KEGG   PATHWAY: mleu05165
Entry
mleu05165                   Pathway                                
Name
Human papillomavirus infection - Mandrillus leucophaeus (drill)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
mleu05165  Human papillomavirus infection
mleu05165

Organism
Mandrillus leucophaeus (drill) [GN:mleu]
Gene
105544955  WNT1; proto-oncogene Wnt-1 [KO:K03209]
105540833  WNT2; protein Wnt-2 [KO:K00182]
105554323  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
105555138  WNT3; proto-oncogene Wnt-3 [KO:K00312]
105528825  WNT3A; protein Wnt-3a [KO:K00312]
105546827  WNT4; protein Wnt-4 [KO:K00408]
105552688  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
105529879  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
105528048  WNT6; protein Wnt-6 [KO:K00445]
105542188  WNT7A; protein Wnt-7a [KO:K00572]
105542469  WNT7B; protein Wnt-7b [KO:K00572]
105531286  WNT8A; protein Wnt-8a [KO:K00714]
105537750  WNT8B; protein Wnt-8b [KO:K00714]
105555135  WNT9B; protein Wnt-9b [KO:K01064]
105528826  WNT9A; protein Wnt-9a [KO:K01064]
105528049  WNT10A; protein Wnt-10a [KO:K01357]
105544910  WNT10B; protein Wnt-10b [KO:K01357]
105546318  WNT11; protein Wnt-11 [KO:K01384]
105550897  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
105535410  FZD7; frizzled-7 [KO:K02432]
105550966  FZD1; LOW QUALITY PROTEIN: frizzled-1 [KO:K02432]
105543809  FZD2; frizzled-2 [KO:K02235]
105542358  FZD3; frizzled-3 [KO:K02329]
105543131  FZD4; frizzled-4 [KO:K02354]
105549403  FZD5; frizzled-5 [KO:K02375]
105542117  FZD6; frizzled-6 isoform X1 [KO:K02376]
105541081  FZD10; frizzled-10 [KO:K02842]
105541030  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
105555178  DVL1; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
105549903  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
105544615  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105529686  AXIN1; axin-1 [KO:K02157]
105548236  AXIN2; axin-2 [KO:K04385]
105551991  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
105529034  APC; adenomatous polyposis coli protein [KO:K02085]
105542652  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
105548790  CSNK1A1L; casein kinase I isoform alpha-like [KO:K08957] [EC:2.7.11.1]
105543443  CSNK1A1; casein kinase I isoform alpha isoform X1 [KO:K08957] [EC:2.7.11.1]
105528129  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
105531321  TCF7; transcription factor 7 isoform X1 [KO:K02620]
105528862  TCF7L1; transcription factor 7-like 1 [KO:K04490]
105530146  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
105540752  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
105540245  TLR3; toll-like receptor 3 [KO:K05401]
105530039  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
105547858  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
105554628  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
105534224  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
105528977  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
105545746  IFNB1; interferon beta [KO:K05415]
105538831  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
105541509  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
105552809  TADA3; transcriptional adapter 3 [KO:K11315]
105549866  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
105539895  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
105546962  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105551470  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
105548954  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
105549707  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
105544659  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
105546828  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105536306  SCRIB; protein scribble homolog [KO:K16175]
105545916  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
105551253  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
105548146  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
105539175  LLGL2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
105536038  LLGL1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
105530074  CRB3; protein crumbs homolog 3 [KO:K06090]
105545897  INADL; LOW QUALITY PROTEIN: inaD-like protein [KO:K06092]
105549626  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
105541774  VWF; von Willebrand factor [KO:K03900]
105546194  THBS1; thrombospondin-1 [KO:K16857]
105553558  THBS2; thrombospondin-2 [KO:K04659]
105547095  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
105548283  THBS4; thrombospondin-4 [KO:K04659]
105544845  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
105528087  FN1; fibronectin [KO:K05717]
105553265  COL1A1; collagen alpha-1(I) chain [KO:K06236]
105535560  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
105544943  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
105546552  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
105546564  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
105541413  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
105541512  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
105543172  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
105543173  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
105551554  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
105551555  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
105539834  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
105538157  collagen alpha-4(VI) chain-like [KO:K06238]
105538158  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
105538159  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
105531466  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
105548366  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
105537944  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
105551977  LAMA2; laminin subunit alpha-2 [KO:K05637]
105549719  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
105545233  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
105548407  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
105532439  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
105544087  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
105540363  LAMB2; laminin subunit beta-2 [KO:K06243]
105536421  LAMB3; laminin subunit beta-3 [KO:K06244]
105544107  LAMB4; laminin subunit beta-4 [KO:K06245]
105550421  LAMC1; laminin subunit gamma-1 [KO:K05635]
105550424  LAMC2; laminin subunit gamma-2 [KO:K06246]
105532867  LAMC3; laminin subunit gamma-3 [KO:K06247]
105553257  CHAD; chondroadherin [KO:K06248]
105543273  RELN; reelin [KO:K06249] [EC:3.4.21.-]
105547229  SPP1; osteopontin isoform X1 [KO:K06250]
105552039  VTN; vitronectin isoform X1 [KO:K06251]
105531513  TNXB; tenascin-X [KO:K06252]
105552734  TNC; tenascin isoform X1 [KO:K06252]
105540723  TNN; tenascin-N [KO:K06252]
105540726  TNR; tenascin-R [KO:K06252]
105547231  IBSP; bone sialoprotein 2 [KO:K06253]
105552123  ITGA1; integrin alpha-1 [KO:K06480]
105552128  ITGA2; integrin alpha-2 [KO:K06481]
105543805  ITGA2B; integrin alpha-IIb [KO:K06476]
105553271  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
105553874  ITGA4; integrin alpha-4 [KO:K06483]
105548552  ITGA5; integrin alpha-5 [KO:K06484]
105548065  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105532010  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
105530532  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
105553436  ITGA9; integrin alpha-9 [KO:K06585]
105550282  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
105530986  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
