KEGG   PATHWAY: biu05168
Entry
biu05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Bos indicus (zebu cattle)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
biu05168  Herpes simplex virus 1 infection
biu05168

Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109577429  LTA; lymphotoxin-alpha [KO:K05468]
109561687  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
109566626  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
109570606  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
109553353  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
109553086  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
109575581  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
109560296  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
109554392  RELA; transcription factor p65 [KO:K04735]
109555878  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
109568764  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
109569840  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
109574464  C-C motif chemokine 2 [KO:K14624]
109568807  NECTIN1; LOW QUALITY PROTEIN: nectin-1 [KO:K06081]
109572641  NECTIN2; nectin-2 isoform X1 [KO:K06531]
109578769  PILRA; paired immunoglobulin-like type 2 receptor alpha [KO:K15411]
109578870  paired immunoglobulin-like type 2 receptor alpha [KO:K15411]
109570927  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
109570168  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
109558343  ITGA5; integrin alpha-5 [KO:K06484]
109574140  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
109567428  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
109563281  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
109566586  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
109572224  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
109562852  interferon beta-2-like [KO:K05415]
109562853  interferon beta-1-like [KO:K05415]
109562855  interferon beta-1 [KO:K05415]
109562667  LOW QUALITY PROTEIN: interferon beta-3-like [KO:K05415]
109562671  interferon beta-2-like [KO:K05415]
109562674  interferon beta-2 [KO:K05415]
109562675  interferon beta-2-like [KO:K05415]
109574238  TP53; cellular tumor antigen p53 [KO:K04451]
109561686  C3; complement C3 [KO:K03990]
109563409  C5; complement C5 [KO:K03994]
109555029  CFP; properdin [KO:K15412]
109571498  TLR2; toll-like receptor 2 [KO:K10159]
109576281  TLR9; toll-like receptor 9 [KO:K10161]
109576356  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
109553388  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
109561728  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
109559201  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
109555285  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
109565970  LOW QUALITY PROTEIN: TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
109563902  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
109559827  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
109564026  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
109566133  IL1B; interleukin-1 beta [KO:K04519]
109574467  CCL5; C-C motif chemokine 5 [KO:K12499]
109558077  IL6; interleukin-6 [KO:K05405]
109577428  TNF; tumor necrosis factor [KO:K03156]
109564477  IL12A; interleukin-12 subunit alpha [KO:K05406]
109561305  IL12B; interleukin-12 subunit beta [KO:K05425]
109562815  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
109567061  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
109567183  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
109575564  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
109570721  IKBKE; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
109559273  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
109562847  interferon alpha-H [KO:K05414]
109562638  interferon alpha-G-like [KO:K05414]
109562641  LOW QUALITY PROTEIN: interferon alpha-1-like [KO:K05414]
109562644  interferon alpha-F [KO:K05414]
109562652  interferon alpha-A [KO:K05414]
109562656  interferon alpha-H-like [KO:K05414]
109562659  interferon alpha-H-like [KO:K05414]
109562660  interferon alpha-H-like [KO:K05414]
109562665  interferon alpha-B-like [KO:K05414]
109562668  interferon alpha-2-like [KO:K05414]
