KEGG   PATHWAY: mnp04024
Entry
mnp04024                    Pathway                                
Name
cAMP signaling pathway - Mustela nigripes (black-footed ferret)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
mnp04024  cAMP signaling pathway
mnp04024

Other DBs
GO: 0019933
Organism
Mustela nigripes (black-footed ferret) [GN:mnp]
Gene
132017508  VIP; VIP peptides [KO:K05264]
132013130  CRH; corticoliberin [KO:K05256]
132017446  CGA; glycoprotein hormones alpha chain [KO:K08522]
132005873  LHB; lutropin subunit beta [KO:K08521]
132008428  GPHA2; glycoprotein hormone alpha-2 [KO:K25483]
131998853  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
132000667  TSHB; thyrotropin subunit beta [KO:K05251]
132022244  POMC; pro-opiomelanocortin [KO:K05228]
132012975  GCG; pro-glucagon [KO:K05259]
132004063  GIP; gastric inhibitory polypeptide [KO:K05258]
132010693  FSHB; follitropin subunit beta [KO:K05250]
132001223  NPPA; natriuretic peptides A isoform X1 [KO:K12334]
132023906  ADCYAP1; LOW QUALITY PROTEIN: pituitary adenylate cyclase-activating polypeptide [KO:K05262]
132015398  ADRB1; beta-1 adrenergic receptor [KO:K04141]
132028308  ADRB2; beta-2 adrenergic receptor [KO:K04142]
132027843  DRD1; D(1A) dopamine receptor [KO:K04144]
132015124  DRD5; D(1B) dopamine receptor [KO:K05840]
132023859  ADORA2A; adenosine receptor A2a [KO:K04266]
132027778  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
132000966  HTR6; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 6 [KO:K04162]
131999946  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
132015817  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
132015512  VIPR2; vasoactive intestinal polypeptide receptor 2 [KO:K04590]
132004276  CRHR1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
132015828  CRHR2; corticotropin-releasing factor receptor 2 isoform X1 [KO:K04579]
132022569  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
131998886  TSHR; thyrotropin receptor [KO:K04249]
132023883  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
132017312  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
132005383  GIPR; gastric inhibitory polypeptide receptor isoform X1 [KO:K04580]
132007863  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
132022568  FSHR; follicle-stimulating hormone receptor isoform X1 [KO:K04247]
132025956  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
132022829  neuroendocrine secretory protein 55 [KO:K04632]
132022063  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
132022064  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
132017607  EDN1; endothelin-1 [KO:K16366]
132001663  EDN2; endothelin-2 [KO:K16367]
132022071  EDN3; endothelin-3 isoform X1 [KO:K05227]
132010051  SST; somatostatin [KO:K05237]
132015015  NPY; pro-neuropeptide Y [KO:K05232]
132009887  GHRL; appetite-regulating hormone isoform X1 [KO:K05254]
132022683  oxytocin-neurophysin 1 [KO:K05243]
132008108  OXT; oxytocin-neurophysin 1 [KO:K05243]
132010255  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
132001755  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
132018247  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
132018690  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
132027927  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
132019827  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
132014913  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
132013000  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
132024571  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
132017739  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
132025624  ADORA1; adenosine receptor A1 [KO:K04265]
132000052  EDNRA; endothelin-1 receptor [KO:K04197]
132000650  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
131998795  SSTR1; somatostatin receptor type 1 isoform X1 [KO:K04217]
132004371  SSTR2; somatostatin receptor type 2 [KO:K04218]
132027253  SSTR5; somatostatin receptor type 5 [KO:K04221]
132023798  HCAR1; hydroxycarboxylic acid receptor 1 isoform X1 [KO:K08401]
132023799  HCAR2; LOW QUALITY PROTEIN: hydroxycarboxylic acid receptor 2 [KO:K08402]
132005373  FFAR2; free fatty acid receptor 2 [KO:K04328]
132005560  free fatty acid receptor 2-like [KO:K04328]
132010540  SUCNR1; LOW QUALITY PROTEIN: succinate receptor 1 [KO:K10042]
132001012  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
132009877  OXTR; oxytocin receptor [KO:K04229]
132010082  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
132001262  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
132015994  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
132011347  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
132016088  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
132028199  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
132021183  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
131999850  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
132011863  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
132019632  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
132005324  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
132014306  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
132026955  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
132026308  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
132005970  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
132007818  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
132022579  CNGA3; cyclic nucleotide-gated cation channel alpha-3 isoform X1 [KO:K04950]
132011151  CNGA4; cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
132005304  CNGB1; cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
132013185  CNGB3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
132015160  calmodulin-1-like [KO:K02183]
132002170  CALML6; calmodulin-like protein 6 [KO:K02183]
132005201  CALM3; calmodulin-3 [KO:K02183]
132020019  calmodulin-like protein 3 [KO:K02183]
132020856  calmodulin-like [KO:K02183]
131999557  CALML4; calmodulin-like protein 4 [KO:K02183]
132021617  CALM2; calmodulin-2 [KO:K02183]
132000098  CALM1; calmodulin-1 [KO:K02183]
132016071  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
132016520  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
132002521  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
132028323  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
132028842  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
132017476  BVES; blood vessel epicardial substance [KO:K21108]
132010179  POPDC2; popeye domain-containing protein 2 [KO:K26206]
132017477  POPDC3; popeye domain-containing protein 3 [KO:K26207]
132026077  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
132012572  HCN2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
131999188  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
132002690  ABCC4; ATP-binding cassette sub-family C member 4 [KO:K05673]
132019619  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
132013837  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
132005677  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
132022713  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
132004469  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
132012048  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
132016639  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
132001060  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
132016577  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
