KEGG   PATHWAY: csai04020
Entry
csai04020                   Pathway                                
Name
Calcium signaling pathway - Cololabis saira (Pacific saury)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
csai04020  Calcium signaling pathway
csai04020

Other DBs
GO: 0019722
Organism
Cololabis saira (Pacific saury) [GN:csai]
Gene
133463866  slc8a1b; sodium/calcium exchanger 1b isoform X1 [KO:K05849]
133445891  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
133459777  slc8a4a; solute carrier family 8 member 4a [KO:K05849]
133460121  slc8a2a; sodium/calcium exchanger 2a [KO:K05849]
133420955  slc8a4b; solute carrier family 8 member 4b isoform X1 [KO:K05849]
133441492  sodium/calcium exchanger 2-like [KO:K05849]
133462423  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
133424574  atp2b1a; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
133448242  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
133448670  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
133456880  atp2b3b; plasma membrane calcium-transporting ATPase 3b isoform X1 [KO:K05850] [EC:7.2.2.10]
133443687  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
133419719  LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M3-like [KO:K04129]
133419846  muscarinic acetylcholine receptor M3-like [KO:K04129]
133463308  chrm3a; muscarinic acetylcholine receptor M3 [KO:K04131]
133464621  chrm5b; muscarinic acetylcholine receptor M5b [KO:K04133]
133462110  chrm5a; muscarinic acetylcholine receptor M5a [KO:K04133]
133441075  adenosine receptor A1-like [KO:K04266]
133455343  adora2ab; adenosine A2a receptor b [KO:K04266]
133451425  adora2aa; adenosine A2a receptor a [KO:K04266]
133459798  adora2b; adenosine receptor A2b [KO:K04267]
133418949  adrb1; beta-1 adrenergic receptor [KO:K04141]
133459518  beta-2 adrenergic receptor-like isoform X1 [KO:K04142]
133446817  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
133450341  adrb3a; adrenoceptor beta 3a [KO:K04143]
133459494  drd1b; dopamine receptor D1b [KO:K04144]
133446830  D(1) dopamine receptor-like [KO:K04144]
133451126  D(1A) dopamine receptor-like [KO:K04144]
133464075  D(1)-like dopamine receptor [KO:K05840]
133419066  D(5)-like dopamine receptor [KO:K05840]
133419783  D(5)-like dopamine receptor [KO:K05840]
133449511  drd5a; D(1B) dopamine receptor [KO:K05840]
133447361  hrh2a; histamine receptor H2a [KO:K04150]
133460326  hrh2b; histamine receptor H2b [KO:K04150]
133447433  htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
133454719  si:dkey-247m21.3; 5-hydroxytryptamine receptor 4 [KO:K04160]
133451062  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 4 [KO:K04160]
133423342  htr5ab; 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate b [KO:K04161]
133456592  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
133450902  htr7c; 5-hydroxytryptamine receptor 7 [KO:K04163]
133463360  5-hydroxytryptamine receptor 7-like [KO:K04163]
133448328  guanine nucleotide-binding protein G(s) subunit alpha-like isoform X1 [KO:K04632]
133457365  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
133452462  gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
133423541  guanine nucleotide-binding protein G(olf) subunit alpha-like [KO:K04633]
133452758  adcy1a; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
133426855  adcy2a; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
133460481  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
133464410  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
133424414  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
133440842  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
133463928  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
133452395  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
133464639  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
133421617  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
133443967  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
133458484  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
133452802  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
133422677  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
133443811  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
133424887  pln; cardiac phospholamban [KO:K05852]
133442324  sarcolipin [KO:K22642]
133419019  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1 [KO:K05853] [EC:7.2.2.10]
133459831  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
133447401  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
133455342  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
133422380  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
133451429  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
133418916  sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1 [KO:K23450]
133459961  stromal interaction molecule 1-like [KO:K16059]
133441910  stim1a; stromal interaction molecule 1a isoform X1 [KO:K16059]
133423978  stim2a; stromal interaction molecule 2 isoform X1 [KO:K18196]
133420103  stim2b; stromal interaction molecule 2 isoform X1 [KO:K18196]
133451598  calcium release-activated calcium channel protein 1-like [KO:K16056]
133454661  orai1b; calcium release-activated calcium channel protein 1 [KO:K16056]
