KEGG   PATHWAY: mmu05166
Entry
mmu05166                    Pathway                                
Name
Human T-cell leukemia virus 1 infection - Mus musculus (house mouse)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
mmu05166  Human T-cell leukemia virus 1 infection
mmu05166

Disease
H00009  Adult T-cell leukemia
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100504404  H2-Ea; histocompatibility 2, class II antigen E alpha [KO:K06752]
100529082  H2-T27; histocompatibility 2, T region locus 27 [KO:K06751]
100683  Trrap; transformation/transcription domain-associated protein [KO:K08874]
103573  Xpo1; exportin 1 [KO:K14290]
104110  Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
104111  Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
105988  Espl1; extra spindle pole bodies 1, separase [KO:K02365] [EC:3.4.22.49]
107995  Cdc20; cell division cycle 20 [KO:K03363]
108802  Calr4; calreticulin 4 [KO:K08057]
110196  Fdps; farnesyl diphosphate synthetase [KO:K00787] [EC:2.5.1.1 2.5.1.10]
110557  H2-Q6; histocompatibility 2, Q region locus 6 [KO:K06751]
110558  H2-Q9; histocompatibility 2, Q region locus 9 [KO:K06751]
110696  H2-M10.3; histocompatibility 2, M region locus 10.3 [KO:K06751]
11512  Adcy6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
11513  Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
11514  Adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
11515  Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
11651  Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
11739  Slc25a4; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 [KO:K05863]
11740  Slc25a5; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 [KO:K05863]
11798  Xiap; X-linked inhibitor of apoptosis [KO:K04725] [EC:2.3.2.27]
11909  Atf2; activating transcription factor 2 [KO:K04450]
11911  Atf4; activating transcription factor 4 [KO:K04374]
11920  Atm; ataxia telangiectasia mutated [KO:K04728] [EC:2.7.11.1]
12010  B2m; beta-2 microglobulin [KO:K08055]
12028  Bax; BCL2-associated X protein [KO:K02159]
12048  Bcl2l1; BCL2-like 1 [KO:K04570]
12236  Bub1b; BUB1B, mitotic checkpoint serine/threonine kinase [KO:K06637] [EC:2.7.11.1]
12237  Bub3; BUB3 mitotic checkpoint protein [KO:K02180]
12257  Tspo; translocator protein [KO:K05770]
12317  Calr; calreticulin [KO:K08057]
12330  Canx; calnexin [KO:K08054]
12427  Ccna1; cyclin A1 [KO:K06627]
12428  Ccna2; cyclin A2 [KO:K06627]
12442  Ccnb2; cyclin B2 [KO:K21770]
12443  Ccnd1; cyclin D1 [KO:K04503]
12444  Ccnd2; cyclin D2 [KO:K10151]
12445  Ccnd3; cyclin D3 [KO:K10152]
12447  Ccne1; cyclin E1 [KO:K06626]
12448  Ccne2; cyclin E2 [KO:K06626]
12500  Cd3d; CD3 antigen, delta polypeptide [KO:K06450]
12501  Cd3e; CD3 antigen, epsilon polypeptide [KO:K06451]
12502  Cd3g; CD3 antigen, gamma polypeptide [KO:K06452]
12504  Cd4; CD4 antigen [KO:K06454]
12566  Cdk2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
12567  Cdk4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
12575  Cdkn1a; cyclin dependent kinase inhibitor 1A [KO:K06625]
12578  Cdkn2a; cyclin dependent kinase inhibitor 2A [KO:K06621]
12579  Cdkn2b; cyclin dependent kinase inhibitor 2B [KO:K04685]
12580  Cdkn2c; cyclin dependent kinase inhibitor 2C [KO:K06622]
12649  Chek1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
12675  Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
12912  Creb1; cAMP responsive element binding protein 1 [KO:K05870]
12913  Creb3; cAMP responsive element binding protein 3 [KO:K09048]
12914  Crebbp; CREB binding protein [KO:K04498] [EC:2.3.1.48]
12915  Atf6b; activating transcription factor 6 beta [KO:K09049]
12981  Csf2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427]
13383  Dlg1; discs large MAGUK scaffold protein 1 [KO:K12076]
13555  E2f1; E2F transcription factor 1 [KO:K17454]
13557  E2f3; E2F transcription factor 3 [KO:K06620]
13653  Egr1; early growth response 1 [KO:K09203]
13654  Egr2; early growth response 2 [KO:K12496]
13712  Elk1; ELK1, member of ETS oncogene family [KO:K04375]
13714  Elk4; ELK4, member of ETS oncogene family [KO:K04376]
14281  Fos; FBJ osteosarcoma oncogene [KO:K04379]
14283  Fosl1; fos-like antigen 1 [KO:K04502]
14534  Kat2a; K(lysine) acetyltransferase 2A [KO:K06062] [EC:2.3.1.48]
