KEGG   PATHWAY: pyu04810
Entry
pyu04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Puma yagouaroundi (jaguarundi)
Class
Cellular Processes; Cell motility
Pathway map
pyu04810  Regulation of actin cytoskeleton
pyu04810

Other DBs
GO: 0030036
Organism
Puma yagouaroundi (jaguarundi) [GN:pyu]
Gene
121009797  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
121009845  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
121010195  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
121010235  PXN; paxillin isoform X1 [KO:K05760]
121010339  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
121010340  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
121010349  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
121010979  FGF18; fibroblast growth factor 18 [KO:K04358]
121011002  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121011070  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
121011198  RHOA; transforming protein RhoA [KO:K04513]
121011444  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121011476  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
121011499  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
121011574  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
121011744  PFN3; profilin-3 [KO:K05759]
121011831  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
121011897  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
121012223  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
121012246  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
121012339  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
121012482  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
121012732  FGF9; fibroblast growth factor 9 [KO:K04358]
121012740  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
121013020  RGCC; regulator of cell cycle RGCC [KO:K26108]
121013243  EZR; LOW QUALITY PROTEIN: ezrin [KO:K08007]
121013664  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
121013778  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
121014032  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
121014117  VAV1; proto-oncogene vav [KO:K05730]
121014270  [KO:K03914]
121014296  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
121014604  ITGA8; integrin alpha-8 [KO:K06584]
121014630  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
121014721  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
121014969  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121015111  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121015169  ENAH; protein enabled homolog isoform X1 [KO:K05746]
121015328  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
121015574  INSRR; insulin receptor-related protein isoform X1 [KO:K05086] [EC:2.7.10.1]
121015589  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
121015925  MYH10; myosin-10 isoform X1 [KO:K10352]
121016065  PFN1; profilin-1 [KO:K05759]
121016402  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
121016741  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
121016943  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
121017018  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
121017257  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
121017297  CRK; adapter molecule crk isoform X1 [KO:K04438]
121017356  ITGAE; integrin alpha-E isoform X1 [KO:K06524]
121017369  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
121017425  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
121017453  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
121017467  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
121017536  ACTB; actin, cytoplasmic 1 [KO:K05692]
121017559  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
121017588  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
121017590  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
121017681  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
121017794  [KO:K04393]
121017923  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
121018033  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
121018052  ACTG1; actin, cytoplasmic 2 [KO:K05692]
121018087  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
121018181  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
121018519  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
121018669  ARHGAP35; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
121018739  FGF21; fibroblast growth factor 21 [KO:K22429]
121018786  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
121019011  MYH14; myosin-14 [KO:K10352]
121019097  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
121019817  MYH11; myosin-11 [KO:K10352]
121020145  ITGB3; integrin beta-3 [KO:K06493]
121020166  [KO:K05757]
121020262  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
121020417  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
121020585  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121020761  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
121021060  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
121021239  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
121021267  [KO:K05764]
121021383  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
121021402  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
121021465  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
121021683  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
121021803  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
121021881  FGF22; fibroblast growth factor 22 [KO:K04358]
121021952  FGF23; fibroblast growth factor 23 [KO:K22428]
121021990  FGF6; fibroblast growth factor 6 [KO:K04358]
121022079  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
121022168  [KO:K06461]
121022199  [KO:K06462]
121022226  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121022236  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
121022241  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
121022669  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
121022813  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
121022826  HRAS; GTPase HRas isoform X1 [KO:K02833]
121022948  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
121022992  ITGAD; integrin alpha-D isoform X1 [KO:K06594]
121023018  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121023034  CRKL; crk-like protein [KO:K04438]
121023215  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
121023384  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
121023661  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
121023688  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
121023725  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
121023744  FGF19; fibroblast growth factor 19 [KO:K22603]
121023745  FGF4; fibroblast growth factor 4 [KO:K04358]
121023791  CFL1; cofilin-1 isoform X1 [KO:K05765]
121023965  INS; insulin [KO:K04526]
121023973  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
121024046  [KO:K05763]
121024061  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
121024395  [KO:K05763]
121024720  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 isoform X1 [KO:K05720]