109562670  interferon alpha-2-like [KO:K05414]
109562673  interferon alpha-3-like [KO:K05414]
109563704  MB21D1; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
109562082  TMEM173; stimulator of interferon genes protein [KO:K12654]
109554414  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
109571193  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
109566263  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
109578406  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
109565977  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
109566145  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
109564329  EIF2AK4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
109565265  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 isoform X1 [KO:K03237]
109571344  EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
109565357  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
109556371  EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
109566281  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
109557456  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
109570926  2'-5'-oligoadenylate synthase 3-like [KO:K14216] [EC:2.7.7.84]
109571283  OAS2; 2'-5'-oligoadenylate synthase 2 isoform X1 [KO:K14216] [EC:2.7.7.84]
109571284  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
109570705  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
109555156  HCFC1; host cell factor 1 [KO:K14966]
109559459  HCFC2; host cell factor 2 [KO:K27390]
109570055  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
109577689  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
109570535  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
109572614  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
109574319  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
109556202  JAK1; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
109561587  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
109568771  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
109559357  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
109564781  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
109572324  ZNF181; zinc finger protein 181 isoform X1 [KO:K09228]
109572328  ZNF585A; zinc finger protein 585A isoform X1 [KO:K09228]
109572332  ZNF569; zinc finger protein 569 [KO:K09228]
109572339  ZNF567; zinc finger protein 567 [KO:K09228]
109572341  ZNF461; zinc finger protein 461 isoform X1 [KO:K09228]
109572343  ZNF568; zinc finger protein 568 isoform X1 [KO:K09228]
109572344  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
109572345  ZNF527; zinc finger protein 527 isoform X1 [KO:K09228]
109572347  ZNF382; zinc finger protein 382 isoform X1 [KO:K09228]
109572348  ZNF599; zinc finger protein 599 [KO:K09228]
109572351  ZNF792; zinc finger protein 792 [KO:K09228]
109572353  zinc finger protein 30 homolog isoform X1 [KO:K09228]
109572354  zinc finger protein 570 [KO:K09228]
109572355  ZFP82; zinc finger protein 82 homolog isoform X1 [KO:K09228]
109572359  ZNF565; zinc finger protein 565 [KO:K09228]
109572363  zinc finger protein 383 isoform X1 [KO:K09228]
109572367  ZNF829; zinc finger protein 829 isoform X1 [KO:K09228]
109572370  ZNF793; zinc finger protein 793 isoform X1 [KO:K09228]
109566478  ZNF79; zinc finger protein 79 isoform X1 [KO:K09228]
109558030  zinc finger protein 786-like [KO:K09228]
109558031  ZNF282; zinc finger protein 282 [KO:K09228]
109576226  ZNF619; zinc finger protein 619 [KO:K09228]
109578794  ZNF713; zinc finger protein 713 [KO:K09228]
109571724  ZNF546; LOW QUALITY PROTEIN: zinc finger protein 546 [KO:K09228]
109571749  LOW QUALITY PROTEIN: zinc finger protein 850-like [KO:K09228]
109571752  ZNF285; LOW QUALITY PROTEIN: zinc finger protein 285 [KO:K09228]
109572868  ZNF283; zinc finger protein 283 isoform X1 [KO:K09228]
109572912  zinc finger protein 607-like isoform X1 [KO:K09228]
109563273  ZNF169; zinc finger protein 169 isoform X1 [KO:K09228]
109563299  ZNF189; zinc finger protein 189 isoform X1 [KO:K09228]
109572112  ZNF304; zinc finger protein 304 isoform X1 [KO:K09228]
109572113  LOW QUALITY PROTEIN: zinc finger protein 548-like [KO:K09228]
109556905  ZFP69B; LOW QUALITY PROTEIN: zinc finger protein ZFP69B [KO:K09228]
