KEGG   PATHWAY: mcf05010
Entry
mcf05010                    Pathway                                
Name
Alzheimer disease - Macaca fascicularis (crab-eating macaque)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
mcf05010  Alzheimer disease
mcf05010

Disease
H00056  Alzheimer disease
Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
101864886  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
101864983  VDAC1; non-selective voltage-gated ion channel VDAC1 [KO:K05862]
101865007  RTN4; reticulon-4 isoform X1 [KO:K20720]
101865043  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
101865051  PSMC5; 26S proteasome regulatory subunit 8 isoform X2 [KO:K03066]
101865119  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
101865168  CALM2; calmodulin-2 isoform X2 [KO:K02183]
101865175  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X4 [KO:K04850]
101865238  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
101865240  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
101865354  CASP8; caspase-8 isoform X3 [KO:K04398] [EC:3.4.22.61]
101865389  ITPR1; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X2 [KO:K04958]
101865397  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
101865454  KIF5A; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
101865478  PSMA3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
101865498  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
101865560  CSNK2A2; casein kinase II subunit alpha' isoform X2 [KO:K03097] [EC:2.7.11.1]
101865627  VDAC2; non-selective voltage-gated ion channel VDAC2 isoform X1 [KO:K15040]
101865772  [KO:K07374]
101865806  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
101865834  NCSTN; nicastrin isoform X2 [KO:K06171]
101865843  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
101865852  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939]
101865873  CDK5; cyclin-dependent kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
101865895  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
101865964  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
101865971  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
101866070  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101866246  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
101866278  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
101866285  FADD; FAS-associated death domain protein [KO:K02373]
101866296  RTN3; reticulon-3 isoform X5 [KO:K20723]
101866339  KLC2; kinesin light chain 2 [KO:K10407]
101866377  CALM3; calmodulin-3 [KO:K02183]
101866436  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101866438  TUBB4B; tubulin beta-4B chain [KO:K07375]
101866439  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101866581  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
101866604  [KO:K07375]
101866612  PSMA8; proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
101866670  NDUFAB1; acyl carrier protein, mitochondrial isoform X1 [KO:K03955]
101866673  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
101866792  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X11 [KO:K03941] [EC:7.1.1.2]
101866824  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X2 [KO:K03961]
101866879  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101866963  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
101867105  TUBA8; tubulin alpha-8 chain isoform X2 [KO:K07374]
101867140  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101867165  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
101867179  PPID; peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
101867267  BECN1; beclin-1 isoform X4 [KO:K08334]
101867270  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
101867279  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
101867324  RELA; transcription factor p65 isoform X1 [KO:K04735]
101867359  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X2 [KO:K05853] [EC:7.2.2.10]
101867500  TUBA1B; tubulin alpha-1B chain [KO:K07374]
101867512  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
101925039  PSMC1; 26S proteasome regulatory subunit 4 isoform X1 [KO:K03062]
101925169  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101925175  TRAF2; TNF receptor-associated factor 2 isoform X4 [KO:K03173] [EC:2.3.2.27]
101925194  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
101925220  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
101925249  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
101925386  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101925452  TUBA3E; tubulin alpha-3E chain [KO:K07374]
101925481  APH1B; gamma-secretase subunit APH-1B isoform X2 [KO:K06172]
101925535  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
101925588  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
101925657  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
101925689  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
101925715  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
101925772  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
101925816  TUBB; tubulin beta chain isoform X1 [KO:K07375]
101925833  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
101925926  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
101925928  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
101925940  TUBB3; tubulin beta-3 chain [KO:K07375]
101925989  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
