KEGG   PATHWAY: nasi05010
Entry
nasi05010                   Pathway                                
Name
Alzheimer disease - Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
nasi05010  Alzheimer disease
nasi05010

Organism
Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise) [GN:nasi]
Gene
112410577  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
112394765  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
112390938  APP; amyloid-beta A4 protein isoform X1 [KO:K04520]
112391986  NAE1; NEDD8-activating enzyme E1 regulatory subunit isoform X1 [KO:K04532]
112407702  APBB1; amyloid-beta A4 precursor protein-binding family B member 1 isoform X1 [KO:K04529]
112391848  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
112403943  BACE1; beta-secretase 1 [KO:K04521] [EC:3.4.23.46]
112408587  BACE2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
112402067  RTN3; reticulon-3 [KO:K20723]
112404845  RTN4; reticulon-4 isoform X1 [KO:K20720]
112392307  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
112394837  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
112395675  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
112403035  NCSTN; nicastrin [KO:K06171]
112413770  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
112393161  APH1B; gamma-secretase subunit APH-1B [KO:K06172]
112396038  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
112415923  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
112410117  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
112402423  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
112404308  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
112412202  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
112408591  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
112404044  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
112404389  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
112397996  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
112414589  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
112394284  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
112408227  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
112394690  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
112400130  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
112411425  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
112391782  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
112409216  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
112399448  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
112400192  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
112405799  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
112414924  NDUFA13; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
112406732  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
112393871  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
112398101  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
112407866  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
112416055  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
112406354  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
112405478  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
112414932  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
112393039  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
112396997  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
112409395  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 isoform X1 [KO:K03966]
112402591  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
112395231  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
112407930  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
112402152  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
112396567  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
112395486  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
112390907  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
112396332  NDUFS7; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
112402525  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
112399795  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
112402670  NADH dehydrogenase [ubiquinone] 1 subunit C2-like [KO:K03968]
112390876  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
112402686  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
112407909  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
112405719  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
112401142  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
112397075  cytochrome c1, heme protein, mitochondrial [KO:K00413]
112403809  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
112399364  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
112400398  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
112398719  cytochrome b-c1 complex subunit 7-like [KO:K00417]
112407331  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
112401388  cytochrome b-c1 complex subunit 8 [KO:K00418]
112415117  cytochrome b-c1 complex subunit 9 [KO:K00419]
112396394  cytochrome b-c1 complex subunit 10 [KO:K00420]
112393437  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
112410961  cytochrome c oxidase subunit 5A, mitochondrial isoform X1 [KO:K02264]
112398970  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
112397274  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
112399312  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
112392309  cytochrome c oxidase subunit 6B1 [KO:K02267]
112398864  cytochrome c oxidase subunit 6C-like [KO:K02268]
112413993  cytochrome c oxidase subunit 6C-like [KO:K02268]
112407288  cytochrome c oxidase subunit 6C [KO:K02268]
112394363  cytochrome c oxidase subunit 6C-like [KO:K02268]
112405272  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
112392299  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
112390829  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
112400382  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
112390686  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
112390687  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
112392581  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
112402273  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
112392832  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
112394303  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
112391122  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
112402934  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
112413021  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
112398819  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
112394257  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
112391537  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
112410517  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
112408626  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
112390936  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
112408416  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
112410884  LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase D-like [KO:K05864] [EC:5.2.1.8]
112400377  PPID; peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
112399681  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
112406956  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2-like [KO:K15040]
112413211  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
112391027  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 3-like [KO:K15041]
112409707  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
112404045  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
112399780  SLC25A31; LOW QUALITY PROTEIN: ADP/ATP translocase 4 [KO:K05863]
112415236  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
112396496  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
112404748  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
112415586  APOE; apolipoprotein E [KO:K04524]
112394081  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
112399577  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
112391694  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
