KEGG   PATHWAY: esp04810
Entry
esp04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Etheostoma spectabile (orangethroat darter)
Class
Cellular Processes; Cell motility
Pathway map
esp04810  Regulation of actin cytoskeleton
esp04810

Other DBs
GO: 0030036
Organism
Etheostoma spectabile (orangethroat darter) [GN:esp]
Gene
116669662  [KO:K06269] [EC:3.1.3.16]
116669702  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
116669838  itgb6; integrin beta-6 [KO:K06589]
116669997  chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
116670002  pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
116670013  [KO:K04410] [EC:2.7.11.1]
116670120  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116670204  [KO:K03916]
116670266  [KO:K03916]
116670305  [KO:K10352]
116670535  [KO:K03916]
116670536  [KO:K03916]
116670542  [KO:K05699]
116670634  rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
116670728  [KO:K06493]
116670942  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116670996  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
116671011  [KO:K05627]
116671118  itgb4; integrin beta-4 isoform X1 [KO:K06525]
116671152  itga3; integrin alpha-3 [KO:K06482]
116671183  [KO:K05700]
116671255  [KO:K22429]
116671320  [KO:K06269] [EC:3.1.3.16]
116671334  [KO:K12758]
116671445  [KO:K06461]
116671519  [KO:K04131]
116671546  [KO:K07861]
116671707  [KO:K00907] [EC:2.7.11.18]
116671786  [KO:K04639]
116671913  [KO:K05093] [EC:2.7.10.1]
116671974  c8g; complement component C8 gamma chain [KO:K03999]
116672030  itgb1; integrin beta-1 isoform X1 [KO:K05719]
116672053  pip4k2a; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
116672078  vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
116672148  mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
116672281  cyrib; protein FAM49B [KO:K27976]
116672459  [KO:K12757]
116672467  arhgef4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
116672532  spata13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
116672982  [KO:K23612]
116673037  chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
116673142  [KO:K04456] [EC:2.7.11.1]
116673193  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116673300  fgf23; fibroblast growth factor 23 [KO:K22428]
116673308  fgf6; fibroblast growth factor 6 isoform X1 [KO:K04358]
116673322  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
116673323  limk1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
116673342  [KO:K04456] [EC:2.7.11.1]
116673693  chrm4; muscarinic acetylcholine receptor M4 [KO:K04132]
116673747  [KO:K13710]
116673792  [KO:K05762]
116673892  [KO:K18584]
116674038  abi2; abl interactor 2 isoform X1 [KO:K05751]
116674147  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
116674771  crk; adapter molecule crk [KO:K04438]
116675754  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
116675778  actn4; alpha-actinin-4 isoform X1 [KO:K05699]
116676055  [KO:K05763]
116678381  [KO:K00922] [EC:2.7.1.153]
116678507  arhgap35; rho GTPase-activating protein 35 [KO:K05732]
116678819  [KO:K03099]
116678893  arhgef12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
116679392  apc2; adenomatous polyposis coli protein 2 [KO:K02085]
116679804  [KO:K06269] [EC:3.1.3.16]
116679824  [KO:K00920] [EC:2.7.1.149]
116682352  [KO:K04275]
116683329  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
116683359  [KO:K06464]
116683501  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
116683602  ssh2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
116685041  [KO:K04409] [EC:2.7.11.1]
116686097  [KO:K08007]
116686209  [KO:K05751]
116686512  [KO:K04358]
116686659  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
116686662  [KO:K10351]
116686679  iqgap1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
116686972  pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
116687052  [KO:K04362] [EC:2.7.10.1]
116687057  [KO:K05731]
116687234  [KO:K00920] [EC:2.7.1.149]
116687400  [KO:K10351]
116687421  itga7; integrin alpha-7 isoform X1 [KO:K06583]
116687422  nckap1l; nck-associated protein 1-like [KO:K05750]
116687553  itga5; integrin alpha-5 [KO:K06484]
116687594  [KO:K05704] [EC:2.7.10.2]
116687703  [KO:K04513]
116687761  [KO:K05755]
116688064  [KO:K12755]
116688259  [KO:K04513]
116688288  [KO:K04393]
116688401  [KO:K23612]
116688418  [KO:K05755]
116688444  brk1; protein BRICK1 [KO:K05752]
