KEGG   PATHWAY: cjc05171
Entry
cjc05171                    Pathway                                
Name
Coronavirus disease - COVID-19 - Callithrix jacchus (white-tufted-ear marmoset)
Description
Coronavirus disease of 2019 (COVID-19) is a highly contagious respiratory infection that is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infects alveolar epithelial cells [mainly alveolar epithelial type 2 (AEC2) cells] through the angiotensin-converting enzyme 2 (ACE2) receptor. Upon the occupancy of ACE2 by SARS-CoV-2, the increased serum level of free Angiotensin II (Ang II) due to a reduction of ACE2-mediated degradation promotes activation of the NF-kappa B pathway via Ang II type 1 receptor (AT1R), followed by  interleukin-6 (IL-6) production. SARS-CoV-2 also activates the innate immune system; macrophage stimulation triggers the overproduction of pro-inflammatory cytokines, including IL-6, and the "cytokine storm", which results in systemic inflammatory response syndrome and multiple organ failure. The combined effects of complement activation, dysregulated neutrophilia, endothelial injury, and hypercoagulability appear to be intertwined to drive the severe features of COVID-19.
Class
Human Diseases; Infectious disease: viral
Pathway map
cjc05171  Coronavirus disease - COVID-19
cjc05171

Disease
H02398  COVID-19
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100384985  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
100385005  [KO:K02942]
100385053  C7; complement component C7 [KO:K03996]
100385218  [KO:K02977]
100385238  [KO:K02885]
100385368  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
100385442  [KO:K02974]
100385444  [KO:K02977]
100385527  RPL32; 60S ribosomal protein L32 [KO:K02912]
100385598  [KO:K02894]
100385614  [KO:K02962]
100385618  [KO:K01370] [EC:3.4.22.36]
100385628  [KO:K02885]
100385661  IL6R; interleukin-6 receptor subunit alpha precursor [KO:K05055]
100385683  [KO:K02998]
100385835  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100385887  [KO:K02981]
100386128  [KO:K02969]
100386180  [KO:K02885]
100386234  [KO:K02964]
100386254  [KO:K02976]
100386289  [KO:K02998]
100386315  [KO:K02998]
100386367  ADAR; double-stranded RNA-specific adenosine deaminase isoform X3 [KO:K12968] [EC:3.5.4.37]
100386428  [KO:K02912]
100386441  [KO:K02977]
100386446  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
100386515  RPS12; 40S ribosomal protein S12 [KO:K02951]
100386524  RPL27; 60S ribosomal protein L27 [KO:K02901]
100386784  C1R; complement C1r subcomponent isoform X1 [KO:K01330] [EC:3.4.21.41]
100386844  RPSA; 40S ribosomal protein SA [KO:K02998]
100386848  IL2; interleukin-2 [KO:K05429]
100386955  [KO:K02984]
100386994  [KO:K02921]
100387038  RPL4; 60S ribosomal protein L4 [KO:K02930]
100387233  CGAS; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:2.7.7.86]
100387244  [KO:K02962]
100387292  MBL2; mannose-binding protein C isoform X1 [KO:K03991]
100387309  [KO:K02998]
100387336  [KO:K02898]
100387372  [KO:K05414]
100387401  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100387458  [KO:K02947]
100387560  [KO:K02962]
100387563  RPL8; 60S ribosomal protein L8 [KO:K02938]
100387574  FCGR2A; low affinity immunoglobulin gamma Fc region receptor II-a isoform X2 [KO:K06472]
100387612  CCL2; C-C motif chemokine 2 [KO:K14624]
100387686  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100387727  RPL19; 60S ribosomal protein L19 [KO:K02885]
100387920  C9; complement component C9 [KO:K04000]
100388144  [KO:K02938]
100388215  C1QA; complement C1q subcomponent subunit A isoform X2 [KO:K03986]
100388301  RPL9; 60S ribosomal protein L9 isoform X1 [KO:K02940]
100388363  [KO:K02923]
100388391  IFNB1; interferon beta [KO:K05415]
100388424  [KO:K02898]
100388493  RELA; transcription factor p65 isoform X1 [KO:K04735]
100388574  [KO:K02997]
100388648  FGA; LOW QUALITY PROTEIN: fibrinogen alpha chain [KO:K03903]
100389129  RPL30; 60S ribosomal protein L30 [KO:K02908]
100389282  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100389323  [KO:K02903]
100389486  C5; complement C5 [KO:K03994]
100389518  [KO:K02947]
