KEGG   PATHWAY: mmu05203
Entry
mmu05203                    Pathway                                
Name
Viral carcinogenesis - Mus musculus (house mouse)
Description
There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers.
Class
Human Diseases; Cancer: overview
Pathway map
mmu05203  Viral carcinogenesis
mmu05203

Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100039786  Gm2423; predicted gene 2423 [KO:K16197]
100041230  H4c17; H4 clustered histone 17 [KO:K11254]
100529082  H2-T27; histocompatibility 2, T region locus 27 [KO:K06751]
105782  Scrib; scribbled planar cell polarity [KO:K16175]
107932  Chd4; chromodomain helicase DNA binding protein 4 [KO:K11643] [EC:5.6.2.-]
107995  Cdc20; cell division cycle 20 [KO:K03363]
109711  Actn1; actinin, alpha 1 [KO:K05699]
110557  H2-Q6; histocompatibility 2, Q region locus 6 [KO:K06751]
110558  H2-Q9; histocompatibility 2, Q region locus 9 [KO:K06751]
110696  H2-M10.3; histocompatibility 2, M region locus 10.3 [KO:K06751]
110957  D1Pas1; DNA segment, Chr 1, Pasteur Institute 1 [KO:K11594] [EC:5.6.2.7]
114713  Rasa2; RAS p21 protein activator 2 [KO:K08053]
11848  Rhoa; ras homolog family member A [KO:K04513]
11909  Atf2; activating transcription factor 2 [KO:K04450]
11911  Atf4; activating transcription factor 4 [KO:K04374]
11972  Atp6v0d1; ATPase, H+ transporting, lysosomal V0 subunit D1 [KO:K02146]
12015  Bad; BCL2-associated agonist of cell death [KO:K02158]
12018  Bak1; BCL2-antagonist/killer 1 [KO:K14021]
12028  Bax; BCL2-associated X protein [KO:K02159]
12266  C3; complement component 3 [KO:K03990]
12367  Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
12370  Casp8; caspase 8 [KO:K04398] [EC:3.4.22.61]
12427  Ccna1; cyclin A1 [KO:K06627]
12428  Ccna2; cyclin A2 [KO:K06627]
12443  Ccnd1; cyclin D1 [KO:K04503]
12444  Ccnd2; cyclin D2 [KO:K10151]
12445  Ccnd3; cyclin D3 [KO:K10152]
12447  Ccne1; cyclin E1 [KO:K06626]
12448  Ccne2; cyclin E2 [KO:K06626]
12534  Cdk1; cyclin dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
12540  Cdc42; cell division cycle 42 [KO:K04393]
12566  Cdk2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
12567  Cdk4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
12571  Cdk6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
12575  Cdkn1a; cyclin dependent kinase inhibitor 1A [KO:K06625]
12576  Cdkn1b; cyclin dependent kinase inhibitor 1B [KO:K06624]
12578  Cdkn2a; cyclin dependent kinase inhibitor 2A [KO:K06621]
12579  Cdkn2b; cyclin dependent kinase inhibitor 2B [KO:K04685]
12649  Chek1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
12771  Ccr3; C-C motif chemokine receptor 3 [KO:K04178]
12773  Ccr4; C-C motif chemokine receptor 4 [KO:K04179]
12774  Ccr5; C-C motif chemokine receptor 5 [KO:K04180]
12776  Ccr8; C-C motif chemokine receptor 8 [KO:K04183]
12912  Creb1; cAMP responsive element binding protein 1 [KO:K05870]
12913  Creb3; cAMP responsive element binding protein 3 [KO:K09048]
12914  Crebbp; CREB binding protein [KO:K04498] [EC:2.3.1.48]
12915  Atf6b; activating transcription factor 6 beta [KO:K09049]
13194  Ddb1; damage specific DNA binding protein 1 [KO:K10610]
13205  Ddx3x; DEAD box helicase 3, X-linked [KO:K11594] [EC:5.6.2.7]
13383  Dlg1; discs large MAGUK scaffold protein 1 [KO:K12076]
13654  Egr2; early growth response 2 [KO:K12496]
13655  Egr3; early growth response 3 [KO:K12497]
14534  Kat2a; K(lysine) acetyltransferase 2A [KO:K06062] [EC:2.3.1.48]
14784  Grb2; growth factor receptor bound protein 2 [KO:K04364]
14884  Gtf2h1; general transcription factor II H, polypeptide 1 [KO:K03141]
14885  Gtf2h4; general transcription factor II H, polypeptide 4 [KO:K03144]