101926075  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
101926080  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
101926377  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
101926424  PSMA4; proteasome subunit alpha type-4 isoform X1 [KO:K02728] [EC:3.4.25.1]
101926433  APP; amyloid-beta precursor protein isoform X1 [KO:K04520]
101926508  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
101926546  IL1A; interleukin-1 alpha isoform X2 [KO:K04383]
101926612  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
101926640  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
101926643  SLC39A6; zinc transporter ZIP6 [KO:K14712]
101926738  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101926805  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
102114795  CALML3; calmodulin-like protein 3 [KO:K02183]
102114833  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
102114855  [KO:K07375]
102114911  NDUFB1; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
102114913  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
102115033  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X2 [KO:K05208]
102115052  FZD3; frizzled-3 isoform X2 [KO:K02329]
102115368  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102115402  BECN2; beclin-2 [KO:K08334]
102115595  ATG101; autophagy-related protein 101 isoform X1 [KO:K19730]
102115672  ATP5PB; ATP synthase peripheral stalk subunit b, mitochondrial isoform X3 [KO:K02127]
102115744  ITPR2; inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 isoform X1 [KO:K04959]
102115795  [KO:K04741] [EC:3.4.22.-]
102115854  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
102115952  DKK4; dickkopf-related protein 4 [KO:K02165]
102115964  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102116003  ITPR3; inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 isoform X1 [KO:K04960]
102116010  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
102116193  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102116211  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
102116447  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
102116497  COX6A2; cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
102116568  VDAC3; non-selective voltage-gated ion channel VDAC3 isoform X1 [KO:K15041]
102116573  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
102116683  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
102116784  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
102116855  SLC39A3; zinc transporter ZIP3 [KO:K14709]
102116918  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
102116923  BACE1; beta-secretase 1 [KO:K04521] [EC:3.4.23.46]
102116936  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
102116996  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
102117050  [KO:K03935] [EC:7.1.1.2]
102117102  [KO:K08738]
102117222  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
102117303  UQCRB; cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
102117377  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
102117433  UQCRC1; cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
102117567  ATP5PF; ATP synthase peripheral stalk subunit F6, mitochondrial isoform X2 [KO:K02131]
102117766  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
102117805  FRAT1; proto-oncogene FRAT1 [KO:K03069]
102117938  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102117978  IRS1; insulin receptor substrate 1 [KO:K16172]
102118159  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
102118171  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
102118238  CSNK1A1; casein kinase I isoform X2 [KO:K08957] [EC:2.7.11.1]
102118472  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X3 [KO:K03954]
102118497  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102118608  COX7A2L; cytochrome c oxidase subunit 7A2-like, mitochondrial isoform X2 [KO:K02270]
102118619  [KO:K02265]
102118744  HRAS; GTPase HRas [KO:K02833]
102118754  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
102118944  TUBB1; tubulin beta-1 chain [KO:K07375]
102119049  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X4 [KO:K03940] [EC:7.1.1.2]
102119159  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
102119369  SNCA; alpha-synuclein isoform X2 [KO:K04528]
102119414  MAPT; microtubule-associated protein tau isoform X33 [KO:K04380]
102119570  ATP5F1E; ATP synthase F(1) complex subunit epsilon, mitochondrial [KO:K02135]
102119582  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
102119626  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
102119749  IL1B; interleukin-1 beta [KO:K04519]
102119841  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
102120205  CYCS; cytochrome c [KO:K08738]
102120527  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
102120762  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
102120871  WNT1; proto-oncogene Wnt-1 [KO:K03209]
102121052  SLC39A14; metal cation symporter ZIP14 isoform X4 [KO:K14720]
102121124  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
102121218  [KO:K07374]
102121241  WNT10B; protein Wnt-10b isoform X2 [KO:K01357]
102121272  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102121324  WNT8B; protein Wnt-8b [KO:K00714]
102121361  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial isoform X1 [KO:K02128]
102121432  [KO:K13241] [EC:1.14.13.39]
102121560  [KO:K02267]