100389531  RPS21; 40S ribosomal protein S21 [KO:K02971]
100389540  [KO:K02993]
100389591  [KO:K02934]
100389593  [KO:K02981]
100389630  CFD; complement factor D isoform X2 [KO:K01334] [EC:3.4.21.46]
100389788  RPL21; 60S ribosomal protein L21 [KO:K02889]
100389839  [KO:K02957]
100390038  [KO:K02942]
100390054  FOS; protein c-Fos [KO:K04379]
100390109  MAPK10; mitogen-activated protein kinase 10 isoform X7 [KO:K04440] [EC:2.7.11.24]
100390179  [KO:K02942]
100390201  [KO:K05414]
100390238  [KO:K02937]
100390258  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100390346  [KO:K02870]
100390347  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100390468  [KO:K02957]
100390587  CXCL8; interleukin-8 [KO:K10030]
100390678  [KO:K02936]
100390962  [KO:K02910]
100391006  [KO:K02917]
100391210  RPL28; 60S ribosomal protein L28 isoform X2 [KO:K02903]
100391362  [KO:K02995]
100391390  [KO:K02976]
100391528  [KO:K02987]
100391601  RPL11; 60S ribosomal protein L11 [KO:K02868]
100391655  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100391814  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100391828  [KO:K02870]
100391846  [KO:K02957]
100391896  [KO:K02984]
100392033  [KO:K02936]
100392267  RPL15; 60S ribosomal protein L15 [KO:K02877]
100392317  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
100392399  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
100392459  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
100392518  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
100392639  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100392644  FGB; fibrinogen beta chain [KO:K03904]
100392699  RPS8; 40S ribosomal protein S8 [KO:K02995]
100392721  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100392997  HBEGF; proheparin-binding EGF-like growth factor [KO:K08523]
100393007  [KO:K02953]
100393096  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
100393190  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
100393271  [KO:K02974]
100393284  RPS5; 40S ribosomal protein S5 [KO:K02989]
100393288  [KO:K02880]
100393371  RPL26L1; endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X2 [KO:K02898]
100393440  IL6; interleukin-6 precursor [KO:K05405]
100393451  [KO:K02974]
100393608  [KO:K02991]
100393609  RPS3A; 40S ribosomal protein S3a [KO:K02984]
100393678  [KO:K02893]
100393717  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
100393929  RPL3L; 60S ribosomal protein L3-like [KO:K02925]
100393950  RPL12; 60S ribosomal protein L12 isoform X2 [KO:K02870]
100394102  [KO:K02885]
100394437  [KO:K02981]
100394454  RPL14; 60S ribosomal protein L14 isoform X1 [KO:K02875]
100394500  NRP1; neuropilin-1 isoform X1 [KO:K06724]
100394517  [KO:K02901]
100394543  [KO:K02896]
100394558  [KO:K02984]
100394605  RPS17; 40S ribosomal protein S17 isoform X2 [KO:K02962]
100394657  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
100394663  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
100394948  [KO:K02877]
100394983  [KO:K02910]
100395054  [KO:K02873]
100395364  TRAF6; TNF receptor-associated factor 6 isoform X2 [KO:K03175] [EC:2.3.2.27]
100395372  [KO:K02877]
100395403  IL12B; interleukin-12 subunit beta [KO:K05425]
100395458  RPS4X; 40S ribosomal protein S4, X isoform isoform X1 [KO:K02987]
100395498  RPS27L; 40S ribosomal protein S27-like isoform X2 [KO:K02978]
100395604  [KO:K02936]
100395673  [KO:K02991]
100395728  [KO:K03991]
100395849  [KO:K02898]
100396012  [KO:K02880]
100396027  RPL13A; 60S ribosomal protein L13a [KO:K02872]
100396218  [KO:K01394] [EC:3.4.24.17]
100396314  [KO:K02974]
100396374  RPL34; 60S ribosomal protein L34 isoform X1 [KO:K02915]
100396382  [KO:K02885]
100396518  RPL36; 60S ribosomal protein L36 [KO:K02920]
100396611  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100396646  RPS11; 40S ribosomal protein S11 [KO:K02949]
100396684  VWF; von Willebrand factor [KO:K03900]
100396729  IL6ST; interleukin-6 receptor subunit beta precursor [KO:K05060]
100396921  C8A; complement component C8 alpha chain [KO:K03997]
100396967  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100397019  [KO:K02872]
100397128  [KO:K02870]