105553894  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105549004  ITGB1; integrin beta-1 [KO:K05719]
105534546  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105528575  ITGB4; integrin beta-4 [KO:K06525]
105533226  ITGB5; integrin beta-5 [KO:K06588]
105547780  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
105555020  ITGB7; integrin beta-7 [KO:K06590]
105534972  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
105546847  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105527924  paxillin isoform X1 [KO:K05760]
105554159  TNF; tumor necrosis factor [KO:K03156]
105541778  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105551442  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105554126  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
105552455  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
105544509  FAS-associated death domain protein [KO:K02373]
105544531  FAS-associated death domain protein-like [KO:K02373]
105535422  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
105552669  caspase-3-like [KO:K02187] [EC:3.4.22.56]
105553959  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105534579  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
105531324  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
105537996  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
105528891  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
105537397  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
105540292  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
105554910  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
105542334  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
105555283  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
105553868  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
105550174  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
105551588  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
105547866  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
105536391  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
105549120  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
105544321  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
105538435  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
105542939  TSC1; hamartin isoform X1 [KO:K07206]
105529748  TSC2; tuberin isoform X1 [KO:K07207]
105542689  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
105551388  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105539063  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105544470  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
105544178  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105549098  BAD; bcl2-associated agonist of cell death [KO:K02158]
105543434  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105539923  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105552763  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105549588  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105547376  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105543389  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105531763  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105540494  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105541755  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105542359  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105546932  FOXO1; forkhead box protein O1 [KO:K07201]
105549206  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
105544234  CDKN1A; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1 [KO:K06625]
105544506  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
105551132  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
105544297  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105545589  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
105552568  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
105538723  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
105550361  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
105531943  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105552849  RB1; retinoblastoma-associated protein [KO:K06618]
105535811  RBL1; retinoblastoma-like protein 1 [KO:K04681]
105545612  RBL2; retinoblastoma-like protein 2 [KO:K16332]
105535289  PSMC1; 26S protease regulatory subunit 4 isoform X1 [KO:K03062]
105528432  E2F1; transcription factor E2F1 [KO:K17454]
105551507  CCNA2; cyclin-A2 [KO:K06627]
105548801  CCNA1; cyclin-A1 [KO:K06627]
105543027  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
105554688  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
105544346  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105537745  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105554929  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105534277  IKBKG; LOW QUALITY PROTEIN: NF-kappa-B essential modulator [KO:K07210]
105548314  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105528449  RELA; transcription factor p65 isoform X1 [KO:K04735]
105537114  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
105539647  NFX1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
105532430  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
105535063  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
105541841  CHD4; chromodomain-helicase-DNA-binding protein 4 [KO:K11643] [EC:5.6.2.-]
105531348  IRF1; interferon regulatory factor 1 isoform X1 [KO:K09444]
105553577  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
105542028  TBP; TATA-box-binding protein isoform X1 [KO:K03120]
105547767  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
105533269  class I histocompatibility antigen, Gogo-OKO alpha chain [KO:K06751]
105540194  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-67 alpha chain-like [KO:K06751]
105553110  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, alpha chain E [KO:K06751]
105533649  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
105533654  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
105541160  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
105554853  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
105535298  mamu class I histocompatibility antigen, alpha chain F isoform X1 [KO:K06751]
105536048  HLA class I histocompatibility antigen, B-14 alpha chain isoform X1 [KO:K06751]
105550871  HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751]
105550892  LOW QUALITY PROTEIN: uncharacterized protein LOC105550892 [KO:K06751]
105555353  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
105529624  ATP6V1A; V-type proton ATPase catalytic subunit A isoform X1 [KO:K02145] [EC:7.1.2.2]
105539383  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
105540145  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
105542115  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
105528516  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
105549625  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
105528830  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
105542920  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
105550840  ATP6V1F; V-type proton ATPase subunit F isoform X1 [KO:K02151]
105532169  ATP6V1G3; V-type proton ATPase subunit G 3 isoform X1 [KO:K02152]
105552742  ATP6V1G1; V-type proton ATPase subunit G 1 isoform X1 [KO:K02152]
105554154  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
105552436  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
105545849  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform 2 [KO:K02154]
105553079  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform 1 [KO:K02154]
105544488  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform 3 [KO:K02154]
