KEGG   PATHWAY: dord05164
Entry
dord05164                   Pathway                                
Name
Influenza A - Dipodomys ordii (Ord's kangaroo rat)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
dord05164  Influenza A
dord05164

Organism
Dipodomys ordii (Ord's kangaroo rat) [GN:dord]
Gene
105981925  LOW QUALITY PROTEIN: tryptase alpha/beta-1-like [KO:K01340] [EC:3.4.21.59]
105991843  Plg; plasminogen [KO:K01315] [EC:3.4.21.7]
105989448  anionic trypsin-2-like [KO:K01312] [EC:3.4.21.4]
105989486  anionic trypsin-2-like [KO:K01312] [EC:3.4.21.4]
105989514  cationic trypsin-3 [KO:K01312] [EC:3.4.21.4]
105989515  anionic trypsin-2-like [KO:K01312] [EC:3.4.21.4]
105989516  anionic trypsin-2-like isoform X1 [KO:K01312] [EC:3.4.21.4]
105989517  anionic trypsin-2-like [KO:K01312] [EC:3.4.21.4]
105989518  anionic trypsin-2 [KO:K01312] [EC:3.4.21.4]
105989519  cationic trypsin-3-like isoform X1 [KO:K01312] [EC:3.4.21.4]
105989524  anionic trypsin-1-like isoform X1 [KO:K01312] [EC:3.4.21.4]
105993941  Tmprss2; transmembrane protease serine 2 isoform X1 [KO:K09633] [EC:3.4.21.122]
105980614  Tmprss4; transmembrane protease serine 4 [KO:K09635] [EC:3.4.21.-]
105980205  Tmprss11d; transmembrane protease serine 11D [KO:K09641] [EC:3.4.21.-]
105981822  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105990722  Oas1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
105985004  Rnasel; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
105999276  Dnajb1; dnaJ homolog subfamily B member 1 [KO:K09507]
105990523  Dnajc3; dnaJ homolog subfamily C member 3 [KO:K09523]
105983707  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
105982756  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
106001010  Trim25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
105993403  Ddx58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
105995788  Ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
105980806  Nlrx1; NLR family member X1 [KO:K12653]
105981763  Mavs; mitochondrial antiviral-signaling protein [KO:K12648]
105986731  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105991714  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
106000155  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105993134  Nfkbib; NF-kappa-B inhibitor beta [KO:K02581]
105982592  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
105991225  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
105989242  Rela; transcription factor p65 isoform X1 [KO:K04735]
106003146  Calcoco2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
105992937  Tlr3; toll-like receptor 3 isoform X1 [KO:K05401]
105990289  Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
105983154  Traf3; TNF receptor-associated factor 3 [KO:K03174]
105989073  Tbk1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
105986544  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
105994272  Irf3; interferon regulatory factor 3 [KO:K05411]
105991983  Ep300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
105981875  Crebbp; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
105996175  Tlr4; toll-like receptor 4 isoform X1 [KO:K10160]
105997681  Tlr7; toll-like receptor 7 isoform X1 [KO:K05404]
105996289  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
105987554  Irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
105998598  Irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
105988223  Il1a; interleukin-1 alpha [KO:K04383]
105988300  Il1b; interleukin-1 beta [KO:K04519]
105991375  Il6; interleukin-6 [KO:K05405]
105985549  Il12a; interleukin-12 subunit alpha [KO:K05406]
106001299  Il12b; interleukin-12 subunit beta [KO:K05425]
105997009  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
105988541  Cxcl8; interleukin-8 [KO:K10030]
105985754  C-C motif chemokine 2-like [KO:K14624]
105983400  Ccl5; C-C motif chemokine 5 [KO:K12499]
106002246  Cxcl10; C-X-C motif chemokine 10 [KO:K12671]
105999070  Icam1; intercellular adhesion molecule 1 [KO:K06490]
105988955  interferon alpha-3-like [KO:K05414]
105988956  interferon alpha-3-like [KO:K05414]
105988976  interferon alpha-2-like [KO:K05414]
105988979  interferon alpha-2-like [KO:K05414]
105988997  interferon alpha-3-like [KO:K05414]
105988998  interferon alpha-3-like [KO:K05414]
105989000  interferon alpha-3-like [KO:K05414]
105988975  Ifnb1; interferon beta [KO:K05415]
105994024  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
105994025  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
105988847  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105999053  Tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
106003265  Socs3; suppressor of cytokine signaling 3 [KO:K04696]
105995197  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
105990116  Stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
105992528  Irf9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
105993986  interferon-induced GTP-binding protein Mx2-like [KO:K14754]
105993987  LOW QUALITY PROTEIN: interferon-induced GTP-binding protein Mx2-like [KO:K14754]
105984887  Adar; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
105982530  Pml; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
105988764  Ifng; interferon gamma [KO:K04687]
105993592  Ifngr1; interferon gamma receptor 1 [KO:K05132]
105994023  Ifngr2; interferon gamma receptor 2 [KO:K05133]
105987218  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
105982132  Ciita; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
106002959  HLA class II histocompatibility antigen, DRB1-11 beta chain-like [KO:K06752]
105999831  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
105999834  HLA class II histocompatibility antigen, DR beta 4 chain-like isoform X1 [KO:K06752]
105999835  HLA class II histocompatibility antigen, DRB1-12 beta chain-like [KO:K06752]
105999836  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
105999837  HLA class II histocompatibility antigen, DRB1-10 beta chain-like [KO:K06752]
105999872  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
105999877  HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 [KO:K06752]
105999881  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
105999888  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
105999890  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
106001844  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
