KEGG   PATHWAY: dord04010
Entry
dord04010                   Pathway                                
Name
MAPK signaling pathway - Dipodomys ordii (Ord's kangaroo rat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
dord04010  MAPK signaling pathway
dord04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Dipodomys ordii (Ord's kangaroo rat) [GN:dord]
Gene
105980311  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105980318  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
105980320  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105980590  Pdgfd; platelet-derived growth factor D [KO:K05450]
105980747  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
105980914  Map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
105980999  Pla2g4e; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
105981023  Rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
105981078  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
105981136  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105981182  [KO:K16342] [EC:3.1.1.4]
105981202  Fgf7; fibroblast growth factor 7 [KO:K04358]
105981244  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
105981524  [KO:K04411]
105981596  Angpt4; angiopoietin-4 [KO:K05467]
105981746  Cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
105981822  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105981830  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105981913  Mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
105981926  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
105982063  Cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
105982090  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
105982099  Taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
105982382  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
105982453  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105982575  Sos2; son of sevenless homolog 2 [KO:K03099]
105982741  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
105982844  Stk3; serine/threonine-protein kinase 3 [KO:K04412]
105983045  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105983087  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
105983179  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105983268  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
105983461  Rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
105983478  Arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
105983546  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
105983753  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
105983993  Tgfb3; transforming growth factor beta-3 isoform X1 [KO:K13377]
105984041  Arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
105984085  Pak1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
105984248  Pgf; placenta growth factor isoform X1 [KO:K16859]
105984299  Taok3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
105984496  Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
105984525  Map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
105984789  Efna1; ephrin-A1 [KO:K05462]
105984796  Tgfb2; transforming growth factor beta-2 isoform X1 [KO:K13376]
105984800  Efna3; ephrin-A3 isoform X1 [KO:K05462]
105984809  Dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
105984831  Efna4; ephrin-A4 [KO:K05462]
105985130  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
105985196  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105985307  Ppm1a; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
105985315  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
105985369  Mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
105985378  Rasa1; ras GTPase-activating protein 1 [KO:K04352]
105985414  Dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
105985440  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
105985625  Mecom; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
105985659  Nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
105985676  Crk; adapter molecule crk [KO:K04438]
105985703  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
105985791  Nf1; neurofibromin isoform X1 [KO:K08052]
105985799  Taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
105985870  Mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
105985880  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
105986166  Mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
105986214  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105986278  Max; protein max isoform X1 [KO:K04453]
105986370  Ptpn7; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
105986371  Elk4; ETS domain-containing protein Elk-4 [KO:K04376]
105986412  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
105986431  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
105986533  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105986663  Fgf8; fibroblast growth factor 8 [KO:K04358]
105986666  Map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
105986723  Nfkb2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
105986731  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105986734  Fos; proto-oncogene c-Fos [KO:K04379]
105986771  Dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105986795  Sos1; son of sevenless homolog 1 [KO:K03099]
105986855  Ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
105986871  Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
105987133  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105987286  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
105987339  Gdnf; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105987347  Fgf10; fibroblast growth factor 10 [KO:K04358]
105987469  Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
105987554  Irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
105987557  Kitlg; kit ligand [KO:K05461]
105987566  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
105987731  [KO:K05448]
105987800  [KO:K05448]
105987853  Srf; serum response factor [KO:K04378]
105987887  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
105988011  Il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
105988089  Bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105988126  Ptpn5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
105988129  Traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
105988212  Dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105988223  Il1a; interleukin-1 alpha [KO:K04383]
105988249  Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
105988260  Il1r1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
105988300  Il1b; interleukin-1 beta [KO:K04519]
105988408  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
105988509  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105988510  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
105988531  Fgf5; fibroblast growth factor 5 [KO:K04358]
105988546  Areg; amphiregulin [KO:K09782]
105988547  Ereg; proepiregulin [KO:K09784]
105988656  Cd14; monocyte differentiation antigen CD14 isoform X1 [KO:K04391]
105988668  Efna5; ephrin-A5 isoform X1 [KO:K05462]
105988744  Fgf1; fibroblast growth factor 1 [KO:K18496]
105988759  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
105988868  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
105988946  Map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
105989026  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
105989063  Fgf4; fibroblast growth factor 4 [KO:K04358]
105989094  Rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
105989099  Vegfb; vascular endothelial growth factor B [KO:K16858]
105989103  Map3k11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
105989171  Ins; insulin [KO:K04526]
105989216  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
105989230  Map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
105989242  Rela; transcription factor p65 isoform X1 [KO:K04735]
105989243  Igf2; insulin-like growth factor II [KO:K13769]
105989294  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
105989461  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
105989470  Braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
105989638  Rap1b; ras-related protein Rap-1b [KO:K07836]
105989682  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
105989710  Dusp6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
105989771  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105989908  Fgf2; fibroblast growth factor 2 [KO:K18497]
105990143  Tgfa; protransforming growth factor alpha [KO:K08774]
105990202  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
105990235  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
105990326  Efna2; ephrin-A2 [KO:K05462]
105990374  Pspn; persephin [KO:K25416]
105990401  Fgf22; fibroblast growth factor 22 [KO:K04358]
105990422  Mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
105990471  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105990698  Mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
105990763  Tgfbr1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
105990787  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
105990812  Ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
105990866  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
105990882  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105990925  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105991035  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105991042  Fgf6; fibroblast growth factor 6 [KO:K04358]
105991062  Cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
105991064  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
105991106  Ntf3; neurotrophin-3 isoform X1 [KO:K04356]