102121830  FZD2; frizzled-2 [KO:K02235]
102121921  BAD; bcl2-associated agonist of cell death [KO:K02158]
102122063  COX8C; cytochrome c oxidase subunit 8C, mitochondrial isoform X3 [KO:K02273]
102122149  [KO:K02128]
102122241  IRS2; insulin receptor substrate 2 [KO:K07187]
102122252  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
102122343  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
102122399  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X5 [KO:K03947]
102122418  CYBB; NADPH oxidase 2 [KO:K21421] [EC:1.-.-.-]
102122521  [KO:K03943] [EC:7.1.1.2]
102122692  [KO:K03853] [EC:3.4.22.53]
102122711  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
102122725  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102122883  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
102122953  PSMC6; 26S proteasome regulatory subunit 10B isoform X2 [KO:K03064]
102123032  [KO:K00416]
102123100  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
102123126  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
102123165  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102123270  COX7B2; cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
102123369  FZD1; frizzled-1 [KO:K02432]
102123489  APC2; adenomatous polyposis coli protein 2 isoform X3 [KO:K02085]
102123521  NOS1; nitric oxide synthase 1 isoform X2 [KO:K13240] [EC:1.14.13.39]
102123735  DKK1; dickkopf-related protein 1 [KO:K02165]
102123745  ATP5F1A; ATP synthase F(1) complex subunit alpha, mitochondrial [KO:K02132]
102123777  SLC39A5; zinc transporter ZIP5 isoform X1 [KO:K14711]
102123783  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 isoform X1 [KO:K03038]
102123916  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
102124180  COX7B; cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
102124346  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
102124626  [KO:K02265]
102124686  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X15 [KO:K03943] [EC:7.1.1.2]
102124745  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
102124773  PSMB3; proteasome subunit beta type-3 isoform X1 [KO:K02735] [EC:3.4.25.1]
102124789  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X2 [KO:K09565] [EC:5.2.1.8]
102124804  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102124843  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
102124883  [KO:K03064]
102125060  [KO:K07375]
102125227  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
102125312  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102125333  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X2 [KO:K03953]
102125825  CSNK2A1; casein kinase II subunit alpha isoform X2 [KO:K03097] [EC:2.7.11.1]
102126003  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X2 [KO:K00234] [EC:1.3.5.1]
102126180  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
102126339  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
102126517  COX7A2; cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
102126553  APC; adenomatous polyposis coli protein isoform X7 [KO:K02085]
102126830  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
102126927  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
102126975  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X2 [KO:K04431] [EC:2.7.12.2]
102127158  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
102127185  [KO:K00236]
102127213  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
102127470  ATP5PO; ATP synthase peripheral stalk subunit OSCP, mitochondrial [KO:K02137]
102127531  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
102127614  [KO:K08738]
102127626  FZD10; frizzled-10 [KO:K02842]
102127751  [KO:K00236]
102128172  FZD7; frizzled-7 [KO:K02432]
102128230  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
102128252  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
102128371  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
102128569  KIF5C; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
102128628  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
102128659  UQCR11; cytochrome b-c1 complex subunit 10 [KO:K00420]
102128802  [KO:K07374]
102128819  IRS4; insulin receptor substrate 4 [KO:K17446]
102129174  WNT2; protein Wnt-2 isoform X1 [KO:K00182]
102129176  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
102129216  [KO:K02127]
102129286  TUBB4A; tubulin beta-4A chain [KO:K07375]
102129485  [KO:K02128]
102129552  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
102129654  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
102129656  AXIN2; axin-2 isoform X2 [KO:K04385]
102129733  COX7C; cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
102129758  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
102129777  FZD8; frizzled-8 [KO:K02375]
102129785  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
102129825  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
102129902  SLC39A12; zinc transporter ZIP12 isoform X1 [KO:K14718]
102130032  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
102130095  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
102130191  COX6B2; cytochrome c oxidase subunit 6B2 [KO:K02267]
102130297  WNT9B; protein Wnt-9b [KO:K01064]
102130397  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
102130649  WNT11; protein Wnt-11 isoform X2 [KO:K01384]
102130865  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
102130917  WNT2B; protein Wnt-2b [KO:K00182]