105985010  Nlrp3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
105981993  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
105980798  caspase-1-like isoform X1 [KO:K01370] [EC:3.4.22.36]
105980688  Il18; interleukin-18 isoform X1 [KO:K05482]
105993237  Il33; interleukin-33 [KO:K12967]
105985370  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105986178  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105999080  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105999614  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
106000559  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
106001473  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105986533  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105983045  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105998099  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105987818  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105989896  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
105992920  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
105985592  Tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
105999403  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
105985196  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105986214  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105991035  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105983179  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105989060  Fadd; FAS-associated death domain protein [KO:K02373]
106002598  FAS-associated death domain protein-like [KO:K02373]
105981481  Casp8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
105991113  Bid; BH3-interacting domain death agonist [KO:K04726]
105994373  Bax; apoptosis regulator BAX [KO:K02159]
105999887  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
105996772  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
105992756  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
105988303  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
105999757  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
105991774  cytochrome c, somatic [KO:K08738]
105994518  cytochrome c, testis-specific [KO:K08738]
105987659  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
105989961  Casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
105992928  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105990849  Cpsf4; cleavage and polyadenylation specificity factor subunit 4 [KO:K14404]
105992522  Pabpn1; polyadenylate-binding protein 2 [KO:K14396]
105983008  Pabpn1l; embryonic polyadenylate-binding protein 2 [KO:K14396]
105995265  Nxf1; nuclear RNA export factor 1 [KO:K14284]
106001490  Nxf3; nuclear RNA export factor 3 [KO:K14284]
105992812  Nxt2; NTF2-related export protein 2 isoform X1 [KO:K14285]
105993685  Nxt1; NTF2-related export protein 1 [KO:K14285]
105994109  NTF2-related export protein 2-like [KO:K14285]
106000901  Hnrnpul1; heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1 [KO:K15047]
105991687  Rae1; mRNA export factor [KO:K14298]
105984056  Nup98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
105983706  Rsad2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
105984902  Fdps; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
106003156  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105981244  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
105981136  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105990471  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105981830  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105997225  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105990935  Actb; actin, cytoplasmic 1 [KO:K05692]
105998427  Actg1; actin, cytoplasmic 2 [KO:K05692]
105980921  Rab11a; ras-related protein Rab-11A [KO:K07904]
105998780  Rab11b; ras-related protein Rab-11B [KO:K07905]
105990187  Xpo1; exportin-1 [KO:K14290]
105987981  Kpna1; importin subunit alpha-5 [KO:K23940]
106003261  Kpna2; importin subunit alpha-1 [KO:K15043]
105988860  Kpna6; importin subunit alpha-7 [KO:K15042]
105998141  Kpna5; importin subunit alpha-6 [KO:K15042]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24225499
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
  Journal
J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
PMID:19565019
  Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
  Journal
J Mol Genet Med 3:167-75 (2008)
Reference
PMID:27751627
  Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
  Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
  Journal
Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
PMID:18588994
  Authors
Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
  Journal
Int J Biochem Cell Biol 40:2671-4 (2008)
DOI:10.1016/j.biocel.2008.05.019
Reference
PMID:23977434
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
PMID:20020828
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
PMID:21698289
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
PMID:19782761
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
PMID:23170167
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
PMID:30487536
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
PMID:29556226
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
PMID:20130137
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
PMID:18980544
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
PMID:27231932
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:21971186
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
PMID:30254192
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
PMID:30545063
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
PMID:21253874
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
PMID:26008706
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
PMID:30079062
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
PMID:23236273
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
dord00900  Terpenoid backbone biosynthesis
dord03013  Nucleocytoplasmic transport
dord03015  mRNA surveillance pathway
dord04010  MAPK signaling pathway
dord04110  Cell cycle
dord04144  Endocytosis
dord04210  Apoptosis
dord04620  Toll-like receptor signaling pathway
dord04621  NOD-like receptor signaling pathway
dord04622  RIG-I-like receptor signaling pathway
dord04630  JAK-STAT signaling pathway
dord05416  Viral myocarditis
KO pathway
ko05164   
LinkDB

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