14963  H2-Bl; histocompatibility 2, blastocyst [KO:K06751]
14964  H2-D1; histocompatibility 2, D region locus 1 [KO:K06751]
14972  H2-K1; histocompatibility 2, K1, K region [KO:K06751]
14980  H2-L; histocompatibility 2, D region locus L [KO:K06751]
14985  H2-M10.1; histocompatibility 2, M region locus 10.1 [KO:K06751]
14990  H2-M2; histocompatibility 2, M region locus 2 [KO:K06751]
14991  H2-M3; histocompatibility 2, M region locus 3 [KO:K06751]
14997  H2-M9; histocompatibility 2, M region locus 9 [KO:K06751]
15006  H2-Q1; histocompatibility 2, Q region locus 1 [KO:K06751]
15007  H2-Q10; histocompatibility 2, Q region locus 10 [KO:K06751]
15013  H2-Q2; histocompatibility 2, Q region locus 2 [KO:K06751]
15015  H2-Q4; histocompatibility 2, Q region locus 4 [KO:K06751]
15018  H2-Q7; histocompatibility 2, Q region locus 7 [KO:K06751]
15024  H2-T10; histocompatibility 2, T region locus 10 [KO:K06751]
15039  H2-T22; histocompatibility 2, T region locus 22 [KO:K06751]
15040  H2-T23; histocompatibility 2, T region locus 23 [KO:K06751]
15042  H2-T24; histocompatibility 2, T region locus 24 [KO:K06751]
15043  H2-T3; histocompatibility 2, T region locus 3 [KO:K06751]
15182  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
15183  Hdac3; histone deacetylase 3 [KO:K11404] [EC:3.5.1.98]
15184  Hdac5; histone deacetylase 5 [KO:K11406] [EC:3.5.1.98]
15185  Hdac6; histone deacetylase 6 [KO:K11407] [EC:3.5.1.98]
15387  Hnrnpk; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
15451  Hpn; hepsin [KO:K08665] [EC:3.4.21.106]
15461  Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
16151  Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210]
16195  Il6st; interleukin 6 signal transducer [KO:K05060]
16391  Irf9; interferon regulatory factor 9 [KO:K04693]
16451  Jak1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
16453  Jak3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
16476  Jun; jun proto-oncogene [KO:K04448]
16653  Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
17000  Ltbr; lymphotoxin B receptor [KO:K03159]
170787  Hdac10; histone deacetylase 10 [KO:K18671] [EC:3.5.1.98]
17096  Lyn; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
17120  Mad1l1; MAD1 mitotic arrest deficient 1-like 1 [KO:K06679]
17164  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
17246  Mdm2; transformed mouse 3T3 cell double minute 2 [KO:K06643] [EC:2.3.2.27]
18033  Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
18034  Nfkb2; nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 [KO:K04469]
18035  Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734]
18176  Nras; neuroblastoma ras oncogene [KO:K07828]
18519  Kat2b; K(lysine) acetyltransferase 2B [KO:K06062] [EC:2.3.1.48]
18706  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
18707  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
18708  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
18709  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
18710  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
18746  Pkm; pyruvate kinase, muscle [KO:K00873] [EC:2.7.1.40]
18747  Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749  Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
18970  Polb; polymerase (DNA directed), beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
19106  Eif2ak2; eukaryotic translation initiation factor 2-alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
19179  Psmc1; protease (prosome, macropain) 26S subunit, ATPase 1 [KO:K03062]
19303  Pxn; paxillin [KO:K05760]
19353  Rac1; Rac family small GTPase 1 [KO:K04392]
19385  Ranbp1; RAN binding protein 1 [KO:K15306]
19645  Rb1; RB transcriptional corepressor 1 [KO:K06618]
