KEGG   PATHWAY: ccan05203
Entry
ccan05203                   Pathway                                
Name
Viral carcinogenesis - Castor canadensis (American beaver)
Description
There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers.
Class
Human Diseases; Cancer: overview
Pathway map
ccan05203  Viral carcinogenesis
ccan05203

Organism
Castor canadensis (American beaver) [GN:ccan]
Gene
109702281  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
109698042  Hras; GTPase HRas isoform X1 [KO:K02833]
109687060  Kras; GTPase KRas [KO:K07827]
109696062  Nras; GTPase NRas [KO:K07828]
109683259  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109684381  Mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
109691946  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
109689841  Atf2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
109693025  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
109688048  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
109692000  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
109687810  Creb3l3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
109700597  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
109693373  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
109676751  cyclic AMP-responsive element-binding protein 5 [KO:K09047]
109699672  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
109687309  Ddb1; DNA damage-binding protein 1 [KO:K10610]
109681358  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
109695924  Ywhaq; 14-3-3 protein theta [KO:K16197]
109697135  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
109682601  Ywhae; 14-3-3 protein epsilon isoform X1 [KO:K06630]
109681582  Ywhag; 14-3-3 protein gamma [KO:K16198]
109700917  Ywhah; 14-3-3 protein eta [KO:K16198]
109699504  Jak1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
109687324  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
109687323  Stat5a; signal transducer and activator of transcription 5A [KO:K11223]
109692057  signal transducer and activator of transcription 5B [KO:K11224]
109678444  caspase-3 [KO:K02187] [EC:3.4.22.56]
109678454  caspase-3-like [KO:K02187] [EC:3.4.22.56]
109694561  Hpn; serine protease hepsin [KO:K08665] [EC:3.4.21.106]
109681900  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109689664  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109682432  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
109694666  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
109682554  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109687142  Rela; transcription factor p65 isoform X1 [KO:K04735]
109700079  Rel; proto-oncogene c-Rel [KO:K09254]
109691303  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
109682963  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
109674834  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
109693086  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
109695602  Ccne2; G1/S-specific cyclin-E2 [KO:K06626]
109698572  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
109700461  Egr2; LOW QUALITY PROTEIN: E3 SUMO-protein ligase EGR2 [KO:K12496]
109681769  Egr3; early growth response protein 3 isoform X1 [KO:K12497]
109696398  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
109682793  Ltbr; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 3 [KO:K03159]
109691537  nuclear autoantigen Sp-100-like isoform X1 [KO:K15413]
109674316  nuclear autoantigen Sp-100-like isoform X1 [KO:K15413]
109699457  nuclear body protein SP140-like protein isoform X1 [KO:K15413]
109692826  Hnrnpk; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
109696503  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
109684842  ATP-dependent RNA helicase DDX3X-like [KO:K11594] [EC:5.6.2.7]
109691676  ATP-dependent RNA helicase DDX3X [KO:K11594] [EC:5.6.2.7]
109691684  ATP-dependent RNA helicase DDX3X-like isoform X1 [KO:K11594] [EC:5.6.2.7]
109688641  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
109688706  cAMP-dependent protein kinase catalytic subunit beta-like [KO:K04345] [EC:2.7.11.11]
109681298  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
109688701  cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
109674057  histone H2B type 1-N [KO:K11252]
109674058  histone H2B type 1 [KO:K11252]
109679009  histone H2B type F-M-like [KO:K11252]
109679010  histone H2B type W-T-like [KO:K11252]
109680353  histone H2B subacrosomal variant-like [KO:K11252]
109703356  histone H2B type 1-A [KO:K11252]
109697910  histone H2B type W-T-like [KO:K11252]
109697911  histone H2B type W-T-like [KO:K11252]
