KEGG   PATHWAY: aamp05165
Entry
aamp05165                   Pathway                                
Name
Human papillomavirus infection - Arvicola amphibius (Eurasian water vole)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
aamp05165  Human papillomavirus infection
aamp05165

Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119824043  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
119801133  Wnt2b; protein Wnt-2b [KO:K00182]
119807630  Wnt2; protein Wnt-2 [KO:K00182]
119813159  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
119817378  Wnt4; protein Wnt-4 [KO:K00408]
119827774  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
119808280  Wnt5b; protein Wnt-5b [KO:K00444]
119821641  Wnt6; protein Wnt-6 [KO:K00445]
119808152  Wnt7a; protein Wnt-7a [KO:K00572]
119823832  Wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
119801469  Wnt8b; protein Wnt-8b [KO:K00714]
119815317  Wnt8a; protein Wnt-8a [KO:K00714]
119812884  Wnt9b; protein Wnt-9b [KO:K01064]
119813175  Wnt9a; protein Wnt-9a [KO:K01064]
119821609  Wnt10a; protein Wnt-10a [KO:K01357]
119823873  Wnt10b; protein Wnt-10b [KO:K01357]
119802903  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
119808392  Wnt16; protein Wnt-16 [KO:K01558]
119803883  Fzd7; frizzled-7 [KO:K02432]
119803894  Fzd1; frizzled-1 [KO:K02432]
119813185  Fzd2; frizzled-2 [KO:K02235]
119800348  Fzd3; frizzled-3 [KO:K02329]
119802675  Fzd4; frizzled-4 [KO:K02354]
119802282  Fzd8; frizzled-8 [KO:K02375]
119820296  Fzd5; frizzled-5 [KO:K02375]
119822803  Fzd6; frizzled-6 [KO:K02376]
119825464  Fzd9; frizzled-9 [KO:K02842]
119825673  Fzd10; frizzled-10 [KO:K02842]
119816593  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
119811174  Dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
119824840  Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
119824224  Gsk3b; LOW QUALITY PROTEIN: glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
119813237  Axin1; axin-1 isoform X1 [KO:K02157]
119813003  Axin2; axin-2 [KO:K04385]
119800867  Apc2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
119815778  Apc; adenomatous polyposis coli protein [KO:K02085]
119808978  Ctnnb1; catenin beta-1 [KO:K02105]
119814283  Csnk1a1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
119810527  Tert; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
119812304  Tcf7; transcription factor 7 isoform X1 [KO:K02620]
119807723  Tcf7l1; transcription factor 7-like 1 isoform X1 [KO:K04490]
119806595  Tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
119802611  Ube3a; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
119812470  Tlr3; toll-like receptor 3 isoform X1 [KO:K05401]
119804058  Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
119818887  Traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
119827931  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
119803361  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
119802528  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
119816165  Ifnb1; LOW QUALITY PROTEIN: interferon beta [KO:K05415]
119817276  interferon beta-like [KO:K05415]
119822927  Ep300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
119811558  LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
119808320  Tada3; transcriptional adapter 3 [KO:K11315]
119818608  cellular tumor antigen p53-like [KO:K04451]
119813419  Tp53; cellular tumor antigen p53 [KO:K04451]
119806257  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
119806133  Pten; LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119802077  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
119814892  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
119815544  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
119802215  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
119826655  Prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
119816609  Prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
119806427  cell division control protein 42 homolog [KO:K04393]
119816496  Cdc42; cell division control protein 42 homolog [KO:K04393]
119822920  Scrib; protein scribble homolog isoform X1 [KO:K16175]
119825325  Dlg1; disks large homolog 1 isoform X1 [KO:K12076]
119802599  Dlg2; LOW QUALITY PROTEIN: disks large homolog 2 [KO:K12075]
119804652  Dlg3; disks large homolog 3 isoform X1 [KO:K21098]
119811244  Llgl1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
119811787  Llgl2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
119819998  Crb3; protein crumbs homolog 3 isoform X1 [KO:K06090]
119816247  Patj; inaD-like protein isoform X1 [KO:K06092]
119818962  Pals1; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
119808130  Vwf; von Willebrand factor [KO:K03900]
119815510  Thbs1; thrombospondin-1 [KO:K16857]
119800800  Thbs3; thrombospondin-3 [KO:K04659]
119821374  Thbs2; thrombospondin-2 [KO:K04659]
119809736  Thbs4; thrombospondin-4 [KO:K04659]
119812455  cartilage oligomeric matrix protein [KO:K04659]
119820335  Fn1; fibronectin isoform X1 [KO:K05717]
119807796  Col1a2; collagen alpha-2(I) chain [KO:K06236]
119811687  Col1a1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
119822685  Col2a1; LOW QUALITY PROTEIN: collagen alpha-1(II) chain [KO:K19719]
119804378  Col4a6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
119804832  Col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
119812350  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
119812512  Col4a2; collagen alpha-2(IV) chain [KO:K06237]
119820835  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
119820836  Col4a3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain [KO:K06237]
119808825  Col6a6; collagen alpha-6(VI) chain [KO:K06238]
119809467  collagen alpha-4(VI) chain-like [KO:K06238]