100397418  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
100397479  [KO:K02974]
100397481  [KO:K02974]
100397484  TNF; tumor necrosis factor [KO:K03156]
100397497  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
100397534  [KO:K02987]
100397554  [KO:K03991]
100397595  [KO:K02936]
100397653  C8B; complement component C8 beta chain [KO:K03998]
100397979  RPS16; 40S ribosomal protein S16 [KO:K02960]
100397989  RPL3; 60S ribosomal protein L3 [KO:K02925]
100398126  [KO:K02893]
100398266  RSL24D1; probable ribosome biogenesis protein RLP24 [KO:K02896]
100398302  [KO:K02984]
100398394  [KO:K02880]
100398428  RPL22L1; 60S ribosomal protein L22-like 1 isoform X2 [KO:K02891]
100398462  TLR7; toll-like receptor 7 [KO:K05404]
100398499  RPL27A; 60S ribosomal protein L27a isoform X1 [KO:K02900]
100398705  [KO:K02991]
100398751  RPL10L; 60S ribosomal protein L10-like [KO:K02866]
100398832  TLR8; toll-like receptor 8 [KO:K10170]
100398849  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100399012  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
100399228  RPS13; 40S ribosomal protein S13 [KO:K02953]
100399251  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
100399394  [KO:K02889]
100399701  TBK1; serine/threonine-protein kinase TBK1 isoform X6 [KO:K05410] [EC:2.7.11.10]
100399899  RPS18; 40S ribosomal protein S18 [KO:K02964]
100399964  RPL17; 60S ribosomal protein L17 [KO:K02880]
100400062  [KO:K02893]
100400365  SELP; P-selectin isoform X1 [KO:K06496]
100400370  [KO:K02998]
100400411  JUN; transcription factor Jun [KO:K04448]
100400501  C3; complement C3 [KO:K03990]
100400611  F13B; coagulation factor XIII B chain isoform X2 [KO:K03906]
100400624  RPL10A; 60S ribosomal protein L10a [KO:K02865]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100400727  MMP1; LOW QUALITY PROTEIN: interstitial collagenase [KO:K01388] [EC:3.4.24.7]
100400836  [KO:K02877]
100400861  [KO:K02910]
100400905  [KO:K02975]
100400912  [KO:K02947]
100401038  RPS3; 40S ribosomal protein S3 [KO:K02985]
100401133  [KO:K02977]
100401150  [KO:K02936]
100401174  RPS24; 40S ribosomal protein S24 isoform X2 [KO:K02974]
100401239  [KO:K02977]
100401520  RPL5; 60S ribosomal protein L5 isoform X1 [KO:K02932]
100401558  [KO:K02872]
100401630  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100401793  RPLP2; 60S acidic ribosomal protein P2 isoform X3 [KO:K02943]
100401849  F13A1; coagulation factor XIII A chain [KO:K03917] [EC:2.3.2.13]
100401854  [KO:K02973]
100401954  [KO:K02932]
100402060  [KO:K02987]
100402218  [KO:K02993]
100402266  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100402436  FGG; fibrinogen gamma chain isoform X1 [KO:K03905]
100402633  [KO:K02920]
100402978  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X3 [KO:K04733] [EC:2.7.11.1]
100403008  [KO:K02942]
100403175  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100403218  C3AR1; C3a anaphylatoxin chemotactic receptor [KO:K04009]
100403300  RPL18; 60S ribosomal protein L18 [KO:K02883]
100403494  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100403655  [KO:K02947]
100403828  RPLP1; 60S acidic ribosomal protein P1 [KO:K02942]
100403855  [KO:K02993]
100403899  RPS19; 40S ribosomal protein S19 [KO:K02966]
100403981  STING1; stimulator of interferon genes protein [KO:K12654]
100404028  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
100404139  [KO:K02981]
100404189  [KO:K02917]
100404198  [KO:K02957]
100404320  [KO:K02873]
100404333  [KO:K02936]
100404377  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100404525  [KO:K02984]
100404611  TLR2; toll-like receptor 2 [KO:K10159]
100404704  [KO:K02993]
100404713  RPS23; 40S ribosomal protein S23 [KO:K02973]
100404787  [KO:K02974]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100405000  [KO:K02870]
100405079  [KO:K02880]
100405093  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100405101  RPL18A; 60S ribosomal protein L18a isoform X2 [KO:K02882]
100405217  [KO:K02915]
100405501  C1QB; complement C1q subcomponent subunit B [KO:K03987]
100405537  [KO:K02976]
100405583  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
100405622  [KO:K02984]
