KEGG   PATHWAY: cpoo04010
Entry
cpoo04010                   Pathway                                
Name
MAPK signaling pathway - Crocodylus porosus (Australian saltwater crocodile)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
cpoo04010  MAPK signaling pathway
cpoo04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Crocodylus porosus (Australian saltwater crocodile) [GN:cpoo]
Gene
109305529  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
109305540  PDGFD; platelet-derived growth factor D [KO:K05450]
109305989  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
109306032  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
109306226  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
109306229  [KO:K04386]
109306232  [KO:K04386]
109306438  [KO:K02583]
109306583  [KO:K04421] [EC:2.7.11.25]
109306630  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
109306671  FGF9; fibroblast growth factor 9 [KO:K04358]
109306836  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
109306951  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109307187  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
109307217  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
109307348  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
109307420  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
109307440  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
109307535  JUN; transcription factor AP-1 [KO:K04448]
109307577  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
109307578  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
109307632  ARTN; artemin [KO:K25415]
109307696  RASA1; ras GTPase-activating protein 1 [KO:K04352]
109307847  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
109307884  FGF10; fibroblast growth factor 10 [KO:K04358]
109307929  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
109308069  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
109308092  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
109308093  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
109308158  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
109308197  [KO:K05452]
109308413  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
109308553  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
109308598  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
109309047  FGF7; fibroblast growth factor 7 [KO:K04358]
109309154  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
109309197  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
109309206  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
109309242  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
109309312  AREG; amphiregulin [KO:K09782]
109309314  FGF5; fibroblast growth factor 5 [KO:K04358]
109309334  FGF2; fibroblast growth factor 2 [KO:K18497]
109309386  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
109309464  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109309512  EREG; proepiregulin [KO:K09784]
109309700  PDGFC; platelet-derived growth factor C [KO:K05450]
109309712  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
109309769  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
109309794  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
109309880  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
109309941  FGF18; fibroblast growth factor 18 [KO:K04358]
109310009  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
109310053  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
109310131  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109310155  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
109310160  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
109310161  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
109310333  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
109310482  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
109310858  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
109310907  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
109310942  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
109311055  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
109311365  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
109311399  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
109311400  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
109311719  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
109311869  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
109312310  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
109312363  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
109312390  FGF22; fibroblast growth factor 22 [KO:K04358]
109312403  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
109312665  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
109312825  CRKL; crk-like protein [KO:K04438]
109312899  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
109312928  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
109312999  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109313059  ANGPT4; angiopoietin-4 [KO:K05467]
109313170  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
109313276  [KO:K04519]
109313381  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
109313605  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
109313679  [KO:K05096] [EC:2.7.10.1]
109313694  FGF16; fibroblast growth factor 16 [KO:K04358]
109313783  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
109313839  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
109314291  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
109314327  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
109314600  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
109314684  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
109314716  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
109314792  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
109314804  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
109314821  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
109314872  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
109314938  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
109315022  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
109315065  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
109315317  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
109315335  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
109315494  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
109315520  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
109315576  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
109315620  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
109315663  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
109315664  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
109315770  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
109315771  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
109315945  [KO:K04856]
109316042  FGF6; fibroblast growth factor 6 [KO:K04358]
109316272  FGF23; fibroblast growth factor 23 [KO:K22428]
109316282  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
109316310  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109316381  KRAS; GTPase KRas isoform X1 [KO:K07827]
109316457  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
109316460  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
109316525  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109316541  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
109316558  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
109316620  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
109316638  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
109316689  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
109316692  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
