KEGG   PATHWAY: cclu04110
Entry
cclu04110                   Pathway                                
Name
Cell cycle - Coregonus clupeaformis (lake whitefish)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
cclu04110  Cell cycle
cclu04110

Other DBs
GO: 0000278
Organism
Coregonus clupeaformis (lake whitefish) [GN:cclu]
Gene
121530809  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
121530915  [KO:K04382] [EC:3.1.3.16]
121531374  cdkn1cb; cyclin-dependent kinase inhibitor 1C [KO:K09993]
121531595  [KO:K06671]
121531644  [KO:K04503]
121531654  [KO:K11479] [EC:2.7.11.1]
121531656  smc1b; structural maintenance of chromosomes protein 1B [KO:K06636]
121531728  [KO:K06624]
121531962  ddx11; ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:5.6.2.7]
121532066  [KO:K06632] [EC:2.7.11.1]
121532161  rbl2; retinoblastoma-like protein 2 [KO:K16332]
121532296  wee2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
121532316  [KO:K10151]
121532324  [KO:K04682]
121532842  cdc6; LOW QUALITY PROTEIN: cell division control protein 6 homolog [KO:K02213]
121533295  [KO:K06620]
121533312  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
121533389  [KO:K03364]
121533408  cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
121533566  [KO:K11266]
121533683  [KO:K04402]
121533694  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
121533892  mcm3l; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae), like [KO:K02541] [EC:5.6.2.3]
121533912  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
121534006  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
121534058  orc1; origin recognition complex subunit 1 isoform X2 [KO:K02603]
121534581  [KO:K04402]
121534634  mcm6l; MCM6 minichromosome maintenance deficient 6, like [KO:K02542] [EC:5.6.2.3]
121534724  [KO:K02210] [EC:5.6.2.3]
121534858  mycb; LOW QUALITY PROTEIN: transcriptional regulator Myc-B [KO:K04377]
121535083  e2f5; transcription factor E2F5 isoform X1 [KO:K04682]
121535122  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
121535270  cul1a; cullin-1a [KO:K03347]
121535339  [KO:K06627]
121535342  [KO:K02212] [EC:5.6.2.3]
121535479  [KO:K11266]
121535493  [KO:K03364]
121535548  orc2; origin recognition complex subunit 2 [KO:K02604]
121535581  fzr1b; fizzy-related protein homolog [KO:K03364]
121535653  [KO:K02542] [EC:5.6.2.3]
121536430  [KO:K25163]
121536559  [KO:K04683]
121536616  [KO:K03353]
121536830  [KO:K13376]
121537086  [KO:K03083] [EC:2.7.11.26]
121537605  [KO:K06630]
121537877  [KO:K06636]
121538171  aurkb; LOW QUALITY PROTEIN: aurora kinase B [KO:K11479] [EC:2.7.11.1]
121538426  [KO:K10500]
121538459  [KO:K17454]
121538598  [KO:K16197]
121538904  [KO:K04382] [EC:3.1.3.16]
121539002  [KO:K09389]
121539016  [KO:K11584]
121539182  [KO:K06067] [EC:3.5.1.98]
121539225  bub1bb; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
121539280  [KO:K13377]
121539360  ppp2r5eb; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
121539397  [KO:K16197]
121539414  orc3; origin recognition complex subunit 3 [KO:K02605]
121539569  [KO:K06671]
121539892  [KO:K06622]
121540327  pttg1; securin isoform X1 [KO:K06635]
121540508  [KO:K04402]
121540531  [KO:K06627]
121540605  [KO:K06624]
121540724  [KO:K06632] [EC:2.7.11.1]
121540814  ticrr; treslin isoform X1 [KO:K26117]
121541156  [KO:K04402]
121541157  [KO:K04402]
