KEGG   PATHWAY: oas04024
Entry
oas04024                    Pathway                                
Name
cAMP signaling pathway - Ovis aries (sheep)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
oas04024  cAMP signaling pathway
oas04024

Other DBs
GO: 0019933
Organism
Ovis aries (sheep) [GN:oas]
Gene
100037684  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
100101233  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100145884  VIP; vasoactive intestinal peptide precursor [KO:K05264]
100169699  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
100170320  ADRB2; beta-2 adrenergic receptor [KO:K04142]
100233164  CNGA3; cyclic nucleotide-gated cation channel alpha-3 isoform X2 [KO:K04950]
100233165  CNGB3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
100294648  NPPA; natriuretic peptides A precursor [KO:K12334]
100294652  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100302078  RHOA; transforming protein RhoA [KO:K04513]
100302341  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100500781  VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X1 [KO:K04590]
100568292  DRD1; D(1A) dopamine receptor [KO:K04144]
101101873  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X2 [KO:K05850] [EC:7.2.2.10]
101102013  [KO:K16056]
101102014  HCAR2; hydroxycarboxylic acid receptor 2 [KO:K08402]
101102067  PLN; cardiac phospholamban [KO:K05852]
101102089  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101102191  RELA; transcription factor p65 [KO:K04735]
101102228  CRHR2; corticotropin-releasing factor receptor 2 isoform X1 [KO:K04579]
101102411  [KO:K04632]
101102442  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
101102897  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101102915  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X2 [KO:K05211]
101103077  PPP1R1B; protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
101103190  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
101103280  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
101103490  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
101103544  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 isoform X1 [KO:K04615]
101103693  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
101103751  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X2 [KO:K01539] [EC:7.2.2.13]
101103800  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101103933  EDN2; endothelin-2 [KO:K16367]
101104284  TSHB; thyrotropin subunit beta [KO:K05251]
101104306  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
101104344  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X2 [KO:K05853] [EC:7.2.2.10]
101104552  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101104894  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
101105547  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X2 [KO:K04260]
101105703  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
101105735  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
101105757  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
101105821  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
101105840  [KO:K02183]
101105852  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
101105943  GRIN2D; glutamate receptor ionotropic, NMDA 2D isoform X2 [KO:K05212]
101106246  [KO:K04513]
101106284  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101106317  RAP1B; ras-related protein Rap-1b [KO:K07836]
101106371  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X9 [KO:K04851]
101106534  [KO:K05673]
101106781  [KO:K05673]
101106898  POPDC2; popeye domain-containing protein 2 isoform X2 [KO:K26206]
101106989  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101107354  VAV1; proto-oncogene vav [KO:K05730]
101107438  BRAF; serine/threonine-protein kinase B-raf isoform X3 [KO:K04365] [EC:2.7.11.1]
101107485  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2 [KO:K09048]
101107526  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
101107545  RRAS; ras-related protein R-Ras [KO:K07829]
101107568  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X2 [KO:K01540]
101107592  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
101107975  SOX9; transcription factor SOX-9 [KO:K18435]
101108001  [KO:K11265] [EC:4.6.1.1]
101108097  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X6 [KO:K04446]
101108203  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101108228  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
101108308  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X2 [KO:K05869] [EC:2.7.11.17]
101108487  HCN2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
101108743  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
101108767  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
101108785  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101108884  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X10 [KO:K04515] [EC:2.7.11.17]
101108953  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
101109370  [KO:K05673]
101109759  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101109786  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
101109816  ADORA1; adenosine receptor A1 isoform X2 [KO:K04265]
101109890  [KO:K05673]
101110007  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
101110015  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101110136  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
101110137  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
101110687  PLD2; phospholipase D2 isoform X2 [KO:K01115] [EC:3.1.4.4]
101111207  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2 [KO:K05853] [EC:7.2.2.10]
101111248  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
101111268  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X2 [KO:K05850] [EC:7.2.2.10]
101111282  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
101111375  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
101111396  HHIP; hedgehog-interacting protein [KO:K06231]
101111546  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
101111729  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
101111756  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101111757  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4 [KO:K13293] [EC:3.1.4.53]
101111766  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X3 [KO:K05853] [EC:7.2.2.10]
101112193  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
101112196  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X8 [KO:K04351]
101112396  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
101112406  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X2 [KO:K07861]
101112667  ADCY7; adenylate cyclase type 7 isoform X7 [KO:K08047] [EC:4.6.1.1]
101112926  ADORA2A; adenosine receptor A2a [KO:K04266]
101112976  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
101113044  ATP1B4; protein ATP1B4 isoform X3 [KO:K01540]
101113228  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
101113509  GIP; gastric inhibitory polypeptide [KO:K05258]
101113525  DRD2; D(2) dopamine receptor [KO:K04145]
101113586  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
101113826  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
101113846  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101113850  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X4 [KO:K04515] [EC:2.7.11.17]
101113882  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101114027  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
101114243  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101114380  GIPR; gastric inhibitory polypeptide receptor isoform X2 [KO:K04580]
101114458  EDN3; endothelin-3 precursor [KO:K05227]
