KEGG   PATHWAY: mmu04062
Entry
mmu04062                    Pathway                                
Name
Chemokine signaling pathway - Mus musculus (house mouse)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
mmu04062  Chemokine signaling pathway
mmu04062

Other DBs
GO: 0070098
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100039863  Ccl27al; C-C motif chemokine ligand 27A like [KO:K16598]
100040048  Ccl27b; C-C motif chemokine ligand 27b [KO:K16598]
100041579  Gm20878; predicted gene, 20878 [KO:K16598]
100042493  Ccl21b; C-C motif chemokine ligand 21B (leucine) [KO:K16062]
100043318  Gng5c; G protein subunit gamma 5C [KO:K04542]
100503710  Gng14; G protein subunit gamma 14 [KO:K04347]
100504239  Ccl21e; C-C motif chemokine ligand 21E [KO:K16062]
100504346  Ccl21f; C-C motif chemokine ligand 21F [KO:K16062]
100862177  Ccl21d; C-C motif chemokine ligand 21D [KO:K16062]
100862247  Gm21586; predicted gene, 21586 [KO:K16598]
102633809  Gm3785; predicted gene 3785 [KO:K04542]
104110  Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
104111  Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
104709  Pik3r6; phosphoinositide-3-kinase regulatory subunit 5 [KO:K21290]
109689  Arrb1; arrestin, beta 1 [KO:K04439]
109880  Braf; Braf transforming gene [KO:K04365] [EC:2.7.11.1]
109905  Rap1a; RAS-related protein 1a [KO:K04353]
110157  Raf1; v-raf-leukemia viral oncogene 1 [KO:K04366] [EC:2.7.11.1]
110355  Grk2; G protein-coupled receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
11512  Adcy6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
11513  Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
11514  Adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
11515  Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
11651  Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
11848  Rhoa; ras homolog family member A [KO:K04513]
12015  Bad; BCL2-associated agonist of cell death [KO:K02158]
12145  Cxcr5; C-X-C motif chemokine receptor 5 [KO:K04190]
12458  Ccr6; C-C motif chemokine receptor 6 [KO:K04181]
12540  Cdc42; cell division cycle 42 [KO:K04393]
12675  Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
12765  Cxcr2; C-X-C motif chemokine receptor 2 [KO:K05050]
12766  Cxcr3; C-X-C motif chemokine receptor 3 [KO:K04188]
12767  Cxcr4; C-X-C motif chemokine receptor 4 [KO:K04189]
12768  Ccr1; C-C motif chemokine receptor 1 [KO:K04176]
12769  Ccr9; C-C motif chemokine receptor 9 [KO:K04184]
12770  Ccr1l1; C-C motif chemokine receptor 1 like 1 [KO:K04176]
12771  Ccr3; C-C motif chemokine receptor 3 [KO:K04178]
12772  Ccr2; C-C motif chemokine receptor 2 [KO:K04177]
12773  Ccr4; C-C motif chemokine receptor 4 [KO:K04179]
12774  Ccr5; C-C motif chemokine receptor 5 [KO:K04180]
12775  Ccr7; C-C motif chemokine receptor 7 [KO:K04182]
12776  Ccr8; C-C motif chemokine receptor 8 [KO:K04183]
12777  Ccr10; C-C motif chemokine receptor 10 [KO:K04185]
12927  Bcar1; breast cancer anti-estrogen resistance 1 [KO:K05726]
12928  Crk; v-crk avian sarcoma virus CT10 oncogene homolog [KO:K04438]
12929  Crkl; v-crk avian sarcoma virus CT10 oncogene homolog-like [KO:K04438]
13051  Cx3cr1; C-X3-C motif chemokine receptor 1 [KO:K04192]
140580  Elmo1; engulfment and cell motility 1 [KO:K12366]
14083  Ptk2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
14191  Fgr; FGR proto-oncogene, Src family tyrosine kinase [KO:K08891] [EC:2.7.10.2]
14677  Gnai1; G protein subunit alpha i1 [KO:K04630]
14678  Gnai2; G protein subunit alpha i2 [KO:K04630]
14679  Gnai3; G protein subunit alpha i3 [KO:K04630]
14682  Gnaq; guanine nucleotide binding protein, alpha q polypeptide [KO:K04634]
14688  Gnb1; guanine nucleotide binding protein (G protein), beta 1 [KO:K04536]
14693  Gnb2; guanine nucleotide binding protein (G protein), beta 2 [KO:K04537]
14695  Gnb3; guanine nucleotide binding protein (G protein), beta 3 [KO:K07825]
14696  Gnb4; guanine nucleotide binding protein (G protein), beta 4 [KO:K04538]
14697  Gnb5; guanine nucleotide binding protein (G protein), beta 5 [KO:K04539]
14699  Gngt1; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 [KO:K04548]
14700  Gng10; guanine nucleotide binding protein (G protein), gamma 10 [KO:K04545]
14701  Gng12; guanine nucleotide binding protein (G protein), gamma 12 [KO:K04347]