121541159  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
121541195  [KO:K02210] [EC:5.6.2.3]
121541213  [KO:K06671]
121541234  [KO:K13375]
121541254  [KO:K05867] [EC:3.1.3.48]
121541291  ccna1; cyclin-A1 isoform X1 [KO:K06627]
121541396  [KO:K04382] [EC:3.1.3.16]
121541571  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
121541667  [KO:K06619] [EC:2.7.10.2]
121541748  [KO:K16198]
121541860  cdca5; sororin [KO:K17390]
121541907  [KO:K13375]
121541952  cdc23; cell division cycle protein 23 homolog [KO:K03355]
121542020  [KO:K11267]
121542568  [KO:K06670]
121542603  [KO:K22399]
121542682  [KO:K06629]
121543224  [KO:K06629]
121543497  [KO:K13376]
121543531  [KO:K10151]
121543679  [KO:K06625]
121544475  [KO:K06637] [EC:2.7.11.1]
121544510  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
121544832  [KO:K11584]
121544909  [KO:K13377]
121545006  [KO:K06067] [EC:3.5.1.98]
121545087  [KO:K16197]
121545129  e2f2; transcription factor E2F2 [KO:K09389]
121545145  ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
121545354  [KO:K16197]
121545568  zbtb17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
121545587  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
121545597  [KO:K17454]
121545877  smc1a; structural maintenance of chromosomes protein 1A [KO:K06636]
121545895  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
121546245  [KO:K06625]
121546662  [KO:K05866] [EC:3.1.3.48]
121546699  [KO:K06670]
121547026  [KO:K04498] [EC:2.3.1.48]
121547132  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
121547218  [KO:K03363]
121547299  [KO:K25163]
121548263  [KO:K04682]
121548306  cdt1; DNA replication factor Cdt1 [KO:K10727]
121548319  [KO:K02608]
121548586  mcm3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
121548633  [KO:K11584]
121548857  [KO:K10151]
121548924  [KO:K11268] [EC:2.3.1.-]
121549011  [KO:K06067] [EC:3.5.1.98]
121549037  bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
121549097  [KO:K11584]
121549775  cul1b; cullin-1b [KO:K03347]
121549843  [KO:K02606]
121549875  prkdc; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
121550033  [KO:K04377]
121550187  [KO:K06641] [EC:2.7.11.1]
121550213  [KO:K04500]
121550215  [KO:K03352]
121550227  [KO:K06634]
121550247  [KO:K03350]
121550723  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
121550901  [KO:K04498] [EC:2.3.1.48]
121550972  [KO:K03868] [EC:2.3.2.32]
121550974  si:ch211-269e2.1; cohesin subunit SA-2 isoform X1 [KO:K06671]
121551031  [KO:K03353]
121551056  [KO:K02209] [EC:5.6.2.3]
121551798  [KO:K04498] [EC:2.3.1.48]
121552201  [KO:K16197]
121552315  knl1; uncharacterized protein knl1 [KO:K11542]
121552601  [KO:K11584]
121552669  [KO:K13377]
121552791  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
121553412  fbxo5; F-box only protein 5 isoform X1 [KO:K10292]
121553443  [KO:K11584]
121553483  [KO:K02087] [EC:2.7.11.22 2.7.11.23]
121553782  [KO:K25163]
121553833  crebbpa; CREB-binding protein isoform X2 [KO:K04498] [EC:2.3.1.48]
121553870  [KO:K06643] [EC:2.3.2.27]
121553940  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
121554021  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
121554249  [KO:K04683]
121554328  [KO:K04451]
121554355  [KO:K11584]
121554374  [KO:K21771]
121554425  [KO:K02537]
121554628  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
