KEGG   PATHWAY: mnp04151
Entry
mnp04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Mustela nigripes (black-footed ferret)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
mnp04151  PI3K-Akt signaling pathway
mnp04151

Other DBs
GO: 0043491
Organism
Mustela nigripes (black-footed ferret) [GN:mnp]
Gene
132002212  EGF; pro-epidermal growth factor [KO:K04357]
132021470  TGFA; protransforming growth factor alpha [KO:K08774]
132016006  AREG; amphiregulin [KO:K09782]
132028621  FGF1; fibroblast growth factor 1 [KO:K18496]
132028444  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
132015368  FGF8; fibroblast growth factor 8 [KO:K04358]
132016131  FGF5; fibroblast growth factor 5 [KO:K04358]
132002632  FGF9; fibroblast growth factor 9 [KO:K04358]
132010674  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
132004528  FGF3; fibroblast growth factor 3 [KO:K04358]
132004607  FGF4; fibroblast growth factor 4 [KO:K04358]
132027828  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
131998728  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
131998918  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
132020822  FGF6; fibroblast growth factor 6 [KO:K04358]
132028292  FGF10; fibroblast growth factor 10 [KO:K04358]
132006489  FGF20; fibroblast growth factor 20 [KO:K04358]
132007507  FGF16; fibroblast growth factor 16 [KO:K04358]
132004742  FGF19; fibroblast growth factor 19 [KO:K22603]
132005252  FGF21; fibroblast growth factor 21 [KO:K22429]
132020823  FGF23; fibroblast growth factor 23 [KO:K22428]
132000669  NGF; beta-nerve growth factor [KO:K02582]
132021809  BDNF; brain-derived neurotrophic factor [KO:K04355]
132020814  NTF3; neurotrophin-3 [KO:K04356]
132004785  NTF4; neurotrophin-4 [KO:K12457]
132016807  INS; insulin isoform X1 [KO:K04526]
132019316  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
132016801  IGF2; insulin-like growth factor II [KO:K13769]
132026405  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
132019214  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
132000852  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
132029044  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
132001267  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
132019375  KITLG; kit ligand isoform X1 [KO:K05461]
132005678  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
132018637  VEGFA; vascular endothelial growth factor A, long form [KO:K05448]
132019569  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
132000164  PGF; placenta growth factor isoform X1 [KO:K16859]
132006384  VEGFC; vascular endothelial growth factor C [KO:K05449]
132006722  VEGFD; vascular endothelial growth factor D [KO:K05449]
132015990  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
132014233  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
132006457  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
132021804  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
132025910  EFNA1; ephrin-A1 [KO:K05462]
132025912  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
132025913  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
132012576  EFNA2; ephrin-A2 [KO:K05462]
132028830  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
132028256  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
132010842  NRTN; neurturin [KO:K25414]
132000735  ARTN; artemin [KO:K25415]
132010856  PSPN; persephin [KO:K25416]
132016105  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
132003912  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
132019789  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
132014436  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
132006317  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
132016838  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
132003670  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
132028463  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
132003442  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
132025841  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
132024768  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
132010913  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
131999088  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
132006175  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
132028321  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
132028318  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
132006358  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
132002715  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
132002900  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
132027432  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
132006391  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
132015770  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
132024682  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
132001601  EPHA2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
132016602  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
132003151  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
132021307  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
131999927  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
132016391  HRAS; GTPase HRas isoform X1 [KO:K02833]
132027717  LOW QUALITY PROTEIN: ras protein let-60-like [KO:K02833]
132019561  KRAS; GTPase KRas isoform X1 [KO:K07827]
132001334  NRAS; GTPase NRas [KO:K07828]
132002077  LOW QUALITY PROTEIN: GTPase NRas-like [KO:K07828]
132011570  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
131999543  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
132010799  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
132008541  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
132023779  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
132026755  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
132013605  IRS1; insulin receptor substrate 1 [KO:K16172]
132000985  TLR2; toll-like receptor 2 [KO:K10159]
132024470  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
132026481  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
131999471  immunoglobulin gamma-1 heavy chain-like [KO:K06856]
131999488  uncharacterized protein LOC131999488 [KO:K06856]
132024902  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
132026784  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
132016657  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
132004499  somatotropin [KO:K05438]
132017641  PRL; prolactin isoform X1 [KO:K05439]
132023321  OSM; oncostatin-M [KO:K05418]
132014406  IL2; interleukin-2 [KO:K05429]
132027540  interleukin-3-like [KO:K04736]
132015023  IL6; interleukin-6 [KO:K05405]
132027869  IL4; interleukin-4 [KO:K05430]
132014103  IL7; interleukin-7 [KO:K05431]
132008962  interferon alpha-1/2-like [KO:K05414]
132009102  interferon alpha-1/2-like [KO:K05414]
132009158  interferon alpha-3-like [KO:K05414]
132009205  interferon alpha-1/2-like [KO:K05414]
132009311  interferon alpha-1/2-like [KO:K05414]
132024131  interferon alpha-1/2-like [KO:K05414]
132024132  interferon alpha-1/2-like [KO:K05414]
132024134  interferon alpha-1/2-like [KO:K05414]
132025116  interferon alpha-1/2-like [KO:K05414]
132025119  interferon alpha-1/2-like [KO:K05414]
132025120  interferon alpha-1/2-like [KO:K05414]
132025121  interferon alpha-1/2-like [KO:K05414]
132025122  interferon alpha-1/2-like [KO:K05414]
132025123  interferon alpha-1/2-like [KO:K05414]
132025124  interferon alpha-14-like [KO:K05414]
132025125  IFNB1; interferon beta [KO:K05415]
132026565  EPO; LOW QUALITY PROTEIN: erythropoietin [KO:K05437]
132003404  CSF3; granulocyte colony-stimulating factor [KO:K05423]
132028281  GHR; growth hormone receptor isoform X1 [KO:K05080]
132028242  PRLR; prolactin receptor [KO:K05081]
132028262  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