116688935  limk2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
116688950  pikfyve; LOW QUALITY PROTEIN: 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
116688992  rgcc; regulator of cell cycle RGCC [KO:K26108]
116689248  [KO:K00889] [EC:2.7.1.68]
116689305  [KO:K06269] [EC:3.1.3.16]
116689310  [KO:K10351]
116689477  itga2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
116689511  ssh1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
116689613  iqgap2; LOW QUALITY PROTEIN: ras GTPase-activating-like protein IQGAP2 [KO:K05767]
116689616  f2r; proteinase-activated receptor 1 [KO:K03914]
116689632  myl7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
116689662  fgf10; fibroblast growth factor 10 [KO:K04358]
116689782  [KO:K03996]
116689863  itgb5; integrin beta-5 [KO:K06588]
116689892  c5; complement C5 isoform X1 [KO:K03994]
116689915  [KO:K02649]
116689928  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
116689954  [KO:K05692]
116690056  rras2; ras-related protein R-Ras2 [KO:K07830]
116690260  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
116690322  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116690326  fgf5; fibroblast growth factor 5 [KO:K04358]
116690346  [KO:K05760]
116690381  [KO:K04362] [EC:2.7.10.1]
116690450  [KO:K05742]
116690676  itga11; integrin alpha-11 isoform X1 [KO:K06587]
116690803  itga10; integrin alpha-10 [KO:K06586]
116691325  arhgef1; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 1 [KO:K12330]
116691327  [KO:K04393]
116691384  [KO:K00889] [EC:2.7.1.68]
116691433  [KO:K05725] [EC:2.7.10.2]
116691511  [KO:K05627]
116691646  itga8; integrin alpha-8 [KO:K06584]
116691940  [KO:K04513]
116691991  [KO:K04275]
116692018  [KO:K04513]
116692170  [KO:K04393]
116692455  [KO:K04513]
116692529  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116692628  [KO:K05722]
116692732  [KO:K05704] [EC:2.7.10.2]
116693071  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116693125  [KO:K06484]
116693290  pip4k2c; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
116693736  [KO:K23612]
116694007  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116694165  [KO:K17457]
116694245  hras; GTPase HRas [KO:K02833]
116694484  kras; GTPase KRas isoform X1 [KO:K07827]
116694598  bcar1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
116694648  [KO:K04130]
116694773  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116694890  pip4k2b; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
116694979  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
116695030  [KO:K05757]
116695039  [KO:K05757]
116695172  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116695178  pfn2; profilin-2 isoform X1 [KO:K05759]
116695388  [KO:K10352]
116695417  [KO:K00922] [EC:2.7.1.153]
116695419  [KO:K03898]
116695430  [KO:K02649]
116695568  mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
116695589  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
116695614  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
116695713  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116695845  [KO:K05768]
116696034  cyfip1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
116696108  pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
116696132  [KO:K04358]
116696146  [KO:K02649]
116696369  cfl1; cofilin-1 [KO:K05765]
116696380  [KO:K04358]
116696408  [KO:K04358]
116696412  fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
116696493  diaph1; protein diaphanous homolog 1 isoform X1 [KO:K05741]
116696497  [KO:K04358]
116696503  lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
116696510  egf; pro-epidermal growth factor [KO:K04357]
116696522  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
116696607  [KO:K04358]
116696701  diaph2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
116696794  [KO:K05763]
116696858  [KO:K04358]
116696869  ins; insulin [KO:K04526]
116696884  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
116696921  fgf16; fibroblast growth factor 16 [KO:K04358]
116696922  [KO:K18496]
116696951  [KO:K05764]
116697059  [KO:K05729]
116697098  [KO:K05766] [EC:3.1.3.16 3.1.3.48]
116697371  cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
116697399  [KO:K26108]
116697577  [KO:K04291]
116697732  arhgef7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
116697845  [KO:K18584]
116697888  [KO:K05762]
116697929  cxcl12; stromal cell-derived factor 1 [KO:K10031]