121024901  [KO:K05759]
121025225  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
121025317  [KO:K06594]
121025338  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
121025344  FGF16; fibroblast growth factor 16 [KO:K04358]
121025715  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
121025806  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
121026094  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
121026761  [KO:K05768]
121026784  [KO:K05768]
121027050  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
121027201  C8B; complement component C8 beta chain isoform X1 [KO:K03998]
121027202  C8A; complement component C8 alpha chain [KO:K03997]
121027288  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
121027595  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
121027738  NRAS; GTPase NRas [KO:K07828]
121028117  PDGFC; platelet-derived growth factor C [KO:K05450]
121028241  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
121028280  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
121028403  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
121028649  ITGB8; integrin beta-8 [KO:K06591]
121029894  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
121030066  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
121030376  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
121030461  ACTR3; actin-related protein 3 [KO:K18584]
121030500  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
121030602  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
121030664  [KO:K05765]
121030700  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
121030775  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
121030789  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
121030799  ITGAV; integrin alpha-V [KO:K06487]
121030938  ABI2; abl interactor 2 isoform X1 [KO:K05751]
121030992  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
121031012  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
121031029  FN1; fibronectin isoform X1 [KO:K05717]
121031058  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
121031643  CFL2; cofilin-2 [KO:K05765]
121031737  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
121031963  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
121032260  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03915]
121032358  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121033118  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
121033141  [KO:K12757]
121033142  [KO:K12757]
121033454  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
121033707  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
121033726  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
121033733  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121033829  PFN2; profilin-2 isoform X1 [KO:K05759]
121034018  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121034124  KNG1; kininogen-1 isoform X1 [KO:K03898]
121034828  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
121034914  C5; complement C5 [KO:K03994]
121034923  GSN; gelsolin isoform X1 [KO:K05768]
121034984  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
121035357  RDX; radixin isoform X1 [KO:K05762]
121035535  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
121035565  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
121035856  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
121036015  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
121036344  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
121036354  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
121036392  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
121036807  VCL; vinculin isoform X1 [KO:K05700]
121036956  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
121037313  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
121037487  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
121037542  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
121037701  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
121037877  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
121038160  [KO:K05764]
121038348  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
121038433  NCKAP1L; nck-associated protein 1-like [KO:K05750]
121038440  ITGA5; integrin alpha-5 [KO:K06484]
121038496  ITGB7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
121038809  KRAS; GTPase KRas isoform X1 [KO:K07827]
121039327  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
121039432  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
121039745  MYL5; myosin light chain 5 [KO:K12753]
121039893  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
121039962  FGF20; fibroblast growth factor 20 [KO:K04358]
121040328  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
121040395  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
121040418  MYH9; myosin-9 [KO:K10352]
121040701  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
121040869  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
121040972  ITGA7; LOW QUALITY PROTEIN: integrin alpha-7 [KO:K06583]
121041241  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121041272  BRK1; protein BRICK1 isoform X1 [KO:K05752]
121041297  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
121041442  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
121041497  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
121041681  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
121041863  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
121041896  ITGA11; integrin alpha-11 [KO:K06587]
121042350  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
121042556  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
121042985  CYRIB; CYFIP-related Rac1 interactor B isoform X1 [KO:K27976]
121043038  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
121043464  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
121043474  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
121043652  [KO:K05765]
121043895  C9; complement component C9 [KO:K04000]
121044092  C7; complement component C7 isoform X1 [KO:K03996]
121044101  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
121044119  C6; complement component C6 [KO:K03995]
121044136  CYRIA; CYFIP-related Rac1 interactor A [KO:K27976]
121044195  PFN4; profilin-4 isoform X1 [KO:K05759]
121044291  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
121044367  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
121044420  FGF10; fibroblast growth factor 10 [KO:K04358]
121044475  ITGA1; integrin alpha-1 [KO:K06480]
121044484  ITGA2; integrin alpha-2 [KO:K06481]
121044805  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
121044891  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
121045013  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
121045100  ITGA2B; integrin alpha-IIb [KO:K06476]
121045237  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
pyu04010  MAPK signaling pathway
pyu04510  Focal adhesion
pyu04520  Adherens junction
KO pathway
ko04810   

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