105991200  Egf; pro-epidermal growth factor [KO:K04357]
105991204  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
105991225  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
105991231  Lamtor3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
105991261  Fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
105991590  Angpt2; angiopoietin-2 [KO:K05466]
105991714  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105991790  Vegfc; vascular endothelial growth factor C [KO:K05449]
105991793  Rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
105991838  Map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
105991859  Rap1a; ras-related protein Rap-1A [KO:K04353]
105991922  Ngf; beta-nerve growth factor [KO:K02582]
105991947  Nras; GTPase NRas [KO:K07828]
105991980  Dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105991989  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
105992022  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
105992028  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
105992052  Cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
105992070  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105992088  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105992181  Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
105992272  Kras; GTPase KRas isoform X1 [KO:K07827]
105992288  Dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105992358  Myc; myc proto-oncogene protein [KO:K04377]
105992369  Fgf20; fibroblast growth factor 20 [KO:K04358]
105992611  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105992616  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105992663  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
105992720  Mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
105992729  [KO:K04441] [EC:2.7.11.24]
105992799  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105992916  Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
105992928  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105992969  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
105992999  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
105993164  Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
105993178  Rasgrp4; RAS guanyl-releasing protein 4 [KO:K12363]
105993255  Rps6ka3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
105993516  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
105993663  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
105993857  Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
105993900  Flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
105993915  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
105994226  Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
105994295  Rras; ras-related protein R-Ras [KO:K07829]
105994311  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
105994328  Cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
105994330  Cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
105994343  [KO:K04867]
105994368  Fgf21; fibroblast growth factor 21 [KO:K22429]
105994369  Ntf4; neurotrophin-4 [KO:K12457]
105994535  Dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105994618  Cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
105994624  Mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
105994860  Tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
105994945  Fgf18; fibroblast growth factor 18 [KO:K04358]
105995229  Fgf16; fibroblast growth factor 16 [KO:K04358]
105995460  Fgf9; fibroblast growth factor 9 [KO:K04358]
105995552  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
105995560  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
105995582  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105995746  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105995771  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105995908  Rapgef2; rap guanine nucleotide exchange factor 2 [KO:K08018]
105995943  Pdgfc; platelet-derived growth factor C [KO:K05450]
105995972  Rasa2; ras GTPase-activating protein 2 [KO:K08053]
105996025  [KO:K04424] [EC:2.7.11.25]
105996069  Mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
105996289  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
105996438  Ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
105996579  Cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
105996586  [KO:K04370]
105996591  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105996777  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105996799  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
105996846  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
105997009  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
105997164  Crkl; crk-like protein [KO:K04438]
105997225  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105997357  Hspb1; LOW QUALITY PROTEIN: heat shock protein beta-1 [KO:K04455]
105997488  Csf1; macrophage colony-stimulating factor 1 [KO:K05453]
105997530  Dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
105997576  Map3k14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
105997656  Figf; vascular endothelial growth factor D [KO:K05449]
105997775  Rps6ka1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
105997824  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
105997926  Map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
105997928  Cdc42; cell division control protein 42 homolog [KO:K04393]
105997971  Relb; transcription factor RelB [KO:K09253]
105997985  Ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
105998021  Map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
105998099  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105998414  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105998545  Map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
105998555  Mapt; microtubule-associated protein tau isoform X1 [KO:K04380]
105998617  Hras; GTPase HRas isoform X1 [KO:K02833]
105998714  Insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
105998779  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
105998878  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
105998906  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105999112  Ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
105999194  Rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
105999228  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
105999255  [KO:K04347]
105999274  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
105999329  [KO:K05096] [EC:2.7.10.1]
105999423  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105999437  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105999606  Mras; ras-related protein M-Ras [KO:K07831]
105999678  Map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
105999841  [KO:K03283]
105999842  Hspa1b; heat shock 70 kDa protein 1B [KO:K03283]
105999850  [KO:K03283]
105999884  Daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
106000122  Dusp9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
106000140  Epha2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
106000147  Flna; filamin-A isoform X1 [KO:K04437]
106000155  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
106000170  Irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
106000271  Stmn1; stathmin [KO:K04381]
106000303  Araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
106000305  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
106000601  Map3k6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
106000675  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
106000874  Tgfb1; transforming growth factor beta-1 [KO:K13375]
106000934  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
106001021  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
106001326  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
106001529  [KO:K04427] [EC:2.7.11.25]
106001540  Cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
106001914  [KO:K12457]
106001938  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
106002210  [KO:K04866]
106002274  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
106002684  Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
106002705  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
106002910  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106003041  Cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
106003047  Cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
106003155  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
106003156  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
106003227  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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MAP kinases.
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Pharmacol Ther 93:193-202 (2002)
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PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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Oncogene 22:5885-96 (2003)
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PMID:12676795
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Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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PMID:12390245
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Genes Cells 7:1099-111 (2002)
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PMID:14597384
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Gene 320:3-21 (2003)
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
dord04070  Phosphatidylinositol signaling system
dord04110  Cell cycle
dord04115  p53 signaling pathway
dord04210  Apoptosis
dord04310  Wnt signaling pathway
dord04668  TNF signaling pathway
KO pathway
ko04010   

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