102131065  [KO:K07375]
102131140  ATG2A; autophagy-related protein 2 homolog A isoform X2 [KO:K17906]
102131162  CALM1; calmodulin-1 [KO:K02183]
102131483  KRAS; GTPase KRas isoform X1 [KO:K07827]
102131553  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
102131578  FZD6; frizzled-6 isoform X1 [KO:K02376]
102131632  DDIT3; DNA damage-inducible transcript 3 protein isoform X2 [KO:K04452]
102131688  WNT3A; protein Wnt-3a isoform X1 [KO:K00312]
102132017  [KO:K00411] [EC:7.1.1.8]
102132064  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
102132250  COX7A1; cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
102132660  WNT6; protein Wnt-6 [KO:K00445]
102132705  [KO:K03949]
102132744  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102132790  COX5B; cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
102133057  UQCRQ; cytochrome b-c1 complex subunit 8 [KO:K00418]
102133184  INS; insulin [KO:K04526]
102133224  ATP5F1C; ATP synthase F(1) complex subunit gamma, mitochondrial isoform X2 [KO:K02136]
102133278  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
102133526  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
102133631  UQCRFS1; cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
102133672  WNT10A; protein Wnt-10a [KO:K01357]
102133756  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102133931  SLC39A7; zinc transporter SLC39A7 isoform X1 [KO:K14713]
102133949  UQCR10; cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
102134019  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
102134079  APBB1; amyloid beta precursor protein binding family B member 1 isoform X4 [KO:K04529]
102134081  FZD4; frizzled-4 isoform X2 [KO:K02354]
102134282  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
102134309  [KO:K00236]
102134477  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
102134478  DKK2; dickkopf-related protein 2 [KO:K02165]
102134506  SLC39A9; zinc transporter ZIP9 isoform X3 [KO:K14715]
102134571  SLC39A10; zinc transporter ZIP10 isoform X2 [KO:K14716]
102134986  [KO:K03955]
102135041  UQCRC2; cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
102135285  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102135636  WNT7B; protein Wnt-7b isoform X2 [KO:K00572]
102135711  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
102135755  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
102135848  COX5A; cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
102135853  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
102135950  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
102136267  UQCRH; cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
102136293  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
102136645  SLC39A1; zinc transporter ZIP1 isoform X1 [KO:K14709]
102136896  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
102137128  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X3 [KO:K03937]
102137250  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
102137291  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
102137297  COX6C; cytochrome c oxidase subunit 6C [KO:K02268]
102137321  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
102137340  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
102137362  [KO:K02272]
102137377  SLC39A8; metal cation symporter ZIP8 isoform X1 [KO:K14714]
102137473  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
102137566  [KO:K07375]
102137573  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 isoform X1 [KO:K03028]
102137623  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
102137913  NRAS; GTPase NRas [KO:K07828]
102137931  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
102138179  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
102138213  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X10 [KO:K04851]
102138273  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
102138471  APOE; apolipoprotein E [KO:K04524]
102138538  [KO:K02263]
102138616  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
102138674  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
102138876  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
102138928  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]
102138971  IL6; interleukin-6 precursor [KO:K05405]
102139017  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
102139081  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
102139269  [KO:K07375]
102139510  COX8A; cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
102139631  TNF; tumor necrosis factor [KO:K03156]
102139855  COX4I2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X2 [KO:K02263]
102140105  ATP5F1B; ATP synthase F(1) complex subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
102140196  KIF5B; kinesin-1 heavy chain [KO:K10396] [EC:5.6.1.3]
102140374  [KO:K11351]
102140446  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
102140609  BACE2; beta-secretase 2 isoform X1 [KO:K07747] [EC:3.4.23.45]
102140615  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
102140841  CSNK1A1L; casein kinase I [KO:K08957] [EC:2.7.11.1]
102140855  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102141145  GAPDH; glyceraldehyde-3-phosphate dehydrogenase isoform X1 [KO:K00134] [EC:1.2.1.12]
102141167  ULK1; serine/threonine-protein kinase ULK1 isoform X4 [KO:K21357] [EC:2.7.11.1]
102141214  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102141324  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