100405643  [KO:K02870]
100405704  MX1; interferon-induced GTP-binding protein Mx1 isoform X1 [KO:K14754]
100405719  RPL23A; 60S ribosomal protein L23a [KO:K02893]
100405901  [KO:K02977]
100406098  [KO:K05414]
100406419  AGTR1; type-1 angiotensin II receptor [KO:K04166]
100406466  [KO:K05414]
100406496  RPS29; 40S ribosomal protein S29 [KO:K02980]
100406520  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X3 [KO:K06059] [EC:3.4.24.86]
100406654  [KO:K02932]
100406669  IL12A; interleukin-12 subunit alpha [KO:K05406]
100406689  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100406769  IL1B; interleukin-1 beta isoform X1 [KO:K04519]
100406774  [KO:K02957]
100406802  [KO:K02932]
100407168  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
100407233  RPS2; 40S ribosomal protein S2 [KO:K02981]
100407253  MASP1; mannan-binding lectin serine protease 1 isoform X6 [KO:K03992] [EC:3.4.21.-]
100407300  RPL26; 60S ribosomal protein L26 [KO:K02898]
100407306  RPL36A; 60S ribosomal protein L36a isoform X1 [KO:K02929]
100407326  [KO:K02949]
100407446  RPL22; 60S ribosomal protein L22 [KO:K02891]
100407499  [KO:K02947]
100407503  RPS14; 40S ribosomal protein S14 [KO:K02955]
100407530  TMPRSS2; transmembrane protease serine 2 isoform X2 [KO:K09633] [EC:3.4.21.122]
100407590  RPL36AL; 60S ribosomal protein L36a-like [KO:K02929]
100408130  [KO:K02971]
100408147  ACE; angiotensin-converting enzyme isoform X1 [KO:K01283] [EC:3.4.15.1]
100408284  RPL13; 60S ribosomal protein L13 [KO:K02873]
100408296  [KO:K02915]
100408305  [KO:K02930]
100408512  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
100408518  [KO:K01283] [EC:3.4.15.1]
100408545  CSF3; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor [KO:K05423]
100408692  RIGI; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
100408774  MASP2; mannan-binding lectin serine protease 2 isoform X1 [KO:K03993] [EC:3.4.21.104]
100408843  RPL7; 60S ribosomal protein L7 isoform X1 [KO:K02937]
100408852  C6; complement component C6 isoform X1 [KO:K03995]
100408882  ACE2; angiotensin-converting enzyme 2 [KO:K09708] [EC:3.4.17.23]
100408929  [KO:K02934]
100409118  RPS9; 40S ribosomal protein S9 [KO:K02997]
100409208  [KO:K02898]
100409227  CFB; complement factor B isoform X1 [KO:K01335] [EC:3.4.21.47]
100409542  [KO:K02934]
100409573  TLR3; toll-like receptor 3 isoform X2 [KO:K05401]
100409718  C5AR1; C5a anaphylatoxin chemotactic receptor 1 [KO:K04010]
100409753  [KO:K02898]
100409857  [KO:K02993]
100409927  RPL37; 60S ribosomal protein L37 [KO:K02922]
100410136  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100410164  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
100410306  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
100410463  [KO:K02984]
100410549  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
100410631  [KO:K02951]
100410666  [KO:K02974]
100410792  [KO:K02984]
100410823  [KO:K02865]
100410858  FAU; FAU ubiquitin-like and ribosomal protein S30 [KO:K02983]
100410963  RPLP0; 60S acidic ribosomal protein P0 [KO:K02941]
100410972  [KO:K02974]
100411085  [KO:K02910]
100411120  [KO:K02875]
100411291  [KO:K02987]
100411501  [KO:K03989]
100411528  [KO:K02880]
100411672  [KO:K02977]
100411779  [KO:K05423]
100411827  [KO:K02927]
100411835  [KO:K02908]
100411901  RPL37A; 60S ribosomal protein L37a [KO:K02921]
100411952  [KO:K02940]
100412041  [KO:K02974]
100412095  RPS27; 40S ribosomal protein S27 [KO:K02978]
100412158  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100412161  [KO:K02976]
100412225  [KO:K02993]
100412232  MAS1; proto-oncogene Mas [KO:K04303]
100412274  C1S; complement C1s subcomponent [KO:K01331] [EC:3.4.21.42]
100412555  RPL35A; 60S ribosomal protein L35a [KO:K02917]
100412650  RPS6; 40S ribosomal protein S6 [KO:K02991]
100412723  [KO:K02893]
100412991  RPS25; 40S ribosomal protein S25 [KO:K02975]
100413070  RPL38; 60S ribosomal protein L38 [KO:K02923]
100413151  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
100413175  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
100413255  RPL35; 60S ribosomal protein L35 [KO:K02918]
100413370  [KO:K02942]
100413622  RPL24; 60S ribosomal protein L24 [KO:K02896]