119822631  Col6a1; collagen alpha-1(VI) chain [KO:K06238]
119809703  Col6a5; collagen alpha-5(VI) chain [KO:K06238]
119823034  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
119820261  Col6a3; collagen alpha-3(VI) chain [KO:K06238]
119814582  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
119823741  Col9a1; LOW QUALITY PROTEIN: collagen alpha-1(IX) chain [KO:K08131]
119817443  Col9a2; collagen alpha-2(IX) chain [KO:K08131]
119803917  Lama1; laminin subunit alpha-1 [KO:K05637]
119820891  Lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
119814499  Lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
119814925  Lama5; laminin subunit alpha-5 [KO:K06240]
119821243  Lama4; laminin subunit alpha-4 isoform X1 [KO:K06241]
119818873  Lamb1; laminin subunit beta-1 [KO:K05636]
119809168  Lamb2; laminin subunit beta-2 [KO:K06243]
119827216  Lamb3; laminin subunit beta-3 [KO:K06244]
119827740  Lamc1; laminin subunit gamma-1 [KO:K05635]
119827480  Lamc2; laminin subunit gamma-2 [KO:K06246]
119819149  Lamc3; laminin subunit gamma-3 [KO:K06247]
119811323  Chad; chondroadherin [KO:K06248]
119803793  Reln; reelin [KO:K06249] [EC:3.4.21.-]
119823299  Spp1; osteopontin [KO:K06250]
119813249  Vtn; vitronectin [KO:K06251]
119827810  Tnr; tenascin-R [KO:K06252]
119827975  Tnn; tenascin-N isoform X1 [KO:K06252]
119822456  Tnxb; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
119816998  Tnc; tenascin isoform X1 [KO:K06252]
119806454  bone sialoprotein 2 [KO:K06253]
119808745  Itga1; integrin alpha-1 [KO:K06480]
119809195  Itga2; integrin alpha-2 [KO:K06481]
119812773  Itga2b; integrin alpha-IIb [KO:K06476]
119812125  Itga3; integrin alpha-3 [KO:K06482]
119819439  Itga4; integrin alpha-4 [KO:K06483]
119822836  Itga5; integrin alpha-5 isoform X1 [KO:K06484]
119819436  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
119803481  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
119816642  Itga8; integrin alpha-8 [KO:K06584]
119810059  Itga9; LOW QUALITY PROTEIN: integrin alpha-9 [KO:K06585]
119800727  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
119809398  Itga11; LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
119818595  Itgav; integrin alpha-V isoform X1 [KO:K06487]
119802025  Itgb1; integrin beta-1 [KO:K05719]
119813347  Itgb3; integrin beta-3 [KO:K06493]
119811868  Itgb4; integrin beta-4 isoform X1 [KO:K06525]
119824871  Itgb5; integrin beta-5 isoform X1 [KO:K06588]
119819234  Itgb6; integrin beta-6 isoform X1 [KO:K06589]
119823057  Itgb7; integrin beta-7 [KO:K06590]
119819639  Itgb8; integrin beta-8 [KO:K06591]
119823930  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
119824800  Pxn; paxillin isoform X1 [KO:K05760]
119822506  Tnf; tumor necrosis factor [KO:K03156]
119808154  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
119801899  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
119827881  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119804936  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
119802203  Fadd; FAS-associated death domain protein [KO:K02373]
119803862  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
119812861  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
119811818  Slc9a3r1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform X1 [KO:K13365]
119811275  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
119812170  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
119810133  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
119820863  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
119814870  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
119823069  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
119803585  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
119799986  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
119809096  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
119818532  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
119827484  Ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
119822257  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
119824016  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
119818479  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
119818916  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
119827044  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
119818627  Tsc1; hamartin isoform X1 [KO:K07206]
119811857  Tsc2; tuberin isoform X1 [KO:K07207]
119807890  Rheb; GTP-binding protein Rheb [KO:K07208]
119816408  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
119813700  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
119814876  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
119813254  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
119823918  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
119820525  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
119815474  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
119816315  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119810503  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119826317  Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119808979  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119817743  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119812102  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119818643  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119820487  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119827246  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119826452  Foxo1; forkhead box protein O1 [KO:K07201]
119807071  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
119823049  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
119827335  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