112402377  FADD; FAS-associated death domain protein [KO:K02373]
112407903  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
112409928  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
112410874  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
112405194  CALM2; calmodulin-2 [KO:K02183]
112393864  CALM1; calmodulin-1 [KO:K02183]
112407558  calmodulin-like [KO:K02183]
112407559  calmodulin-like protein 3 [KO:K02183]
112400993  calmodulin-like [KO:K02183]
112415452  CALM3; calmodulin-3 [KO:K02183]
112396846  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112393713  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
112401437  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112392624  PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268]
112402326  BAD; bcl2-associated agonist of cell death [KO:K02158]
112409526  cytochrome c-like [KO:K08738]
112396438  cytochrome c-like [KO:K08738]
112403640  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
112406320  cytochrome c [KO:K08738]
112414113  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
112394162  cytochrome c-like [KO:K08738]
112391536  cytochrome c 2 [KO:K08738]
112409026  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
112402819  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
112409662  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
112402293  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
112410727  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
112406800  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
112410930  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
112395611  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
112402291  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
112412530  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
112412538  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
112391181  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
112411379  GRIN1; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 1 [KO:K05208]
112409459  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
112391785  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
112410166  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
112415322  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
112391637  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
112400535  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
112399841  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
112402631  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
112405766  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
112412232  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112399342  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112391188  RYR3; ryanodine receptor 3 [KO:K04963]
112400978  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
112391770  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
112414026  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
112399328  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
112408746  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
112392609  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
112403903  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
112415136  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
112394394  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
112410245  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
112398926  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
112411269  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
112409119  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
112400298  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
112395723  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112412478  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112413113  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112401166  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
112394733  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
112411162  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
112391568  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
112405777  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
112402972  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
112408302  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
112397842  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
112407694  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
112394329  LOW QUALITY PROTEIN: proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
112390511  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
112393512  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
112411209  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
112400305  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
112395588  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
112397484  PSMB5; proteasome subunit beta type-5 isoform X1 [KO:K02737] [EC:3.4.25.1]
112399645  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
112411625  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
112395057  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
112393894  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
112415577  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
112392865  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
112402501  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
112410256  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
112415342  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
112396717  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
112399787  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
112408843  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
112410424  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
112394144  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
112400541  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
112411787  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
112402405  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
112411618  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
112393636  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
112392213  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
112403006  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
112414505  26S proteasome complex subunit SEM1 isoform X1 [KO:K10881]
112415739  LOW QUALITY PROTEIN: caspase-12-like [KO:K04741] [EC:3.4.22.-]
112408771  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
112402123  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
112403123  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
112394514  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
112396401  SLC39A3; zinc transporter ZIP3 [KO:K14709]
112410614  SLC39A2; zinc transporter ZIP2 [KO:K14709]
112401724  SLC39A1; zinc transporter ZIP1 [KO:K14709]
112397039  SLC39A4; zinc transporter ZIP4 [KO:K14710]
112394087  SLC39A5; zinc transporter ZIP5 [KO:K14711]
112412454  SLC39A6; zinc transporter ZIP6 [KO:K14712]
112413836  SLC39A7; zinc transporter SLC39A7 [KO:K14713]
112393806  SLC39A8; zinc transporter ZIP8 [KO:K14714]
112396091  SLC39A9; zinc transporter ZIP9 [KO:K14715]
112392109  SLC39A10; zinc transporter ZIP10 [KO:K14716]
112410381  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
112402903  SLC39A12; zinc transporter ZIP12 isoform X1 [KO:K14718]
112402478  SLC39A13; zinc transporter ZIP13 isoform X1 [KO:K14719]
112401467  SLC39A14; zinc transporter ZIP14 isoform X1 [KO:K14720]
112394200  SLC11A2; natural resistance-associated macrophage protein 2 [KO:K21398]
112405887  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
112415982  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
112406937  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
112404054  DKK2; dickkopf-related protein 2 [KO:K02165]
112399597  DKK1; dickkopf-related protein 1 [KO:K02165]
112413117  DKK4; LOW QUALITY PROTEIN: dickkopf-related protein 4 [KO:K02165]
112394416  WNT1; proto-oncogene Wnt-1 [KO:K03209]
112413029  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