100413631  [KO:K02923]
100413736  [KO:K02936]
100413757  [KO:K02966]
100413856  RPS7; 40S ribosomal protein S7 [KO:K02993]
100414020  [KO:K02974]
100414095  [KO:K02962]
100414110  [KO:K02974]
100414129  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100414132  IRF3; interferon regulatory factor 3 isoform X4 [KO:K05411]
100414154  [KO:K02885]
100414273  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
100414289  [KO:K02898]
100414356  [KO:K02898]
100414359  RPS26; 40S ribosomal protein S26 [KO:K02976]
100414509  RPL23; 60S ribosomal protein L23 [KO:K02894]
100414516  [KO:K05414]
100414659  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100414678  [KO:K02936]
100414739  RPS28; 40S ribosomal protein S28 [KO:K02979]
100415260  RPL6; 60S ribosomal protein L6 [KO:K02934]
100415309  [KO:K02987]
100415321  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100415355  RPL10; 60S ribosomal protein L10 isoform X2 [KO:K02866]
100415383  [KO:K02984]
100415466  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
100415523  RPL31; 60S ribosomal protein L31 [KO:K02910]
100415625  [KO:K02912]
100894768  C1QC; complement C1q subcomponent subunit C [KO:K03988]
100894890  [KO:K02929]
100894965  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
100895129  [KO:K02910]
100895451  RPL39L; 60S ribosomal protein L39-like isoform X1 [KO:K02924]
100896043  [KO:K02980]
100896246  [KO:K02993]
100896443  [KO:K02955]
103787203  RPS20; 40S ribosomal protein S20 [KO:K02969]
103787557  [KO:K02981]
103787664  [KO:K02877]
103788241  [KO:K02927]
103788504  [KO:K02915]
103788510  [KO:K02896]
103788586  [KO:K02964]
103788718  [KO:K02889]
103789172  [KO:K02915]
103789488  [KO:K02896]
103790956  [KO:K02973]
103791474  [KO:K02915]
103791541  [KO:K02929]
103791583  [KO:K02991]
103791927  [KO:K02934]
103791991  [KO:K02958]
103792356  [KO:K02966]
103792363  C2; complement C2 [KO:K01332] [EC:3.4.21.43]
103792402  RPS10; 40S ribosomal protein S10 isoform X4 [KO:K02947]
103792812  RPL29; 60S ribosomal protein L29 [KO:K02905]
103792824  [KO:K02920]
103793162  [KO:K02984]
103793369  [KO:K05414]
103793556  [KO:K06856]
103793772  [KO:K02929]
103793891  [KO:K02896]
103794402  [KO:K02987]
103794477  [KO:K02903]
103794898  [KO:K02984]
103795168  [KO:K02896]
103795388  [KO:K02880]
103795420  OAS2; 2'-5'-oligoadenylate synthase 2 isoform X2 [KO:K14216] [EC:2.7.7.84]
103795515  [KO:K02927]
103796047  [KO:K02927]
103796056  [KO:K02921]
103796361  [KO:K02927]
103796729  [KO:K02912]
108587804  [KO:K02980]
108587809  [KO:K02980]
108587858  [KO:K02978]
108587881  [KO:K02976]
108588012  [KO:K02978]
108588053  [KO:K02905]
108588089  [KO:K02977]
108588253  [KO:K02936]
108588255  [KO:K02910]
108588284  [KO:K02912]
108588312  [KO:K02898]
108588468  [KO:K02915]
108588476  [KO:K02978]
108588480  [KO:K02993]
108588627  [KO:K02922]
108588663  [KO:K02974]
108588670  [KO:K02977]
108588751  [KO:K02885]
108588776  [KO:K02981]
108588797  [KO:K02979]
108588815  [KO:K02889]
108588868  [KO:K02889]
108588938  [KO:K02977]
108588985  [KO:K02932]
108589033  [KO:K02898]
108589314  [KO:K02974]
108589342  [KO:K02898]
108589416  [KO:K02978]
108589472  [KO:K02978]
108589529  [KO:K02978]
108589542  [KO:K02922]
108589548  [KO:K02991]
108589623  [KO:K02910]
108589749  [KO:K02889]
108589801  [KO:K02978]
108589849  [KO:K02893]
108589884  [KO:K02957]
108589918  [KO:K02880]
108589993  [KO:K02905]
108590303  [KO:K02924]
108590594  [KO:K02910]
108590603  [KO:K02889]
108590720  [KO:K02905]
108590731  [KO:K02885]
108590737  [KO:K02910]
108590784  [KO:K02974]
108590957  [KO:K02971]
108590961  [KO:K02905]
108591035  [KO:K02974]
108591143  [KO:K02976]
108591201  [KO:K02929]
108591209  [KO:K02922]
108591240  [KO:K02898]
108591274  [KO:K02910]
108591275  [KO:K02924]
108591413  [KO:K02978]
108591553  [KO:K02998]
108591598  [KO:K02977]
108591657  [KO:K02924]
108591684  [KO:K02893]
108591692  [KO:K02978]
108591766  [KO:K02880]
108591802  [KO:K02978]
108591845  [KO:K02984]
108591869  [KO:K02880]
108591873  [KO:K02924]
108591893  [KO:K02929]
108591975  [KO:K02978]
108592020  [KO:K02927]
108592084  [KO:K02905]
108592092  [KO:K02998]