14960  H2-Aa; histocompatibility 2, class II antigen A, alpha [KO:K06752]
14961  H2-Ab1; histocompatibility 2, class II antigen A, beta 1 [KO:K06752]
14963  H2-Bl; histocompatibility 2, blastocyst [KO:K06751]
14964  H2-D1; histocompatibility 2, D region locus 1 [KO:K06751]
14969  H2-Eb1; histocompatibility 2, class II antigen E beta [KO:K06752]
14972  H2-K1; histocompatibility 2, K1, K region [KO:K06751]
14980  H2-L; histocompatibility 2, D region locus L [KO:K06751]
14985  H2-M10.1; histocompatibility 2, M region locus 10.1 [KO:K06751]
14990  H2-M2; histocompatibility 2, M region locus 2 [KO:K06751]
14991  H2-M3; histocompatibility 2, M region locus 3 [KO:K06751]
14997  H2-M9; histocompatibility 2, M region locus 9 [KO:K06751]
14998  H2-DMa; histocompatibility 2, class II, locus DMa [KO:K06752]
14999  H2-DMb1; histocompatibility 2, class II, locus Mb1 [KO:K06752]
15000  H2-DMb2; histocompatibility 2, class II, locus Mb2 [KO:K06752]
15001  H2-Oa; histocompatibility 2, O region alpha locus [KO:K06752]
15002  H2-Ob; histocompatibility 2, O region beta locus [KO:K06752]
15006  H2-Q1; histocompatibility 2, Q region locus 1 [KO:K06751]
15007  H2-Q10; histocompatibility 2, Q region locus 10 [KO:K06751]
15013  H2-Q2; histocompatibility 2, Q region locus 2 [KO:K06751]
15015  H2-Q4; histocompatibility 2, Q region locus 4 [KO:K06751]
15018  H2-Q7; histocompatibility 2, Q region locus 7 [KO:K06751]
15024  H2-T10; histocompatibility 2, T region locus 10 [KO:K06751]
15039  H2-T22; histocompatibility 2, T region locus 22 [KO:K06751]
15040  H2-T23; histocompatibility 2, T region locus 23 [KO:K06751]
15042  H2-T24; histocompatibility 2, T region locus 24 [KO:K06751]
15043  H2-T3; histocompatibility 2, T region locus 3 [KO:K06751]
15461  Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
15894  Icam1; intercellular adhesion molecule 1 [KO:K06490]
16150  Ikbkb; inhibitor of kappaB kinase beta [KO:K07209] [EC:2.7.11.10]
16151  Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210]
16168  Il15; interleukin 15 [KO:K05433]
16169  Il15ra; interleukin 15 receptor, alpha chain [KO:K05074]
16177  Il1r1; interleukin 1 receptor, type I [KO:K04386]
16178  Il1r2; interleukin 1 receptor, type II [KO:K04387]
16183  Il2; interleukin 2 [KO:K05429]
16184  Il2ra; interleukin 2 receptor, alpha chain [KO:K05068]
16185  Il2rb; interleukin 2 receptor, beta chain [KO:K05069]
16186  Il2rg; interleukin 2 receptor, gamma chain [KO:K05070]
16193  Il6; interleukin 6 [KO:K05405]
16408  Itgal; integrin alpha L [KO:K05718]
16414  Itgb2; integrin beta 2 [KO:K06464]
16415  Itgb2l; integrin beta 2-like [KO:K06464]
16451  Jak1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
16453  Jak3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
16476  Jun; jun proto-oncogene [KO:K04448]
16653  Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
16818  Lck; lymphocyte protein tyrosine kinase [KO:K05856] [EC:2.7.10.2]
16992  Lta; lymphotoxin A [KO:K05468]
17000  Ltbr; lymphotoxin B receptor [KO:K03159]
17120  Mad1l1; MAD1 mitotic arrest deficient 1-like 1 [KO:K06679]
17126  Smad2; SMAD family member 2 [KO:K04500]
17127  Smad3; SMAD family member 3 [KO:K23605]
17128  Smad4; SMAD family member 4 [KO:K04501]
17222  Anapc1; anaphase promoting complex subunit 1 [KO:K03348]
17393  Mmp7; matrix metallopeptidase 7 [KO:K01397] [EC:3.4.24.23]
17701  Msx1; msh homeobox 1 [KO:K09341]
17702  Msx2; msh homeobox 2 [KO:K09341]
17703  Msx3; msh homeobox 3 [KO:K09341]
17869  Myc; myelocytomatosis oncogene [KO:K04377]
18018  Nfatc1; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [KO:K04446]
18019  Nfatc2; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 [KO:K17332]
18021  Nfatc3; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 [KO:K17333]
18033  Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
18034  Nfkb2; nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 [KO:K04469]
18035  Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734]
18045  Nfyb; nuclear transcription factor-Y beta [KO:K08065]
18176  Nras; neuroblastoma ras oncogene [KO:K07828]
18186  Nrp1; neuropilin 1 [KO:K06724]
18519  Kat2b; K(lysine) acetyltransferase 2B [KO:K06062] [EC:2.3.1.48]
