Entry Name JAK-STAT signaling pathway - Rattus norvegicus (rat)
Description The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Rattus norvegicus (rat) [GN:
rno ]
Gene 114103 Il5ra; interleukin-5 receptor subunit alpha precursor [KO:K05067 ]
114851 Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625 ]
116465 Ifngr1; interferon gamma receptor 1 precursor [KO:K05132 ]
116630 Csf2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427 ]
117539 Il10ra; interleukin-10 receptor subunit alpha precursor [KO:K05134 ]
140924 Il2rg; cytokine receptor common subunit gamma precursor [KO:K05070 ]
155140 Il23a; interleukin-23 subunit alpha precursor [KO:K05426 ]
170911 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
171060 Il13ra2; interleukin-13 receptor subunit alpha-2 precursor [KO:K05077 ]
171081 Csf2rb; cytokine receptor common subunit beta precursor [KO:K04738 ]
171333 Il12rb1; interleukin-12 receptor subunit beta-1 precursor [KO:K05063 ]
171334 Il12rb2; interleukin-12 receptor subunit beta-2 precursor [KO:K05064 ]
171499 Crlf2; cytokine receptor-like factor 2 precursor [KO:K05078 ]
24336 Epor; erythropoietin receptor precursor [KO:K05079 ]
24387 Gfap; glial fibrillary acidic protein [KO:K05640 ]
24499 Il6r; interleukin-6 receptor subunit alpha precursor [KO:K05055 ]
245983 Il11ra1; interleukin-11 receptor subunit alpha precursor [KO:K05056 ]
246144 Il3ra; interleukin-3 receptor subunit alpha precursor [KO:K04737 ]
24628 Pdgfb; platelet-derived growth factor subunit B precursor [KO:K17386 ]
24684 Prlr; prolactin receptor isoform a precursor [KO:K05081 ]
24888 Bcl2l1; bcl-2-like protein 1 isoform 2 [KO:K04570 ]
24918 Stat5a; signal transducer and activator of transcription 5A [KO:K11223 ]
25084 Il4r; interleukin-4 receptor subunit alpha precursor [KO:K05071 ]
25124 Stat1; signal transducer and activator of transcription 1-alpha/beta isoform beta [KO:K11220 ]
25125 Stat3; signal transducer and activator of transcription 3 [KO:K04692 ]
25126 Stat5b; signal transducer and activator of transcription 5B [KO:K11224 ]
25177 Fhl1; four and a half LIM domains protein 1 isoform 3 [KO:K14365 ]
25205 Il6st; interleukin-6 receptor subunit beta precursor [KO:K05060 ]
25235 Ghr; growth hormone receptor precursor [KO:K05080 ]
25266 Pdgfa; platelet-derived growth factor subunit A precursor [KO:K04359 ]
25267 Pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363 ] [EC:2.7.10.1 ]
252963 Il13ra1; interleukin-13 receptor subunit alpha-1 precursor [KO:K05076 ]
252971 Socs1; suppressor of cytokine signaling 1 [KO:K04694 ]
25313 Egf; pro-epidermal growth factor precursor [KO:K04357 ]
25513 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
25610 Csf3; granulocyte colony-stimulating factor precursor [KO:K05423 ]
25622 Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform 2 [KO:K07293 ] [EC:3.1.3.48 ]
25704 Il2ra; interleukin-2 receptor subunit alpha precursor [KO:K05068 ]
25746 Il2rb; interleukin-2 receptor subunit beta precursor [KO:K05069 ]
287659 Socs7; suppressor of cytokine signaling 7 [KO:K04699 ]
288264 Ifnar1; interferon alpha/beta receptor 1 isoform 1 precursor [KO:K05130 ]
288774 Stat2; signal transducer and activator of transcription 2 [KO:K11221 ]
288905 Il27ra; interleukin-27 receptor subunit alpha precursor [KO:K19598 ]
294797 Il7r; interleukin-7 receptor subunit alpha precursor [KO:K05072 ]
29741 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
298213 Ifna2; interferon alpha family, gene 2 precursor [KO:K05414 ]
298518 Csf3r; granulocyte colony-stimulating factor receptor precursor [KO:K05061 ]
300772 Pias1; E3 SUMO-protein ligase PIAS1 [KO:K04706 ] [EC:2.3.2.-]
304091 Il10rb; interleukin-10 receptor subunit beta precursor [KO:K05135 ]
305828 Socs4; suppressor of cytokine signaling 4 [KO:K04697 ]
307200 Socs6; suppressor of cytokine signaling 6 [KO:K04699 ]
308716 Il20ra; interleukin-20 receptor subunit alpha precursor [KO:K05136 ]
310132 Osmr; oncostatin-M-specific receptor subunit beta precursor [KO:K05057 ]
311030 Stam2; signal transducing adapter molecule 2 [KO:K04705 ]
313173 Cntfr; ciliary neurotrophic factor receptor subunit alpha precursor [KO:K05059 ]