108592183  [KO:K02893]
108592290  [KO:K02893]
108592426  [KO:K02922]
108592737  [KO:K02924]
108592801  [KO:K02922]
108592823  [KO:K02915]
108592894  [KO:K02978]
108592931  [KO:K02889]
108592932  [KO:K02893]
108592948  [KO:K02889]
108593120  [KO:K02978]
108593129  [KO:K02917]
108593139  [KO:K02880]
108593226  [KO:K02889]
108593243  [KO:K02929]
108593374  [KO:K02981]
108593413  [KO:K02951]
108593503  [KO:K02974]
108593512  [KO:K02929]
108593632  [KO:K02979]
108593633  [KO:K02978]
108593667  [KO:K02998]
108593752  [KO:K02936]
108593798  [KO:K02974]
108593825  [KO:K02898]
108593942  [KO:K02978]
108593961  [KO:K02922]
108593963  [KO:K02893]
108594028  [KO:K02889]
108594116  [KO:K02978]
108594119  [KO:K02974]
118142913  [KO:K02927]
118142940  [KO:K02934]
118142948  [KO:K02957]
118143092  [KO:K02922]
118143125  [KO:K02962]
118143170  [KO:K02896]
118143171  [KO:K02898]
118143794  [KO:K02978]
118144144  [KO:K02977]
118144155  [KO:K02937]
118144937  [KO:K02910]
118145074  [KO:K02998]
118145538  [KO:K02977]
118145623  [KO:K02921]
118146375  [KO:K02977]
118146404  [KO:K02922]
118147716  [KO:K02942]
118147935  [KO:K02980]
118147943  [KO:K02936]
118148436  [KO:K02893]
118148519  [KO:K02889]
118149224  [KO:K02977]
118149437  [KO:K02947]
118150096  [KO:K02896]
118150139  [KO:K02947]
118150143  [KO:K02924]
118150206  [KO:K02957]
118150286  [KO:K02947]
118150453  [KO:K02905]
118150934  [KO:K02987]
118150936  [KO:K02977]
118151041  [KO:K02900]
118151346  [KO:K02998]
118151561  [KO:K02974]
118152162  [KO:K02912]
118152706  [KO:K02905]
118152707  [KO:K02957]
118152838  [KO:K02969]
118152843  [KO:K02934]
118152862  [KO:K02889]
118152993  [KO:K02934]
118153476  [KO:K02977]
118153695  [KO:K02889]
118153787  [KO:K02912]
118153894  [KO:K02977]
118155347  [KO:K02991]
118155393  [KO:K02991]
128928024  IFNAR2; interferon alpha/beta receptor 2 isoform X2 [KO:K05131]
128928036  [KO:K02925]
128928145  [KO:K02984]
128928158  [KO:K05414]
128928793  [KO:K02905]
128929277  [KO:K02905]
128930091  [KO:K02975]
128930410  [KO:K02912]
128930505  [KO:K02912]
128930506  [KO:K02998]
128930535  [KO:K02889]
128930664  [KO:K02889]
128931322  [KO:K02998]
128931663  [KO:K02929]
128931796  [KO:K02905]
128932004  [KO:K02893]
128932203  [KO:K05414]
128932211  [KO:K02962]
128932552  [KO:K02962]
Compound
C00027  Hydrogen peroxide
C00046  RNA
C00165  Diacylglycerol
C00290  Fibrin
C00533  Nitric oxide
C00704  Superoxide
C00873  Angiotensin I
C02135  Angiotensin II
C15850  Angiotensin (1-7)
C20640  Cyclic GMP-AMP
Reference
PMID:33132005
  Authors
Harrison AG, Lin T, Wang P
  Title
Mechanisms of SARS-CoV-2 Transmission and Pathogenesis.
  Journal
Trends Immunol S1471-4906(20)30233-7 (2020)
DOI:10.1016/j.it.2020.10.004
Reference
PMID:33077917
  Authors
Perico L, Benigni A, Casiraghi F, Ng LFP, Renia L, Remuzzi G
  Title
Immunity, endothelial injury and complement-induced coagulopathy in COVID-19.
  Journal
Nat Rev Nephrol 17:46-64 (2021)
DOI:10.1038/s41581-020-00357-4
Reference
PMID:32820801
  Authors
Battagello DS, Dragunas G, Klein MO, Ayub ALP, Velloso FJ, Correa RG
  Title
Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission.
  Journal
Clin Sci (Lond) 134:2137-2160 (2020)
DOI:10.1042/CS20200904
Reference
PMID:32353634
  Authors
Felsenstein S, Herbert JA, McNamara PS, Hedrich CM
  Title
COVID-19: Immunology and treatment options.
  Journal
Clin Immunol 215:108448 (2020)
DOI:10.1016/j.clim.2020.108448
Reference
PMID:33014208
  Authors
Hojyo S, Uchida M, Tanaka K, Hasebe R, Tanaka Y, Murakami M, Hirano T
  Title
How COVID-19 induces cytokine storm with high mortality.
  Journal
Inflamm Regen 40:37 (2020)
DOI:10.1186/s41232-020-00146-3
Reference
PMID:32544563
  Authors
Mahmudpour M, Roozbeh J, Keshavarz M, Farrokhi S, Nabipour I
  Title
COVID-19 cytokine storm: The anger of inflammation.
  Journal
Cytokine 133:155151 (2020)
DOI:10.1016/j.cyto.2020.155151
Reference
PMID:32635353
  Authors
Farooqi F, Dhawan N, Morgan R, Dinh J, Nedd K, Yatzkan G
  Title
Treatment of Severe COVID-19 with Tocilizumab Mitigates Cytokine Storm and Averts Mechanical Ventilation During Acute Respiratory Distress: A Case Report and Literature Review.