119808297  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
119823258  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
119803317  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
119807882  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
119820977  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
119804174  G1/S-specific cyclin-E2-like [KO:K06626]
119826163  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
119803337  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
119800094  Rb1; retinoblastoma-associated protein [KO:K06618]
119814594  Rbl1; retinoblastoma-like protein 1 [KO:K04681]
119802072  Rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
119819347  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
119815142  E2f1; transcription factor E2F1 [KO:K17454]
119823710  LOW QUALITY PROTEIN: cyclin-A2-like [KO:K06627]
119826737  Ccna2; cyclin-A2 [KO:K06627]
119826760  Ccna1; cyclin-A1 [KO:K06627]
119809052  Atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
119809137  Atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
119822340  vascular endothelial growth factor A-like [KO:K05448]
119822341  vascular endothelial growth factor A-like isoform X1 [KO:K05448]
119816335  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
119812324  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
119804668  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119801102  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119803437  Rela; transcription factor p65 isoform X1 [KO:K04735]
119803501  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
119825969  Nfx1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
119820755  histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
119816884  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
119820706  histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
119820797  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
119806335  Chd4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
119811273  Irf1; interferon regulatory factor 1 [KO:K09444]
121677274  Tbpl2; TATA box-binding protein-like 2 [KO:K03120]
119820429  TATA-box-binding protein [KO:K03120]
119820614  Tbpl1; TATA box-binding protein-like 1 [KO:K03120]
119822313  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
119822317  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
119822318  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
119822319  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like [KO:K06751]
119822320  patr class I histocompatibility antigen, B-2 alpha chain-like [KO:K06751]
119822321  H-2 class I histocompatibility antigen, D-37 alpha chain-like isoform X1 [KO:K06751]
119822487  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
119822489  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
119822615  class I histocompatibility antigen, Gogo-A*0501 alpha chain-like [KO:K06751]
119822485  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
119822617  class I histocompatibility antigen, Gogo-A*0501 alpha chain-like [KO:K06751]
119823810  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
119823811  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
119823305  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
119823809  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119823812  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119804666  Bcap31; B-cell receptor-associated protein 31 [KO:K14009]
119826678  B-cell receptor-associated protein 31-like [KO:K14009]
119824496  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
119808023  Atp6v1b1; LOW QUALITY PROTEIN: V-type proton ATPase subunit B, kidney isoform [KO:K02147]
119813387  Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
119807856  Atp6v1c2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
119823117  Atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
119814857  V-type proton ATPase subunit D [KO:K02149]
119818609  Atp6v1d; V-type proton ATPase subunit D [KO:K02149]
119808179  Atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
119808411  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
119807656  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
119828141  Atp6v1g3; V-type proton ATPase subunit G 3 isoform X1 [KO:K02152]
119822528  Atp6v1g2; V-type proton ATPase subunit G 2 [KO:K02152]
119817591  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
119826211  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
119811158  Atp6v0a1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
119811779  Tcirg1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
119824754  Atp6v0a2; V-type proton ATPase 116 kDa subunit a2 [KO:K02154]
119806679  Atp6v0a4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
119801787  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
119826034  Atp6v0d2; V-type proton ATPase subunit d 2 [KO:K02146]
119812550  Atp6v0e1; V-type proton ATPase subunit e 1 [KO:K02153]
119806372  Atp6v0e2; V-type proton ATPase subunit e 2 [KO:K02153]
119812171  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
119816905  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
119805330  Atp6ap1; V-type proton ATPase subunit S1 [KO:K03662]
119800992  Egf; pro-epidermal growth factor [KO:K04357]
119812357  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
119813014  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
119818434  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
119806329  Sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
119800249  Hras; GTPase HRas isoform X1 [KO:K02833]
119804230  GTPase KRas-like [KO:K07827]
119806318  Kras; GTPase KRas isoform X1 [KO:K07827]
