KEGG   PATHWAY: setr05161
Entry
setr05161                   Pathway                                
Name
Hepatitis B - Suncus etruscus (white-toothed pygmy shrew)
Description
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA. The cccDNA is the template for transcription of all viral RNAs including the pregenomic RNA (pgRNA), encoding for 7 viral proteins: large, middle, and small envelope proteins (LHBs, MHBs, and SHBs) that form the surface antigen (HBsAg), the core antigen (HBcAg), the e antigen (HBeAg), the HBV polymerase, and the regulatory protein X (HBx). The pgRNA interacts with the viral polymerase protein to initiate the encapsidation into the core particles. Through endoplasmic reticulum, the core particles finish assembling with the envelope proteins and are released. HBV infection leads to a wide spectrum of liver diseases raging from chronic hepatitis, cirrhosis to hepatocellular carcinoma. The mechanism of liver injury is still not clear. However, HBV proteins target host proteins, involved in a variety of functions, thus regulating transcription, cellular signaling cascades, proliferation, differentiation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
setr05161  Hepatitis B
setr05161

Disease
H00412  Hepatitis B
Organism
Suncus etruscus (white-toothed pygmy shrew) [GN:setr]
Gene
125996177  E2F3; transcription factor E2F3 [KO:K06620]
125996221  TNF; tumor necrosis factor [KO:K03156]
125996226  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
125996324  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
125996366  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
125996497  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
125997181  MYC; myc proto-oncogene protein [KO:K04377]
125997372  NRAS; GTPase NRas [KO:K07828]
125997897  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
125998025  TP53; LOW QUALITY PROTEIN: cellular tumor antigen p53 [KO:K04451]
125998044  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125998189  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
125998702  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
125998781  [KO:K04498] [EC:2.3.1.48]
125998783  [KO:K04498] [EC:2.3.1.48]
125999018  SOS2; son of sevenless homolog 2 [KO:K03099]
125999078  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
125999080  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
125999183  DDX3X; ATP-dependent RNA helicase DDX3X [KO:K11594] [EC:5.6.2.7]
125999215  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
125999333  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
125999355  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
126000416  [KO:K11594] [EC:5.6.2.7]
126001031  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
126001218  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
126001552  PIK3R1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
126001850  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
126002106  [KO:K08738]
126002675  IFNB1; interferon beta [KO:K05415]
126003310  EGR3; early growth response protein 3 isoform X1 [KO:K12497]
126003348  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
126003391  [KO:K15041]
126003414  TLR2; toll-like receptor 2 [KO:K10159]
126003551  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
126003615  [KO:K05414]
126003784  IFNA6; interferon alpha-6 [KO:K05414]
126003919  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
126004027  [KO:K16197]
126004037  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
126004042  FOS; protein c-Fos [KO:K04379]
126004140  SLC10A1; LOW QUALITY PROTEIN: hepatic sodium/bile acid cotransporter [KO:K14341]
126004459  CCNA2; cyclin-A2 [KO:K06627]
126004522  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
126006104  PTK2B; LOW QUALITY PROTEIN: protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
126006106  [KO:K11594] [EC:5.6.2.7]
126006111  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
126006193  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
126006234  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
126006273  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
126006324  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
126006370  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
126006407  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
126006491  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
126006575  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
126006708  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
126006816  TLR3; toll-like receptor 3 [KO:K05401]
126006870  [KO:K16197]
126006887  [KO:K02187] [EC:3.4.22.56]
126006901  [KO:K04450]
126007206  [KO:K02187] [EC:3.4.22.56]
126007207  [KO:K02187] [EC:3.4.22.56]
126008206  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
126008676  [KO:K04400] [EC:3.4.22.63]
126008735  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
126008918  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
126008959  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
126009005  STAT1; LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
126009008  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
126009035  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
126009077  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
126009210  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
126009470  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
126009607  TLR4; LOW QUALITY PROTEIN: toll-like receptor 4 [KO:K10160]
126009755  [KO:K08738]
126009984  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
126010754  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
126010825  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
126010979  JUN; transcription factor Jun [KO:K04448]
126011086  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
126011154  E2F2; transcription factor E2F2 [KO:K09389]
126011501  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
126011762  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
126012035  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
126012036  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126012179  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
126013417  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126013516  [KO:K08738]
126013713  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
126013729  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