121554634  [KO:K03083] [EC:2.7.11.26]
121554832  [KO:K06624]
121555286  [KO:K09993]
121555414  [KO:K06643] [EC:2.3.2.27]
121555775  [KO:K16197]
121555793  [KO:K06626]
121555832  [KO:K06067] [EC:3.5.1.98]
121555949  [KO:K08866] [EC:2.7.12.1]
121555986  atrx; transcriptional regulator ATRX [KO:K10779]
121556169  [KO:K13377]
121556760  [KO:K04683]
121556930  [KO:K22399]
121557060  [KO:K04685]
121557526  [KO:K10292]
121557559  [KO:K06631] [EC:2.7.11.21]
121557697  [KO:K04503]
121557942  [KO:K02216] [EC:2.7.11.1]
121558003  [KO:K04682]
121558616  [KO:K08866] [EC:2.7.12.1]
121558906  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
121559122  [KO:K06626]
121559174  [KO:K06643] [EC:2.3.2.27]
121559233  [KO:K06620]
121559813  [KO:K06643] [EC:2.3.2.27]
121559994  [KO:K10292]
121560114  pds5a; LOW QUALITY PROTEIN: sister chromatid cohesion protein PDS5 homolog A [KO:K11267]
121561158  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
121561241  [KO:K06643] [EC:2.3.2.27]
121561501  [KO:K09392]
121561847  pds5b; sister chromatid cohesion protein PDS5 homolog B isoform X1 [KO:K11267]
121563153  ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 isoform X1 [KO:K06630]
121563950  mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
121565867  ywhag2; 14-3-3 protein gamma-2 [KO:K16198]
121566218  cdkn1ca; cyclin-dependent kinase inhibitor 1Ca [KO:K09993]
121566827  [KO:K16197]
121567313  tfdp2; transcription factor Dp-2 isoform X1 [KO:K09392]
121567336  [KO:K03456]
121567461  [KO:K06630]
121567690  [KO:K13375]
121567818  [KO:K25228]
121567943  [KO:K16198]
121568015  atm; serine-protein kinase ATM isoform X2 [KO:K04728] [EC:2.7.11.1]
121568737  [KO:K04498] [EC:2.3.1.48]
121568933  [KO:K10151]
121568972  [KO:K02209] [EC:5.6.2.3]
121569034  [KO:K03868] [EC:2.3.2.32]
121569037  [KO:K04498] [EC:2.3.1.48]
121569578  [KO:K11584]
121569717  [KO:K03350]
121569899  [KO:K04377]
121570021  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
121570091  [KO:K04501]
121570386  [KO:K10151]
121570545  cdk21; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
121571091  [KO:K02537]
121571135  [KO:K04451]
121571246  [KO:K11584]
121571266  hdac8; histone deacetylase 8 [KO:K11405] [EC:3.5.1.98]
121571292  [KO:K25163]
121571471  [KO:K06670]
121571539  [KO:K02087] [EC:2.7.11.22 2.7.11.23]
121571637  [KO:K03083] [EC:2.7.11.26]
121571774  [KO:K04501]
121571803  [KO:K02091] [EC:2.7.11.22]
121571865  [KO:K03348]
121572166  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
121572434  [KO:K04501]
121572454  ccnb3; LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B3 [KO:K21771]
121572959  [KO:K04802]
121573042  orc4; origin recognition complex subunit 4 [KO:K02606]
121573146  cdc45; cell division control protein 45 homolog [KO:K06628]
121573328  [KO:K04503]
121573629  [KO:K02202] [EC:2.7.11.22 2.7.11.23]
121573659  [KO:K06671]
121573846  [KO:K04501]
121573854  [KO:K06672]
121573859  [KO:K03875]
121573935  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
121574003  [KO:K04382] [EC:3.1.3.16]
121574005  [KO:K03094]
121574093  [KO:K16198]
121574184  [KO:K10779]
121574724  [KO:K02540] [EC:5.6.2.3]
121575150  [KO:K02206] [EC:2.7.11.22]
121575165  [KO:K02089] [EC:2.7.11.22]
121575271  [KO:K02365] [EC:3.4.22.49]
121575291  [KO:K06625]
121575608  mych; myelocytomatosis oncogene homolog [KO:K04377]
121575615  rbl1; retinoblastoma-like protein 1 [KO:K04681]
