KEGG   PATHWAY: pyu04510
Entry
pyu04510                    Pathway                                
Name
Focal adhesion - Herpailurus yagouaroundi (jaguarundi)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pyu04510  Focal adhesion
pyu04510

Other DBs
GO: 0005925
Organism
Herpailurus yagouaroundi (jaguarundi) [GN:pyu]
Gene
121009797  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
121010235  PXN; paxillin isoform X1 [KO:K05760]
121010339  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
121010340  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
121010516  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121011002  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121011033  [KO:K04659]
121011180  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
121011198  RHOA; transforming protein RhoA [KO:K04513]
121011444  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121011476  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
121011499  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
121011719  LAMB3; laminin subunit beta-3 [KO:K06244]
121011824  LAMC1; laminin subunit gamma-1 [KO:K05635]
121011826  LAMC2; laminin subunit gamma-2 [KO:K06246]
121011911  TNR; tenascin-R isoform X1 [KO:K06252]
121011915  TNN; tenascin-N [KO:K06252]
121012223  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
121012246  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
121012339  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
121012482  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
121012786  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
121013178  THBS2; thrombospondin-2 [KO:K04659]
121013479  LAMA2; laminin subunit alpha-2 [KO:K05637]
121013551  SHC3; SHC-transforming protein 3 [KO:K17448]
121013664  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
121013927  THBS4; thrombospondin-4 [KO:K04659]
121014117  VAV1; proto-oncogene vav [KO:K05730]
121014377  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
121014479  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
121014480  [KO:K06237]
121014604  ITGA8; integrin alpha-8 [KO:K06584]
121014630  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
121014969  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121015111  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121015188  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
121015308  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121015654  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
121016570  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121016741  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
121016805  FLNB; filamin-B isoform X1 [KO:K27392]
121016943  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
121017018  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
121017185  VTN; vitronectin [KO:K06251]
121017297  CRK; adapter molecule crk isoform X1 [KO:K04438]
121017467  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
121017536  ACTB; actin, cytoplasmic 1 [KO:K05692]
121017559  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
121017681  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
121017794  [KO:K04393]
121017912  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
121017923  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
121018052  ACTG1; actin, cytoplasmic 2 [KO:K05692]
121018087  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
121018202  PARVA; alpha-parvin isoform X1 [KO:K06275]
121018618  [KO:K06274]
121018669  ARHGAP35; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
121018827  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
121019369  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
121019527  EMP2; epithelial membrane protein 2 [KO:K26256]
121019662  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
121019932  LAMA5; laminin subunit alpha-5 [KO:K06240]
121020018  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
121020145  ITGB3; integrin beta-3 [KO:K06493]
121020417  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
121020585  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121020751  [KO:K16060]
121020761  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
121020801  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
121021060  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
121021126  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
121021239  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
121021402  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
121021683  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
121021803  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
121021890  SHC2; SHC-transforming protein 2 [KO:K17447]
121021950  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
121021991  VWF; von Willebrand factor [KO:K03900]
121022226  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121022241  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
121022329  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
121022813  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
121022826  HRAS; GTPase HRas isoform X1 [KO:K02833]
121023018  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121023034  CRKL; crk-like protein [KO:K04438]
121023384  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
121023688  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
121023732  VEGFB; vascular endothelial growth factor B [KO:K16858]
121023852  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
121023947  BAD; bcl2-associated agonist of cell death [KO:K02158]
121025062  FLNA; filamin-A isoform X1 [KO:K04437]
121025478  [KO:K04725] [EC:2.3.2.27]
121025662  VEGFD; vascular endothelial growth factor D [KO:K05449]
121025715  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
121025749  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
121025762  [KO:K06237]
121025897  CHAD; chondroadherin [KO:K06248]
121026171  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
121026716  [KO:K04659]
121026718  [KO:K04659]
121026924  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
121027050  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
121027214  JUN; transcription factor AP-1 [KO:K04448]
121027595  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
121027680  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
121028117  PDGFC; platelet-derived growth factor C [KO:K05450]
121028174  ZYX; zyxin [KO:K06273]
121028241  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
121028446  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
121028448  CAV1; caveolin-1 isoform X1 [KO:K06278]
121028449  CAV2; caveolin-2 isoform X1 [KO:K12958]
121028649  ITGB8; integrin beta-8 [KO:K06591]
121028725  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
121028796  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
121028845  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
121028897  LAMB1; laminin subunit beta-1 [KO:K05636]
121028898  LAMB4; laminin subunit beta-4 [KO:K06245]
121029442  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
121029504  VEGFA; vascular endothelial growth factor A [KO:K05448]
121029643  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
121029911  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
121029920  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
121030602  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
121030700  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
121030775  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
121030799  ITGAV; integrin alpha-V [KO:K06487]
121031012  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
121031029  FN1; fibronectin isoform X1 [KO:K05717]
121031628  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
121031737  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
121031963  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
121032059  PGF; placenta growth factor isoform X1 [KO:K16859]
121032358  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121032687  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
121032847  SPP1; osteopontin isoform X1 [KO:K06250]
121032895  [KO:K06253]
121033019  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121033084  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
121033118  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
121033141  [KO:K12757]
121033142  [KO:K12757]
121033166  LAMA1; laminin subunit alpha-1 [KO:K05637]
121033454  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
121033506  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
121033657  [KO:K06238]
121033659  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
121033660  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
121033733  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121034018  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121034375  LAMC3; laminin subunit gamma-3 [KO:K06247]
121034638  TLN1; talin-1 isoform X1 [KO:K06271]
121034886  TNC; tenascin isoform X1 [KO:K06252]
121035131  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
121035518  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
121035565  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
121035838  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
121035839  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
121036286  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
121036344  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
121036354  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
121036392  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
121036807  VCL; vinculin isoform X1 [KO:K05700]
121036923  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121037487  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
121037646  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
121037709  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
121038440  ITGA5; integrin alpha-5 [KO:K06484]
121038496  ITGB7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
121038661  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
121038897  EMP1; epithelial membrane protein 1 [KO:K26255]
121039327  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
121039641  VEGFC; vascular endothelial growth factor C [KO:K05449]
121039745  MYL5; myosin light chain 5 [KO:K12753]
121040200  [KO:K06275]
121040328  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
121040395  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
121040524  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
121040701  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
121040776  RAP1B; ras-related protein Rap-1b [KO:K07836]
121040972  ITGA7; LOW QUALITY PROTEIN: integrin alpha-7 [KO:K06583]
121040996  [KO:K06275]
121041241  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121041311  CAV3; caveolin-3 [KO:K12959]
121041482  THBS1; thrombospondin-1 [KO:K16857]
121041497  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
121041673  SHC4; SHC-transforming protein 4 [KO:K17449]
121041796  TLN2; talin-2 isoform X1 [KO:K06271]
121041863  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
121041896  ITGA11; integrin alpha-11 [KO:K06587]
121042263  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
121042474  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121043038  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
121044101  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
121044291  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
121044367  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
121044475  ITGA1; integrin alpha-1 [KO:K06480]
121044484  ITGA2; integrin alpha-2 [KO:K06481]
121044798  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
121044805  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
121044914  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
121045013  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
121045100  ITGA2B; integrin alpha-IIb [KO:K06476]
121045237  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
pyu04010  MAPK signaling pathway
pyu04060  Cytokine-cytokine receptor interaction
pyu04070  Phosphatidylinositol signaling system
pyu04110  Cell cycle
pyu04151  PI3K-Akt signaling pathway
pyu04310  Wnt signaling pathway
pyu04512  ECM-receptor interaction
pyu04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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