KEGG   PATHWAY: bmus05169
Entry
bmus05169                   Pathway                                
Name
Epstein-Barr virus infection - Balaenoptera musculus (blue whale)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
bmus05169  Epstein-Barr virus infection
bmus05169

Organism
Balaenoptera musculus (blue whale) [GN:bmus]
Gene
118884422  CR2; complement receptor type 2 isoform X1 [KO:K04012]
118881436  CD19; B-lymphocyte antigen CD19 [KO:K06465]
118903824  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
118903935  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
118903936  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
118903937  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
118903938  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
118904120  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
118904242  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
118904507  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
118903201  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
118903704  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
118903744  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
118896009  TLR2; toll-like receptor 2 [KO:K10159]
118904029  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
118902731  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
118888703  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
118899213  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
118901691  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
118905110  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
118905068  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
118883002  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118887797  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118889045  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118891010  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
118895446  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
118899660  RELA; transcription factor p65 isoform X1 [KO:K04735]
118903810  TNF; tumor necrosis factor [KO:K03156]
118900814  IL6; interleukin-6 [KO:K05405]
118896522  DDX58; LOW QUALITY PROTEIN: antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
118881552  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
118890316  TRAF3; LOW QUALITY PROTEIN: TNF receptor-associated factor 3 [KO:K03174]
118902324  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
118893413  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
118898799  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
118884995  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
118896746  interferon alpha-1-like [KO:K05414]
118896908  interferon alpha-1-like [KO:K05414]
118896929  interferon alpha-1-like [KO:K05414]
118896943  interferon alpha-1-like [KO:K05414]
118897134  interferon alpha-1-like [KO:K05414]
118897323  IFNB1; interferon beta [KO:K05415]
118894360  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
118894162  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
118895748  JAK1; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
118892841  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
118898022  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
118901552  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
118889721  IRF9; interferon regulatory factor 9 [KO:K04693]
118905730  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
118879885  OAS2; 2'-5'-oligoadenylate synthase 2 isoform X1 [KO:K14216] [EC:2.7.7.84]
118879886  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
118879887  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
118895773  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
118903184  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
118882330  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
118899681  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
118897732  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
118901996  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
118905808  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
118880049  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
118884925  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
118904117  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
118898515  cytochrome c 2 [KO:K08738]
118892887  cytochrome c [KO:K08738]
118901102  cytochrome c [KO:K08738]
118902432  cytochrome c-like [KO:K08738]
118903341  cytochrome c-like [KO:K08738]
118890770  cytochrome c-like [KO:K08738]
118901894  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
118881129  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
118887867  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
118889206  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
118899674  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
118899779  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
118899710  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
118900086  CD247; T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
118900911  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
118889595  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
118885935  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
118890518  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
118900035  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
118887032  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
118894397  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
118897875  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
118886879  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
118886724  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
118886569  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
118903467  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
118885558  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
118892497  26S proteasome non-ATPase regulatory subunit 7-like [KO:K03038]
118899649  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
118886635  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
118888723  26S proteasome non-ATPase regulatory subunit 4-like [KO:K03029]
118897855  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
118885820  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
118881725  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
118900618  SEM1; 26S proteasome complex subunit SEM1 isoform X1 [KO:K10881]
118904086  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
118904059  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
118903269  tapasin [KO:K08058]
118889704  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
118892014  CALR; calreticulin [KO:K08057]
118883801  LOW QUALITY PROTEIN: calreticulin-like [KO:K08057]
118897193  LOW QUALITY PROTEIN: calreticulin-like [KO:K08057]
118892390  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
118903642  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
118903643  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
118903649  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
118903671  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
118889777  beta-2-microglobulin-like [KO:K08055]
118889778  beta-2-microglobulin isoform X1 [KO:K08055]
118889765  SNW1; SNW domain-containing protein 1 [KO:K06063]
118883104  LOW QUALITY PROTEIN: SNW domain-containing protein 1-like [KO:K06063]
118889727  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
118905354  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
118882367  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
118880184  NCOR2; LOW QUALITY PROTEIN: nuclear receptor corepressor 2 [KO:K06065]
118892945  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
118896689  SAP30; histone deacetylase complex subunit SAP30 isoform X1 [KO:K19202]
118898046  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
118882099  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
118895469  RBPJ; LOW QUALITY PROTEIN: recombining binding protein suppressor of hairless [KO:K06053]
118894997  HES1; transcription factor HES-1 [KO:K06054]