109316697  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
109316878  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
109316881  KITLG; kit ligand isoform X1 [KO:K05461]
109317000  HSPB1; heat shock protein beta-1 [KO:K04455]
109317109  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
109317118  NF1; neurofibromin isoform X1 [KO:K08052]
109317236  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
109317278  CRK; adapter molecule crk isoform X1 [KO:K04438]
109317391  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
109317416  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
109317431  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
109317454  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
109317501  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
109317538  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
109317585  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
109317599  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
109317734  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
109317843  NGF; beta-nerve growth factor [KO:K02582]
109317850  NRAS; GTPase NRas [KO:K07828]
109317882  RAP1A; ras-related protein Rap-1A [KO:K04353]
109317923  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
109318038  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
109318199  HRAS; GTPase HRas isoform X1 [KO:K02833]
109318230  MAX; protein max isoform X1 [KO:K04453]
109318298  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
109318305  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
109318414  STMN1; stathmin isoform X1 [KO:K04381]
109318435  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
109318449  [KO:K05466]
109318538  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
109318608  [KO:K03283]
109318635  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
109318950  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
109318998  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
109319002  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
109319184  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
109319436  SRF; serum response factor isoform X1 [KO:K04378]
109319468  SOS1; son of sevenless homolog 1 [KO:K03099]
109319469  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
109319524  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
109319653  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
109319735  TGFB2; transforming growth factor beta-2 [KO:K13376]
109319750  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
109319861  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
109319877  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
109319932  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109319979  MAP3K21; mitogen-activated protein kinase kinase kinase MLK4 isoform X1 [KO:K17534] [EC:2.7.11.25]
109320045  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
109320062  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
109320128  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
109320185  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
109320192  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
109320265  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
109320284  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
109320626  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109320691  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
109320781  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
109320783  [KO:K16342] [EC:3.1.1.4]
109320784  [KO:K16342] [EC:3.1.1.4]
109320785  [KO:K16342] [EC:3.1.1.4]
109320786  [KO:K16342] [EC:3.1.1.4]
109320829  FGF21; fibroblast growth factor 21 [KO:K22429]
109320830  NTF4; neurotrophin-4 [KO:K12457]
109320833  [KO:K07827]
109320837  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
109320856  TGFB3; LOW QUALITY PROTEIN: transforming growth factor beta-3 [KO:K13377]
109320893  SOS2; son of sevenless homolog 2 [KO:K03099]
109320953  INS; insulin [KO:K04526]
109321068  [KO:K16342] [EC:3.1.1.4]
109321069  [KO:K16342] [EC:3.1.1.4]
109321161  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
109321262  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
109321288  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
109321294  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
109321384  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109321430  PGF; placenta growth factor [KO:K16859]
109321438  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
109321500  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
109321502  RRAS2; ras-related protein R-Ras2 [KO:K07830]
109321539  FOS; proto-oncogene c-Fos [KO:K04379]
109321579  [KO:K16342] [EC:3.1.1.4]
109321582  BDNF; brain-derived neurotrophic factor [KO:K04355]
109321606  FGF3; fibroblast growth factor 3 [KO:K04358]
109321613  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
109321619  [KO:K16342] [EC:3.1.1.4]
109321622  [KO:K16342] [EC:3.1.1.4]
109321630  FGF4; fibroblast growth factor 4 isoform X1 [KO:K04358]
109321645  FGF19; fibroblast growth factor 19 [KO:K22603]
109321647  [KO:K16342] [EC:3.1.1.4]
109321681  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
109321863  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
109321893  FGF20; fibroblast growth factor 20 [KO:K04358]
109322061  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
109322084  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
109322120  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
109322137  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
109322182  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
109322249  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
109322321  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
109322513  [KO:K04420] [EC:2.7.11.25]
109322639  [KO:K04420] [EC:2.7.11.25]
109322736  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
109322762  [KO:K04388] [EC:2.7.11.30]
109322843  MAP3K20; mitogen-activated protein kinase kinase kinase MLT isoform X1 [KO:K04424] [EC:2.7.11.25]
109322848  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
109322868  MRAS; ras-related protein M-Ras [KO:K07831]
109323075  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
109323099  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
109323212  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
109323426  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
109323582  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
109323706  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
109323829  FGF8; fibroblast growth factor 8 [KO:K04358]
109323858  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
109323949  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109323969  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109323987  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
109324023  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
109324154  [KO:K03283]
109324217  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
109324251  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109324296  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
109324468  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
109324482  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
109324502  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
109324696  EFNA3; ephrin-A3 [KO:K05462]
109324698  EFNA1; ephrin-A1 [KO:K05462]
109324793  EFNA4; ephrin-A4 [KO:K05462]
109324852  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
109324916  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
cpoo04070  Phosphatidylinositol signaling system
cpoo04110  Cell cycle
cpoo04115  p53 signaling pathway
cpoo04210  Apoptosis
cpoo04310  Wnt signaling pathway
KO pathway
ko04010   

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