132020030  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
132019255  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
132007353  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
132007615  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
132025933  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
132026795  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
132028244  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
132012360  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
132011007  EPOR; erythropoietin receptor [KO:K05079]
132002214  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
132000969  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
132024863  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
132011164  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
132015941  COL1A2; collagen alpha-2(I) chain [KO:K06236]
132003979  COL1A1; collagen alpha-1(I) chain [KO:K06236]
132020319  COL2A1; collagen alpha-1(II) chain [KO:K19719]
132002766  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
132002767  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
132013607  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
132013610  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
132007451  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
132007483  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
132010492  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238]
132011781  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
132011782  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
132012489  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
132012490  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
132013678  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
132000645  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
132017222  COL9A1; LOW QUALITY PROTEIN: collagen alpha-1(IX) chain [KO:K08131]
132022096  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
132023488  LAMA1; laminin subunit alpha-1 [KO:K05637]
132018153  LAMA2; laminin subunit alpha-2 [KO:K05637]
132023533  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
132022076  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
132018374  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
132016044  LAMB1; laminin subunit beta-1 [KO:K05636]
132011312  LAMB2; laminin subunit beta-2 [KO:K06243]
132025545  LAMB3; laminin subunit beta-3 [KO:K06244]
132016046  LAMB4; laminin subunit beta-4 [KO:K06245]
132025447  LAMC1; laminin subunit gamma-1 [KO:K05635]
132025448  LAMC2; laminin subunit gamma-2 [KO:K06246]
132024323  LAMC3; laminin subunit gamma-3 [KO:K06247]
132004361  CHAD; chondroadherin [KO:K06248]
132016015  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
131999619  THBS1; thrombospondin-1 [KO:K16857]
132009762  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
132018467  THBS2; thrombospondin-2 [KO:K04659]
132025902  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
132028767  THBS4; thrombospondin-4 [KO:K04659]
132013520  FN1; fibronectin isoform X1 [KO:K05717]
132001259  SPP1; osteopontin [KO:K06250]
132003652  VTN; vitronectin [KO:K06251]
132024473  TNC; tenascin isoform X1 [KO:K06252]
132017830  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
132025491  TNR; tenascin-R [KO:K06252]
132026107  TNN; tenascin-N [KO:K06252]
132019941  VWF; von Willebrand factor [KO:K03900]
132013970  IBSP; bone sialoprotein 2 [KO:K06253]
132028298  ITGA1; integrin alpha-1 [KO:K06480]
132028299  ITGA2; integrin alpha-2 [KO:K06481]
132003633  ITGA2B; integrin alpha-IIb [KO:K06476]
132004044  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
132013879  ITGA4; integrin alpha-4 [KO:K06483]
132019757  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
132013834  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
132019766  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
132020145  ITGA8; integrin alpha-8 [KO:K06584]
132011667  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
132001411  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
131999559  ITGA11; integrin alpha-11 [KO:K06587]
132013895  ITGAV; integrin alpha-V [KO:K06487]
132020196  ITGB1; integrin beta-1 [KO:K05719]
132004398  ITGB3; integrin beta-3 [KO:K06493]
132003460  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
132011872  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
132013780  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
132019724  ITGB7; integrin beta-7 [KO:K06590]
132015891  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
132014328  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
132001008  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
132010495  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
132012033  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
132000809  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
132011173  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
132028693  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
132028743  F2R; proteinase-activated receptor 1 [KO:K03914]
132019827  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
132014913  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
132024516  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
132011227  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
132001071  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
132007415  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
132019925  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
132002996  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
132001826  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
132026562  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
132019915  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
132012030  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
131999766  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
131999942  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
132019950  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
132016147  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
132001069  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
132017487  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
132012969  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
132010751  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
132005567  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
132024511  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
132018736  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
132015082  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
132000997  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
132020499  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
132027069  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
132015083  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
132003975  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
132016030  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
132003533  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
132004319  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
132027002  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
132010698  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
132000924  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
132028269  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
132015241  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
132024295  TSC1; hamartin isoform X1 [KO:K07206]
132027018  TSC2; tuberin isoform X1 [KO:K07207]
132015553  RHEB; GTP-binding protein Rheb [KO:K07208]
132027015  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
132001170  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
132004086  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