18706  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
18707  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
18708  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
18709  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
18710  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
18747  Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749  Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
18970  Polb; polymerase (DNA directed), beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
19055  Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348] [EC:3.1.3.16]
19056  Ppp3cb; protein phosphatase 3, catalytic subunit, beta isoform [KO:K04348] [EC:3.1.3.16]
19057  Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348] [EC:3.1.3.16]
19058  Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [KO:K06268]
19059  Ppp3r2; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [KO:K06268]
19211  Pten; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
19384  Ran; RAN, member RAS oncogene family [KO:K07936]
19385  Ranbp1; RAN binding protein 1 [KO:K15306]
19428  Rasl2-9; RAS-like, family 2, locus 9 [KO:K07936]
19645  Rb1; RB transcriptional corepressor 1 [KO:K06618]
19697  Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
19698  Relb; avian reticuloendotheliosis viral (v-rel) oncogene related B [KO:K09253]
20375  Spi1; Spi-1 proto-oncogene [KO:K09438]
20525  Slc2a1; solute carrier family 2 (facilitated glucose transporter), member 1 [KO:K07299]
20807  Srf; serum response factor [KO:K04378]
20850  Stat5a; signal transducer and activator of transcription 5A [KO:K11223]
20851  Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
208647  Creb3l2; cAMP responsive element binding protein 3-like 2 [KO:K09048]
208677  Creb3l3; cAMP responsive element binding protein 3-like 3 [KO:K09048]
210044  Adcy2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
21374  Tbp; TATA box binding protein [KO:K03120]
21423  Tcf3; transcription factor 3 [KO:K09063]
217232  Cdc27; cell division cycle 27 [KO:K03350]
21752  Tert; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
21803  Tgfb1; transforming growth factor, beta 1 [KO:K13375]
21808  Tgfb2; transforming growth factor, beta 2 [KO:K13376]
21809  Tgfb3; transforming growth factor, beta 3 [KO:K13377]
21812  Tgfbr1; transforming growth factor, beta receptor I [KO:K04674] [EC:2.7.11.30]
21813  Tgfbr2; transforming growth factor, beta receptor II [KO:K04388] [EC:2.7.11.30]
21894  Tln1; talin 1 [KO:K06271]
21926  Tnf; tumor necrosis factor [KO:K03156]
21937  Tnfrsf1a; tumor necrosis factor receptor superfamily, member 1a [KO:K03158]
21939  Cd40; CD40 antigen [KO:K03160]
22059  Trp53; transformation related protein 53 [KO:K04451]
22333  Vdac1; voltage-dependent anion channel 1 [KO:K05862]
22334  Vdac2; voltage-dependent anion channel 2 [KO:K15040]
22335  Vdac3; voltage-dependent anion channel 3 [KO:K15041]
224129  Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
224753  H2-M10.4; histocompatibility 2, M region locus 10.4 [KO:K06751]
224754  H2-M11; histocompatibility 2, M region locus 11 [KO:K06751]
224756  H2-M1; histocompatibility 2, M region locus 1 [KO:K06751]
224761  H2-M10.5; histocompatibility 2, M region locus 10.5 [KO:K06751]
22695  Zfp36; zinc finger protein 36 [KO:K15308]
227606  Tbpl2; TATA box binding protein like 2 [KO:K03120]
231991  Creb5; cAMP responsive element binding protein 5 [KO:K09047]
234729  Vac14; Vac14 homolog (S. cerevisiae) [KO:K15305]
237336  Tbpl1; TATA box binding protein-like 1 [KO:K03120]
23797  Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
23871  Ets1; E26 avian leukemia oncogene 1, 5' domain [KO:K02678]
23872  Ets2; E26 avian leukemia oncogene 2, 3' domain [KO:K21932]
240095  H2-M5; histocompatibility 2, M region locus 5 [KO:K06751]
242705  E2f2; E2F transcription factor 2 [KO:K09389]
245000  Atr; ataxia telangiectasia and Rad3 related [KO:K06640] [EC:2.7.11.1]
26395  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
26396  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
26398  Map2k4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
26401  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
26406  Map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