105550558  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform 4 [KO:K02154]
105551462  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
105530486  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
105529461  ATP6V0E2; V-type proton ATPase subunit e 2 isoform X1 [KO:K02153]
105544970  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
105529763  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
105555070  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
105534270  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
105532399  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105529594  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105538707  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
105551898  SOS1; son of sevenless homolog 1 [KO:K03099]
105553627  SOS2; son of sevenless homolog 2 [KO:K03099]
105549333  HRAS; GTPase HRas isoform X1 [KO:K02833]
105550009  KRAS; GTPase KRas [KO:K07827]
105554356  NRAS; GTPase NRas isoform X1 [KO:K07828]
105542175  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105530797  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105530027  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105541405  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105544764  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105553184  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105529183  PTGER4; LOW QUALITY PROTEIN: prostaglandin E2 receptor EP4 subtype [KO:K04261]
105548339  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
105548340  neuroendocrine secretory protein 55 [KO:K04632]
105532068  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
105540992  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105538055  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105539167  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
105549382  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
105539715  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105554054  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
105554841  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
105530028  CREB3L3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
105550535  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105533710  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
105548891  UBR4; E3 ubiquitin-protein ligase UBR4 [KO:K10691] [EC:2.3.2.27]
105552947  TUBG2; tubulin gamma-2 chain isoform X1 [KO:K10389]
105552950  tubulin gamma-1 chain isoform X1 [KO:K10389]
105538680  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
105553682  pyruvate kinase PKM-like isoform X1 [KO:K00873] [EC:2.7.1.40]
105533798  interferon alpha-1/13 [KO:K05414]
105533799  IFNA8; interferon alpha-8 [KO:K05414]
105533800  IFNA2; interferon alpha-2 [KO:K05414]
105537891  IFNA6; interferon alpha-6 [KO:K05414]
105537892  interferon alpha-14 [KO:K05414]
105537894  interferon alpha-17 isoform X1 [KO:K05414]
105546382  interferon alpha/beta receptor 1-like [KO:K05130]
105553144  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
105546376  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
105543512  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105549798  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
105535217  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
105529948  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
105532728  IRF9; interferon regulatory factor 9 [KO:K04693]
105530227  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
105527941  OASL; 2'-5'-oligoadenylate synthase-like protein isoform X1 [KO:K14608]
105542585  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
105542586  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
105555167  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
105552936  JAG1; protein jagged-1 isoform X1 [KO:K06052]
105543315  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
105533886  NOTCH2; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 2 [KO:K20994]
105540118  NOTCH3; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 3 [KO:K20995]
105531504  neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
105541857  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
105539034  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
105552392  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
105537347  LFNG; LOW QUALITY PROTEIN: beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
105554459  MAML2; mastermind-like protein 2 [KO:K06061]
105543639  MAML3; mastermind-like protein 3 [KO:K06061]
105537282  MAML1; mastermind-like protein 1 [KO:K06061]
105552087  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
105528556  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
105540665  HES1; transcription factor HES-1 [KO:K06054]
105539875  HES6; transcription cofactor HES-6 [KO:K09087]
105545995  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091]
105543230  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1 [KO:K09091]
105537958  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Human papillomavirus oncoproteins: pathways to transformation.
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Human papillomavirus proteins as prospective therapeutic targets.
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The molecular biology of cervical cancer.
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Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
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Human papillomaviruses and cell signaling.
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Sci STKE 2005:pe29 (2005)
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Viruses 7:4734-55 (2015)
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Reference
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In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
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Sci Rep 5:13446 (2015)
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James CD, Roberts S
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Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
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Pathogens 5:E8 (2016)
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The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
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Viruses 7:3530-51 (2015)
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Reference
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PDZ domains: the building blocks regulating tumorigenesis.
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Reference
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Reference
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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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Reference
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Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
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Reference
PMID:23536685
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  Title
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Related
pathway
mleu04064  NF-kappa B signaling pathway
mleu04110  Cell cycle
mleu04115  p53 signaling pathway
mleu04150  mTOR signaling pathway
mleu04151  PI3K-Akt signaling pathway
mleu04210  Apoptosis
mleu04310  Wnt signaling pathway
mleu04330  Notch signaling pathway
mleu04510  Focal adhesion
mleu04520  Adherens junction
mleu04530  Tight junction
mleu04612  Antigen processing and presentation
mleu04620  Toll-like receptor signaling pathway
mleu04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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