133459946  orai2; protein orai-2 [KO:K16057]
133424498  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
133448540  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
133457377  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
133456705  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
133456958  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1 [KO:K04853]
133449049  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857]
133457197  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
133421663  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
133442970  cacna1ab; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b [KO:K04344]
133455435  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
133450780  LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
133458404  voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
133452776  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
133419661  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
133422269  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
133422543  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
133442765  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
133459519  chrna7a; neuronal acetylcholine receptor subunit alpha-7a [KO:K04809]
133447051  chrna8; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
133461023  chrna11; cholinergic receptor, nicotinic, alpha 11 [KO:K04809]
133441030  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
133455421  grin1a; glutamate receptor ionotropic, NMDA 1a isoform X1 [KO:K05208]
133451190  glutamate receptor ionotropic, NMDA 1-like isoform X1 [KO:K05208]
133422461  grin2aa; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
133458283  glutamate receptor ionotropic, NMDA 2B-like [KO:K05210]
133460457  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2B-like [KO:K05210]
133422717  glutamate receptor ionotropic, NMDA 2B-like [KO:K05210]
133419132  glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
133421918  grin2ca; glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca [KO:K05211]
133433859  glutamate receptor ionotropic, NMDA 2D [KO:K05212]
133460922  glutamate receptor ionotropic, NMDA 2D-like [KO:K05212]
133454456  grin3a; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
133458742  grin3bb; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
133462631  glutamate receptor ionotropic, NMDA 3B-like [KO:K05214]
133459830  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
133450463  p2rx2; P2X purinoceptor 2 [KO:K05216]
133447605  p2rx3a; P2X purinoceptor 3a isoform X1 [KO:K05217]
133447657  P2X purinoceptor 3-like [KO:K05217]
133450936  P2X purinoceptor 4-like isoform X1 [KO:K05218]
133459804  p2rx5; P2X purinoceptor 5 [KO:K05219]
133442262  P2X purinoceptor 5-like [KO:K05219]
133451515  p2rx7; P2X purinoceptor 7 [KO:K05220]
133459660  ryanodine receptor 1-like isoform X1 [KO:K04961]
133442018  ryr1b; ryanodine receptor 1b isoform X1 [KO:K04961]
133419851  ryr2a; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
133463190  ryr2b; ryanodine receptor 2 isoform X1 [KO:K04962]
133464370  ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
133462280  ryanodine receptor 3-like isoform X1 [KO:K04963]
133452976  casq1a; calsequestrin-1a [KO:K23468]
133420611  calsequestrin-1-like isoform X1 [KO:K23468]
133445880  calsequestrin-2-like [KO:K23445]
133424981  calsequestrin-2-like [KO:K23445]
133423421  aspartyl/asparaginyl beta-hydroxylase-like [KO:K00476] [EC:1.14.11.16]
133447644  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
133420944  cysteinyl leukotriene receptor 1-like [KO:K04322]
133444364  muscarinic acetylcholine receptor M2-like [KO:K04130]
133424496  chrm2a; muscarinic acetylcholine receptor M2a [KO:K04130]
133454746  adra1ab; alpha-1A adrenergic receptor [KO:K04135]
133451009  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
133459252  alpha-1A adrenergic receptor-like [KO:K04136]
133446907  alpha-1A adrenergic receptor-like [KO:K04136]
133460729  adra1d; alpha-1D adrenergic receptor [KO:K04137]
133422908  agtr1b; type-1 angiotensin II receptor [KO:K04166]
133420141  endothelin receptor type B-like isoform X1 [KO:K04197]
133440982  ednraa; endothelin receptor type Aa [KO:K04197]
133420894  endothelin receptor type B-like [KO:K04197]
133445579  endothelin receptor type B-like [KO:K04198]
133447203  endothelin receptor type B-like [KO:K04198]
133453125  ednrba; endothelin receptor Ba [KO:K04198]
133455066  proteinase-activated receptor 1-like [KO:K03914]
133450413  f2r; proteinase-activated receptor 1 [KO:K03914]
133464405  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
133461932  metabotropic glutamate receptor 1-like [KO:K04603]
133459397  grm5a; glutamate receptor, metabotropic 5a [KO:K04604]
133441685  grm5b; metabotropic glutamate receptor 5b [KO:K04604]
133445563  gastrin-releasing peptide receptor-like [KO:K04169]
133456365  gastrin-releasing peptide receptor-like [KO:K04169]
133449415  hrh1; histamine H1 receptor [KO:K04149]
133457826  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
133445540  htr2aa; 5-hydroxytryptamine receptor 2A [KO:K04157]
133420617  htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [KO:K04157]
133464050  lutropin-choriogonadotropic hormone receptor-like [KO:K04248]