26413  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26414  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
26417  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
26419  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
26420  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
26427  Creb3l1; cAMP responsive element binding protein 3-like 1 [KO:K09048]
30939  Pttg1; pituitary tumor-transforming gene 1 [KO:K06635]
328572  Ep300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
333715  H2-M10.2; histocompatibility 2, M region locus 10.2 [KO:K06751]
381091  H2-Eb2; histocompatibility 2, class II antigen E beta2 [KO:K06752]
382056  Crtc1; CREB regulated transcription coactivator 1 [KO:K15309]
399549  H2-M10.6; histocompatibility 2, M region locus 10.6 [KO:K06751]
432530  Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
50883  Chek2; checkpoint kinase 2 [KO:K06641] [EC:2.7.11.1]
52206  Anapc4; anaphase promoting complex subunit 4 [KO:K03351]
52563  Cdc23; CDC23 cell division cycle 23 [KO:K03355]
52717  Anapc16; anaphase promoting complex subunit 16 [KO:K25229]
53859  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
547349  H2-K1; MHC class I family member [KO:K06751]
56150  Mad2l1; MAD2 mitotic arrest deficient-like 1 [KO:K02537]
56310  Gps2; G protein pathway suppressor 2 [KO:K15307]
56317  Anapc7; anaphase promoting complex subunit 7 [KO:K03354]
59008  Anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
630294  H2-T25; histocompatibility-2, T region locus 25 [KO:K06751]
66156  Anapc11; anaphase promoting complex subunit 11 [KO:K03358]
66440  Cdc26; cell division cycle 26 [KO:K03359]
667977  H2-T26; histocompatibility 2, T region locus 26 [KO:K06751]
68999  Anapc10; anaphase promoting complex subunit 10 [KO:K03357]
69010  Anapc13; anaphase promoting complex subunit 13 [KO:K12456]
69717  Gm10499; predicted gene 10499 [KO:K06751]
69957  Cdc16; CDC16 cell division cycle 16 [KO:K03353]
70461  Crtc3; CREB regulated transcription coactivator 3 [KO:K16334]
70549  Tln2; talin 2 [KO:K06271]
71810  Ranbp3; RAN binding protein 3 [KO:K15304]
72049  Tnfrsf13c; tumor necrosis factor receptor superfamily, member 13c [KO:K05151]
73181  Nfatc4; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 [KO:K17334]
73333  Slc25a31; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 [KO:K05863]
74343  Crtc2; CREB regulated transcription coactivator 2 [KO:K16333]
74769  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
75430  Anapc15; anaphase promoting complex C subunit 15 [KO:K25228]
75471  1700009N14Rik; RIKEN cDNA 1700009N14 gene [KO:K07936]
78284  Creb3l4; cAMP responsive element binding protein 3-like 4 [KO:K09048]
81601  Kat5; K(lysine) acetyltransferase 5 [KO:K11304] [EC:2.3.1.48]
99152  Anapc2; anaphase promoting complex subunit 2 [KO:K03349]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
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BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
Reference
PMID:15040584
  Authors
Vicente-Manzanares M, Sanchez-Madrid F
  Title
Role of the cytoskeleton during leukocyte responses.
  Journal
Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
Reference
PMID:27334587
  Authors
Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
  Journal
J Virol 90:7607-17 (2016)
DOI:10.1128/JVI.00407-16
Reference
PMID:15988028
  Authors
Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
  Title
A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
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Mol Cell Biol 25:6178-98 (2005)
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Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
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Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
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Viruses 3:861-85 (2011)
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HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
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Viruses 8:58 (2016)
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PMID:22783232
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Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
