1. Oxidoreductases

 2. Transferases

 3. Hydrolases

   3.1  Acting on ester bonds

   3.2  Glycosylases

   3.3  Acting on ether bonds

   3.4  Acting on peptide bonds (peptidases)

   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds

     3.5.1  In linear amides

       3.5.1.1  asparaginase

       3.5.1.2  glutaminase

       3.5.1.3  omega-amidase

       3.5.1.4  amidase

       3.5.1.5  urease

       3.5.1.6  beta-ureidopropionase

       3.5.1.7  ureidosuccinase

       3.5.1.8  formylaspartate deformylase

       3.5.1.9  arylformamidase

       3.5.1.10  formyltetrahydrofolate deformylase

       3.5.1.11  penicillin amidase

       3.5.1.12  biotinidase

       3.5.1.13  aryl-acylamidase

       3.5.1.14  N-acyl-aliphatic-L-amino acid amidohydrolase

       3.5.1.15  aspartoacylase

       3.5.1.16  acetylornithine deacetylase

       3.5.1.17  acyl-lysine deacylase

       3.5.1.18  succinyl-diaminopimelate desuccinylase

       3.5.1.19  nicotinamidase

       3.5.1.20  citrullinase

       3.5.1.21  N-acetyl-beta-alanine deacetylase

       3.5.1.22  pantothenase

       3.5.1.23  ceramidase

       3.5.1.24  choloylglycine hydrolase

       3.5.1.25  N-acetylglucosamine-6-phosphate deacetylase

       3.5.1.26  N4-(beta-N-acetylglucosaminyl)-L-asparaginase

       3.5.1.28  N-acetylmuramoyl-L-alanine amidase

       3.5.1.29  2-(acetamidomethylene)succinate hydrolase

       3.5.1.30  5-aminopentanamidase

       3.5.1.31  formylmethionine deformylase

       3.5.1.32  hippurate hydrolase

       3.5.1.33  N-acetylglucosamine deacetylase

       3.5.1.35  D-glutaminase

       3.5.1.36  N-methyl-2-oxoglutaramate hydrolase

       3.5.1.38  glutamin-(asparagin-)ase

       3.5.1.39  alkylamidase

       3.5.1.40  acylagmatine amidase

       3.5.1.41  chitin deacetylase

       3.5.1.42  nicotinamide-nucleotide amidase

       3.5.1.43  peptidyl-glutaminase

       3.5.1.44  protein-glutamine glutaminase

       3.5.1.46  6-aminohexanoate-oligomer exohydrolase

       3.5.1.47  N-acetyldiaminopimelate deacetylase

       3.5.1.48  acetylspermidine deacetylase

       3.5.1.49  formamidase

       3.5.1.50  pentanamidase

       3.5.1.51  4-acetamidobutyryl-CoA deacetylase

       3.5.1.52  peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase

       3.5.1.53  N-carbamoylputrescine amidase

       3.5.1.54  allophanate hydrolase

       3.5.1.55  long-chain-fatty-acyl-glutamate deacylase

       3.5.1.56  N,N-dimethylformamidase

       3.5.1.57  tryptophanamidase

       3.5.1.58  N-benzyloxycarbonylglycine hydrolase

       3.5.1.59  N-carbamoylsarcosine amidase

       3.5.1.60  N-(long-chain-acyl)ethanolamine deacylase

       3.5.1.62  acetylputrescine deacetylase

       3.5.1.63  4-acetamidobutyrate deacetylase

       3.5.1.64  Nalpha-benzyloxycarbonylleucine hydrolase

       3.5.1.65  theanine hydrolase

       3.5.1.66  2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase

       3.5.1.67  4-methyleneglutaminase

       3.5.1.68  N-formylglutamate deformylase

       3.5.1.69  glycosphingolipid deacylase

       3.5.1.70  aculeacin-A deacylase

       3.5.1.71  N-feruloylglycine deacylase

       3.5.1.72  D-benzoylarginine-4-nitroanilide amidase

       3.5.1.73  carnitinamidase

       3.5.1.74  chenodeoxycholoyltaurine hydrolase

       3.5.1.75  urethanase

       3.5.1.76  arylalkyl acylamidase

       3.5.1.77  N-carbamoyl-D-amino-acid hydrolase

       3.5.1.78  glutathionylspermidine amidase

       3.5.1.79  phthalyl amidase

       3.5.1.81  N-acyl-D-amino-acid deacylase

       3.5.1.82  N-acyl-D-glutamate deacylase

       3.5.1.83  N-acyl-D-aspartate deacylase

       3.5.1.84  biuret amidohydrolase

       3.5.1.85  (S)-N-acetyl-1-phenylethylamine hydrolase

       3.5.1.86  mandelamide amidase