133457522  ntsr1; LOW QUALITY PROTEIN: neurotensin receptor type 1 [KO:K04211]
133448512  oxtra; oxytocin receptor [KO:K04229]
133448602  oxtrb; oxytocin receptor b isoform X1 [KO:K04229]
133423971  arg8-vasotocin receptor-like [KO:K04226]
133443842  avpr1aa; arginine vasopressin receptor 1Aa [KO:K04226]
133451890  ltb4r2b; leukotriene B4 receptor 2b [KO:K04297]
133462424  ptafr; platelet-activating factor receptor [KO:K04279]
133421615  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
133422770  ptger1c; prostaglandin E receptor 1c (subtype EP1) [KO:K04258]
133458490  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
133458746  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
133424294  B2 bradykinin receptor-like [KO:K03916]
133462053  B2 bradykinin receptor-like [KO:K03916]
133462232  B2 bradykinin receptor-like [KO:K03916]
133462259  B2 bradykinin receptor-like [KO:K03916]
133462445  bdkrb1; B1 bradykinin receptor [KO:K03916]
133455148  substance-P receptor-like [KO:K04222]
133450860  tacr1a; tachykinin receptor 1a [KO:K04222]
133421138  tacr2; substance-K receptor isoform X1 [KO:K04223]
133434436  tacr3l; tachykinin receptor 3-like [KO:K04224]
133450979  tacr3a; tachykinin receptor 3a [KO:K04224]
133458521  tbxa2r; thromboxane A2 receptor isoform X1 [KO:K04264]
133444636  trhr2; thyrotropin releasing hormone receptor 2 [KO:K04282]
133460596  thyrotropin-releasing hormone receptor-like [KO:K04282]
133461267  trhrb; thyrotropin-releasing hormone receptor b [KO:K04282]
133440887  trhra; thyrotropin-releasing hormone receptor [KO:K04282]
133456746  thyrotropin-releasing hormone receptor [KO:K04282]
133445863  cckbrb; cholecystokinin receptor [KO:K04194]
133425006  cholecystokinin receptor-like [KO:K04194]
133420277  cckar; cholecystokinin receptor type A isoform X1 [KO:K04194]
133452129  C-X-C chemokine receptor type 4-like [KO:K04189]
133446305  C-X-C chemokine receptor type 4-like [KO:K04189]
133454954  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
133450546  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
133458368  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04635]
133462577  gna11b; guanine nucleotide-binding protein subunit alpha-11b [KO:K04635]
133450545  gna14a; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
133458369  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04637]
133447340  egf; pro-epidermal growth factor [KO:K04357]
133449374  tgfa; protransforming growth factor alpha [KO:K08774]
133452227  platelet-derived growth factor subunit A-like [KO:K04359]
133421623  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
133442483  pdgfba; platelet-derived growth factor beta polypeptide a isoform X1 [KO:K17386]
133446800  pdgfc; platelet-derived growth factor C [KO:K05450]
133441689  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
133446896  fgf1a; putative fibroblast growth factor 1 isoform X1 [KO:K18496]
133460212  putative fibroblast growth factor 1 isoform X1 [KO:K18496]
133447443  fgf2; fibroblast growth factor 2 [KO:K18497]
133444921  fgf8b; fibroblast growth factor 8b [KO:K04358]
133424339  fibroblast growth factor 6-like [KO:K04358]
133424340  fibroblast growth factor 6-like [KO:K04358]
133452698  fgf20a; fibroblast growth factor 20a [KO:K04358]
133446982  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
133419364  fgf4; fibroblast growth factor 4 [KO:K04358]
133419372  fgf3; fibroblast growth factor 3 [KO:K04358]
133447536  fgf16; fibroblast growth factor 16 [KO:K04358]
133447642  fgf20b; fibroblast growth factor 20b [KO:K04358]
133447765  fgf24; fibroblast growth factor 24 [KO:K04358]
133420008  fgf7; fibroblast growth factor 7 [KO:K04358]
133450978  fgf5; fibroblast growth factor 5 [KO:K04358]
133443952  fibroblast growth factor 4B-like isoform X1 [KO:K04358]
133451130  fibroblast growth factor 10-like [KO:K04358]
133457719  fgf22; fibroblast growth factor 22 [KO:K04358]
133463451  fgf8a; fibroblast growth factor 8 [KO:K04358]
133419357  fgf19; fibroblast growth factor 19 [KO:K22603]
133419083  fgf21; fibroblast growth factor 21 [KO:K22429]
133424368  fibroblast growth factor 23-like [KO:K22428]
133424543  fibroblast growth factor 23-like [KO:K22428]
133443951  fibroblast growth factor 23 [KO:K22428]
133418532  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
133447107  vegfba; vascular endothelial growth factor A isoform X1 [KO:K05448]
133424945  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
133454015  vegfc; vascular endothelial growth factor C [KO:K05449]
133420137  vegfd; vascular endothelial growth factor D [KO:K05449]
133449295  ngfb; nerve growth factor [KO:K02582]
133456461  ngfa; neurotrophin-7 [KO:K02582]
133424112  hgfa; hepatocyte growth factor a [KO:K05460]
133444304  hgfb; hepatocyte growth factor [KO:K05460]
133448629  mst1; hepatocyte growth factor-like protein [KO:K23441]
133454651  gdnfa; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
133451080  gdnfb; glial cell line-derived neurotrophic factor [KO:K05452]
133452222  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
133423117  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
133419771  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