126013791  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
126015505  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
126015663  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
126015667  [KO:K06626]
126015739  [KO:K08738]
126016071  [KO:K08738]
126016198  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
126016279  CCNA1; cyclin-A1 [KO:K06627]
126016334  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
126016454  [KO:K04741] [EC:3.4.22.-]
126016931  [KO:K11223]
126016963  [KO:K11224]
126017297  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
126017313  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
126017330  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
126017349  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
126017425  PCNA; proliferating cell nuclear antigen [KO:K04802]
126017431  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
126017556  E2F1; transcription factor E2F1 [KO:K17454]
126017658  DDB2; DNA damage-binding protein 2 [KO:K10140]
126017861  BAD; bcl2-associated agonist of cell death [KO:K02158]
126017912  DDB1; DNA damage-binding protein 1 [KO:K10610]
126017923  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
126017927  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
126018296  [KO:K04802]
126018803  FADD; FAS-associated death domain protein [KO:K02373]
126018828  IRF7; interferon regulatory factor 7 [KO:K09447]
126019025  RELA; transcription factor p65 [KO:K04735]
126019084  HRAS; GTPase HRas [KO:K02833]
126019129  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
126020038  [KO:K08738]
126020042  [KO:K08738]
126020077  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
126020129  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
126020260  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
126020311  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
126020515  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
126020600  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
126021869  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
126021920  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
126021976  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
126022154  STAT2; LOW QUALITY PROTEIN: signal transducer and activator of transcription 2 [KO:K11221]
126022683  BID; BH3-interacting domain death agonist [KO:K04726]
126022823  KRAS; GTPase KRas isoform X1 [KO:K07827]
126022862  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
126022904  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
126023016  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
126023864  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
126024011  [KO:K08738]
126024083  YWHAQ; 14-3-3 protein theta [KO:K16197]
126024144  [KO:K15041]
126024492  [KO:K11594] [EC:5.6.2.7]
126026058  [KO:K05130]
126026082  [KO:K05130]
126027203  IRF3; interferon regulatory factor 3 [KO:K05411]
126027215  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
126027342  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
126027544  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
126027978  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
126028133  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126028183  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
126028468  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
126029670  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
126029685  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
126029893  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
126030121  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
126030200  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
126030203  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
126030267  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
126030861  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126031061  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
126031102  [KO:K08738]
126031156  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
126032054  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
126032265  CXCL8; interleukin-8 [KO:K10030]
126033344  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
126033346  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126033633  EGR2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
126033690  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
126033704  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126033816  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
Compound
C00076  Calcium cation
Reference
PMID:30059722
  Authors
Caballero A, Tabernero D, Buti M, Rodriguez-Frias F
  Title
Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy.
  Journal
Antiviral Res 158:34-44 (2018)
DOI:10.1016/j.antiviral.2018.07.019
Reference
PMID:22869468
  Authors
Walsh R, Locarnini S
  Title
Hepatitis B precore protein: pathogenic potential and therapeutic promise.
  Journal
Yonsei Med J 53:875-85 (2012)
DOI:10.3349/ymj.2012.53.5.875
Reference
PMID:26239691
  Authors
Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS
  Title
Present and future therapies of hepatitis B: From discovery to cure.
  Journal
Hepatology 62:1893-908 (2015)
DOI:10.1002/hep.28025
Reference
PMID:26776362
  Authors
Morikawa K, Suda G, Sakamoto N
  Title
Viral life cycle of hepatitis B virus: Host factors and druggable targets.
  Journal
Hepatol Res 46:871-7 (2016)
DOI:10.1111/hepr.12650
Reference
PMID:19201080
  Authors
Feitelson MA, Reis HM, Tufan NL, Sun B, Pan J, Lian Z
  Title
Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease.
  Journal
Cancer Lett 286:69-79 (2009)
DOI:10.1016/j.canlet.2008.12.010
Reference
PMID:19263472
  Authors
Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Tahashi Y, Mori S, Uemura Y, Sakaida N, Fujisawa J, Seki T, Kobayashi K, Yokote K, Koike K, Okazaki K
  Title
Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B.
  Journal
Hepatology 49:1203-17 (2009)
DOI:10.1002/hep.22765
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
  Journal
J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:16891440
  Authors
Park NH, Song IH, Chung YH
  Title
Chronic hepatitis B in hepatocarcinogenesis.
  Journal
Postgrad Med J 82:507-15 (2006)
DOI:10.1136/pgmj.2006.047431
Reference
PMID:28820498
  Authors
Lin S, Zhang YJ
  Title
Interference of Apoptosis by Hepatitis B Virus.