132006605  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
132001582  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
132010644  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
132027533  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
132020541  eukaryotic translation initiation factor 4E-like [KO:K03259]
132013646  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
132017832  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
132004290  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
132019717  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
132010218  small ribosomal subunit protein eS6-like [KO:K02991]
132010247  small ribosomal subunit protein eS6-like [KO:K02991]
132024707  RPS6; small ribosomal subunit protein eS6 [KO:K02991]
132004247  small ribosomal subunit protein eS6-like [KO:K02991]
132003742  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
132011076  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
132001092  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
132024360  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
132018177  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
132021942  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
132014062  SGK3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
132000311  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132025379  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132005674  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
132011478  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
132015995  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
132016218  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
132001490  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
132006351  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
132005478  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
132028487  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
132016884  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
132004258  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
131999245  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
132028637  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
132007618  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
132011814  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
131999885  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
132000267  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
132018044  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
132025408  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
132019210  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
132000016  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
132000270  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
132023924  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
132018009  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
132013588  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
132019308  HSP90B1; endoplasmin [KO:K09487]
132010972  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
132025950  CRTC2; LOW QUALITY PROTEIN: CREB-regulated transcription coactivator 2 [KO:K16333]
132023668  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
132004931  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
131999463  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
132007343  MTCP1; protein p13 MTCP-1 [KO:K16837]
132015570  NOS3; nitric oxide synthase 3 isoform X1 [KO:K13242] [EC:1.14.13.39]
132003500  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
132012195  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
132019576  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
132006113  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
131999826  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
132022051  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
132003303  G6PC1; glucose-6-phosphatase catalytic subunit 1 isoform X1 [KO:K01084] [EC:3.1.3.9]
132003680  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
132012988  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
132014301  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
132017399  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
132018107  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
132019499  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
132019778  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
132019857  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
132015946  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
132019951  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
132018063  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
132005318  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
132014173  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
132018343  FOXO3; LOW QUALITY PROTEIN: forkhead box protein O3 [KO:K09408]
132005434  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
132026045  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
132021346  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
132009118  LOW QUALITY PROTEIN: 14-3-3 protein beta/alpha-like [KO:K16197]
132021123  YWHAQ; 14-3-3 protein theta [KO:K16197]
132014207  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
132021962  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
132004535  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
132023358  YWHAH; 14-3-3 protein eta [KO:K16198]
132026603  YWHAG; 14-3-3 protein gamma [KO:K16198]
132019536  BAD; bcl2-associated agonist of cell death [KO:K02158]
132021817  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
132023669  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
132001514  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
132013496  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
132013851  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
132009003  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
132019205  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
132008271  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
132008517  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
132015669  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
132009653  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
132024618  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
132025947  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
132015844  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
132017831  ATF6B; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
132001445  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
132024263  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
132019697  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
132006829  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
132016695  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
132006530  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
132018657  RELA; transcription factor p65 [KO:K04735]
132001757  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
132017380  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
132019435  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
132003790  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
mnp00010  Glycolysis / Gluconeogenesis
mnp04010  MAPK signaling pathway
mnp04012  ErbB signaling pathway
mnp04062  Chemokine signaling pathway
mnp04064  NF-kappa B signaling pathway
mnp04068  FoxO signaling pathway
mnp04110  Cell cycle
mnp04115  p53 signaling pathway
mnp04150  mTOR signaling pathway
mnp04210  Apoptosis
mnp04370  VEGF signaling pathway
mnp04510  Focal adhesion
mnp04620  Toll-like receptor signaling pathway
mnp04630  JAK-STAT signaling pathway
mnp04662  B cell receptor signaling pathway
mnp04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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