360697 Ifngr2; interferon gamma receptor 2 precursor [KO:K05133 ]
362628 Ifnlr1; interferon lambda receptor 1 precursor [KO:K05140 ]
362629 Il22ra1; interleukin-22 receptor subunit alpha-1 [KO:K05138 ]
362896 Stat6; signal transducer and activator of transcription 6 [KO:K11225 ]
365395 Clcf1; cardiotrophin-like cytokine factor 1 isoform 1 precursor [KO:K05421 ]
366508 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
367264 Stat4; signal transducer and activator of transcription 4 [KO:K11222 ]
367858 Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833 ]
444986 Il22ra2; interleukin-22 receptor subunit alpha-2 precursor [KO:K05139 ]
498798 Stam; signal transducing adapter molecule 1 [KO:K04705 ]
500491 Ifna16l1; interferon, alpha 16-like 1 precursor [KO:K05414 ]
500616 Socs5; suppressor of cytokine signaling 5 [KO:K04698 ]
501043 Il20rb; interleukin-20 receptor subunit beta [KO:K05137 ]
502959 Ifna1l1; similar to put. precursor MuIFN-alpha 5 precursor [KO:K05414 ]
502961 Ifna4l2; similar to Interferon alpha-1 precursor [KO:K05414 ]
60430 Mcl1; induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539 ]
60584 Lif; leukemia inhibitory factor precursor [KO:K05419 ]
60664 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
64546 Il12b; interleukin-12 subunit beta precursor [KO:K05425 ]
652957 Csf2ra; granulocyte-macrophage colony-stimulating factor receptor subunit alpha precursor [KO:K05066 ]
686326 Ifnar2; interferon alpha and beta receptor subunit 2 isoform 1 precursor [KO:K05131 ]
688621 Tslp; thymic stromal lymphopoietin isoform X1 [KO:K05436 ]
688622 Il31ra; interleukin-31 receptor subunit alpha precursor [KO:K22630 ]
689932 Il23r; interleukin-23 receptor isoform X1 [KO:K05065 ]
690369 Il15ra; interleukin-15 receptor subunit alpha precursor [KO:K05074 ]
690894 Ifna1; interferon alpha family, gene 5 precursor [KO:K05414 ]
81504 Grb2; growth factor receptor-bound protein 2 [KO:K04364 ]
81680 Lifr; leukemia inhibitory factor receptor precursor [KO:K05058 ]
83422 Pias2; E3 SUMO-protein ligase PIAS2 isoform 2 [KO:K16063 ] [EC:2.3.2.-]
83614 Pias3; E3 SUMO-protein ligase PIAS3 [KO:K16064 ] [EC:2.3.2.-]
83681 Cish; cytokine-inducible SH2-containing protein [KO:K04701 ]
84405 Il12a; interleukin-12 subunit alpha precursor [KO:K05406 ]
84607 Socs2; suppressor of cytokine signaling 2 [KO:K04695 ]
85243 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
89829 Socs3; suppressor of cytokine signaling 3 [KO:K04696 ]
Reference Authors Harrison DA
Title The Jak/STAT pathway.
Journal Reference Authors Kiu H, Nicholson SE
Title Biology and significance of the JAK/STAT signalling pathways.
Journal Reference Authors Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title Direct effects of type I interferons on cells of the immune system.
Journal Reference Authors Fish EN, Platanias LC
Title Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal Reference Authors Ivanenkov YA, Balakin KV, Lavrovsky Y
Title Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal Reference Authors O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal Reference Authors Zoranovic T, Grmai L, Bach EA
Title Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal Reference Authors Ungureanu D, Silvennoinen O
Title SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal Reference Authors Richard AJ, Stephens JM
Title The role of JAK-STAT signaling in adipose tissue function.
Journal Reference Authors Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal Reference Authors Hirano T, Ishihara K, Hibi M
Title Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal Reference Authors Rane SG, Reddy EP
Title Janus kinases: components of multiple signaling pathways.
Journal Reference Authors Heim MH
Title The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal Reference Authors Morris R, Kershaw NJ, Babon JJ
Title The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal Reference Authors Tzeng HT, Chyuan IT, Lai JH
Title Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal Reference Authors Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal Related rno04060 Cytokine-cytokine receptor interaction
KO pathway