109572115  ZNF550; zinc finger protein 550 isoform X1 [KO:K09228]
109572118  zinc finger protein 501-like isoform X1 [KO:K09228]
109572119  zinc finger protein OZF-like [KO:K09228]
109572114  zinc finger protein 416-like isoform X1 [KO:K09228]
109572120  zinc finger protein 501-like [KO:K09228]
109572121  LOW QUALITY PROTEIN: zinc finger protein 773-like [KO:K09228]
109572122  zinc finger protein OZF-like isoform X1 [KO:K09228]
109572123  zinc finger protein 772-like isoform X1 [KO:K09228]
109572164  ZNF114; zinc finger protein 114 [KO:K09228]
109572169  ZNF175; zinc finger protein 175 [KO:K09228]
109572170  zinc finger protein 432-like isoform X1 [KO:K09228]
109572171  zinc finger protein 613-like isoform X1 [KO:K09228]
109572173  ZNF614; zinc finger protein 614 [KO:K09228]
109572174  zinc finger protein OZF-like isoform X1 [KO:K09228]
109572175  ZNF577; LOW QUALITY PROTEIN: zinc finger protein 577 [KO:K09228]
109578323  ZNF205; zinc finger protein 205 isoform X1 [KO:K09228]
109578327  ZNF200; zinc finger protein 200 [KO:K09228]
109569964  ZNF214; zinc finger protein 214 [KO:K09228]
109572418  ZFP14; zinc finger protein 14 homolog [KO:K09228]
109572420  LOW QUALITY PROTEIN: zinc finger protein 568-like [KO:K09228]
109572435  ZNF667; zinc finger protein 667 isoform X1 [KO:K09228]
109572438  ZNF583; zinc finger protein 583 [KO:K09228]
109569093  zinc finger protein 558 [KO:K09228]
109572690  zinc finger protein 180-like isoform X1 [KO:K09228]
109557760  ZNF398; zinc finger protein 398 isoform X1 [KO:K09228]
109557763  ZNF777; zinc finger protein 777 [KO:K09228]
109557764  ZNF746; zinc finger protein 746 isoform X1 [KO:K09228]
109559164  ZNF641; zinc finger protein 641 [KO:K09228]
109563357  ZFP37; zinc finger protein 37 homolog [KO:K09228]
109555330  ZNF275; zinc finger protein 275 [KO:K09228]
109560809  zinc finger protein 354B-like [KO:K09228]
109553493  zinc finger protein 596-like isoform X1 [KO:K09228]
109568028  ZNF133; zinc finger protein 133 [KO:K09228]
109568029  zinc finger protein 133-like isoform X1 [KO:K09228]
109571807  uncharacterized protein LOC109571807 [KO:K09228]
109571810  zinc finger protein 347-like [KO:K09228]
109571048  ZNF268; zinc finger protein 268 isoform X1 [KO:K09228]
109571049  ZNF605; zinc finger protein 605 isoform X1 [KO:K09228]
109572179  zinc finger protein 350-like isoform X1 [KO:K09228]
109572191  zinc finger protein 850-like [KO:K09228]
109572192  zinc finger protein 211-like [KO:K09228]
109572193  zinc finger protein 211-like [KO:K09228]
109572195  zinc finger protein 211-like [KO:K09228]
109572196  zinc finger protein 154-like [KO:K09228]
109572197  zinc finger protein 211-like [KO:K09228]
109575837  ZNF621; zinc finger protein 621 [KO:K09228]
109577062  ZFP57; zinc finger protein 57 homolog isoform X1 [KO:K09228]
109578399  RBAK; RB-associated KRAB zinc finger protein isoform X1 [KO:K09228]
109578400  ZNF12; zinc finger protein 12 [KO:K09228]
109578416  ZNF768; zinc finger protein 768 [KO:K09228]
109578417  zinc finger protein 764-like isoform X1 [KO:K09228]
109568761  zinc finger protein 501-like [KO:K09228]
109571613  LOW QUALITY PROTEIN: zinc finger protein 345-like [KO:K09228]
109571614  zinc finger protein 606 isoform X1 [KO:K09228]
109571617  ZNF132; zinc finger protein 132 [KO:K09228]
109571619  ZNF135; zinc finger protein 135 [KO:K09228]
109571621  zinc finger protein 324A-like [KO:K09228]
109572725  ZNF23; zinc finger protein 23 isoform X1 [KO:K09228]
109572776  zinc finger protein 256-like isoform X1 [KO:K09228]
109576411  zinc finger protein 77-like isoform X1 [KO:K09228]
109571812  zinc finger protein 665-like [KO:K09228]
109571814  zinc finger protein 665-like [KO:K09228]
109571815  zinc finger protein 665-like [KO:K09228]
109571817  zinc finger protein 160-like [KO:K09228]
109571820  zinc finger protein 665-like [KO:K09228]
109571828  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
109572979  LOW QUALITY PROTEIN: zinc finger protein OZF-like [KO:K09228]
109572986  ZFP1; zinc finger protein 1 homolog isoform X1 [KO:K09228]
109571811  zinc finger protein 665-like [KO:K09228]
109576604  ZNF184; zinc finger protein 184 [KO:K09228]
109576605  ZNF311; LOW QUALITY PROTEIN: zinc finger protein 311 [KO:K09228]