119801497  Nras; GTPase NRas [KO:K07828]
119808272  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
119805902  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
119809903  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119827491  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
119824680  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119813356  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119827843  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
119809953  Ptger4; prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261]
119814107  Gnas; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
119814944  neuroendocrine secretory protein 55 isoform X1 [KO:K04632]
119800975  Prkacb; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
119802004  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
119802627  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
119820446  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
119814789  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
119821362  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
119801303  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
119826298  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
119806715  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
119807891  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
119817428  Ubr4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
119812087  tubulin gamma-1 chain isoform X1 [KO:K10389]
119813245  Tubg2; tubulin gamma-2 chain [KO:K10389]
119810483  Pkm; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
119827726  pyruvate kinase PKM-like isoform X1 [KO:K00873] [EC:2.7.1.40]
119823978  pyruvate kinase PKM [KO:K00873] [EC:2.7.1.40]
121677052  interferon alpha-12-like [KO:K05414]
121677053  interferon alpha-12-like [KO:K05414]
121677054  interferon alpha-9-like [KO:K05414]
119817047  interferon alpha-12-like [KO:K05414]
119817048  LOW QUALITY PROTEIN: interferon alpha-12-like [KO:K05414]
119817051  interferon alpha-12-like [KO:K05414]
119817054  interferon alpha-12-like [KO:K05414]
119817055  interferon alpha-12-like [KO:K05414]
119817056  interferon alpha-12-like [KO:K05414]
119817057  interferon alpha-12-like [KO:K05414]
119817059  interferon alpha-12-like [KO:K05414]
119817275  interferon alpha-12-like [KO:K05414]
119805874  interferon alpha-12-like [KO:K05414]
119805875  interferon alpha-12-like [KO:K05414]
119805877  interferon alpha-12-like [KO:K05414]
119805879  interferon alpha-12-like [KO:K05414]
119805881  interferon alpha-12-like [KO:K05414]
119805882  interferon alpha-12-like [KO:K05414]
119805887  interferon alpha-12-like [KO:K05414]
119805888  interferon alpha-12-like [KO:K05414]
119805889  interferon alpha-12-like [KO:K05414]
119805892  interferon alpha-9-like [KO:K05414]
119825470  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
119824686  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
119816123  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
119809989  Tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
119803912  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
119803231  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
119799968  Irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
119808127  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
119824526  Oasl; 2'-5'-oligoadenylate synthase-like protein isoform X1 [KO:K14608]
119824527  2'-5'-oligoadenylate synthase-like protein 2 [KO:K14608]
119824623  Mx1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
119825258  interferon-induced GTP-binding protein Mx1-like isoform X1 [KO:K14754]
119817971  Isg15; ubiquitin-like protein ISG15 [KO:K12159]
119815184  Jag1; LOW QUALITY PROTEIN: protein jagged-1 [KO:K06052]
119819233  Notch1; neurogenic locus notch homolog protein 1 [KO:K02599]
119800786  Notch2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
119808103  Notch3; neurogenic locus notch homolog protein 3 [KO:K20995]
119822523  Notch4; neurogenic locus notch homolog protein 4 [KO:K20996]
119818546  Psen1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
119823893  Mfng; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
119811847  Rfng; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
119825059  Lfng; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
119810495  Maml2; mastermind-like protein 2 [KO:K06061]
119813309  Maml1; mastermind-like protein 1 isoform X1 [KO:K06061]
119826920  Maml3; mastermind-like protein 3 [KO:K06061]
119821241  Rbpj; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
119815053  Rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053]
119824983  Hes1; transcription factor HES-1 [KO:K06054]
119821053  Hes6; transcription cofactor HES-6 isoform X1 [KO:K09087]
119817534  Hes2; transcription factor HES-2 [KO:K09087]
119812708  Hes7; transcription factor HES-7 isoform X1 [KO:K09087]
119816044  Hes3; transcription factor HES-3 [KO:K09088]
119816039  Hes5; transcription factor HES-5 [KO:K06055]
119821171  Hey2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
119816886  Heyl; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
119826657  Hey1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
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Moody CA, Laimins LA
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Human papillomavirus oncoproteins: pathways to transformation.
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Nat Rev Cancer 10:550-60 (2010)
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Reference
PMID:25752815
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Chen J
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Signaling pathways in HPV-associated cancers and therapeutic implications.