132027429  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
132001295  RAP1A; ras-related protein Rap-1A [KO:K04353]
132019439  RAP1B; ras-related protein Rap-1b [KO:K07836]
132012341  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
132001226  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
132024270  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
132010871  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
132026481  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
132019253  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
132004336  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
132024667  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
132028608  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
132011318  RHOA; transforming protein RhoA [KO:K04513]
132018466  AFDN; afadin isoform X1 [KO:K05702]
132001008  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
132010495  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
132012033  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
132000809  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
132011173  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
132028693  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
132000311  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132025379  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132005674  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
132015636  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
132011570  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
131999543  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
132010799  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
132008541  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
132023779  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
132026755  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
132001064  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
132011072  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
132003482  PPP1R1B; protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
132023151  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
132017911  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
132021249  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
132013496  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
132008271  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
132008517  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
132015669  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
132009653  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
132024618  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
132025947  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
132015844  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
132019189  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
132026956  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
132021809  BDNF; brain-derived neurotrophic factor [KO:K04355]
132000157  FOS; protein c-Fos [KO:K04379]
132000935  JUN; transcription factor Jun [KO:K04448]
132016115  GLI3; transcriptional activator GLI3 isoform X1 [KO:K06230]
132019835  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
132024752  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
131999905  HHIP; hedgehog-interacting protein [KO:K06231]
131999888  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
132001757  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
132018657  RELA; transcription factor p65 [KO:K04735]
132003393  SOX9; transcription factor SOX-9 [KO:K18435]
132009578  AMH; muellerian-inhibiting factor [KO:K04665]
132019116  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
132003806  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
132004037  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
132023704  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
132028743  F2R; proteinase-activated receptor 1 [KO:K03914]
132019536  BAD; bcl2-associated agonist of cell death [KO:K02158]
132005105  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
132023518  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
132021141  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
132019394  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
132021891  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
132005525  TNNI3; troponin I, cardiac muscle [KO:K12044]
132017334  PLN; cardiac phospholamban [KO:K05852]
132023139  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
132003946  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
132026779  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
132016195  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
132024208  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
132026908  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
132020616  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
132004461  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
132005170  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
132024546  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
132010691  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
132028345  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
132000814  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
132006667  glutamate receptor 3 [KO:K05199]
132028857  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
132015768  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
132001352  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 isoform X1 [KO:K01539] [EC:7.2.2.13]
132025789  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
132025790  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
132005001  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
132003427  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
132025324  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
132012176  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
132007387  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
132006211  FXYD1; phospholemman isoform X1 [KO:K13360]
132001864  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
132023129  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
132025632  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
132011558  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
132019371  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
132007493  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
132019988  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
132011423  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
132007466  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
132026153  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
132019526  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
132022676  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
132000981  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
132010973  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
132011178  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
132028660  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
132018452  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
DOI:10.1007/s00210-007-0246-7
Reference
PMID:24450633
  Authors
Roberts OL, Dart C
  Title
cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
  Journal
Biochem Soc Trans 42:89-97 (2014)
DOI:10.1042/BST20130253
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:21852968
  Authors
Bozzi Y, Dunleavy M, Henshall DC
  Title
Cell signaling underlying epileptic behavior.