  Journal
Trop Med Infect Dis 5:E112 (2020)
DOI:10.3390/tropicalmed5030112
Reference
PMID:32376392
  Authors
Jamilloux Y, Henry T, Belot A, Viel S, Fauter M, El Jammal T, Walzer T, Francois B, Seve P
  Title
Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions.
  Journal
Autoimmun Rev 19:102567 (2020)
DOI:10.1016/j.autrev.2020.102567
Reference
PMID:32722596
  Authors
Kiselevskiy M, Shubina I, Chikileva I, Sitdikova S, Samoylenko I, Anisimova N, Kirgizov K, Suleimanova A, Gorbunova T, Varfolomeeva S
  Title
Immune Pathogenesis of COVID-19 Intoxication: Storm or Silence?
  Journal
Pharmaceuticals (Basel) 13:166 (2020)
DOI:10.3390/ph13080166
Reference
PMID:32922297
  Authors
Curran CS, Rivera DR, Kopp JB
  Title
COVID-19 Usurps Host Regulatory Networks.
  Journal
Front Pharmacol 11:1278 (2020)
DOI:10.3389/fphar.2020.01278
Reference
PMID:33055229
  Authors
Quan C, Li C, Ma H, Li Y, Zhang H
  Title
Immunopathogenesis of Coronavirus-Induced Acute Respiratory Distress Syndrome (ARDS): Potential Infection-Associated Hemophagocytic Lymphohistiocytosis.
  Journal
Clin Microbiol Rev 34:e00074-20 (2020)
DOI:10.1128/CMR.00074-20
Reference
PMID:32973803
  Authors
Ahmed-Hassan H, Sisson B, Shukla RK, Wijewantha Y, Funderburg NT, Li Z, Hayes D Jr, Demberg T, Liyanage NPM
  Title
Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections.
  Journal
Front Immunol 11:1979 (2020)
DOI:10.3389/fimmu.2020.01979
Reference
PMID:32346093
  Authors
Tay MZ, Poh CM, Renia L, MacAry PA, Ng LFP
  Title
The trinity of COVID-19: immunity, inflammation and intervention.
  Journal
Nat Rev Immunol 20:363-374 (2020)
DOI:10.1038/s41577-020-0311-8
Reference
PMID:32979938
  Authors
Xia H, Cao Z, Xie X, Zhang X, Chen JY, Wang H, Menachery VD, Rajsbaum R, Shi PY
  Title
Evasion of Type I Interferon by SARS-CoV-2.
  Journal
Cell Rep 33:108234 (2020)
DOI:10.1016/j.celrep.2020.108234
Reference
PMID:32661197
  Authors
Hartenian E, Nandakumar D, Lari A, Ly M, Tucker JM, Glaunsinger BA
  Title
The molecular virology of coronaviruses.
  Journal
J Biol Chem 295:12910-12934 (2020)
DOI:10.1074/jbc.REV120.013930
Reference
PMID:32978971
  Authors
Amor S, Fernandez Blanco L, Baker D
  Title
Innate immunity during SARS-CoV-2: evasion strategies and activation trigger hypoxia and vascular damage.
  Journal
Clin Exp Immunol 202:193-209 (2020)
DOI:10.1111/cei.13523
Reference
PMID:32467561
  Authors
Catanzaro M, Fagiani F, Racchi M, Corsini E, Govoni S, Lanni C
  Title
Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2.
  Journal
Signal Transduct Target Ther 5:84 (2020)
DOI:10.1038/s41392-020-0191-1
Reference
PMID:32687918
  Authors
Jafarzadeh A, Chauhan P, Saha B, Jafarzadeh S, Nemati M
  Title
Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions.
  Journal
Life Sci 257:118102 (2020)
DOI:10.1016/j.lfs.2020.118102
Reference
PMID:32376901
  Authors
Merad M, Martin JC
  Title
Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages.
  Journal
Nat Rev Immunol 20:355-362 (2020)
DOI:10.1038/s41577-020-0331-4
Reference
PMID:32246101
  Authors
South AM, Tomlinson L, Edmonston D, Hiremath S, Sparks MA
  Title
Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic.
  Journal
Nat Rev Nephrol 16:305-307 (2020)
DOI:10.1038/s41581-020-0279-4
Reference
PMID:32433641
  Authors
Furuhashi M, Moniwa N, Takizawa H, Ura N, Shimamoto K
  Title
Potential differential effects of renin-angiotensin system inhibitors on SARS-CoV-2 infection and lung injury in COVID-19.
  Journal
Hypertens Res 43:837-840 (2020)
DOI:10.1038/s41440-020-0478-1
Reference
PMID:32423094
  Authors
Gemmati D, Bramanti B, Serino ML, Secchiero P, Zauli G, Tisato V
  Title
COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?