19650  Rbl1; RB transcriptional corepressor like 1 [KO:K04681]
19651  Rbl2; RB transcriptional corepressor like 2 [KO:K16332]
19664  Rbpj; recombination signal binding protein for immunoglobulin kappa J region [KO:K06053]
19668  Rbpjl; recombination signal binding protein for immunoglobulin kappa J region-like [KO:K06053]
19696  Rel; reticuloendotheliosis oncogene [KO:K09254]
19697  Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
20259  Scin; scinderin [KO:K05768]
20684  Sp100; nuclear antigen Sp100 [KO:K15413]
20779  Src; Rous sarcoma oncogene [KO:K05704] [EC:2.7.10.2]
20807  Srf; serum response factor [KO:K04378]
20848  Stat3; signal transducer and activator of transcription 3 [KO:K04692]
20850  Stat5a; signal transducer and activator of transcription 5A [KO:K11223]
20851  Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
208647  Creb3l2; cAMP responsive element binding protein 3-like 2 [KO:K09048]
208677  Creb3l3; cAMP responsive element binding protein 3-like 3 [KO:K09048]
208727  Hdac4; histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
209357  Gtf2h3; general transcription factor IIH, polypeptide 3 [KO:K03143]
20963  Syk; spleen tyrosine kinase [KO:K05855] [EC:2.7.10.2]
21374  Tbp; TATA box binding protein [KO:K03120]
22029  Traf1; TNF receptor-associated factor 1 [KO:K03172]
22030  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
22031  Traf3; TNF receptor-associated factor 3 [KO:K03174]
22033  Traf5; TNF receptor-associated factor 5 [KO:K09849]
22059  Trp53; transformation related protein 53 [KO:K04451]
22215  Ube3a; ubiquitin protein ligase E3A [KO:K10587] [EC:2.3.2.26]
22335  Vdac3; voltage-dependent anion channel 3 [KO:K15041]
224753  H2-M10.4; histocompatibility 2, M region locus 10.4 [KO:K06751]
224754  H2-M11; histocompatibility 2, M region locus 11 [KO:K06751]
224756  H2-M1; histocompatibility 2, M region locus 1 [KO:K06751]
224761  H2-M10.5; histocompatibility 2, M region locus 10.5 [KO:K06751]
22627  Ywhae; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide [KO:K06630]
22628  Ywhag; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide [KO:K16198]
22629  Ywhah; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide [KO:K16198]
22630  Ywhaq; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta [KO:K16197]
22631  Ywhaz; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [KO:K16197]
227606  Tbpl2; TATA box binding protein like 2 [KO:K03120]
227753  Gsn; gelsolin [KO:K05768]
229906  Gtf2b; general transcription factor IIB [KO:K03124]
231991  Creb5; cAMP responsive element binding protein 5 [KO:K09047]
232232  Hdac11; histone deacetylase 11 [KO:K11418] [EC:3.5.1.98]
234729  Vac14; Vac14 homolog (S. cerevisiae) [KO:K15305]
235459  Gtf2a2; general transcription factor II A, 2 [KO:K03123]
237336  Tbpl1; TATA box binding protein-like 1 [KO:K03120]
23894  Gtf2h2; general transcription factor II H, polypeptide 2 [KO:K03142]
240095  H2-M5; histocompatibility 2, M region locus 5 [KO:K06751]
242341  Atp6v0d2; ATPase, H+ transporting, lysosomal V0 subunit D2 [KO:K02146]
252870  Usp7; ubiquitin specific peptidase 7 [KO:K11838] [EC:3.4.19.12]
26413  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26417  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
26427  Creb3l1; cAMP responsive element binding protein 3-like 1 [KO:K09048]
27401  Skp2; S-phase kinase-associated protein 2 [KO:K03875]
319155  H4c3; H4 clustered histone 3 [KO:K11254]
319156  H4c4; H4 clustered histone 4 [KO:K11254]
319157  H4c6; H4 clustered histone 6 [KO:K11254]
319158  H4c9; H4 clustered histone 9 [KO:K11254]
319159  H4c11; H4 clustered histone 11 [KO:K11254]
319160  H4c12; H4 clustered histone 12 [KO:K11254]