101114661  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101114778  DRD5; D(1B) dopamine receptor [KO:K05840]
101114783  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
101115080  RAP1A; ras-related protein Rap-1A [KO:K04353]
101115216  CALM1; calmodulin-1 isoform X2 [KO:K02183]
101115476  FXYD1; phospholemman isoform X2 [KO:K13360]
101115485  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
101115640  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X5 [KO:K04632]
101115800  AFDN; afadin isoform X17 [KO:K05702]
101115870  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
101116201  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101116338  CALM3; calmodulin-3 [KO:K02183]
101116393  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101116562  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X6 [KO:K04850]
101117029  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101117275  BDNF; brain-derived neurotrophic factor [KO:K04355]
101117327  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
101117337  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
101117348  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
101117505  [KO:K13293] [EC:3.1.4.53]
101117928  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
101118148  [KO:K01539] [EC:7.2.2.13]
101118179  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101118398  [KO:K01539] [EC:7.2.2.13]
101118462  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101118500  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
101118556  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
101118626  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X4 [KO:K00232] [EC:1.3.3.6]
101118637  CNGA4; cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
101118870  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
101119139  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
101119242  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101119264  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101119430  GPHA2; glycoprotein hormone alpha-2 [KO:K25483]
101119637  GLI3; transcriptional activator GLI3 [KO:K06230]
101119642  ACOX3; LOW QUALITY PROTEIN: peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
101119758  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
101119926  FFAR2; free fatty acid receptor 2 [KO:K04328]
101120547  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
101120651  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
101120665  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
101120709  VAV3; guanine nucleotide exchange factor VAV3 isoform X5 [KO:K05730]
101120826  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101121046  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
101121291  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1 [KO:K13296] [EC:3.1.4.17]
101121428  POPDC3; popeye domain-containing protein 3 [KO:K26207]
101121455  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
101121525  CRH; corticoliberin [KO:K05256]
101121534  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
101121647  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
101121685  BVES; blood vessel epicardial substance isoform X2 [KO:K21108]
101121773  AMH; muellerian-inhibiting factor precursor [KO:K04665]
101121944  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101121961  TNNI3; troponin I, cardiac muscle [KO:K12044]
101122172  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
101122401  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101122415  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
101122570  SUCNR1; succinate receptor 1 [KO:K10042]
101123008  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101123197  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101123247  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101123436  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
101123557  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
101123572  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
101123600  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
101123635  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
105602258  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105605916  [KO:K05673]
105614203  [KO:K05673]
105614854  [KO:K02183]
106991387  [KO:K05673]
114113232  [KO:K07836]
114116812  [KO:K04513]
114117245  [KO:K01540]
114117324  [KO:K05850] [EC:7.2.2.10]
114117869  [KO:K01540]
114118392  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
121820456  [KO:K02183]
442996  GHRL; appetite-regulating hormone precursor [KO:K05254]
443006  SST; somatostatin precursor [KO:K05237]
443013  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
443025  CRHR1; corticotropin-releasing factor receptor 1 precursor [KO:K04578]
443094  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
443118  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
443137  SSTR2; somatostatin receptor type 2 [KO:K04218]
443138  OXTR; oxytocin receptor [KO:K04229]
443179  GCG; pro-glucagon isoform X1 [KO:K05259]
443202  SSTR1; somatostatin receptor type 1 [KO:K04217]
443210  SSTR5; somatostatin receptor type 5 [KO:K04221]
443212  POMC; pro-opiomelanocortin precursor [KO:K05228]
443218  FOS; protein c-Fos [KO:K04379]
443219  JUN; transcription factor Jun [KO:K04448]
443230  CALM2; calmodulin [KO:K02183]
443231  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
443238  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
443271  GRIA1; glutamate receptor 1 isoform X3 [KO:K05197]
443272  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
443273  GRIA3; glutamate receptor 3 isoform X2 [KO:K05199]
443274  GRIA4; glutamate receptor 4 isoform X4 [KO:K05200]
443281  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X9 [KO:K05208]
443299  FSHR; follicle-stimulating hormone receptor precursor [KO:K04247]
443337  ADCYAP1; pituitary adenylate cyclase-activating polypeptide precursor [KO:K05262]
443347  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
443361  NPY1R; neuropeptide Y receptor type 1 isoform X1 [KO:K04204]
443381  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
443384  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
443387  FSHB; follitropin subunit beta precursor [KO:K05250]
443390  OXT; oxytocin-neurophysin 1 precursor [KO:K05243]
443395  LHB; lutropin subunit beta precursor [KO:K08521]
443428  TSHR; thyrotropin receptor precursor [KO:K04249]
443453  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
443457  PPARA; peroxisome proliferator-activated receptor alpha isoform X2 [KO:K07294]
443465  EDNRA; endothelin-1 receptor precursor [KO:K04197]
443482  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
443498  EDN1; endothelin-1 precursor [KO:K16366]
443508  NPY; pro-neuropeptide Y precursor [KO:K05232]
443528  ADRB1; beta-1 adrenergic receptor [KO:K04141]
443538  CGA; glycoprotein hormones alpha chain precursor [KO:K08522]
494435  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
541609  GLP1R; glucagon-like peptide 1 receptor isoform X1 [KO:K04581]
641303  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X5 [KO:K06270]
780444  BAD; bcl2-associated agonist of cell death [KO:K02158]
780520  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
DOI:10.1007/s00210-007-0246-7
Reference
PMID:24450633
  Authors
Roberts OL, Dart C
  Title
cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
  Journal
Biochem Soc Trans 42:89-97 (2014)
DOI:10.1042/BST20130253
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:21852968
  Authors
Bozzi Y, Dunleavy M, Henshall DC
  Title
Cell signaling underlying epileptic behavior.
