KEGG   PATHWAY: uah05165
Entry
uah05165                    Pathway                                
Name
Human papillomavirus infection - Ursus arctos (brown bear)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
uah05165  Human papillomavirus infection
uah05165

Organism
Ursus arctos (brown bear) [GN:uah]
Gene
113240885  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
113240906  ITGA11; integrin alpha-11 [KO:K06587]
113240937  PKM; pyruvate kinase PKM isoform X2 [KO:K00873] [EC:2.7.1.40]
113241173  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
113241234  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
113241346  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
113241382  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
113241468  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
113241493  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
113241630  SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
113241737  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
113241808  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
113242050  THBS1; thrombospondin-1 [KO:K16857]
113242339  TBPL2; TATA box-binding protein-like 2 [KO:K03120]
113242466  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
113242584  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
113242735  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
113242822  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
113242823  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2 [KO:K09048]
113242838  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
113242985  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X2 [KO:K11219] [EC:2.7.10.2]
113243231  TCF7L1; transcription factor 7-like 1 [KO:K04490]
113243290  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
113243572  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
113243706  [KO:K06751]
113243710  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
113243711  TNF; tumor necrosis factor [KO:K03156]
113243732  TNXB; tenascin-X isoform X4 [KO:K06252]
113243767  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
113243812  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
113243878  [KO:K06751]
113243978  FADD; FAS-associated death domain protein [KO:K02373]
113243982  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
113244006  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
113244028  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
113244102  RELA; LOW QUALITY PROTEIN: transcription factor p65 [KO:K04735]
113244148  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
113244178  BAD; bcl2-associated agonist of cell death [KO:K02158]
113244182  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
113244227  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
113244232  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
113244264  FZD8; frizzled-8 [KO:K02375]
113244394  NRAS; GTPase NRas isoform X2 [KO:K07828]
113244420  WNT2B; protein Wnt-2b [KO:K00182]
113244432  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
113244483  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
113244620  ITGB4; integrin beta-4 isoform X3 [KO:K06525]
113244628  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
113244637  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
113244663  NHERF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
113244704  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
113245080  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
113245138  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
113245270  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
113245324  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
113245367  AXIN1; axin-1 isoform X1 [KO:K02157]
113245546  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
113245635  DLG3; LOW QUALITY PROTEIN: disks large homolog 3 [KO:K21098]
113245987  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
113246115  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
113246356  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
113247020  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113247109  TBP; TATA-box-binding protein [KO:K03120]
113247125  THBS2; thrombospondin-2 [KO:K04659]
113247197  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
113247257  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
113247468  WNT3A; protein Wnt-3a [KO:K00312]
113247507  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
113247647  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
113247705  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
113247748  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
113248307  PALS1; protein PALS1 isoform X1 [KO:K06091]
113248328  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
113248466  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
113248639  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
113248677  WNT10A; protein Wnt-10a [KO:K01357]
113248714  NOTCH3; neurogenic locus notch homolog protein 3 isoform X1 [KO:K20995]
113250049  HES6; transcription cofactor HES-6 isoform X1 [KO:K09087]
113250051  [KO:K11583]
113250163  [KO:K06751]