109576615  LOW QUALITY PROTEIN: zinc finger protein OZF-like [KO:K09228]
109553811  ZNF248; LOW QUALITY PROTEIN: zinc finger protein 248 [KO:K09228]
109553813  zinc finger protein 37A-like isoform X1 [KO:K09228]
109553814  ZNF25; zinc finger protein 25 [KO:K09228]
109555026  ZNF41; zinc finger protein 41 [KO:K09228]
109578418  ZNF688; zinc finger protein 688 isoform X1 [KO:K09228]
109560943  ZNF557; zinc finger protein 557 [KO:K09228]
109560969  zinc finger protein 555-like [KO:K09228]
109572513  ZNF473; zinc finger protein 473 [KO:K09228]
109554740  ZFP92; zinc finger protein 92 homolog [KO:K09228]
109555038  ZNF157; LOW QUALITY PROTEIN: zinc finger protein 157 [KO:K09228]
109557766  ZNF783; protein ZNF783 isoform X1 [KO:K09228]
109557769  ZNF212; zinc finger protein 212 isoform X1 [KO:K09228]
109561780  LOW QUALITY PROTEIN: zinc finger protein 77-like [KO:K09228]
109561782  zinc finger protein 77-like isoform X1 [KO:K09228]
109565725  ZNF514; zinc finger protein 514 isoform X1 [KO:K09228]
109571051  ZNF84; zinc finger protein 84 isoform X1 [KO:K09228]
109571052  ZNF10; LOW QUALITY PROTEIN: zinc finger protein 10 [KO:K09228]
109571053  ZNF891; zinc finger protein 891 [KO:K09228]
109571054  ZNF140; zinc finger protein 140 isoform X1 [KO:K09228]
109561551  zinc finger protein 791-like isoform X1 [KO:K09228]
109561552  zinc finger protein 709-like [KO:K09228]
109561553  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
109561554  zinc finger protein 709-like [KO:K09228]
109561555  zinc finger protein 709-like [KO:K09228]
109561557  ZNF317; zinc finger protein 317 isoform X1 [KO:K09228]
109561560  zinc finger protein 708-like [KO:K09228]
109561561  LOW QUALITY PROTEIN: zinc finger protein 266-like [KO:K09228]
109561562  LOW QUALITY PROTEIN: zinc finger protein 699-like isoform X1 [KO:K09228]
109561564  ZNF177; zinc finger protein 177 isoform X1 [KO:K09228]
109571873  zinc finger protein 420-like [KO:K09228]
109571878  ZIM3; LOW QUALITY PROTEIN: zinc finger imprinted 3 [KO:K09228]
109571883  LOW QUALITY PROTEIN: zinc finger protein 304-like [KO:K09228]
109571888  LOW QUALITY PROTEIN: zinc finger protein OZF-like [KO:K09228]
109571889  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
109571891  zinc finger protein 154-like [KO:K09228]
109571893  ZNF8; zinc finger protein 8 [KO:K09228]
109571896  ZNF584; zinc finger protein 584 [KO:K09228]
109571902  zinc finger protein 883 [KO:K09228]
109571908  zinc finger protein 420-like isoform X1 [KO:K09228]
109571914  zinc finger protein 501-like isoform X1 [KO:K09228]
109573040  zinc finger protein 585A-like [KO:K09228]
109572262  zinc finger protein 112-like isoform X1 [KO:K09228]
109572263  zinc finger protein 227 isoform X1 [KO:K09228]
109572284  zinc finger protein 160-like isoform X1 [KO:K09228]
109572285  zinc finger protein 347-like [KO:K09228]
109572286  zinc finger protein 665-like [KO:K09228]
109572264  zinc finger protein 226-like isoform X1 [KO:K09228]
109572317  LOW QUALITY PROTEIN: zinc finger protein 805-like [KO:K09228]
109572265  ZNF235; zinc finger protein 235 [KO:K09228]
109572266  ZNF404; LOW QUALITY PROTEIN: zinc finger protein 404 [KO:K09228]
109578479  ZNF316; zinc finger protein 316 [KO:K09228]
109578480  ZNF853; zinc finger protein 853 [KO:K09228]
109571384  ZNF74; zinc finger protein 74 isoform X1 [KO:K09228]
109572532  ZFP90; zinc finger protein 90 homolog [KO:K09228]
109572568  zinc finger protein 211-like [KO:K09228]
109572569  zinc finger protein 211-like [KO:K09228]
109573730  zinc finger protein 624 isoform X1 [KO:K09228]
109578726  zinc finger protein 689 [KO:K09228]
109576722  uncharacterized protein LOC109576722 [KO:K09228]
109578081  ZNF597; zinc finger protein 597 [KO:K09228]
109578094  ZNF3; zinc finger protein 3 isoform X1 [KO:K09228]
109553859  LOW QUALITY PROTEIN: zinc finger protein 33B-like [KO:K09228]
109573973  ZNF436; zinc finger protein 436 isoform X1 [KO:K09228]
109571705  zinc finger protein 529-like [KO:K09228]
109562214  ZNF300; zinc finger protein 300 [KO:K09228]
109576459  zinc finger protein 77-like isoform X1 [KO:K09228]
109554881  ZNF81; zinc finger protein 81 [KO:K09228]
109571938  zinc finger protein 665-like isoform X1 [KO:K09228]
109571940  LOW QUALITY PROTEIN: zinc finger protein 665-like [KO:K09228]