  Journal
Front Behav Neurosci 5:45 (2011)
DOI:10.3389/fnbeh.2011.00045
Reference
PMID:10880354
  Authors
Lizcano JM, Morrice N, Cohen P
  Title
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
  Journal
Biochem J 349:547-57 (2000)
DOI:10.1042/bj3490547
Reference
PMID:21744067
  Authors
Gerlo S, Kooijman R, Beck IM, Kolmus K, Spooren A, Haegeman G
  Title
Cyclic AMP: a selective modulator of NF-kappaB action.
  Journal
Cell Mol Life Sci 68:3823-41 (2011)
DOI:10.1007/s00018-011-0757-8
Reference
PMID:7688165
  Authors
Lauder JM
  Title
Neurotransmitters as growth regulatory signals: role of receptors and second messengers.
  Journal
Trends Neurosci 16:233-40 (1993)
DOI:10.1016/0166-2236(93)90162-F
Reference
PMID:17077866
  Authors
Voglis G, Tavernarakis N
  Title
The role of synaptic ion channels in synaptic plasticity.
  Journal
EMBO Rep 7:1104-10 (2006)
DOI:10.1038/sj.embor.7400830
Reference
PMID:21346730
  Authors
Altarejos JY, Montminy M
  Title
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.
  Journal
Nat Rev Mol Cell Biol 12:141-51 (2011)
DOI:10.1038/nrm3072
Reference
PMID:24062645
  Authors
Bozzi Y, Borrelli E
  Title
The role of dopamine signaling in epileptogenesis.
  Journal
Front Cell Neurosci 7:157 (2013)
DOI:10.3389/fncel.2013.00157
Reference
PMID:14715909
  Authors
Ceulemans H, Bollen M
  Title
Functional diversity of protein phosphatase-1, a cellular economizer and reset button.
  Journal
Physiol Rev 84:1-39 (2004)
DOI:10.1152/physrev.00013.2003
Reference
PMID:16571352
  Authors
Lipinski RJ, Gipp JJ, Zhang J, Doles JD, Bushman W
  Title
Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.
  Journal
Exp Cell Res 312:1925-38 (2006)
DOI:10.1016/j.yexcr.2006.02.019
Reference
PMID:21693691
  Authors
Lasala C, Schteingart HF, Arouche N, Bedecarras P, Grinspon RP, Picard JY, Josso N, di Clemente N, Rey RA
  Title
SOX9 and SF1 are involved in cyclic AMP-mediated upregulation of anti-Mullerian gene expression in the testicular prepubertal Sertoli cell line SMAT1.
  Journal
Am J Physiol Endocrinol Metab 301:E539-47 (2011)
DOI:10.1152/ajpendo.00187.2011
Reference
PMID:19460777
  Authors
Rosenkranz AC, Rauch BH, Freidel K, Schror K
  Title
Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT.
  Journal
Cardiovasc Res 83:778-84 (2009)
DOI:10.1093/cvr/cvp163
Reference
PMID:11117527
  Authors
Lazennec G, Canaple L, Saugy D, Wahli W
  Title
Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.
  Journal
Mol Endocrinol 14:1962-75 (2000)
DOI:10.1210/mend.14.12.0575
Reference
PMID:16460276
  Authors
Murthy KS
  Title
Signaling for contraction and relaxation in smooth muscle of the gut.
  Journal
Annu Rev Physiol 68:345-74 (2006)
DOI:10.1146/annurev.physiol.68.040504.094707
Reference
PMID:18064650
  Authors
Birukova AA, Zagranichnaya T, Alekseeva E, Bokoch GM, Birukov KG
  Title
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
  Journal
J Cell Physiol 215:715-24 (2008)
DOI:10.1002/jcp.21354
Reference
PMID:9204709
  Authors
Houslay MD, Milligan G
  Title
Tailoring cAMP-signalling responses through isoform multiplicity.
  Journal
Trends Biochem Sci 22:217-24 (1997)
DOI:10.1016/S0968-0004(97)01050-5
Related
pathway
oas00071  Fatty acid degradation
oas04015  Rap1 signaling pathway
oas04020  Calcium signaling pathway
oas04151  PI3K-Akt signaling pathway
oas04210  Apoptosis
oas04260  Cardiac muscle contraction
oas04340  Hedgehog signaling pathway
oas04720  Long-term potentiation
oas04740  Olfactory transduction
oas04972  Pancreatic secretion
oas04976  Bile secretion
KO pathway
ko04024   

DBGET integrated database retrieval system