113250298  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
113250384  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
113250386  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
113250444  WNT6; protein Wnt-6 [KO:K00445]
113250491  FN1; fibronectin isoform X4 [KO:K05717]
113250522  FZD5; frizzled-5 [KO:K02375]
113250525  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
113250581  FZD7; frizzled-7 isoform X1 [KO:K02432]
113250592  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
113250654  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220]
113250684  ITGAV; integrin alpha-V isoform X3 [KO:K06487]
113250699  ITGA4; integrin alpha-4 [KO:K06483]
113250771  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
113250846  ITGB6; integrin beta-6 isoform X3 [KO:K06589]
113251259  CCNA1; cyclin-A1 [KO:K06627]
113251282  FOXO1; forkhead box protein O1 [KO:K07201]
113251325  RB1; retinoblastoma-associated protein [KO:K06618]
113251490  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
113251538  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
113251539  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
113251621  WNT8B; protein Wnt-8b [KO:K00714]
113251823  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
113251942  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
113251972  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
113252071  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
113252236  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
113252355  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
113252366  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
113252374  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
113252506  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
113252851  FZD6; frizzled-6 [KO:K02376]
113252853  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
113252919  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
113252979  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
113253020  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
113253229  LAMA1; laminin subunit alpha-1 isoform X2 [KO:K05637]
113253232  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
113253294  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
113253430  HES1; transcription factor HES-1 [KO:K06054]
113253557  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
113253775  ITGA9; integrin alpha-9 [KO:K06585]
113253816  CTNNB1; catenin beta-1 [KO:K02105]
113253922  [KO:K06238]
113253923  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
113253925  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
113253964  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
113253989  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113254017  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
113254396  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
113254486  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
113254577  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
113254597  PATJ; inaD-like protein isoform X1 [KO:K06092]
113254730  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
113254775  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' isoform X2 [KO:K03661]
113254799  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113254991  APC; adenomatous polyposis coli protein isoform X3 [KO:K02085]
113255163  THBS4; thrombospondin-4 [KO:K04659]
113255228  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
113255266  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
113255341  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
113255562  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
113255629  CCNA2; cyclin-A2 [KO:K06627]
113255691  MAML3; mastermind-like protein 3 isoform X1 [KO:K06061]
113256295  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
113256330  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
113256363  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
113256419  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
113256451  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
113256462  ITGA7; integrin alpha-7 isoform X3 [KO:K06583]
113256649  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
113256705  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
113256730  COMP; cartilage oligomeric matrix protein [KO:K04659]
113256765  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
113256862  LAMB2; laminin subunit beta-2 [KO:K06243]
113256990  WNT5A; protein Wnt-5a [KO:K00444]
113257053  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
113257147  TADA3; transcriptional adapter 3 isoform X1 [KO:K11315]
113257190  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
113257229  WNT7A; protein Wnt-7a [KO:K00572]
113257365  WNT1; proto-oncogene Wnt-1 [KO:K03209]
113257444  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
113257484  COL2A1; collagen alpha-1(II) chain [KO:K19719]
113257516  ITGA5; integrin alpha-5 isoform X4 [KO:K06484]
113257662  WNT10B; protein Wnt-10b [KO:K01357]
113257792  KRAS; GTPase KRas isoform X1 [KO:K07827]
113257870  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