14702  Gng2; guanine nucleotide binding protein (G protein), gamma 2 [KO:K07826]
14704  Gng3; guanine nucleotide binding protein (G protein), gamma 3 [KO:K04540]
14706  Gng4; guanine nucleotide binding protein (G protein), gamma 4 [KO:K04541]
14707  Gng5; G protein subunit gamma 5 [KO:K04542]
14708  Gng7; guanine nucleotide binding protein (G protein), gamma 7 [KO:K04543]
14709  Gng8; guanine nucleotide binding protein (G protein), gamma 8 [KO:K04544]
14710  Gngt2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 [KO:K04549]
14772  Grk4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
14773  Grk5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
14784  Grb2; growth factor receptor bound protein 2 [KO:K04364]
14825  Cxcl1; C-X-C motif chemokine ligand 1 [KO:K05505]
15162  Hck; hemopoietic cell kinase [KO:K08893] [EC:2.7.10.2]
15461  Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
15945  Cxcl10; C-X-C motif chemokine ligand 10 [KO:K12671]
16150  Ikbkb; inhibitor of kappaB kinase beta [KO:K07209] [EC:2.7.11.10]
16151  Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210]
16428  Itk; IL2 inducible T cell kinase [KO:K07363] [EC:2.7.10.2]
16452  Jak2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
16453  Jak3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
16653  Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
16963  Xcl1; chemokine (C motif) ligand 1 [KO:K05507]
170758  Rac3; Rac family small GTPase 3 [KO:K07861]
17096  Lyn; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
17329  Cxcl9; C-X-C motif chemokine ligand 9 [KO:K05416]
17969  Ncf1; neutrophil cytosolic factor 1 [KO:K08011]
18033  Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
18035  Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734]
18036  Nfkbib; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta [KO:K02581]
18176  Nras; neuroblastoma ras oncogene [KO:K07828]
18479  Pak1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
18706  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
18707  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
18708  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
18709  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
18710  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
18747  Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749  Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
18751  Prkcb; protein kinase C, beta [KO:K19662] [EC:2.7.11.13]
18753  Prkcd; protein kinase C, delta [KO:K06068] [EC:2.7.11.13]
18762  Prkcz; protein kinase C, zeta [KO:K18952] [EC:2.7.11.13]
18795  Plcb1; phospholipase C, beta 1 [KO:K05858] [EC:3.1.4.11]
18796  Plcb2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
18797  Plcb3; phospholipase C, beta 3 [KO:K05858] [EC:3.1.4.11]
18798  Plcb4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
18803  Plcg1; phospholipase C, gamma 1 [KO:K01116] [EC:3.1.4.11]
18829  Ccl21a; C-C motif chemokine ligand 21 (serine) [KO:K16062]
19229  Ptk2b; PTK2 protein tyrosine kinase 2 beta [KO:K05871] [EC:2.7.10.2]
19303  Pxn; paxillin [KO:K05760]
19353  Rac1; Rac family small GTPase 1 [KO:K04392]
19354  Rac2; Rac family small GTPase 2 [KO:K07860]
19395  Rasgrp2; RAS, guanyl releasing protein 2 [KO:K12361]
19697  Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
19877  Rock1; Rho-associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.39]
19878  Rock2; Rho-associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.39]
20290  Ccl1; C-C motif chemokine ligand 1 [KO:K05514]
20292  Ccl11; C-C motif chemokine ligand 11 [KO:K16597]
20293  Ccl12; C-C motif chemokine ligand 12 [KO:K14624]
20295  Ccl17; C-C motif chemokine ligand 17 [KO:K21083]
20296  Ccl2; C-C motif chemokine ligand 2 [KO:K14624]
20297  Ccl20; C-C motif chemokine ligand 20 [KO:K14625]
20299  Ccl22; C-C motif chemokine ligand 22 [KO:K21095]
20300  Ccl25; C-C motif chemokine ligand 25 [KO:K13072]
20301  Ccl27a; C-C motif chemokine ligand 27A [KO:K16598]
20302  Ccl3; C-C motif chemokine ligand 3 [KO:K05408]
20303  Ccl4; C-C motif chemokine ligand 4 [KO:K12964]
20304  Ccl5; C-C motif chemokine ligand 5 [KO:K12499]
20305  Ccl6; C-C motif chemokine ligand 6 [KO:K05510]
20306  Ccl7; C-C motif chemokine ligand 7 [KO:K05509]