133448761  erbb3a; receptor tyrosine-protein kinase erbB-3a isoform X1 [KO:K05084] [EC:2.7.10.1]
133457181  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
133424882  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
133446041  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
133458269  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
133446945  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
133460013  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
133455174  fgfr1b; fibroblast growth factor receptor 1b isoform X1 [KO:K04362] [EC:2.7.10.1]
133451402  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
133463216  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
133462938  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
133460057  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
133447081  kdrl; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
133423358  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
133446863  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
133458271  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
133438997  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
133454953  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
133451272  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
133444479  NT-3 growth factor receptor-like [KO:K05101] [EC:2.7.10.1]
133456756  NT-3 growth factor receptor-like [KO:K05101] [EC:2.7.10.1]
133456763  NT-3 growth factor receptor-like [KO:K05101] [EC:2.7.10.1]
133443732  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
133448613  macrophage-stimulating protein receptor-like [KO:K05100] [EC:2.7.10.1]
133448983  mst1rb; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
133464072  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
133462659  M1-specific T cell receptor beta chain-like [KO:K10785]
133462670  immunoglobulin lambda-1 light chain-like [KO:K10785]
133456195  uncharacterized protein LOC133456195 [KO:K06856]
133456801  immunoglobulin gamma-1 heavy chain-like [KO:K06856]
133446094  plcd4b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
133425113  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
133425169  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like isoform X1 [KO:K05857] [EC:3.1.4.11]
133419715  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like [KO:K05857] [EC:3.1.4.11]
133419720  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like [KO:K05857] [EC:3.1.4.11]
133453141  plcd1b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b isoform X1 [KO:K05857] [EC:3.1.4.11]
133421807  plcd3a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [KO:K05857] [EC:3.1.4.11]
133423614  plcd1a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a isoform X1 [KO:K05857] [EC:3.1.4.11]
133464380  plcb1l; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
133418720  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
133420813  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
133462872  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
133463587  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
133458677  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like isoform X1 [KO:K01116] [EC:3.1.4.11]
133457101  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
133443937  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
133419472  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
133443765  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1-like [KO:K05861] [EC:3.1.4.11]
133448733  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
133448914  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
133444381  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
133456934  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
133445545  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
133423196  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
133423198  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
133423381  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
133450453  tpcn1; two pore channel protein 1 isoform X1 [KO:K16896]
133418900  tpcn2; two pore channel protein 2 [KO:K14077]
133421922  mcoln1b; mucolipin-1b isoform X1 [KO:K04992]
133450507  mcoln1a; mucolipin-1a [KO:K04992]
133458470  mcoln2; mucolipin-2 isoform X1 [KO:K04993]
133451978  mucolipin-3-like [KO:K04994]
133458600  mcoln3b; mucolipin-3 [KO:K04994]
133433194  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
133448961  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
133421817  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
133449797  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
133464187  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
133460033  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
133464017  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
133419146  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
133455117  zgc:56235; voltage-dependent anion-selective channel protein 2-like [KO:K15041]
133450691  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
133459583  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
133447085  slc25a5; ADP/ATP translocase 2 [KO:K05863]
133433807  slc25a4; ADP/ATP translocase 1 [KO:K05863]
133463677  ppifa; peptidylprolyl isomerase Fa [KO:K09565] [EC:5.2.1.8]