       3.5.1.87  N-carbamoyl-L-amino-acid hydrolase

       3.5.1.88  peptide deformylase

       3.5.1.89  N-acetylglucosaminylphosphatidylinositol deacetylase

       3.5.1.90  adenosylcobinamide hydrolase

       3.5.1.91  N-substituted formamide deformylase

       3.5.1.92  pantetheine hydrolase

       3.5.1.93  glutaryl-7-aminocephalosporanic-acid acylase

       3.5.1.94  gamma-glutamyl-gamma-aminobutyrate hydrolase

       3.5.1.95  N-malonylurea hydrolase

       3.5.1.96  succinylglutamate desuccinylase

       3.5.1.97  acyl-homoserine-lactone acylase

       3.5.1.98  histone deacetylase

       3.5.1.99  fatty acid amide hydrolase

       3.5.1.100  (R)-amidase

       3.5.1.101  L-proline amide hydrolase

       3.5.1.102  2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase

       3.5.1.103  N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase

       3.5.1.104  peptidoglycan-N-acetylglucosamine deacetylase

       3.5.1.105  chitin disaccharide deacetylase

       3.5.1.106  N-formylmaleamate deformylase

       3.5.1.107  maleamate amidohydrolase

       3.5.1.108  UDP-3-O-acyl-N-acetylglucosamine deacetylase

       3.5.1.109  sphingomyelin deacylase

       3.5.1.110  ureidoacrylate amidohydrolase

       3.5.1.111  2-oxoglutaramate amidase

       3.5.1.112  2'-N-acetylparomamine deacetylase

       3.5.1.113  2'''-acetyl-6'''-hydroxyneomycin C deacetylase

       3.5.1.114  N-acyl-aromatic-L-amino acid amidohydrolase

       3.5.1.115  mycothiol S-conjugate amidase

       3.5.1.116  ureidoglycolate amidohydrolase

       3.5.1.117  6-aminohexanoate-oligomer endohydrolase

       3.5.1.118  gamma-glutamyl hercynylcysteine S-oxide hydrolase

       3.5.1.119  Pup amidohydrolase

       3.5.1.121  protein N-terminal asparagine amidohydrolase

       3.5.1.122  protein N-terminal glutamine amidohydrolase

       3.5.1.123  gamma-glutamylanilide hydrolase

       3.5.1.124  protein deglycase

       3.5.1.125  N2-acetyl-L-2,4-diaminobutanoate deacetylase

       3.5.1.126  oxamate amidohydrolase

       3.5.1.127  jasmonoyl-L-amino acid hydrolase

       3.5.1.128  deaminated glutathione amidase

       3.5.1.129  N5-(cytidine 5'-diphosphoramidyl)-L-glutamine hydrolase

       3.5.1.130  [amino group carrier protein]-lysine hydrolase

       3.5.1.131  1-carboxybiuret hydrolase

       3.5.1.132  [amino group carrier protein]-ornithine hydrolase

       3.5.1.133  Nalpha-acyl-L-glutamine aminoacylase

       3.5.1.134  (indol-3-yl)acetyl-L-aspartate hydrolase

       3.5.1.135  N4-acetylcytidine amidohydrolase

       3.5.1.136  N,N'-diacetylchitobiose non-reducing end deacetylase

       3.5.1.137  N-methylcarbamate hydrolase

       3.5.1.138  lipoamidase

     3.5.2  In cyclic amides

     3.5.3  In linear amidines

     3.5.4  In cyclic amidines

     3.5.5  In nitriles

     3.5.99  In other compounds

   3.6  Acting on acid anhydrides

   3.7  Acting on carbon-carbon bonds

   3.8  Acting on halide bonds

   3.9  Acting on phosphorus-nitrogen bonds

   3.10  Acting on sulfur-nitrogen bonds

   3.11  Acting on carbon-phosphorus bonds

   3.12  Acting on sulfur-sulfur bonds

   3.13  Acting on carbon-sulfur bonds

 4. Lyases

   4.1  Carbon-carbon lyases

   4.2  Carbon-oxygen lyases

     4.2.1  Hydro-lyases

       4.2.1.1  carbonic anhydrase

       4.2.1.2  fumarate hydratase

       4.2.1.3  aconitate hydratase

       4.2.1.5  arabinonate dehydratase

       4.2.1.6  galactonate dehydratase

       4.2.1.7  altronate dehydratase

       4.2.1.8  mannonate dehydratase

       4.2.1.9  dihydroxy-acid dehydratase

       4.2.1.10  3-dehydroquinate dehydratase

       4.2.1.11  phosphopyruvate hydratase

       4.2.1.12  phosphogluconate dehydratase

       4.2.1.17  enoyl-CoA hydratase

