 [KO:K05197]
101529969  GRIA2; glutamate receptor 2 isoform X2 [KO:K05198]
101529293  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
101529444  GRIA4; glutamate receptor 4 isoform X2 [KO:K05200]
101535310  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
101527265  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
101529459  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 isoform X1 [KO:K01539] [EC:7.2.2.13]
101529874  sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
101525499  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 isoform X1 [KO:K01539] [EC:7.2.2.13]
101528092  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
101526976  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
101531594  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
101519981  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
101530725  FXYD1; phospholemman [KO:K13360]
101536442  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
101516219  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
101518840  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X2 [KO:K05850] [EC:7.2.2.10]
101535352  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
101519832  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
101531324  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X2 [KO:K05850] [EC:7.2.2.10]
101536063  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101524545  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101519864  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101529015  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101529313  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
101521260  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
101525897  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
101534500  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
101536684  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
101525470  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
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J Am Coll Cardiol 54:1747-62 (2009)
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Prog Biophys Mol Biol 85:261-78 (2004)
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Front Physiol 2:67 (2011)
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Mol Endocrinol 14:1962-75 (2000)
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Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
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J Cell Physiol 215:715-24 (2008)
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Related
pathway
opi00071  Fatty acid degradation
opi04015  Rap1 signaling pathway
opi04020  Calcium signaling pathway
opi04151  PI3K-Akt signaling pathway
opi04210  Apoptosis
opi04260  Cardiac muscle contraction
opi04340  Hedgehog signaling pathway
opi04720  Long-term potentiation
opi04740  Olfactory transduction
opi04972  Pancreatic secretion
opi04976  Bile secretion
KO pathway
ko04024   
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