113257972  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X7 [KO:K11643] [EC:5.6.2.-]
113257988  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
113257990  VWF; von Willebrand factor [KO:K03900]
113258003  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
113258043  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
113258061  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
113258151  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
113258223  [KO:K04632]
113258272  E2F1; transcription factor E2F1 isoform X2 [KO:K17454]
113258337  JAG1; protein jagged-1 [KO:K06052]
113258464  LAMB4; laminin subunit beta-4 [KO:K06245]
113258474  LAMB1; LOW QUALITY PROTEIN: laminin subunit beta-1 [KO:K05636]
113258573  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
113258648  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
113258722  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
113258768  GNAS; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
113258790  LAMA5; laminin subunit alpha-5 [KO:K06240]
113258887  RELN; reelin [KO:K06249] [EC:3.4.21.-]
113258968  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
113258976  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
113259415  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1 [KO:K09091]
113259434  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
113259467  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
113259790  FZD1; frizzled-1 [KO:K02432]
113259807  MAML2; mastermind-like protein 2 isoform X1 [KO:K06061]
113259981  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
113260072  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
113260096  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
113260108  COL1A2; collagen alpha-2(I) chain [KO:K06236]
113260290  [KO:K05414]
113260291  [KO:K05414]
113260293  [KO:K05414]
113260294  [KO:K05414]
113260295  IFNB1; interferon beta [KO:K05415]
113260470  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
113260525  NFX1; transcriptional repressor NF-X1 isoform X3 [KO:K12236]
113260787  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
113260915  COL6A2; LOW QUALITY PROTEIN: collagen alpha-2(VI) chain [KO:K06238]
113260927  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
113261040  VEGFA; LOW QUALITY PROTEIN: vascular endothelial growth factor A [KO:K05448]
113261138  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
113261164  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
113261281  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
113261302  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
113261534  [KO:K06751]
113261557  MAML1; mastermind-like protein 1 [KO:K06061]
113261712  IRF1; interferon regulatory factor 1 isoform X2 [KO:K09444]
113261735  TCF7; transcription factor 7 isoform X2 [KO:K02620]
113261737  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
113261780  WNT8A; protein Wnt-8a [KO:K00714]
113262099  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
113262137  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
113262153  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
113262259  CASP3; caspase-3 isoform X3 [KO:K02187] [EC:3.4.22.56]
113262283  TLR3; toll-like receptor 3 [KO:K05401]
113262587  TNN; tenascin-N [KO:K06252]
113262643  LAMB3; laminin subunit beta-3 isoform X3 [KO:K06244]
113262671  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
113262733  LAMC1; laminin subunit gamma-1 [KO:K05635]
113262734  LAMC2; laminin subunit gamma-2 [KO:K06246]
113262761  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
113262794  TNR; tenascin-R isoform X1 [KO:K06252]
113262825  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
113262966  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113263101  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
113263166  SPP1; osteopontin isoform X1 [KO:K06250]
113263194  COL6A1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
113263284  WNT2; protein Wnt-2 [KO:K00182]
113263593  UBE3A; ubiquitin-protein ligase E3A isoform X2 [KO:K10587] [EC:2.3.2.26]
113263868  ITGA1; integrin alpha-1 isoform X2 [KO:K06480]
113263908  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
113263933  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
113263944  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
113263990  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
113264101  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
113264707  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
113264714  LAMA4; laminin subunit alpha-4 isoform X2 [KO:K06241]
113264732  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
113264783  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
113264796  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
113264906  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
113264990  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
113265246  AXIN2; axin-2 isoform X1 [KO:K04385]
113265309  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
113265349  FZD2; frizzled-2 [KO:K02235]
113265351  ITGA2B; integrin alpha-IIb [KO:K06476]
113265410  [KO:K10389]
113265411  [KO:K10389]
113265420  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