       4.2.1.18  methylglutaconyl-CoA hydratase

       4.2.1.19  imidazoleglycerol-phosphate dehydratase

       4.2.1.20  tryptophan synthase

       4.2.1.22  cystathionine beta-synthase

       4.2.1.24  porphobilinogen synthase

       4.2.1.25  L-arabinonate dehydratase

       4.2.1.27  acetylenecarboxylate hydratase

       4.2.1.28  propanediol dehydratase

       4.2.1.30  glycerol dehydratase

       4.2.1.31  maleate hydratase

       4.2.1.32  L(+)-tartrate dehydratase

       4.2.1.33  3-isopropylmalate dehydratase

       4.2.1.34  (S)-2-methylmalate dehydratase

       4.2.1.35  (R)-2-methylmalate dehydratase

       4.2.1.36  homoaconitate hydratase

       4.2.1.39  gluconate dehydratase

       4.2.1.40  glucarate dehydratase

       4.2.1.41  5-dehydro-4-deoxyglucarate dehydratase

       4.2.1.42  galactarate dehydratase

       4.2.1.43  2-dehydro-3-deoxy-L-arabinonate dehydratase

       4.2.1.44  myo-inosose-2 dehydratase

       4.2.1.45  CDP-glucose 4,6-dehydratase

       4.2.1.46  dTDP-glucose 4,6-dehydratase

       4.2.1.47  GDP-mannose 4,6-dehydratase

       4.2.1.48  D-glutamate cyclase

       4.2.1.49  urocanate hydratase

       4.2.1.50  pyrazolylalanine synthase

       4.2.1.51  prephenate dehydratase

       4.2.1.53  oleate hydratase

       4.2.1.54  lactoyl-CoA dehydratase

       4.2.1.55  3-hydroxybutyryl-CoA dehydratase

       4.2.1.56  itaconyl-CoA hydratase

       4.2.1.57  isohexenylglutaconyl-CoA hydratase

       4.2.1.59  3-hydroxyacyl-[acyl-carrier-protein] dehydratase

       4.2.1.62  5alpha-hydroxysteroid dehydratase

       4.2.1.65  3-cyanoalanine hydratase

       4.2.1.66  cyanide hydratase

       4.2.1.67  D-fuconate dehydratase

       4.2.1.68  L-fuconate dehydratase

       4.2.1.69  cyanamide hydratase

       4.2.1.70  pseudouridylate synthase

       4.2.1.73  protoaphin-aglucone dehydratase (cyclizing)

       4.2.1.74  medium-chain-enoyl-CoA hydratase

       4.2.1.75  uroporphyrinogen-III synthase

       4.2.1.76  UDP-glucose 4,6-dehydratase

       4.2.1.77  trans-L-3-hydroxyproline dehydratase

       4.2.1.79  2-methylcitrate dehydratase

       4.2.1.80  2-oxopent-4-enoate hydratase

       4.2.1.81  D(-)-tartrate dehydratase

       4.2.1.82  xylonate dehydratase

       4.2.1.83  4-oxalomesaconate hydratase

       4.2.1.84  nitrile hydratase

       4.2.1.85  dimethylmaleate hydratase

       4.2.1.87  octopamine dehydratase

       4.2.1.88  synephrine dehydratase

       4.2.1.90  L-rhamnonate dehydratase

       4.2.1.91  arogenate dehydratase

       4.2.1.92  hydroperoxide dehydratase

       4.2.1.93  ATP-dependent NAD(P)H-hydrate dehydratase

       4.2.1.94  scytalone dehydratase

       4.2.1.95  kievitone hydratase

       4.2.1.96  4a-hydroxytetrahydrobiopterin dehydratase

       4.2.1.97  phaseollidin hydratase

       4.2.1.98  16alpha-hydroxyprogesterone dehydratase

       4.2.1.99  2-methylisocitrate dehydratase

       4.2.1.100  cyclohexa-1,5-dienecarbonyl-CoA hydratase

       4.2.1.103  cyclohexyl-isocyanide hydratase

       4.2.1.104  cyanase

       4.2.1.105  2-hydroxyisoflavanone dehydratase

       4.2.1.106  bile-acid 7alpha-dehydratase

       4.2.1.107  3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase

       4.2.1.108  ectoine synthase

       4.2.1.109  methylthioribulose 1-phosphate dehydratase

       4.2.1.110  aldos-2-ulose dehydratase

       4.2.1.111  1,5-anhydro-D-fructose dehydratase

       4.2.1.112  acetylene hydratase

       4.2.1.113  o-succinylbenzoate synthase

       4.2.1.114  methanogen homoaconitase

       4.2.1.115  UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting)

       4.2.1.116  3-hydroxypropionyl-CoA dehydratase

       4.2.1.117  2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)

