KEGG   PATHWAY: hmh04024
Entry
hmh04024                    Pathway                                
Name
cAMP signaling pathway - Hylobates moloch (silvery gibbon)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
hmh04024  cAMP signaling pathway
hmh04024

Other DBs
GO: 0019933
Organism
Hylobates moloch (silvery gibbon) [GN:hmh]
Gene
116456110  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
116456200  [KO:K01540]
116456218  FOS; protein c-Fos [KO:K04379]
116456701  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
116456808  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
116456825  DRD5; D(1B) dopamine receptor [KO:K05840]
116457100  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
116457249  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
116457306  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2 [KO:K05860] [EC:3.1.4.11]
116457338  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
116457363  JUN; transcription factor Jun [KO:K04448]
116457382  ADORA1; adenosine receptor A1 isoform X1 [KO:K04265]
116457700  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
116457712  KCNK2; potassium channel subfamily K member 2 [KO:K04913]
116457903  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116458053  RYR2; ryanodine receptor 2 isoform X6 [KO:K04962]
116458301  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
116458344  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
116458418  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
116458509  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
116458566  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
116459050  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
116459068  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
116459126  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116459149  ADORA2A; LOW QUALITY PROTEIN: adenosine receptor A2a [KO:K04266]
116459675  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
116460172  EDN1; endothelin-1 isoform X2 [KO:K16366]
116460219  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
116460519  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
116460758  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
116460769  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116461131  OXT; oxytocin-neurophysin 1 [KO:K05243]
116461620  [KO:K08014]
116461629  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540]
116461805  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
116462105  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116462231  [KO:K13293] [EC:3.1.4.53]
116462297  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
116462359  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
116462427  SSTR5; somatostatin receptor type 5 [KO:K04221]
116462563  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
116462715  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
116462749  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116463099  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
116463128  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116463168  [KO:K05264]
116463212  [KO:K05264]
116463273  [KO:K04632]
116463274  [KO:K04632]
116463279  [KO:K05227]
116463360  [KO:K04632]
116463361  [KO:K04632]
116463365  [KO:K05227]
116463465  [KO:K05198]
116463489  [KO:K05198]
116464223  [KO:K04630]
116464225  [KO:K04630]
116464499  HHIP; hedgehog-interacting protein [KO:K06231]
116465815  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
116466695  OXTR; oxytocin receptor [KO:K04229]
116466735  GHRL; appetite-regulating hormone isoform X2 [KO:K05254]
116466736  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
116466754  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116466852  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
116466871  [KO:K02183]
116466901  POPDC2; popeye domain-containing protein 2 isoform X1 [KO:K26206]
116467052  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
116467386  ABCC4; ATP-binding cassette sub-family C member 4 isoform X1 [KO:K05673]
116467516  [KO:K02183]
116468126  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
116468452  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
116468684  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
116468695  ADCYAP1; LOW QUALITY PROTEIN: pituitary adenylate cyclase-activating polypeptide [KO:K05262]
116468912  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
116468949  BAD; bcl2-associated agonist of cell death [KO:K02158]
116468975  GPHA2; glycoprotein hormone alpha-2 [KO:K25483]
116469011  RELA; transcription factor p65 isoform X1 [KO:K04735]
116469079  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
116469214  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
116469215  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
116469279  [KO:K04513]
116469376  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
116469384  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
116469461  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
116469471  CGA; glycoprotein hormones alpha chain isoform X1 [KO:K08522]
116469557  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
116469564  TSHB; thyrotropin subunit beta [KO:K05251]
116469612  RAP1A; ras-related protein Rap-1A [KO:K04353]
116469652  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
116469686  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
116469844  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116469897  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
116470186  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X2 [KO:K05853] [EC:7.2.2.10]
116470222  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116470322  BVES; blood vessel epicardial substance [KO:K21108]
116470346  POPDC3; popeye domain-containing protein 3 [KO:K26207]
116470946  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
116471090  F2R; proteinase-activated receptor 1 [KO:K03914]
116471246  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
116471452  PLN; cardiac phospholamban isoform X4 [KO:K05852]
116471641  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
116471690  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
116471691  ADRB2; beta-2 adrenergic receptor [KO:K04142]
116471714  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
116471746  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
116471873  DRD1; D(1A) dopamine receptor [KO:K04144]
116471970  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116472274  EDN2; endothelin-2 isoform X1 [KO:K16367]
116472525  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
116472713  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
116472753  PDE3A; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
116473104  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
116473267  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
116473278  ADCY10; adenylate cyclase type 10 isoform X4 [KO:K11265] [EC:4.6.1.1]
116473372  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X9 [KO:K04851]
116473478  RHOA; transforming protein RhoA [KO:K04513]
116473687  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
116473818  AFDN; afadin isoform X3 [KO:K05702]
116474613  CALML5; calmodulin-like protein 5 [KO:K02183]
116474621  CALML3; calmodulin-like protein 3 [KO:K02183]
116474677  GIP; gastric inhibitory polypeptide [KO:K05258]
116474754  PPP1R1B; protein phosphatase 1 regulatory subunit 1B [KO:K15494]
116475000  CRHR1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
116475074  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
116475280  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
116475316  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 isoform X1 [KO:K04615]
116475347  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
116475410  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
116475833  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
116475911  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X2 [KO:K05208]
116476303  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
116476405  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
116476485  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1 [KO:K13296] [EC:3.1.4.17]