113265609  ITGA3; integrin alpha-3 isoform X2 [KO:K06482]
113265614  COL1A1; collagen alpha-1(I) chain [KO:K06236]
113265620  CHAD; chondroadherin [KO:K06248]
113265668  [KO:K04393]
113265670  WNT3; proto-oncogene Wnt-3 [KO:K00312]
113266124  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
113266205  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
113266332  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
113266339  TNC; tenascin isoform X4 [KO:K06252]
113266506  WNT16; protein Wnt-16 [KO:K01558]
113266526  LAMC3; laminin subunit gamma-3 [KO:K06247]
113266547  TSC1; hamartin isoform X1 [KO:K07206]
113266692  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
113266766  RBPJ; recombining binding protein suppressor of hairless isoform X4 [KO:K06053]
113266887  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154]
113267036  PXN; LOW QUALITY PROTEIN: paxillin [KO:K05760]
113267061  OASL; 2'-5'-oligoadenylate synthase-like protein [KO:K14608]
113267107  FZD10; frizzled-10 [KO:K02842]
113267192  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113267235  TRAF3; TNF receptor-associated factor 3 isoform X2 [KO:K03174]
113267251  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2 [KO:K11584]
113267368  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
113267646  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
113267800  FZD9; frizzled-9 [KO:K02842]
113268102  ATP6V1H; V-type proton ATPase subunit H isoform X2 [KO:K02144]
113268232  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
113268247  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
113268357  HDAC1; histone deacetylase 1 isoform X2 [KO:K06067] [EC:3.5.1.98]
113268542  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
113268543  CDC42; cell division control protein 42 homolog [KO:K04393]
113268897  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
113269030  VTN; vitronectin [KO:K06251]
113269338  WNT11; protein Wnt-11 [KO:K01384]
113269385  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
113269406  FZD4; frizzled-4 [KO:K02354]
113269864  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X6 [KO:K02148]
113269945  FZD3; frizzled-3 isoform X1 [KO:K02329]
113269966  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
113270020  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
113270366  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
113270433  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X12 [KO:K10691] [EC:2.3.2.27]
113270510  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
113270537  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113270575  HES3; transcription factor HES-3 isoform X1 [KO:K09088]
113270610  HES5; transcription factor HES-5 [KO:K06055]
113270615  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
113270636  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]
113270654  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
113270655  HES4; transcription factor HES-4 [KO:K09089]
113270678  HES2; transcription factor HES-2 [KO:K09087]
113270858  CREBBP; CREB-binding protein isoform X3 [KO:K04498] [EC:2.3.1.48]
113271152  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
113271160  HES7; transcription factor HES-7 isoform X1 [KO:K09087]
113271290  LLGL1; LOW QUALITY PROTEIN: lethal(2) giant larvae protein homolog 1 [KO:K06094]
123000236  [KO:K06751]
125282300  HRAS; GTPase HRas isoform X1 [KO:K02833]
125283239  [KO:K05414]
125283240  [KO:K05414]
125283241  [KO:K05414]
125283243  [KO:K05414]
125283244  [KO:K05414]
125283245  [KO:K05414]
125283246  [KO:K05414]
125283247  [KO:K05414]
125283248  [KO:K05414]
125283564  [KO:K06751]
130541819  [KO:K11583]
130542428  [KO:K14608]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:20592731
  Authors
Moody CA, Laimins LA
  Title
Human papillomavirus oncoproteins: pathways to transformation.
  Journal
Nat Rev Cancer 10:550-60 (2010)
DOI:10.1038/nrc2886
Reference
PMID:25752815
  Authors
Chen J
  Title
Signaling pathways in HPV-associated cancers and therapeutic implications.
  Journal
Rev Med Virol 25 Suppl 1:24-53 (2015)
DOI:10.1002/rmv.1823
Reference
PMID:26008697
  Authors
Tummers B, Burg SH
  Title
High-risk human papillomavirus targets crossroads in immune signaling.
  Journal
Viruses 7:2485-506 (2015)
DOI:10.3390/v7052485
Reference
PMID:19684440
  Authors
Lehoux M, D'Abramo CM, Archambault J
  Title
Molecular mechanisms of human papillomavirus-induced carcinogenesis.
  Journal
Public Health Genomics 12:268-80 (2009)
DOI:10.1159/000214918
Reference
PMID:23164805
  Authors
Pang CL, Thierry F
  Title
Human papillomavirus proteins as prospective therapeutic targets.
  Journal
Microb Pathog 58:55-65 (2013)
DOI:10.1016/j.micpath.2012.11.002
Reference
PMID:19156753
  Authors
Yugawa T, Kiyono T
  Title
Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
  Journal
Rev Med Virol 19:97-113 (2009)
DOI:10.1002/rmv.605
Reference
PMID:17645777
  Authors
Narisawa-Saito M, Kiyono T
  Title
Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
  Journal
Cancer Sci 98:1505-11 (2007)
DOI:10.1111/j.1349-7006.2007.00546.x
Reference
PMID:11486705
  Authors
Wolf JK, Ramirez PT.
  Title
The molecular biology of cervical cancer.