  Journal
Int J Mol Sci 21:E3474 (2020)
DOI:10.3390/ijms21103474
Reference
PMID:33184193
  Authors
Kielian M
  Title
Enhancing host cell infection by SARS-CoV-2.
  Journal
Science 370:765-766 (2020)
DOI:10.1126/science.abf0732
Reference
PMID:32327719
  Authors
Risitano AM, Mastellos DC, Huber-Lang M, Yancopoulou D, Garlanda C, Ciceri F, Lambris JD
  Title
Complement as a target in COVID-19?
  Journal
Nat Rev Immunol 20:343-344 (2020)
DOI:10.1038/s41577-020-0320-7
Reference
PMID:32461141
  Authors
Noris M, Benigni A, Remuzzi G
  Title
The case of complement activation in COVID-19 multiorgan impact.
  Journal
Kidney Int 98:314-322 (2020)
DOI:10.1016/j.kint.2020.05.013
Reference
PMID:32559343
  Authors
Polycarpou A, Howard M, Farrar CA, Greenlaw R, Fanelli G, Wallis R, Klavinskis LS, Sacks S
  Title
Rationale for targeting complement in COVID-19.
  Journal
EMBO Mol Med 12:e12642 (2020)
DOI:10.15252/emmm.202012642
Reference
PMID:32439870
  Authors
Teuwen LA, Geldhof V, Pasut A, Carmeliet P
  Title
COVID-19: the vasculature unleashed.
  Journal
Nat Rev Immunol 20:389-391 (2020)
DOI:10.1038/s41577-020-0343-0
Reference
PMID:32643798
  Authors
Jodele S, Kohl J
  Title
Tackling COVID-19 infection through complement-targeted immunotherapy.
  Journal
Br J Pharmacol 178:2832-2848 (2021)
DOI:10.1111/bph.15187
Reference
PMID:32608159
  Authors
Chauhan AJ, Wiffen LJ, Brown TP
  Title
COVID-19: A collision of complement, coagulation and inflammatory pathways.
  Journal
J Thromb Haemost 18:2110-2117 (2020)
DOI:10.1111/jth.14981
Reference
PMID:32558620
  Authors
Colling ME, Kanthi Y
  Title
COVID-19-associated coagulopathy: An exploration of mechanisms.
  Journal
Vasc Med 25:471-478 (2020)
DOI:10.1177/1358863X20932640
Reference
PMID:32586214
  Authors
McFadyen JD, Stevens H, Peter K
  Title
The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications.
  Journal
Circ Res 127:571-587 (2020)
DOI:10.1161/CIRCRESAHA.120.317447
Reference
PMID:32995777
  Authors
Shi M, Wang L, Fontana P, Vora S, Zhang Y, Fu TM, Lieberman J, Wu H
  Title
SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism.
  Journal
bioRxiv 2020.09.18.302901 (2020)
DOI:10.1101/2020.09.18.302901
Reference
PMID:32693241
  Authors
Paniri A, Akhavan-Niaki H
  Title
Emerging role of IL-6 and NLRP3 inflammasome as potential therapeutic targets to combat COVID-19: Role of lncRNAs in cytokine storm modulation.
  Journal
Life Sci 257:118114 (2020)
DOI:10.1016/j.lfs.2020.118114
Reference
PMID:32405269
  Authors
Omarjee L, Janin A, Perrot F, Laviolle B, Meilhac O, Mahe G
  Title
Targeting T-cell senescence and cytokine storm with rapamycin to prevent severe progression in COVID-19.
  Journal
Clin Immunol 216:108464 (2020)
DOI:10.1016/j.clim.2020.108464
Reference
PMID:32337664
  Authors
Zhang S, Li L, Shen A, Chen Y, Qi Z
  Title
Rational Use of Tocilizumab in the Treatment of Novel Coronavirus Pneumonia.
  Journal
Clin Drug Investig 40:511-518 (2020)
DOI:10.1007/s40261-020-00917-3
Related
pathway
cjc03015  mRNA surveillance pathway
cjc04144  Endocytosis
cjc04270  Vascular smooth muscle contraction
cjc04610  Complement and coagulation cascades
cjc04611  Platelet activation
cjc04613  Neutrophil extracellular trap formation
cjc04614  Renin-angiotensin system
cjc04620  Toll-like receptor signaling pathway
cjc04621  NOD-like receptor signaling pathway
cjc04622  RIG-I-like receptor signaling pathway
cjc04623  Cytosolic DNA-sensing pathway
cjc04630  JAK-STAT signaling pathway
cjc04650  Natural killer cell mediated cytotoxicity
cjc04666  Fc gamma R-mediated phagocytosis
cjc04668  TNF signaling pathway
cjc04670  Leukocyte transendothelial migration
KO pathway
ko05171   

DBGET integrated database retrieval system