121575623  [KO:K16197]
121576356  [KO:K26093]
121576467  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
121576648  [KO:K04498] [EC:2.3.1.48]
121576771  [KO:K11266]
121576889  [KO:K16332]
121576935  [KO:K04682]
121576945  [KO:K10151]
121577040  [KO:K11479] [EC:2.7.11.1]
121577046  [KO:K04503]
121577240  [KO:K04402]
121577651  [KO:K10152]
121577830  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
121577842  [KO:K02089] [EC:2.7.11.22]
121577935  mcm2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
121578302  [KO:K04377]
121578398  [KO:K02180]
121578538  [KO:K06625]
121579067  [KO:K02607]
121579138  ywhag1; 14-3-3 protein gamma-1 [KO:K16198]
121579236  [KO:K03094]
121579237  [KO:K04382] [EC:3.1.3.16]
121579543  [KO:K13375]
121579588  [KO:K03355]
121579683  tp53; cellular tumor antigen p53 [KO:K04451]
121579957  [KO:K10779]
121579994  [KO:K06671]
121580008  rb1; retinoblastoma-associated protein [KO:K06618]
121580194  [KO:K12456]
121580534  [KO:K16332]
121580732  cdc7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
121580962  [KO:K03347]
121580972  [KO:K03363]
121581029  [KO:K02212] [EC:5.6.2.3]
121581145  [KO:K02542] [EC:5.6.2.3]
121581203  [KO:K03364]
121581215  [KO:K11266]
121581240  [KO:K06624]
121581455  [KO:K04402]
121581887  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
121581987  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
121582175  [KO:K04501]
121582180  [KO:K06672]
121582186  [KO:K03875]
121582280  [KO:K05868]
121582330  [KO:K02608]
121582418  [KO:K16198]
121582511  [KO:K06619] [EC:2.7.10.2]
121582529  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
121582538  [KO:K05868]
121582553  [KO:K04402]
121582554  [KO:K04402]
121583029  [KO:K06632] [EC:2.7.11.1]
121583165  [KO:K04402]
121583381  [KO:K10292]
121583457  [KO:K05868]
121584232  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
121584370  nipbla; nipped-B-like protein A [KO:K06672]
121584372  [KO:K11547]
121584373  [KO:K11547]
121584382  smad4; mothers against decapentaplegic homolog 4 [KO:K04501]
121584512  [KO:K06641] [EC:2.7.11.1]
121584611  [KO:K04382] [EC:3.1.3.16]
121584646  [KO:K04500]
121584734  [KO:K03354]
121584942  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
121584994  [KO:K04802]
121585122  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
121585234  [KO:K06634]
121585891  [KO:K10779]
121585906  [KO:K13376]
121585942  [KO:K06670]
121585963  [KO:K16197]
121586059  [KO:K06620]
121586076  [KO:K26116]
121586261  [KO:K06626]
121586364  [KO:K06670]
121586708  sgo1; shugoshin 1 isoform X1 [KO:K11580]
121586747  [KO:K02091] [EC:2.7.11.22]
121586837  [KO:K06620]
121586843  [KO:K06067] [EC:3.5.1.98]
121587437  stag1a; cohesin subunit SA-1a [KO:K06671]
121587440  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
123481292  [KO:K11267]
123484320  [KO:K04683]
123484461  [KO:K02216] [EC:2.7.11.1]
123485187  [KO:K04685]
123491333  [KO:K02607]
123492065  [KO:K16197]
123492149  [KO:K06630]
123492671  [KO:K06632] [EC:2.7.11.1]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
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Related
pathway
cclu03030  DNA replication
cclu04010  MAPK signaling pathway
cclu04120  Ubiquitin mediated proteolysis
cclu04210  Apoptosis
KO pathway
ko04110   

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