109571941  zinc finger protein 665-like [KO:K09228]
109571942  zinc finger protein 160-like [KO:K09228]
109571943  zinc finger protein 160-like [KO:K09228]
109572006  zinc finger protein 271-like isoform X1 [KO:K09228]
109572008  zinc finger protein 571-like [KO:K09228]
109572009  zinc finger protein 345-like isoform X1 [KO:K09228]
109572010  zinc finger protein 2 homolog [KO:K09228]
109572011  zinc finger protein 160-like [KO:K09228]
109572012  zinc finger protein 331-like [KO:K09228]
109572013  zinc finger protein 160-like [KO:K09228]
109572014  zinc finger protein 677-like isoform X1 [KO:K09228]
109572015  zinc finger protein 347-like [KO:K09228]
109572018  zinc finger protein 160-like [KO:K09228]
109572019  zinc finger protein OZF-like [KO:K09228]
109572020  zinc finger protein 160-like isoform X1 [KO:K09228]
109573091  zinc finger protein 665-like isoform X1 [KO:K09228]
109573093  zinc finger protein 845-like [KO:K09228]
109578199  zinc finger protein 300-like [KO:K09228]
109553936  LOW QUALITY PROTEIN: zinc finger protein 658B-like [KO:K09228]
109561345  ZNF879; zinc finger protein 879 isoform X1 [KO:K09228]
109561346  ZNF354C; zinc finger protein 354C [KO:K09228]
109561347  zinc finger protein 454 isoform X1 [KO:K09228]
109556443  ZNF684; zinc finger protein 684 isoform X1 [KO:K09228]
109556448  ZFP69; zinc finger protein ZFP69 isoform X1 [KO:K09228]
109561929  ZNF354A; zinc finger protein 354A isoform X1 [KO:K09228]
109563245  ZNF484; zinc finger protein 484 isoform X1 [KO:K09228]
109563247  ZNF782; zinc finger protein 782 [KO:K09228]
109568356  zinc finger protein 250-like isoform X1 [KO:K09228]
109568357  ZNF7; zinc finger protein 7 isoform X1 [KO:K09228]
109568367  ZNF34; zinc finger protein 34 isoform X1 [KO:K09228]
109568373  ZNF623; zinc finger protein 623 [KO:K09228]
109572021  ZNF331; LOW QUALITY PROTEIN: zinc finger protein 331 [KO:K09228]
109572022  zinc finger protein 160-like [KO:K09228]
109572023  zinc finger protein 724-like isoform X1 [KO:K09228]
109572033  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
109553278  zinc finger protein 705A-like [KO:K09228]
109571884  zinc finger protein 543-like [KO:K09228]
109578093  zinc finger protein 501-like [KO:K09228]
109578096  zinc finger protein 501-like [KO:K09228]
109571944  zinc finger protein 664-like [KO:K09228]
109572016  zinc finger protein 383-like [KO:K09228]
109572116  zinc finger protein 548-like [KO:K09228]
109572180  zinc finger protein 182-like [KO:K09228]
109572315  zinc finger protein 264-like [KO:K09228]
109561435  bone marrow stromal antigen 2-like [KO:K06731]
109561436  bone marrow stromal antigen 2-like [KO:K06731]
109558719  IFNG; interferon gamma [KO:K04687]
109563984  IFNGR1; interferon gamma receptor 1 [KO:K05132]
109569763  IFNGR2; interferon gamma receptor 2 [KO:K05133]
109562906  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
109576585  DAXX; death domain-associated protein 6 [KO:K02308]
109571816  nuclear autoantigen Sp-100-like isoform X1 [KO:K15413]
109571834  nuclear body protein SP140-like protein isoform X1 [KO:K15413]
109575524  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
109577139  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
109577140  LOW QUALITY PROTEIN: antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
109577300  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
109576595  TAPBP; tapasin [KO:K08058]
109575507  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
109561526  CALR; calreticulin [KO:K08057]
109577067  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
109577074  BOLA class I histocompatibility antigen, alpha chain BL3-6-like isoform X1 [KO:K06751]
109577076  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
109577078  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
109577080  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
109577083  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
109577088  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
109577113  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
109576723  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
109561936  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
109565431  LOW QUALITY PROTEIN: beta-2-microglobulin-like [KO:K08055]