116476491  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
116476593  CNGA4; cyclic nucleotide-gated cation channel alpha-4 isoform X1 [KO:K04951]
116476722  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
116476877  GRIA4; glutamate receptor 4 isoform X4 [KO:K05200]
116476953  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
116476994  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
116477278  FSHB; follitropin subunit beta [KO:K05250]
116477742  [KO:K08402]
116477786  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
116477930  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
116477947  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
116478211  RRAS; ras-related protein R-Ras [KO:K07829]
116478221  LHB; lutropin subunit beta [KO:K08521]
116478253  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
116478308  CALM3; calmodulin-3 [KO:K02183]
116478343  VAV1; proto-oncogene vav [KO:K05730]
116478447  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
116478588  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
116478691  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116478696  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
116478895  FXYD1; phospholemman [KO:K13360]
116478979  RAP1B; ras-related protein Rap-1b [KO:K07836]
116479049  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
116479072  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
116479209  TNNI3; troponin I, cardiac muscle isoform X2 [KO:K12044]
116479387  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
116479633  FFAR2; free fatty acid receptor 2 [KO:K04328]
116479954  SST; somatostatin [KO:K05237]
116480242  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
116480274  SUCNR1; succinate receptor 1 [KO:K10042]
116480287  [KO:K04392]
116480307  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
116480405  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
116480413  POMC; pro-opiomelanocortin [KO:K05228]
116480512  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
116480602  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
116480604  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
116480683  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116480865  GLI1; zinc finger protein GLI1 [KO:K16797]
116481263  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116481786  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
116481827  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
116482295  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116482339  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
116482892  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
116482899  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
116483045  GIPR; gastric inhibitory polypeptide receptor isoform X1 [KO:K04580]
116483146  CALM2; calmodulin-2 isoform X1 [KO:K02183]
116483253  FSHR; follicle-stimulating hormone receptor [KO:K04247]
116483262  SOX9; transcription factor SOX-9 [KO:K18435]
116483343  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116483376  ADRB1; beta-1 adrenergic receptor [KO:K04141]
116483394  CNGA3; cyclic nucleotide-gated cation channel alpha-3 [KO:K04950]
116483464  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X2 [KO:K05211]
116483538  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
116483548  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116483558  SSTR2; somatostatin receptor type 2 isoform X2 [KO:K04218]
116483725  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 [KO:K00232] [EC:1.3.3.6]
116483790  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
116483934  HCN2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
116484128  AMH; muellerian-inhibiting factor [KO:K04665]
116484638  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
116484821  TSHR; thyrotropin receptor isoform X1 [KO:K04249]
116484980  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
116485006  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
116485109  SSTR1; somatostatin receptor type 1 [KO:K04217]
116485139  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116485193  CALM1; calmodulin-1 isoform X2 [KO:K02183]
116809597  NPY; pro-neuropeptide Y [KO:K05232]
116809731  VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X2 [KO:K04590]
116810385  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X3 [KO:K05870]
116810653  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
116810741  GCG; pro-glucagon [KO:K05259]
116810870  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116810950  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
116811385  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
116811398  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
116811686  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
116812014  GRIA3; glutamate receptor 3 isoform X2 [KO:K05199]
116812065  [KO:K04632]
116812107  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
116812192  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
116812469  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
116812488  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
116812519  GLI3; transcriptional activator GLI3 [KO:K06230]
116812590  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X2 [KO:K04587]
116812597  CRHR2; corticotropin-releasing factor receptor 2 isoform X2 [KO:K04579]
116812715  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X5 [KO:K09047]
116812889  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116812933  NPPA; natriuretic peptides A [KO:K12334]
116813019  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
116813140  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
116813235  CRH; corticoliberin [KO:K05256]
116813387  CNGB3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
116813595  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
116813883  CALML6; calmodulin-like protein 6 [KO:K02183]
116813930  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
116814165  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
116814342  [KO:K04369] [EC:2.7.12.2]
116814401  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
116814406  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
116814428  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
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Pharmaceuticals (Basel) 5:1291-331 (2012)
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cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
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Cell Calcium 55:385-393 (2014)
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Shirshev SV
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Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
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Biochemistry (Mosc) 76:981-98 (2011)
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Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
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Biochem Soc Trans 42:89-97 (2014)
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J Mol Cell Cardiol 41:183-214 (2006)
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J Am Coll Cardiol 54:1747-62 (2009)
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Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
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Prog Biophys Mol Biol 85:261-78 (2004)
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Circ Res 108:85-97 (2011)
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Front Physiol 2:67 (2011)
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Mol Endocrinol 14:1962-75 (2000)
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Related
pathway
hmh00071  Fatty acid degradation
hmh04015  Rap1 signaling pathway
hmh04020  Calcium signaling pathway
hmh04151  PI3K-Akt signaling pathway
hmh04210  Apoptosis
hmh04260  Cardiac muscle contraction
hmh04340  Hedgehog signaling pathway
hmh04720  Long-term potentiation
hmh04740  Olfactory transduction
hmh04972  Pancreatic secretion
hmh04976  Bile secretion
KO pathway
ko04024   

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