  Journal
Cancer Invest 19:621-9 (2001)
DOI:10.1081/CNV-100104290
Reference
PMID:10793105
  Authors
zur Hausen H
  Title
Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
  Journal
J Natl Cancer Inst 92:690-8 (2000)
DOI:10.1093/jnci/92.9.690
Reference
PMID:16259056
  Authors
Kim YT, Zhao M
  Title
Aberrant cell cycle regulation in cervical carcinoma.
  Journal
Yonsei Med J 46:597-613 (2005)
DOI:10.3349/ymj.2005.46.5.597
Reference
PMID:15956361
  Authors
McCance DJ
  Title
Human papillomaviruses and cell signaling.
  Journal
Sci STKE 2005:pe29 (2005)
DOI:10.1126/stke.2882005pe29
Reference
PMID:15342967
  Authors
Motoyama S, Ladines-Llave CA, Luis Villanueva S, Maruo T
  Title
The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
  Journal
Kobe J Med Sci 50:9-19 (2004)
Reference
PMID:24316445
  Authors
Tommasino M
  Title
The human papillomavirus family and its role in carcinogenesis.
  Journal
Semin Cancer Biol 26:13-21 (2014)
DOI:10.1016/j.semcancer.2013.11.002
Reference
PMID:26295406
  Authors
Bello JO, Nieva LO, Paredes AC, Gonzalez AM, Zavaleta LR, Lizano M
  Title
Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
  Journal
Viruses 7:4734-55 (2015)
DOI:10.3390/v7082842
Reference
PMID:26289783
  Authors
Shah M, Anwar MA, Park S, Jafri SS, Choi S
  Title
In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
  Journal
Sci Rep 5:13446 (2015)
DOI:10.1038/srep13446
Reference
PMID:26797638
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
  Journal
Pathogens 5:E8 (2016)
DOI:10.3390/pathogens5010008
Reference
PMID:26147797
  Authors
Ganti K, Broniarczyk J, Manoubi W, Massimi P, Mittal S, Pim D, Szalmas A, Thatte J, Thomas M, Tomaic V, Banks L
  Title
The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
  Journal
Viruses 7:3530-51 (2015)
DOI:10.3390/v7072785
Reference
PMID:21954943
  Authors
Subbaiah VK, Kranjec C, Thomas M, Banks L
  Title
PDZ domains: the building blocks regulating tumorigenesis.
  Journal
Biochem J 439:195-205 (2011)
DOI:10.1042/BJ20110903
Reference
PMID:23175122
  Authors
Banks L, Pim D, Thomas M
  Title
Human tumour viruses and the deregulation of cell polarity in cancer.
  Journal
Nat Rev Cancer 12:877-86 (2012)
DOI:10.1038/nrc3400
Reference
PMID:19029942
  Authors
Thomas M, Narayan N, Pim D, Tomaic V, Massimi P, Nagasaka K, Kranjec C, Gammoh N, Banks L
  Title
Human papillomaviruses, cervical cancer and cell polarity.
  Journal
Oncogene 27:7018-30 (2008)
DOI:10.1038/onc.2008.351
Reference
PMID:19901438
  Authors
Jayshree RS, Sreenivas A, Tessy M, Krishna S
  Title
Cell intrinsic & extrinsic factors in cervical carcinogenesis.
  Journal
Indian J Med Res 130:286-95 (2009)
Reference
PMID:16862386
  Authors
Garnett TO, Duerksen-Hughes PJ
  Title
Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.
  Journal
Arch Virol 151:2321-35 (2006)
DOI:10.1007/s00705-006-0821-0
Reference
PMID:26022660
  Authors
Zhang L, Wu J, Ling MT, Zhao L, Zhao KN
  Title
The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
  Journal
Mol Cancer 14:87 (2015)
DOI:10.1186/s12943-015-0361-x
Reference
PMID:22078316
  Authors
Venuti A, Paolini F, Nasir L, Corteggio A, Roperto S, Campo MS, Borzacchiello G
  Title
Papillomavirus E5: the smallest oncoprotein with many functions.