  Journal
Viruses 9:E230 (2017)
DOI:10.3390/v9080230
Reference
PMID:16173017
  Authors
Zhang X, Dong N, Yin L, Cai N, Ma H, You J, Zhang H, Wang H, He R, Ye L
  Title
Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues.
  Journal
J Med Virol 77:374-81 (2005)
DOI:10.1002/jmv.20466
Reference
PMID:18481805
  Authors
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK
  Title
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria.
  Journal
IUBMB Life 60:473-80 (2008)
DOI:10.1002/iub.68
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:9195957
  Authors
Cong YS, Yao YL, Yang WM, Kuzhandaivelu N, Seto E
  Title
The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein.
  Journal
J Biol Chem 272:16482-9 (1997)
DOI:10.1074/jbc.272.26.16482
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:9738022
  Authors
Lee YH, Yun Y
  Title
HBx protein of hepatitis B virus activates Jak1-STAT signaling.
  Journal
J Biol Chem 273:25510-5 (1998)
DOI:10.1074/jbc.273.39.25510
Reference
PMID:18251977
  Authors
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  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:17059849
  Authors
Chami M, Oules B, Paterlini-Brechot P
  Title
Cytobiological consequences of calcium-signaling alterations induced by human viral proteins.
  Journal
Biochim Biophys Acta 1763:1344-62 (2006)
DOI:10.1016/j.bbamcr.2006.09.025
Reference
PMID:11743185
  Authors
Ganem D
  Title
Virology. The X files--one step closer to closure.
  Journal
Science 294:2299-300 (2001)
DOI:10.1126/science.1067850
Reference
PMID:15132991
  Authors
Chung TW, Lee YC, Kim CH
  Title
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.
  Journal
FASEB J 18:1123-5 (2004)
DOI:10.1096/fj.03-1429fje
Reference
PMID:18605975
  Authors
Gurtsevitch VE
  Title
Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis.
  Journal
Biochemistry (Mosc) 73:504-13 (2008)
DOI:10.1134/S0006297908050039
Reference
PMID:21994545
  Authors
Schadler S, Hildt E
  Title
HBV life cycle: entry and morphogenesis.
  Journal
Viruses 1:185-209 (2009)
DOI:10.3390/v1020185
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:28704708
  Authors
Nosratabadi R, Alavian SM, Zare-Bidaki M, Shahrokhi VM, Arababadi MK
  Title
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection.
  Journal
Mol Immunol 90:64-73 (2017)
DOI:10.1016/j.molimm.2017.07.002
Reference
PMID:24530748
  Authors
Bagheri V, Askari A, Arababadi MK, Kennedy D
  Title
Can Toll-Like Receptor (TLR) 2 be considered as a new target for immunotherapy against hepatitis B infection?
  Journal
Hum Immunol 75:549-54 (2014)
DOI:10.1016/j.humimm.2014.02.018
Reference
PMID:25550115
  Authors
Zhang E, Lu M
  Title
Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection.
  Journal
Med Microbiol Immunol 204:11-20 (2015)
DOI:10.1007/s00430-014-0370-1
Reference
PMID:20375222
  Authors
Yu S, Chen J, Wu M, Chen H, Kato N, Yuan Z
  Title
Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.
  Journal
J Gen Virol 91:2080-90 (2010)
DOI:10.1099/vir.0.020552-0
Reference
PMID:23363957
  Authors
Revill P, Yuan Z
  Title
New insights into how HBV manipulates the innate immune response to establish acute and persistent infection.
  Journal
Antivir Ther 18:1-15 (2013)
DOI:10.3851/IMP2542
Reference
PMID:28893934
  Authors
Hopcraft SE, Damania B
  Title
Tumour viruses and innate immunity.
  Journal
Philos Trans R Soc Lond B Biol Sci 372:20160267 (2017)
DOI:10.1098/rstb.2016.0267
Reference
PMID:22504921
  Authors
Dandri M, Locarnini S
  Title
New insight in the pathobiology of hepatitis B virus infection.
  Journal
Gut 61 Suppl 1:i6-17 (2012)
DOI:10.1136/gutjnl-2012-302056
Related
pathway
setr04010  MAPK signaling pathway
setr04064  NF-kappa B signaling pathway
setr04110  Cell cycle
setr04115  p53 signaling pathway
setr04151  PI3K-Akt signaling pathway
setr04210  Apoptosis
setr04620  Toll-like receptor signaling pathway
setr04622  RIG-I-like receptor signaling pathway
setr04630  JAK-STAT signaling pathway
KO pathway
ko05161   

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