319161  H4c18; H4 clustered histone 18 [KO:K11254]
319177  H2bc1; H2B clustered histone 1 [KO:K11252]
319178  H2bc3; H2B clustered histone 3 [KO:K11252]
319179  H2bc6; H2B clustered histone 6 [KO:K11252]
319180  H2bc7; H2B clustered histone 7 [KO:K11252]
319181  H2bc8; H2B clustered histone 8 [KO:K11252]
319182  H2bc9; H2B clustered histone 9 [KO:K11252]
319183  H2bc11; H2B clustered histone 11 [KO:K11252]
319184  H2bc12; H2B clustered histone 12 [KO:K11252]
319185  H2bc13; H2B clustered histone 13 [KO:K11252]
319186  H2bc14; H2B clustered histone 14 [KO:K11252]
319187  H2bc15; H2B clustered histone 15 [KO:K11252]
319188  H2bc22; H2B clustered histone 22 [KO:K11252]
319189  H2bc18; H2B clustered histone 18 [KO:K11252]
319190  H2bc21; H2B clustered histone 21 [KO:K11252]
320332  H4c16; H4 histone 16 [KO:K11254]
326619  H4c1; H4 clustered histone 1 [KO:K11254]
326620  H4c2; H4 clustered histone 2 [KO:K11254]
328572  Ep300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
333715  H2-M10.2; histocompatibility 2, M region locus 10.2 [KO:K06751]
382522  H2bc26; H2B clustered histone 26 [KO:K11252]
399549  H2-M10.6; histocompatibility 2, M region locus 10.6 [KO:K06751]
433759  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
54123  Irf7; interferon regulatory factor 7 [KO:K09447]
54131  Irf3; interferon regulatory factor 3 [KO:K05411]
54401  Ywhab; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide [KO:K16197]
547349  H2-K1; MHC class I family member [KO:K06751]
56233  Hdac7; histone deacetylase 7 [KO:K11408] [EC:3.5.1.98]
56463  Snd1; staphylococcal nuclease and tudor domain containing 1 [KO:K15979]
58801  Pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
60595  Actn4; actinin alpha 4 [KO:K05699]
630294  H2-T25; histocompatibility-2, T region locus 25 [KO:K06751]
66354  Snw1; SNW domain containing 1 [KO:K06063]
665596  H2bc23; H2B clustered histone 23 [KO:K11252]
665622  H2bc24; H2B clustered histone 24 [KO:K11252]
667977  H2-T26; histocompatibility 2, T region locus 26 [KO:K06751]
66973  Mrps18b; mitochondrial ribosomal protein S18B [KO:K16174]
67653  4930544G11Rik; RIKEN cDNA 4930544G11 gene [KO:K04513]
68024  H2bc4; H2B clustered histone 4 [KO:K11252]
68153  Gtf2e2; general transcription factor II E, polypeptide 2 (beta subunit) [KO:K03137]
69116  Ubr4; ubiquitin protein ligase E3 component n-recognin 4 [KO:K10691] [EC:2.3.2.27]
69382  H2bl1; H2B.L histone variant 1 [KO:K11252]
69386  H4c8; H4 clustered histone 8 [KO:K11254]
69389  H2bw2; H2B.W histone 2 [KO:K11252]
69717  Gm10499; predicted gene 10499 [KO:K06751]
70315  Hdac8; histone deacetylase 8 [KO:K11405] [EC:3.5.1.98]
71609  Tradd; TNFRSF1A-associated via death domain [KO:K03171]
71828  Gtf2a1l; general transcription factor IIA, 1-like [KO:K03122]
74197  Gtf2e1; general transcription factor II E, polypeptide 1 (alpha subunit) [KO:K03136]
74769  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
78284  Creb3l4; cAMP responsive element binding protein 3-like 4 [KO:K09048]
78303  H2bc27; H2B clustered histone 27 [KO:K11252]
79221  Hdac9; histone deacetylase 9 [KO:K11409] [EC:3.5.1.98]
83602  Gtf2a1; general transcription factor II A, 1 [KO:K03122]
83945  Dnaja3; DnaJ heat shock protein family (Hsp40) member A3 [KO:K09504]
97122  H4c14; H4 clustered histone 14 [KO:K11254]
99169  [KO:K03136]
Reference
PMID:18201576
  Authors
McLaughlin-Drubin ME, Munger K
  Title
Viruses associated with human cancer.
  Journal
Biochim Biophys Acta 1782:127-50 (2008)
DOI:10.1016/j.bbadis.2007.12.005
Reference
PMID:21102637
  Authors
Moore PS, Chang Y
  Title
Why do viruses cause cancer? Highlights of the first century of human tumour virology.