109677141  histone H2B type 2-F [KO:K11252]
109684967  late histone H2B.L4-like [KO:K11252]
109677420  histone H2B type 1 [KO:K11252]
109677431  histone H2B type 1-M [KO:K11252]
109677449  histone H2B type 1 [KO:K11252]
109677460  histone H2B type 1 [KO:K11252]
109677471  histone H2B type 1 [KO:K11252]
109677486  histone H2B type 2-E [KO:K11252]
109677496  histone H2B type 2-E [KO:K11252]
109677503  histone H2B type 1 [KO:K11252]
109677513  histone H2B type 2-E [KO:K11252]
109677524  histone H2B type 1 [KO:K11252]
109677535  histone H2B type 1-B [KO:K11252]
109700481  histone H2B type 3-B [KO:K11252]
109700482  histone H2B type 3-A [KO:K11252]
109674061  histone H4 [KO:K11254]
109684193  histone H4 [KO:K11254]
109677546  histone H4 [KO:K11254]
109677557  histone H4 [KO:K11254]
109677565  histone H4 [KO:K11254]
109677576  histone H4 [KO:K11254]
109682703  Bax; apoptosis regulator BAX [KO:K02159]
109681589  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
109694060  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
109695112  cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
109691659  LOW QUALITY PROTEIN: cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
109697941  Tbpl1; TATA box-binding protein-like protein 1 [KO:K03120]
109698475  Tbpl2; TATA box-binding protein-like protein 2 [KO:K03120]
109700768  Tbp; TATA-box-binding protein [KO:K03120]
109702231  TATA box-binding protein-like protein 2 [KO:K03120]
109695879  Usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
109693333  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
109703390  Rbpj; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
109689293  Rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053]
109685383  Snw1; LOW QUALITY PROTEIN: SNW domain-containing protein 1 [KO:K06063]
109695938  Gtf2h1; general transcription factor IIH subunit 1 [KO:K03141]
109685703  Gtf2h2c; general transcription factor IIH subunit 2-like protein isoform X1 [KO:K03142]
109684879  Gtf2h3; general transcription factor IIH subunit 3 isoform X1 [KO:K03143]
109693527  Gtf2h4; general transcription factor IIH subunit 4 [KO:K03144]
109681158  Gtf2e1; general transcription factor IIE subunit 1 [KO:K03136]
109692167  Gtf2e2; transcription initiation factor IIE subunit beta isoform X1 [KO:K03137]
109701634  staphylococcal nuclease domain-containing protein 1 [KO:K15979]
109701524  staphylococcal nuclease domain-containing protein 1 isoform X1 [KO:K15979]
109681682  Crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
109690951  Ep300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
109682132  Gtf2b; transcription initiation factor IIB [KO:K03124]
109696351  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
109688460  G1/S-specific cyclin-D2-like [KO:K10151]
109688461  G1/S-specific cyclin-D2 [KO:K10151]
109682157  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
109684671  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
109684667  CTD kinase subunit alpha-like [KO:K02091] [EC:2.7.11.22]
109677666  Ccna1; cyclin-A1 [KO:K06627]
109681820  Ccna2; cyclin-A2 [KO:K06627]
109702695  Skp2; S-phase kinase-associated protein 2 [KO:K03875]
109693538  Mrps18b; 28S ribosomal protein S18b, mitochondrial [KO:K16174]
109699424  Traf1; TNF receptor-associated factor 1 [KO:K03172]
109699331  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
109688807  Traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
109692314  Traf5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
109698332  Jak3; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
109696666  Lyn; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
109688078  Syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
109696209  Atp6v0d2; LOW QUALITY PROTEIN: V-type proton ATPase subunit d 2 [KO:K02146]
109691245  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
109698606  Ube3a; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
109699995  disks large homolog 1 [KO:K12076]
109690802  Scrib; protein scribble homolog isoform X1 [KO:K16175]
109696166  Pxn; paxillin isoform X1 [KO:K05760]
109686692  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
109683903  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
109699136  Psmc1; 26S protease regulatory subunit 4 isoform X1 [KO:K03062]
109691094  Rb1; retinoblastoma-associated protein isoform X1 [KO:K06618]
109693733  Rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
109701269  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
109686244  Ubr4; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase UBR4 [KO:K10691] [EC:2.3.2.27]