20307  Ccl8; C-C motif chemokine ligand 8 [KO:K16596]
20308  Ccl9; C-C motif chemokine ligand 9 [KO:K22671]
20309  Cxcl15; C-X-C motif chemokine ligand 15 [KO:K10034]
20310  Cxcl2; C-X-C motif chemokine ligand 2 [KO:K05505]
20311  Cxcl5; C-X-C motif chemokine ligand 5 [KO:K05506]
20312  Cx3cl1; C-X3-C motif chemokine ligand 1 [KO:K05508]
20315  Cxcl12; C-X-C motif chemokine ligand 12 [KO:K10031]
20416  Shc1; src homology 2 domain-containing transforming protein C1 [KO:K06279]
20418  Shc3; src homology 2 domain-containing transforming protein C3 [KO:K17448]
20662  Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
20663  Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
20779  Src; Rous sarcoma oncogene [KO:K05704] [EC:2.7.10.2]
20846  Stat1; signal transducer and activator of transcription 1 [KO:K11220]
20847  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
20848  Stat3; signal transducer and activator of transcription 3 [KO:K04692]
20851  Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
210044  Adcy2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
215449  Rap1b; RAS related protein 1b [KO:K07836]
216148  Shc2; SHC (Src homology 2 domain containing) transforming protein 2 [KO:K17447]
216869  Arrb2; arrestin, beta 2 [KO:K04439]
21844  Tiam1; T cell lymphoma invasion and metastasis 1 [KO:K05731]
22324  Vav1; vav 1 oncogene [KO:K05730]
22325  Vav2; vav 2 oncogene [KO:K05730]
22376  Was; Wiskott-Aldrich syndrome [KO:K05747]
224129  Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
227288  Cxcr1; C-X-C motif chemokine receptor 1 [KO:K04175]
234779  Plcg2; phospholipase C, gamma 2 [KO:K05859] [EC:3.1.4.11]
23797  Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
23832  Xcr1; chemokine (C motif) receptor 1 [KO:K04193]
24013  Grk1; G protein-coupled receptor kinase 1 [KO:K00909] [EC:2.7.11.14]
24047  Ccl19; C-C motif chemokine ligand 19 [KO:K05512]
26385  Grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
26395  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
26413  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26417  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
271849  Shc4; SHC (Src homology 2 domain containing) family, member 4 [KO:K17449]
277360  Prex1; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 [KO:K12365]
30955  Pik3cg; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289] [EC:2.7.1.153]
320129  Grk3; G protein-coupled receptor kinase 3 [KO:K00910] [EC:2.7.11.15]
320207  Pik3r5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K21290]
330122  Cxcl3; C-X-C motif chemokine ligand 3 [KO:K05505]
432530  Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
541307  Ccl26; C-C motif chemokine ligand 26 [KO:K21096]
55985  Cxcl13; C-X-C motif chemokine ligand 13 [KO:K10032]
56066  Cxcl11; chemokine (C-X-C motif) ligand 11 [KO:K12672]
56221  Ccl24; C-C motif chemokine ligand 24 [KO:K21097]
56484  Foxo3; forkhead box O3 [KO:K09408]
56637  Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
56744  Pf4; platelet factor 4 [KO:K05407]
56838  Ccl28; C-C motif chemokine ligand 28 [KO:K05513]
57257  Vav3; vav 3 oncogene [KO:K05730]
57266  Cxcl14; C-X-C motif chemokine ligand 14 [KO:K10033]
57349  Ppbp; pro-platelet basic protein [KO:K10029]
606496  Gsk3a; glycogen synthase kinase 3 alpha [KO:K08822] [EC:2.7.11.26]
621580  Gm21953; predicted gene, 21953 [KO:K16598]
64337  Gng13; guanine nucleotide binding protein (G protein), gamma 13 [KO:K04547]
66066  Gng11; guanine nucleotide binding protein (G protein), gamma 11 [KO:K04546]
66102  Cxcl16; C-X-C motif chemokine ligand 16 [KO:K10035]
67653  4930544G11Rik; RIKEN cDNA 4930544G11 gene [KO:K04513]
74769  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
80901  Cxcr6; C-X-C motif chemokine receptor 6 [KO:K04191]
93742  Pard3; par-3 family cell polarity regulator [KO:K04237]
94176  Dock2; dedicator of cyto-kinesis 2 [KO:K12367]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
mmu04010  MAPK signaling pathway
mmu04060  Cytokine-cytokine receptor interaction
mmu04120  Ubiquitin mediated proteolysis
mmu04630  JAK-STAT signaling pathway
mmu04670  Leukocyte transendothelial migration
mmu04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

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