102141417  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
102141433  COX6A1; cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
102141594  SLC39A4; zinc transporter ZIP4 isoform X2 [KO:K14710]
102141631  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
102141873  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
102142021  ATP5PD; ATP synthase peripheral stalk subunit d, mitochondrial isoform X2 [KO:K02138]
102142026  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102142058  FZD9; frizzled-9 [KO:K02842]
102142308  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
102142406  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102142460  WNT16; protein Wnt-16 [KO:K01558]
102142525  SLC39A13; zinc transporter ZIP13 isoform X2 [KO:K14719]
102142948  [KO:K03949]
102142969  GRIN2D; glutamate receptor ionotropic, NMDA 2D isoform X2 [KO:K05212]
102142970  AXIN1; axin-1 isoform X1 [KO:K02157]
102143028  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
102143058  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
102143103  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X8 [KO:K06691]
102143139  FZD5; frizzled-5 [KO:K02375]
102143226  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
102143409  [KO:K03938]
102143464  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102143674  SLC25A31; ADP/ATP translocase 4 isoform X2 [KO:K05863]
102143756  COX6B1; cytochrome c oxidase subunit 6B1 [KO:K02267]
102143975  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
102143985  SLC39A11; zinc transporter ZIP11 isoform X6 [KO:K14717]
102144138  [KO:K02183]
102144182  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
102144252  CSNK1E; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
102144265  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
102144280  COX4I1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X2 [KO:K02263]
102144461  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
102144739  ATP5F1D; ATP synthase F(1) complex subunit delta, mitochondrial isoform X1 [KO:K02134]
102144790  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
102145011  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102145061  LRP5; low-density lipoprotein receptor-related protein 5 isoform X6 [KO:K03068]
102145434  [KO:K03947]
102145737  CYC1; cytochrome c1, heme protein, mitochondrial isoform X1 [KO:K00413]
102145866  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
102145886  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
102145957  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X16 [KO:K00236]
102145991  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
102146039  NAE1; NEDD8-activating enzyme E1 regulatory subunit isoform X2 [KO:K04532]
102146369  [KO:K03938]
102146380  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
102146522  [KO:K03965]
102146604  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102146976  CALML5; calmodulin-like protein 5 [KO:K02183]
102146984  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
102147252  SEM1; 26S proteasome complex subunit SEM1 isoform X1 [KO:K10881]
107127908  [KO:K08738]
107129296  [KO:K03062]
107130218  [KO:K08738]
123567561  [KO:K02272]
123568376  [KO:K02272]
123568388  [KO:K03959]
123569396  [KO:K07375]
123570066  [KO:K00237]
123570224  [KO:K02272]
123571146  [KO:K02270]
123572509  [KO:K02272]
123572831  [KO:K02272]
123573614  [KO:K02268]
123573956  [KO:K02272]
123574038  [KO:K03948]
123574408  [KO:K02272]
123574442  [KO:K02272]
123575162  [KO:K02272]
123575527  [KO:K03948]
135964343  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
135964355  [KO:K07210]
135964855  [KO:K07375]
135966624  [KO:K00237]
135967611  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
135969579  [KO:K07375]
135970143  [KO:K02183]
135970856  [KO:K07375]
141406880  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
141409493  [KO:K05863]
7857739  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
7857740  COX2; cytochrome c oxidase subunit II [KO:K02261]
7857741  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
7857742  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
7857743  COX3; cytochrome c oxidase subunit III [KO:K02262]
7857744  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
7857745  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
7857746  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
7857747  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
7857748  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
7857749  CYTB; cytochrome b [KO:K00412]
7857750  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
7857751  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Front Cell Neurosci 13:227 (2019)
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Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma.
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Front Neurosci 10:459 (2016)
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Related
pathway
mcf00190  Oxidative phosphorylation
mcf03050  Proteasome
mcf04020  Calcium signaling pathway
mcf04140  Autophagy - animal
mcf04141  Protein processing in endoplasmic reticulum
mcf04210  Apoptosis
mcf04310  Wnt signaling pathway
mcf04910  Insulin signaling pathway
mcf04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   

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