118893258  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
118890080  RUNX3; runt-related transcription factor 3 [KO:K09279]
118883580  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
118881035  USP7; ubiquitin carboxyl-terminal hydrolase 7 [KO:K11838] [EC:3.4.19.12]
118901737  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
118886638  TP53; cellular tumor antigen p53 [KO:K04451]
118903446  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
118893498  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
118881017  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
118897376  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
118899128  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
118891806  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
118879828  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
118892181  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118894592  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118894671  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118891709  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118892996  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
118901944  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
118884787  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118900614  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118890216  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118887081  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
118885436  RELB; transcription factor RelB [KO:K09253]
118883030  NFKB2; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p100 subunit [KO:K04469]
118885950  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
118884721  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
118904489  NFKBIE; NF-kappa-B inhibitor epsilon isoform X1 [KO:K05872]
118886388  MAP2K4; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
118892192  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118893249  MAPK9; LOW QUALITY PROTEIN: mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
118896118  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118883114  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118896967  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
118903372  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
118886770  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
118886696  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
118904356  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
118904357  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
118901762  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
118901763  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
118901549  JUN; transcription factor AP-1 [KO:K04448]
118882986  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
118896646  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
118903074  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
118880531  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
118898802  CD44; CD44 antigen isoform X1 [KO:K06256]
118881949  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
118901341  CD58; lymphocyte function-associated antigen 3 [KO:K06492]
118892377  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
118890222  VIM; vimentin [KO:K07606]
118905339  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
118891748  JAK3; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
118887532  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
118883303  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
118897548  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
118890472  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
118904177  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
118881721  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
118905421  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
118888611  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
118882620  BLNK; B-cell linker protein isoform X1 [KO:K07371]
118885802  PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
118892325  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
118902318  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
118898958  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
118901914  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
118903037  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
118902505  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
118900613  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
118895372  CCNA2; cyclin-A2 [KO:K06627]
118884235  CCNA1; LOW QUALITY PROTEIN: cyclin-A1 [KO:K06627]
118884513  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
118883460  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
118902675  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
118884336  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
118881917  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
118886299  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
118904073  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
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Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
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Ning S
  Title
Innate immune modulation in EBV infection.
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Herpesviridae 2:1 (2011)
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Reference
PMID:28408983
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Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
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F1000Res 6:386 (2017)
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Reference
PMID:24586164
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van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
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Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
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Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Semin Cancer Biol 22:144-53 (2012)
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Exp Mol Med 47:e133 (2015)
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Cell Mol Immunol 4:185-96 (2007)
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Viruses 5:1587-606 (2013)
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Nat Rev Immunol 1:75-82 (2001)
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J Biol Chem 278:47753-61 (2003)
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Cancers (Basel) 10:E213 (2018)
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J Virol 83:4652-69 (2009)
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Virology 388:236-47 (2009)
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Future Virol 4:79-91 (2009)
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Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
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Front Oncol 8:265 (2018)
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Epstein-Barr virus: induction and control of cell transformation.
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J Cell Physiol 196:207-18 (2003)
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Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
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Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
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PLoS Pathog 7:e1001275 (2011)
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Related
pathway
bmus03050  Proteasome
bmus04010  MAPK signaling pathway
bmus04020  Calcium signaling pathway
bmus04064  NF-kappa B signaling pathway
bmus04110  Cell cycle
bmus04115  p53 signaling pathway
bmus04210  Apoptosis
bmus04612  Antigen processing and presentation
bmus04620  Toll-like receptor signaling pathway
bmus04622  RIG-I-like receptor signaling pathway
bmus04630  JAK-STAT signaling pathway
bmus04662  B cell receptor signaling pathway
KO pathway
ko05169   
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