109700777  Jun; transcription factor AP-1 [KO:K04448]
109682801  Chd4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
109692991  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
109682730  Hdac2; LOW QUALITY PROTEIN: histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
109681334  Hdac3; histone deacetylase 3 isoform X1 [KO:K11404] [EC:3.5.1.98]
109682405  LOW QUALITY PROTEIN: histone deacetylase 4-like [KO:K11406] [EC:3.5.1.98]
109689544  histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
109692146  Hdac6; histone deacetylase 6 isoform X1 [KO:K11407] [EC:3.5.1.98]
109691609  Hdac7; histone deacetylase 7 isoform X1 [KO:K11408] [EC:3.5.1.98]
109690638  uncharacterized protein LOC109690638 [KO:K11405] [EC:3.5.1.98]
109701320  LOW QUALITY PROTEIN: histone deacetylase 9-like [KO:K11409] [EC:3.5.1.98]
109697653  Hdac10; histone deacetylase 10 [KO:K18671] [EC:3.5.1.98]
109694311  Hdac11; histone deacetylase 11 [KO:K11418] [EC:3.5.1.98]
109698004  Pkm; pyruvate kinase PKM [KO:K00873] [EC:2.7.1.40]
109685847  Irf9; interferon regulatory factor 9 [KO:K04693]
109674903  histone acetyltransferase KAT2B isoform X1 [KO:K06062] [EC:2.3.1.48]
109695784  Kat2a; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
109678624  TFIIA-alpha and beta-like factor [KO:K03122]
109678626  TFIIA-alpha and beta-like factor [KO:K03122]
109683998  Gtf2a1; transcription initiation factor IIA subunit 1 [KO:K03122]
109698214  Gtf2a2; transcription initiation factor IIA subunit 2 [KO:K03123]
109682143  Srf; serum response factor isoform X1 [KO:K04378]
109691919  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
109697260  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
109690889  Rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
109694921  Cdc42; cell division control protein 42 homolog [KO:K04393]
109692922  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109697844  Rhoa; transforming protein RhoA [KO:K04513]
109690388  transforming protein RhoA-like isoform X1 [KO:K04513]
109683468  adseverin [KO:K05768]
109692477  Gsn; gelsolin isoform X1 [KO:K05768]
109685993  LOW QUALITY PROTEIN: alpha-actinin-1-like [KO:K05699]
109695844  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
109686224  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
109701107  cyclin-dependent kinase 4 inhibitor B-like [KO:K06621]
109701109  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
109700303  Chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
109694044  Cdc20; cell division cycle protein 20 homolog [KO:K03363]
109675345  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
109675312  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
109697820  Vac14; protein VAC14 homolog isoform X1 [KO:K15305]
109684342  Ranbp1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
109696397  Polb; DNA polymerase beta isoform X1 [KO:K02330] [EC:2.7.7.7 4.2.99.-]
109698071  Irf7; interferon regulatory factor 7 [KO:K09447]
109700609  Il6st; interleukin-6 receptor subunit beta [KO:K05060]
109696490  LOW QUALITY PROTEIN: C-C chemokine receptor type 5-like [KO:K04180]
109695748  Ccr8; C-C chemokine receptor type 8 [KO:K04183]
109696497  Ccr3; C-C chemokine receptor type 3 [KO:K04178]
109693701  Ccr4; C-C chemokine receptor type 4 [KO:K04179]
109688375  Mapkapk2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
109689613  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
109683261  Bad; bcl2-associated agonist of cell death [KO:K02158]
109701119  Pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
109694300  C3; complement C3 [KO:K03990]
109698715  complement C3 [KO:K03990]
109687279  HLA class I histocompatibility antigen, Cw-1 alpha chain-like isoform X1 [KO:K06751]
109687282  patr class I histocompatibility antigen, alpha chain E-like [KO:K06751]
109687284  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, B-2 alpha chain-like [KO:K06751]
109687287  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
109690375  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
109690377  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
109700906  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
Reference
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  Authors
McLaughlin-Drubin ME, Munger K
  Title
Viruses associated with human cancer.
  Journal
Biochim Biophys Acta 1782:127-50 (2008)
DOI:10.1016/j.bbadis.2007.12.005
Reference
PMID:21102637
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Moore PS, Chang Y
  Title
Why do viruses cause cancer? Highlights of the first century of human tumour virology.