  Journal
Nat Rev Cancer 10:878-89 (2010)
DOI:10.1038/nrc2961
Reference
PMID:19400863
  Authors
Kalland KH, Ke XS, Oyan AM
  Title
Tumour virology--history, status and future challenges.
  Journal
APMIS 117:382-99 (2009)
DOI:10.1111/j.1600-0463.2009.02452.x
Reference
PMID:17979705
  Authors
Boccardo E, Villa LL
  Title
Viral origins of human cancer.
  Journal
Curr Med Chem 14:2526-39 (2007)
DOI:10.2174/092986707782023316
Reference
PMID:21084867
  Authors
Saha A, Kaul R, Murakami M, Robertson ES
  Title
Tumor viruses and cancer biology: Modulating signaling pathways for therapeutic intervention.
  Journal
Cancer Biol Ther 10:961-78 (2010)
DOI:10.4161/cbt.10.10.13923
Reference
PMID:21152115
  Authors
Zheng ZM
  Title
Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor viruses.
  Journal
Int J Biol Sci 6:730-55 (2010)
DOI:10.7150/ijbs.6.730
Reference
PMID:19956178
  Authors
Martin D, Gutkind JS
  Title
Human tumor-associated viruses and new insights into the molecular mechanisms of cancer.
  Journal
Oncogene 27 Suppl 2:S31-42 (2008)
DOI:10.1038/onc.2009.351
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:21966251
  Authors
Nishida N, Goel A
  Title
Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review.
  Journal
Curr Genomics 12:130-7 (2011)
DOI:10.2174/138920211795564359
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:9343405
  Authors
Klein NP, Schneider RJ
  Title
Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras.
  Journal
Mol Cell Biol 17:6427-36 (1997)
DOI:10.1128/MCB.17.11.6427
Reference
PMID:16039586
  Authors
Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC
  Title
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
  Journal
Mol Cell 19:159-70 (2005)
DOI:10.1016/j.molcel.2005.06.009
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
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McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:12770701
  Authors
Verma SC, Robertson ES
  Title
Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
  Journal
FEMS Microbiol Lett 222:155-63 (2003)
DOI:10.1016/S0378-1097(03)00261-1
Reference
PMID:10354594
  Authors
Schulz TF, Moore PS
  Title
Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
  Journal
Trends Microbiol 7:196-200 (1999)
DOI:10.1016/S0966-842X(99)01495-X
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PMID:10855768
  Authors
Schulz TF
  Title
Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8): epidemiology and pathogenesis.
  Journal
J Antimicrob Chemother 45 Suppl T3:15-27 (2000)
DOI:10.1093/jac/45.suppl_4.15
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PMID:9594662
  Authors
Moore PS, Chang Y
  Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
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Trends Genet 14:144-50 (1998)
DOI:10.1016/S0168-9525(98)01408-5
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PMID:20534855
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Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Havemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF
  Title
Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.
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J Virol 84:8231-40 (2010)
DOI:10.1128/JVI.01696-09
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PMID:21421561
  Authors
Bagneris C, Briggs LC, Savva R, Ebrahimi B, Barrett TE
  Title
Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff.
  Journal
Nucleic Acids Res 39:5744-56 (2011)
DOI:10.1093/nar/gkr111
Reference
PMID:15919895
  Authors
Glaunsinger B, Chavez L, Ganem D
  Title
The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.
  Journal
J Virol 79:7396-401 (2005)
DOI:10.1128/JVI.79.12.7396-7401.2005
Related
pathway
mmu03022  Basal transcription factors
mmu03320  PPAR signaling pathway
mmu04010  MAPK signaling pathway
mmu04062  Chemokine signaling pathway
mmu04064  NF-kappa B signaling pathway
mmu04110  Cell cycle
mmu04115  p53 signaling pathway
mmu04142  Lysosome
mmu04151  PI3K-Akt signaling pathway
mmu04210  Apoptosis
mmu04630  JAK-STAT signaling pathway
mmu04662  B cell receptor signaling pathway
mmu04810  Regulation of actin cytoskeleton
mmu05160  Hepatitis C
mmu05161  Hepatitis B
mmu05165  Human papillomavirus infection
mmu05166  Human T-cell leukemia virus 1 infection
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05169  Epstein-Barr virus infection
KO pathway
ko05203   

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