133418769  peptidyl-prolyl cis-trans isomerase A-like [KO:K09565] [EC:5.2.1.8]
133456868  tnnc1b; troponin C type 1b (slow) [KO:K05865]
133457008  tnnc1a; troponin C type 1a (slow) [KO:K05865]
133457513  troponin C, skeletal muscle [KO:K12042]
133457514  tnnc2.2; troponin C, skeletal muscle [KO:K12042]
133464024  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
133418469  calm1b; calmodulin-1b [KO:K02183]
133459485  calml4a; calmodulin-like protein 4a [KO:K02183]
133418670  calmodulin-alpha-like [KO:K02183]
133448252  calmodulin-1 [KO:K02183]
133454854  calmodulin-alpha-like [KO:K02183]
133454855  calmodulin-alpha-like [KO:K02183]
133441770  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
133419560  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
133441734  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like [KO:K00871] [EC:2.7.11.19]
133464643  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
133460050  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
133420765  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
133445627  mylka; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
133458717  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
133452769  mylk4a; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
133418940  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
133422273  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
133424287  camk1da; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
133448596  camk1a; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
133448805  camk1b; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
133448954  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
133456659  camk1gb; calcium/calmodulin-dependent protein kinase IGb [KO:K08794] [EC:2.7.11.17]
133451492  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
133460009  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
133419583  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
133420253  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
133455135  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
133422178  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
133463234  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
133458687  si:ch73-60h1.1; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
133459656  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
133447243  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
133420633  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
133455491  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
133451452  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
133453099  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
133463362  calcineurin subunit B type 1 [KO:K06268]
133448787  tfeb; transcription factor EB isoform X1 [KO:K15590]
133425592  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
133460618  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
133448366  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
133456237  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
133444438  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
133463456  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
133452538  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
133450964  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
133451748  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
133446357  pde1a; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
133452849  pde1cb; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
133448300  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B-like [KO:K13755] [EC:3.1.4.17]
133418528  ptk2bb; protein tyrosine kinase 2 beta, b [KO:K05871] [EC:2.7.10.2]
133425339  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
133464706  itpkb; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
133447618  si:ch73-22a13.3; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
133441791  itpkcb; inositol-trisphosphate 3-kinase Cb [KO:K00911] [EC:2.7.1.127]
133462517  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
133444442  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
133421516  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
133441753  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
133422491  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
133433875  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
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Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
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J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
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Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
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J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
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Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
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Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
csai04010  MAPK signaling pathway
csai04070  Phosphatidylinositol signaling system
csai04210  Apoptosis
KO pathway
ko04020   
LinkDB

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