  Journal
Front Behav Neurosci 5:45 (2011)
DOI:10.3389/fnbeh.2011.00045
Reference
PMID:10880354
  Authors
Lizcano JM, Morrice N, Cohen P
  Title
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
  Journal
Biochem J 349:547-57 (2000)
DOI:10.1042/bj3490547
Reference
PMID:21744067
  Authors
Gerlo S, Kooijman R, Beck IM, Kolmus K, Spooren A, Haegeman G
  Title
Cyclic AMP: a selective modulator of NF-kappaB action.
  Journal
Cell Mol Life Sci 68:3823-41 (2011)
DOI:10.1007/s00018-011-0757-8
Reference
PMID:7688165
  Authors
Lauder JM
  Title
Neurotransmitters as growth regulatory signals: role of receptors and second messengers.
  Journal
Trends Neurosci 16:233-40 (1993)
DOI:10.1016/0166-2236(93)90162-F
Reference
PMID:17077866
  Authors
Voglis G, Tavernarakis N
  Title
The role of synaptic ion channels in synaptic plasticity.
  Journal
EMBO Rep 7:1104-10 (2006)
DOI:10.1038/sj.embor.7400830
Reference
PMID:21346730
  Authors
Altarejos JY, Montminy M
  Title
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.
  Journal
Nat Rev Mol Cell Biol 12:141-51 (2011)
DOI:10.1038/nrm3072
Reference
PMID:24062645
  Authors
Bozzi Y, Borrelli E
  Title
The role of dopamine signaling in epileptogenesis.
  Journal
Front Cell Neurosci 7:157 (2013)
DOI:10.3389/fncel.2013.00157
Reference
PMID:14715909
  Authors
Ceulemans H, Bollen M
  Title
Functional diversity of protein phosphatase-1, a cellular economizer and reset button.
  Journal
Physiol Rev 84:1-39 (2004)
DOI:10.1152/physrev.00013.2003
Reference
PMID:16571352
  Authors
Lipinski RJ, Gipp JJ, Zhang J, Doles JD, Bushman W
  Title
Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.
  Journal
Exp Cell Res 312:1925-38 (2006)
DOI:10.1016/j.yexcr.2006.02.019
Reference
PMID:21693691
  Authors
Lasala C, Schteingart HF, Arouche N, Bedecarras P, Grinspon RP, Picard JY, Josso N, di Clemente N, Rey RA
  Title
SOX9 and SF1 are involved in cyclic AMP-mediated upregulation of anti-Mullerian gene expression in the testicular prepubertal Sertoli cell line SMAT1.
  Journal
Am J Physiol Endocrinol Metab 301:E539-47 (2011)
DOI:10.1152/ajpendo.00187.2011
Reference
PMID:19460777
  Authors
Rosenkranz AC, Rauch BH, Freidel K, Schror K
  Title
Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT.
  Journal
Cardiovasc Res 83:778-84 (2009)
DOI:10.1093/cvr/cvp163
Reference
PMID:11117527
  Authors
Lazennec G, Canaple L, Saugy D, Wahli W
  Title
Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.
  Journal
Mol Endocrinol 14:1962-75 (2000)
DOI:10.1210/mend.14.12.0575
Reference
PMID:16460276
  Authors
Murthy KS
  Title
Signaling for contraction and relaxation in smooth muscle of the gut.
  Journal
Annu Rev Physiol 68:345-74 (2006)
DOI:10.1146/annurev.physiol.68.040504.094707
Reference
PMID:18064650
  Authors
Birukova AA, Zagranichnaya T, Alekseeva E, Bokoch GM, Birukov KG
  Title
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
  Journal
J Cell Physiol 215:715-24 (2008)
DOI:10.1002/jcp.21354
Reference
PMID:9204709
  Authors
Houslay MD, Milligan G
  Title
Tailoring cAMP-signalling responses through isoform multiplicity.
  Journal
Trends Biochem Sci 22:217-24 (1997)
DOI:10.1016/S0968-0004(97)01050-5
Related
pathway
mnp00071  Fatty acid degradation
mnp04015  Rap1 signaling pathway
mnp04020  Calcium signaling pathway
mnp04151  PI3K-Akt signaling pathway
mnp04210  Apoptosis
mnp04260  Cardiac muscle contraction
mnp04340  Hedgehog signaling pathway
mnp04720  Long-term potentiation
mnp04740  Olfactory transduction
mnp04972  Pancreatic secretion
mnp04976  Bile secretion
KO pathway
ko04024   
LinkDB

DBGET integrated database retrieval system