109565432  beta-2-microglobulin [KO:K08055]
109576545  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109576596  HLA class II histocompatibility antigen, DO alpha chain-like isoform X1 [KO:K06752]
109577038  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109577039  SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
109577041  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109577042  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
109576666  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109577307  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
109577316  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
109576780  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109562203  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
109559805  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109570415  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
109557823  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
109574805  PIK3R1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
109561418  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109556345  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
109572496  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109570286  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109566571  TSC1; hamartin isoform X1 [KO:K07206]
109578279  TSC2; tuberin isoform X1 [KO:K07207]
109557810  RHEB; GTP-binding protein Rheb [KO:K07208]
109570401  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
109553533  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
109577154  SRPK1; LOW QUALITY PROTEIN: SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
109573856  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
109573586  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
109577051  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
109572723  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
109565293  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
109567458  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
109565998  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
109571228  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
109554394  NXF1; nuclear RNA export factor 1 [KO:K14284]
109555062  nuclear RNA export factor 3-like [KO:K14284]
109554829  LOW QUALITY PROTEIN: nuclear RNA export factor 3-like [KO:K14284]
109554900  nuclear RNA export factor 3-like [KO:K14284]
109574142  ALYREF; THO complex subunit 4 [KO:K12881]
109570480  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109570785  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109579171  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
109559729  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
109572519  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
109554562  FADD; FAS-associated death domain protein [KO:K02373]
109569521  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
109559782  BH3-interacting domain death agonist-like isoform X1 [KO:K04726]
109559783  BH3-interacting domain death agonist-like isoform X1 [KO:K04726]
109571977  apoptosis regulator BAX [KO:K02159]
109571778  BAX; apoptosis regulator BAX [KO:K02159]
109577301  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
109554386  BAD; bcl2-associated agonist of cell death [KO:K02158]
109577782  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
109567345  BCL2L1; bcl-2-like protein 1 [KO:K04570]
109565507  bcl-2-like protein 1 [KO:K04570]
109566483  cytochrome c [KO:K08738]
109566484  cytochrome c [KO:K08738]
109557512  cytochrome c [KO:K08738]
109559418  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
109570433  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
109553316  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
biu03040  Spliceosome
biu03050  Proteasome
biu04115  p53 signaling pathway
biu04151  PI3K-Akt signaling pathway
biu04210  Apoptosis
biu04610  Complement and coagulation cascades
biu04612  Antigen processing and presentation
biu04620  Toll-like receptor signaling pathway
biu04622  RIG-I-like receptor signaling pathway
biu04630  JAK-STAT signaling pathway
KO pathway
ko05168   
LinkDB

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