       4.2.1.118  3-dehydroshikimate dehydratase

       4.2.1.119  enoyl-CoA hydratase 2

       4.2.1.120  4-hydroxybutanoyl-CoA dehydratase

       4.2.1.121  colneleate synthase

       4.2.1.122  tryptophan synthase (indole-salvaging)

       4.2.1.123  tetrahymanol synthase

       4.2.1.124  arabidiol synthase

       4.2.1.125  dammarenediol II synthase

       4.2.1.126  N-acetylmuramic acid 6-phosphate etherase

       4.2.1.127  linalool dehydratase

       4.2.1.128  lupan-3beta,20-diol synthase

       4.2.1.129  squalene---hopanol cyclase

       4.2.1.130  D-lactate dehydratase

       4.2.1.131  carotenoid 1,2-hydratase

       4.2.1.132  2-hydroxyhexa-2,4-dienoate hydratase

       4.2.1.133  copal-8-ol diphosphate hydratase

       4.2.1.134  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

       4.2.1.135  UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)

       4.2.1.136  ADP-dependent NAD(P)H-hydrate dehydratase

       4.2.1.137  sporulenol synthase

       4.2.1.138  (+)-caryolan-1-ol synthase

       4.2.1.139  pterocarpan synthase

       4.2.1.140  gluconate/galactonate dehydratase

       4.2.1.141  2-dehydro-3-deoxy-D-arabinonate dehydratase

       4.2.1.142  5'-oxoaverantin cyclase

       4.2.1.143  versicolorin B synthase

       4.2.1.144  3-amino-5-hydroxybenzoate synthase

       4.2.1.145  capreomycidine synthase

       4.2.1.146  L-galactonate dehydratase

       4.2.1.147  5,6,7,8-tetrahydromethanopterin hydro-lyase

       4.2.1.148  2-methylfumaryl-CoA hydratase

       4.2.1.149  crotonobetainyl-CoA hydratase

       4.2.1.150  short-chain-enoyl-CoA hydratase

       4.2.1.151  chorismate dehydratase

       4.2.1.152  hydroperoxy icosatetraenoate dehydratase

       4.2.1.153  3-methylfumaryl-CoA hydratase

       4.2.1.154  tetracenomycin F2 cyclase

       4.2.1.155  (methylthio)acryloyl-CoA hydratase

       4.2.1.156  L-talarate dehydratase

       4.2.1.157  (R)-2-hydroxyisocaproyl-CoA dehydratase

       4.2.1.158  galactarate dehydratase (D-threo-forming)

       4.2.1.159  dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase

       4.2.1.160  2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase

       4.2.1.161  bisanhydrobacterioruberin hydratase

       4.2.1.162  6-deoxy-6-sulfo-D-gluconate dehydratase

       4.2.1.163  2-oxo-hept-4-ene-1,7-dioate hydratase

       4.2.1.164  dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase

       4.2.1.165  chlorophyllide a 31-hydratase

       4.2.1.166  phosphinomethylmalate isomerase

       4.2.1.167  (R)-2-hydroxyglutaryl-CoA dehydratase

       4.2.1.168  GDP-4-dehydro-6-deoxy-alpha-D-mannose 3-dehydratase

       4.2.1.169  3-vinyl bacteriochlorophyllide d 31-hydratase

       4.2.1.170  2-(omega-methylthio)alkylmalate dehydratase

       4.2.1.171  cis-L-3-hydroxyproline dehydratase

       4.2.1.172  trans-4-hydroxy-L-proline dehydratase

       4.2.1.173  ent-8alpha-hydroxylabd-13-en-15-yl diphosphate synthase

       4.2.1.174  peregrinol diphosphate synthase

       4.2.1.175  (R)-3-(aryl)lactoyl-CoA dehydratase

       4.2.1.176  L-lyxonate dehydratase

       4.2.1.177  (2S)-3-sulfopropanediol dehydratase

       4.2.1.178  difructose-dianhydride-III synthase

       4.2.1.179  difructose-anhydride-I synthase

       4.2.1.180  (E)-benzylidenesuccinyl-CoA hydratase

       4.2.1.181  3-carboxymethyl-3-hydroxy-acyl-[acp] dehydratase

       4.2.1.182  phosphomevalonate dehydratase

       4.2.1.183  etheroleic acid synthase

     4.2.2  Acting on polysaccharides

     4.2.3  Acting on phosphates

     4.2.99  Other carbon-oxygen lyases

   4.3  Carbon-nitrogen lyases

   4.4  Carbon-sulfur lyases

   4.5  Carbon-halide lyases

   4.6  Phosphorus-oxygen lyases

   4.7  carbon-phosphorus lyases

   4.8  Nitrogen-oxygen lyases

   4.98  ATP-independent chelatases

   4.99  Other lyases

 5. Isomerases

 6. Ligases

 7. Translocases