  Journal
Mol Cancer 10:140 (2011)
DOI:10.1186/1476-4598-10-140
Reference
PMID:11753669
  Authors
DiMaio D, Mattoon D
  Title
Mechanisms of cell transformation by papillomavirus E5 proteins.
  Journal
Oncogene 20:7866-73 (2001)
DOI:10.1038/sj.onc.1204915
Reference
PMID:22262402
  Authors
Ganguly N
  Title
Human papillomavirus-16 E5 protein: oncogenic role and therapeutic value.
  Journal
Cell Oncol (Dordr) 35:67-76 (2012)
DOI:10.1007/s13402-011-0069-x
Reference
PMID:23731971
  Authors
DiMaio D, Petti LM
  Title
The E5 proteins.
  Journal
Virology 445:99-114 (2013)
DOI:10.1016/j.virol.2013.05.006
Reference
PMID:23403708
  Authors
De Marco F
  Title
Oxidative stress and HPV carcinogenesis.
  Journal
Viruses 5:708-31 (2013)
DOI:10.3390/v5020708
Reference
PMID:26643553
  Authors
Wieringa HW, van der Zee AG, de Vries EG, van Vugt MA
  Title
Breaking the DNA damage response to improve cervical cancer treatment.
  Journal
Cancer Treat Rev 42:30-40 (2016)
DOI:10.1016/j.ctrv.2015.11.008
Reference
PMID:19861444
  Authors
Chung CH, Gillison ML
  Title
Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications.
  Journal
Clin Cancer Res 15:6758-62 (2009)
DOI:10.1158/1078-0432.CCR-09-0784
Reference
PMID:11325599
  Authors
Koromilas AE, Li S, Matlashewski G
  Title
Control of interferon signaling in human papillomavirus infection.
  Journal
Cytokine Growth Factor Rev 12:157-70 (2001)
DOI:10.1016/S1359-6101(00)00023-X
Reference
PMID:10702232
  Authors
Park JS, Kim EJ, Kwon HJ, Hwang ES, Namkoong SE, Um SJ
  Title
Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis.
  Journal
J Biol Chem 275:6764-9 (2000)
DOI:10.1074/jbc.275.10.6764
Reference
PMID:22499770
  Authors
Sandberg A, Lindell G, Kallstrom BN, Branca RM, Danielsson KG, Dahlberg M, Larson B, Forshed J, Lehtio J
  Title
Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes.
  Journal
Mol Cell Proteomics 11:M112.016998 (2012)
DOI:10.1074/mcp.M112.016998
Reference
PMID:9990017
  Authors
Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P
  Title
Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
  Journal
Proc Natl Acad Sci U S A 96:1291-6 (1999)
DOI:10.1073/pnas.96.4.1291
Reference
PMID:15175323
  Authors
Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
  Journal
J Biol Chem 279:35664-70 (2004)
DOI:10.1074/jbc.M403385200
Reference
PMID:18505829
  Authors
Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
  Title
NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
  Journal
Mol Cell Biol 28:4819-28 (2008)
DOI:10.1128/MCB.01969-07
Reference
PMID:23536685
  Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
  Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
  Journal
J Virol 87:6062-72 (2013)
DOI:10.1128/JVI.00330-13
Related
pathway
uah04064  NF-kappa B signaling pathway
uah04110  Cell cycle
uah04115  p53 signaling pathway
uah04150  mTOR signaling pathway
uah04151  PI3K-Akt signaling pathway
uah04210  Apoptosis
uah04310  Wnt signaling pathway
uah04330  Notch signaling pathway
uah04510  Focal adhesion
uah04520  Adherens junction
uah04530  Tight junction
uah04612  Antigen processing and presentation
uah04620  Toll-like receptor signaling pathway
uah04630  JAK-STAT signaling pathway
KO pathway
ko05165   

DBGET integrated database retrieval system