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Nat Rev Cancer 10:878-89 (2010)
DOI:10.1038/nrc2961
Reference
PMID:19400863
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  Title
Tumour virology--history, status and future challenges.
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APMIS 117:382-99 (2009)
DOI:10.1111/j.1600-0463.2009.02452.x
Reference
PMID:17979705
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  Title
Viral origins of human cancer.
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Curr Med Chem 14:2526-39 (2007)
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PMID:21084867
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  Title
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Cancer Biol Ther 10:961-78 (2010)
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PMID:21152115
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  Title
Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor viruses.
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Reference
PMID:19956178
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  Title
Human tumor-associated viruses and new insights into the molecular mechanisms of cancer.
  Journal
Oncogene 27 Suppl 2:S31-42 (2008)
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Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
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J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
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Reference
PMID:21647825
  Authors
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  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
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J Gastroenterol 46:974-90 (2011)
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Reference
PMID:21966251
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Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review.
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Curr Genomics 12:130-7 (2011)
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Reference
PMID:19854353
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  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
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Reference
PMID:9343405
  Authors
Klein NP, Schneider RJ
  Title
Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras.
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Mol Cell Biol 17:6427-36 (1997)
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Reference
PMID:16039586
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  Title
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
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Mol Cell 19:159-70 (2005)
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Reference
PMID:21994562
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Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
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Viruses 1:630-46 (2009)
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Reference
PMID:11099494
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Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
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J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:10824878
  Authors
Arbuthnot P, Capovilla A, Kew M
  Title
Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways.
  Journal
J Gastroenterol Hepatol 15:357-68 (2000)
DOI:10.1046/j.1440-1746.2000.02069.x
Reference
PMID:9837909
  Authors
Gottlob K, Fulco M, Levrero M, Graessmann A
  Title
The hepatitis B virus HBx protein inhibits caspase 3 activity.
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Schulz TF, Moore PS
  Title
Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
  Journal
Trends Microbiol 7:196-200 (1999)
DOI:10.1016/S0966-842X(99)01495-X
Reference
PMID:10855768
  Authors
Schulz TF
  Title
Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8): epidemiology and pathogenesis.
  Journal
J Antimicrob Chemother 45 Suppl T3:15-27 (2000)
DOI:10.1093/jac/45.suppl_4.15
Reference
PMID:9594662
  Authors
Moore PS, Chang Y
  Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
  Journal
Trends Genet 14:144-50 (1998)
DOI:10.1016/S0168-9525(98)01408-5
Reference
PMID:20534855
  Authors
Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Havemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF
  Title
Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.
  Journal
J Virol 84:8231-40 (2010)
DOI:10.1128/JVI.01696-09
Reference
PMID:21421561
  Authors
Bagneris C, Briggs LC, Savva R, Ebrahimi B, Barrett TE
  Title
Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff.
  Journal
Nucleic Acids Res 39:5744-56 (2011)
DOI:10.1093/nar/gkr111
Reference
PMID:15919895
  Authors
Glaunsinger B, Chavez L, Ganem D
  Title
The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.
  Journal
J Virol 79:7396-401 (2005)
DOI:10.1128/JVI.79.12.7396-7401.2005
Related
pathway
ccan03022  Basal transcription factors
ccan03320  PPAR signaling pathway
ccan04010  MAPK signaling pathway
ccan04062  Chemokine signaling pathway
ccan04064  NF-kappa B signaling pathway
ccan04110  Cell cycle
ccan04115  p53 signaling pathway
ccan04142  Lysosome
ccan04151  PI3K-Akt signaling pathway
ccan04210  Apoptosis
ccan04630  JAK-STAT signaling pathway
ccan04662  B cell receptor signaling pathway
ccan04810  Regulation of actin cytoskeleton
ccan05160  Hepatitis C
ccan05161  Hepatitis B
ccan05165  Human papillomavirus infection
ccan05166  Human T-cell leukemia virus 1 infection
ccan05167  Kaposi sarcoma-associated herpesvirus infection
ccan05169  Epstein-Barr virus infection
KO pathway
ko05203   
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