112408222  WNT2; protein Wnt-2 [KO:K00182]
112410477  WNT3; proto-oncogene Wnt-3 [KO:K00312]
112413363  WNT3A; protein Wnt-3a [KO:K00312]
112414265  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
112400593  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
112391774  WNT5B; protein Wnt-5b [KO:K00444]
112411853  WNT6; protein Wnt-6 [KO:K00445]
112411995  WNT7A; protein Wnt-7a [KO:K00572]
112394578  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
112404476  WNT8A; protein Wnt-8a [KO:K00714]
112392982  WNT8B; protein Wnt-8b [KO:K00714]
112410284  WNT9B; protein Wnt-9b [KO:K01064]
112413204  WNT9A; protein Wnt-9a [KO:K01064]
112411902  WNT10A; protein Wnt-10a [KO:K01357]
112394239  WNT10B; protein Wnt-10b [KO:K01357]
112408006  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
112408236  WNT16; protein Wnt-16 [KO:K01558]
112413270  FZD1; frizzled-1 [KO:K02432]
112407859  FZD7; frizzled-7 [KO:K02432]
112410297  FZD2; frizzled-2 [KO:K02235]
112414984  FZD3; frizzled-3 [KO:K02329]
112412116  FZD4; frizzled-4 [KO:K02354]
112413704  LOW QUALITY PROTEIN: frizzled-8-like [KO:K02375]
112395239  FZD5; frizzled-5 [KO:K02375]
112399709  FZD6; frizzled-6 [KO:K02376]
112401141  FZD9; frizzled-9 [KO:K02842]
112408809  FZD10; frizzled-10 [KO:K02842]
112402333  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
112391705  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
112410850  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
112409865  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
112415175  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
112390405  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
112392971  LOW QUALITY PROTEIN: proto-oncogene FRAT1-like [KO:K03069]
112398418  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
112401264  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
112395454  CSNK2B; casein kinase II subunit beta [KO:K03115]
112409352  AXIN1; axin-1 isoform X1 [KO:K02157]
112410145  AXIN2; axin-2 [KO:K04385]
112396302  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
112398645  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
112405503  CTNNB1; catenin beta-1 [KO:K02105]
112395213  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
112402885  KIF5B; kinesin-1 heavy chain [KO:K10396]
112407096  KIF5C; kinesin heavy chain [KO:K10396]
112394305  KIF5A; kinesin heavy chain [KO:K10396]
112402111  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
112413947  KLC4; kinesin light chain 4 [KO:K10407]
112408545  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
112415259  KLC3; kinesin light chain 3 [KO:K10407]
112411846  tubulin alpha-4A chain [KO:K07374]
112411848  tubulin alpha-1D chain-like [KO:K07374]
112412198  tubulin alpha-3 chain [KO:K07374]
112412208  LOW QUALITY PROTEIN: putative tubulin-like protein alpha-4B [KO:K07374]
112412210  tubulin alpha-3 chain-like [KO:K07374]
112407547  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
112394116  tubulin alpha-1B chain [KO:K07374]
112394117  tubulin alpha-1C chain [KO:K07374]
112391670  TUBA8; tubulin alpha-8 chain [KO:K07374]
112395403  TUBB; tubulin beta chain [KO:K07375]
112403082  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
112411441  TUBB4B; tubulin beta-4B chain [KO:K07375]
112412254  TUBB6; tubulin beta-6 chain [KO:K07375]
112400249  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
112395264  tubulin beta-2B chain [KO:K07375]
112393335  uncharacterized protein LOC112393335 [KO:K07375]
112395381  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
112402519  HRAS; GTPase HRas isoform X1 [KO:K02833]
112391643  KRAS; GTPase KRas isoform X1 [KO:K07827]
112413065  NRAS; GTPase NRas [KO:K07828]
112402589  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
112398096  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
112407243  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112393112  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112400165  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112400678  NOX1; LOW QUALITY PROTEIN: NADPH oxidase 1 [KO:K08008]
112414233  cytochrome b-245 heavy chain isoform X1 [KO:K21421] [EC:1.-.-.-]
112410941  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
112402272  RELA; transcription factor p65 [KO:K04735]
112393728  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112394495  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
112403598  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
112395421  TNF; tumor necrosis factor [KO:K03156]
112395338  IL6; interleukin-6 [KO:K05405]
112398992  IL1A; interleukin-1 alpha [KO:K04383]
112398981  IL1B; interleukin-1 beta [KO:K04519]
112397834  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
112393804  SNCA; alpha-synuclein [KO:K04528]
112405182  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
112392983  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
112413114  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
112400454  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
112402369  INS; insulin [KO:K04526]
112400209  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
112396733  IRS1; insulin receptor substrate 1 [KO:K16172]
112405567  IRS2; insulin receptor substrate 2 [KO:K07187]
112399963  LOW QUALITY PROTEIN: insulin receptor substrate 1-like [KO:K17445]
112401927  IRS4; LOW QUALITY PROTEIN: insulin receptor substrate 4 [KO:K17446]
112404930  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112400438  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112414874  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112402798  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112403325  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112406349  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112405757  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112408453  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112415459  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112402675  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
112396223  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
112404650  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
112394332  ATG101; autophagy-related protein 101 isoform X1 [KO:K19730]
112402073  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
112398136  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
112402536  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
112396689  BECN2; beclin-2 [KO:K08334]
112399407  BECN1; beclin-1 isoform X1 [KO:K08334]
112401454  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
112392873  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
112413286  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
112406619  nuclear receptor-binding factor 2-like isoform X1 [KO:K21246]
112410059  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
112402180  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
112408831  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
112410399  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
112412032  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
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J Clin Invest 114:23-7 (2004)
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Neurochem Int 52:621-33 (2008)
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Calcium channel blockers and Alzheimer's disease.
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Nat Rev Neurosci 2:595-8 (2001)
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Physiol Behav 92:93-7 (2007)
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Int J Biochem Cell Biol 44:1983-6 (2012)
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Related
pathway
nasi00190  Oxidative phosphorylation
nasi03050  Proteasome
nasi04020  Calcium signaling pathway
nasi04140  Autophagy - animal
nasi04141  Protein processing in endoplasmic reticulum
nasi04210  Apoptosis
nasi04310  Wnt signaling pathway
nasi04910  Insulin signaling pathway
nasi04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
LinkDB

DBGET integrated database retrieval system