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Rev Med Virol 25 Suppl 1:24-53 (2015)
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Reference
PMID:26008697
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High-risk human papillomavirus targets crossroads in immune signaling.
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Viruses 7:2485-506 (2015)
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Reference
PMID:19684440
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Molecular mechanisms of human papillomavirus-induced carcinogenesis.
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Public Health Genomics 12:268-80 (2009)
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Reference
PMID:23164805
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Human papillomavirus proteins as prospective therapeutic targets.
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Microb Pathog 58:55-65 (2013)
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Reference
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Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
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Rev Med Virol 19:97-113 (2009)
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Reference
PMID:17645777
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Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
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Cancer Sci 98:1505-11 (2007)
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Reference
PMID:11486705
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Wolf JK, Ramirez PT.
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The molecular biology of cervical cancer.
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Cancer Invest 19:621-9 (2001)
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Reference
PMID:10793105
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zur Hausen H
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Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
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J Natl Cancer Inst 92:690-8 (2000)
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Reference
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Kim YT, Zhao M
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Aberrant cell cycle regulation in cervical carcinoma.
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Yonsei Med J 46:597-613 (2005)
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Reference
PMID:15956361
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McCance DJ
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Human papillomaviruses and cell signaling.
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Sci STKE 2005:pe29 (2005)
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Reference
PMID:15342967
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Motoyama S, Ladines-Llave CA, Luis Villanueva S, Maruo T
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Kobe J Med Sci 50:9-19 (2004)
Reference
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Tommasino M
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The human papillomavirus family and its role in carcinogenesis.
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Semin Cancer Biol 26:13-21 (2014)
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Reference
PMID:26295406
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Bello JO, Nieva LO, Paredes AC, Gonzalez AM, Zavaleta LR, Lizano M
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Viruses 7:4734-55 (2015)
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Reference
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In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
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Sci Rep 5:13446 (2015)
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Reference
PMID:26797638
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James CD, Roberts S
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Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
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Pathogens 5:E8 (2016)
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Reference
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Ganti K, Broniarczyk J, Manoubi W, Massimi P, Mittal S, Pim D, Szalmas A, Thatte J, Thomas M, Tomaic V, Banks L
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The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
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Viruses 7:3530-51 (2015)
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Reference
PMID:21954943
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Subbaiah VK, Kranjec C, Thomas M, Banks L
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PDZ domains: the building blocks regulating tumorigenesis.
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Biochem J 439:195-205 (2011)
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Reference
PMID:23175122
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Human tumour viruses and the deregulation of cell polarity in cancer.
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Nat Rev Cancer 12:877-86 (2012)
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Reference
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Human papillomaviruses, cervical cancer and cell polarity.
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Oncogene 27:7018-30 (2008)
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Reference
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Cell intrinsic & extrinsic factors in cervical carcinogenesis.
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Indian J Med Res 130:286-95 (2009)
Reference
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Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.
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Reference
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Zhang L, Wu J, Ling MT, Zhao L, Zhao KN
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The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
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Reference
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Papillomavirus E5: the smallest oncoprotein with many functions.
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Reference
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Mechanisms of cell transformation by papillomavirus E5 proteins.
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Reference
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Human papillomavirus-16 E5 protein: oncogenic role and therapeutic value.
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Cell Oncol (Dordr) 35:67-76 (2012)
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The E5 proteins.
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Reference
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Reference
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Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications.
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Control of interferon signaling in human papillomavirus infection.
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Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis.
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Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes.
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Mol Cell Proteomics 11:M112.016998 (2012)
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Reference
PMID:9990017
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Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Proc Natl Acad Sci U S A 96:1291-6 (1999)
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Reference
PMID:15175323
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Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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J Biol Chem 279:35664-70 (2004)
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Reference
PMID:18505829
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Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
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Reference
PMID:23536685
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Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
  Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
  Journal
J Virol 87:6062-72 (2013)
DOI:10.1128/JVI.00330-13
Related
pathway
aamp04064  NF-kappa B signaling pathway
aamp04110  Cell cycle
aamp04115  p53 signaling pathway
aamp04150  mTOR signaling pathway
aamp04151  PI3K-Akt signaling pathway
aamp04210  Apoptosis
aamp04310  Wnt signaling pathway
aamp04330  Notch signaling pathway
aamp04510  Focal adhesion
aamp04520  Adherens junction
aamp04530  Tight junction
aamp04612  Antigen processing and presentation
aamp04620  Toll-like receptor signaling pathway
aamp04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

DBGET integrated database retrieval system