116697981  itga4; integrin alpha-4 [KO:K06483]
116698137  [KO:K04358]
116698140  mras; ras-related protein M-Ras [KO:K07831]
116698207  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
116698403  itga6; LOW QUALITY PROTEIN: integrin alpha-6 [KO:K06485]
116698421  [KO:K05717]
116698498  [KO:K05730]
116698538  [KO:K12757]
116698567  [KO:K02649]
116698585  [KO:K04358]
116698610  rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
116698735  [KO:K04189]
116698815  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116698830  [KO:K06485]
116698833  [KO:K05719]
116698983  [KO:K04347]
116698986  [KO:K05768]
116699144  [KO:K00889] [EC:2.7.1.68]
116699195  [KO:K00922] [EC:2.7.1.153]
116699207  [KO:K02649]
116699211  [KO:K00907] [EC:2.7.11.18]
116699217  c8a; complement component C8 alpha chain [KO:K03997]
116699236  [KO:K05759]
116699426  [KO:K04369] [EC:2.7.12.2]
116699428  [KO:K04369] [EC:2.7.12.2]
116699669  [KO:K05754]
116700073  [KO:K07532]
116700092  [KO:K05731]
116700176  msn; moesin [KO:K05763]
116700229  [KO:K05733] [EC:2.7.11.1]
116700286  fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
116700400  [KO:K04359]
116700588  [KO:K05732]
116700737  [KO:K04438]
116700867  diaph3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
116700882  [KO:K05766] [EC:3.1.3.16 3.1.3.48]
116700940  [KO:K17386]
116701095  [KO:K05743] [EC:2.7.11.1]
116701103  [KO:K05095] [EC:2.7.10.1]
116701200  [KO:K27976]
116701381  [KO:K05718]
116701571  itgb8; integrin beta-8 [KO:K06591]
116701576  wasf2; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
116701641  [KO:K05725] [EC:2.7.10.2]
116701654  [KO:K00889] [EC:2.7.1.68]
116701733  [KO:K05692]
116701833  [KO:K04393]
116701869  [KO:K05742]
116702297  [KO:K06493]
116702356  [KO:K05627]
116702491  [KO:K04392]
116702550  [KO:K06269] [EC:3.1.3.16]
116702588  [KO:K05757]
116702591  [KO:K04639]
116702842  myh9; myosin-9 [KO:K10352]
116702937  [KO:K00907] [EC:2.7.11.18]
116702948  [KO:K10352]
116703151  pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116703193  actb; actin, cytoplasmic 1 [KO:K05692]
116703217  mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
116703304  fgf3; fibroblast growth factor 3 [KO:K04358]
116703305  fgf4; fibroblast growth factor 4 [KO:K04358]
116703389  fgf19; fibroblast growth factor 19 [KO:K22603]
116703510  [KO:K10352]
116703555  rras; ras-related protein R-Ras [KO:K07830]
116703632  [KO:K04347]
116703686  [KO:K04291]
116703753  [KO:K04371] [EC:2.7.11.24]
116703772  [KO:K07827]
116703860  [KO:K00889] [EC:2.7.1.68]
116703898  crkl; crk-like protein [KO:K04438]
116704085  [KO:K02649]
116704092  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
116704120  gsn; gelsolin isoform X1 [KO:K05768]
116704133  c6; complement component C6 [KO:K03995]
116704136  c7; complement component C7 [KO:K03996]
116704193  [KO:K03914]
116704223  c9; complement component C9 [KO:K04000]
116704312  lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
116704390  [KO:K17457]
116704504  [KO:K07860]
116704545  [KO:K04358]
116704553  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
116704619  [KO:K07861]
116704787  itga1; integrin alpha-1 [KO:K06480]
116704991  nckap1; nck-associated protein 1 isoform X1 [KO:K05750]
116705039  actr2; actin-related protein 2 [KO:K17260]
116705099  [KO:K04456] [EC:2.7.11.1]
116705361  fgf7; fibroblast growth factor 7 [KO:K04358]
116705372  [KO:K10031]
116705377  [KO:K05700]
116705452  [KO:K04131]
116705472  dstn; destrin [KO:K05765]
116705541  [KO:K10352]
116705775  itga9; integrin alpha-9 [KO:K06585]
116705828  gna12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
116705871  [KO:K17388] [EC:2.7.11.39]
116705878  enah; LOW QUALITY PROTEIN: protein enabled homolog [KO:K05746]
116706015  wasf1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
116706059  [KO:K04133]
116706084  ezr; ezrin [KO:K08007]
116706182  [KO:K27976]
116706203  fn1; fibronectin isoform X1 [KO:K05717]
116706251  pak5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
116706431  [KO:K06269] [EC:3.1.3.16]
116707200  [KO:K06269] [EC:3.1.3.16]
116707274  vav1; proto-oncogene vav isoform X1 [KO:K05730]
116707305  [KO:K17260]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
esp04010  MAPK signaling pathway
esp04510  Focal adhesion
esp04520  Adherens junction
KO pathway
ko04810   

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