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Front Microbiol 3:179 (2012)
DOI:10.3389/fmicb.2012.00179
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PMID:23248621
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Bai XT, Nicot C
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Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
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Front Microbiol 3:400 (2012)
DOI:10.3389/fmicb.2012.00400
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PMID:18421579
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HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
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Apoptosis 13:733-47 (2008)
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The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.
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Cell Death Differ 12 Suppl 1:905-15 (2005)
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Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
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HTLV-1 p13, a small protein with a busy agenda.
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Mol Aspects Med 31:350-8 (2010)
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Viruses 3:714-49 (2011)
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Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
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Viruses 3:1001-14 (2011)
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Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
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Oncogene 24:5952-64 (2005)
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Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
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Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
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Biochim Biophys Acta 1813:731-41 (2011)
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Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
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Pathogens 5:E8 (2016)
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Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
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J Biol Chem 290:26270-81 (2015)
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Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
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Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
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Blood 97:2137-44 (2001)
DOI:10.1182/blood.v97.7.2137
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PMID:15310405
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Azran I, Schavinsky-Khrapunsky Y, Aboud M
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Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
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Retrovirology 1:20 (2004)
DOI:10.1186/1742-4690-1-20
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PMID:11244044
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Yoshida M
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Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
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Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
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PMID:12802280
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Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
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Inactivation of hTERT transcription by Tax.
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Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
mmu03013  Nucleocytoplasmic transport
mmu04010  MAPK signaling pathway
mmu04064  NF-kappa B signaling pathway
mmu04110  Cell cycle
mmu04115  p53 signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04210  Apoptosis
mmu04350  TGF-beta signaling pathway
mmu04612  Antigen processing and presentation
mmu04660  T cell receptor signaling pathway
mmu04668  TNF signaling pathway
KO pathway
ko05166   

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