KEGG   PATHWAY: ncar04024
Entry
ncar04024                   Pathway                                
Name
cAMP signaling pathway - Sciurus carolinensis (gray squirrel)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
ncar04024  cAMP signaling pathway
ncar04024

Other DBs
GO: 0019933
Organism
Sciurus carolinensis (gray squirrel) [GN:ncar]
Gene
124989596  VIP peptides [KO:K05264]
124962701  corticoliberin-like [KO:K05256]
124989487  glycoprotein hormones alpha chain isoform X1 [KO:K08522]
124967103  lutropin subunit beta [KO:K08521]
124958312  glycoprotein hormone alpha-2 [KO:K25483]
124977701  glycoprotein hormone beta-5 [KO:K25484]
124965259  thyrotropin subunit beta [KO:K05251]
124963358  pro-opiomelanocortin-like [KO:K05228]
124980966  LOW QUALITY PROTEIN: pro-glucagon-like [KO:K05259]
124979278  gastric inhibitory polypeptide-like [KO:K05258]
124960440  follitropin subunit beta [KO:K05250]
124963564  natriuretic peptides A-like [KO:K12334]
124965628  pituitary adenylate cyclase-activating polypeptide [KO:K05262]
124985454  beta-1 adrenergic receptor [KO:K04141]
124987131  beta-2 adrenergic receptor [KO:K04142]
124987160  LOW QUALITY PROTEIN: D(1A) dopamine receptor-like [KO:K04144]
124994008  D(1B) dopamine receptor-like [KO:K05840]
124990229  LOW QUALITY PROTEIN: adenosine receptor A2a-like [KO:K04266]
124986375  5-hydroxytryptamine receptor 4 [KO:K04160]
124994553  5-hydroxytryptamine receptor 6 [KO:K04162]
124978009  prostaglandin E2 receptor EP2 subtype isoform X1 [KO:K04259]
124990759  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
124990907  vasoactive intestinal polypeptide receptor 2 [KO:K04590]
124980578  corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
124990813  corticotropin-releasing factor receptor 2 isoform X1 [KO:K04579]
124963615  lutropin-choriogonadotropic hormone receptor [KO:K04248]
124977009  thyrotropin receptor [KO:K04249]
124965743  adrenocorticotropic hormone receptor-like [KO:K04200]
124988973  glucagon-like peptide 1 receptor [KO:K04581]
124967430  gastric inhibitory polypeptide receptor-like isoform X1 [KO:K04580]
124971371  glucose-dependent insulinotropic receptor [KO:K08424]
124963360  follicle-stimulating hormone receptor isoform X1 [KO:K04247]
124961045  atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
124978161  neuroendocrine secretory protein 55 [KO:K04632]
124975134  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
124987997  endothelin-1-like [KO:K16366]
124961570  endothelin-2-like [KO:K16367]
124977284  endothelin-3-like isoform X1 [KO:K05227]
124993501  somatostatin [KO:K05237]
124991809  pro-neuropeptide Y [KO:K05232]
124970958  appetite-regulating hormone isoform X1 [KO:K05254]
124977447  oxytocin-neurophysin 1-like [KO:K05243]
124977461  oxytocin-neurophysin 1 [KO:K05243]
124987250  5-hydroxytryptamine receptor 1A [KO:K04153]
124987985  5-hydroxytryptamine receptor 1B [KO:K04153]
124989763  5-hydroxytryptamine receptor 1E [KO:K04153]
124992342  5-hydroxytryptamine receptor 1F [KO:K04153]
124960431  5-hydroxytryptamine receptor 1D [KO:K04153]
124958827  muscarinic acetylcholine receptor M1 [KO:K04129]
124991906  muscarinic acetylcholine receptor M2 [KO:K04130]
124959858  D(2) dopamine receptor [KO:K04145]
124988516  gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
124964896  gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
124962441  adenosine receptor A1 isoform X1 [KO:K04265]
124994507  endothelin-1 receptor [KO:K04197]
124983187  neuropeptide Y receptor type 1 [KO:K04204]
124972219  somatostatin receptor type 1 [KO:K04217]
124979671  somatostatin receptor type 2 [KO:K04218]
124970709  somatostatin receptor type 5 [KO:K04221]
124991123  hydroxycarboxylic acid receptor 1-like [KO:K08401]
124990985  hydroxycarboxylic acid receptor 2 [KO:K08402]
124966390  free fatty acid receptor 2 isoform X1 [KO:K04328]
124966391  free fatty acid receptor 2-like [KO:K04328]
124993366  succinate receptor 1-like [KO:K10042]
124966893  prostaglandin E2 receptor EP3 subtype [KO:K04260]
124971102  oxytocin receptor [KO:K04229]
124993493  growth hormone secretagogue receptor type 1 [KO:K04284]
124992673  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
124988012  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
124991078  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
124990345  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
124987010  adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
124962927  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
124978229  LOW QUALITY PROTEIN: adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
124992559  adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
124983776  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
124966834  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
124965096  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
124970113  LOW QUALITY PROTEIN: adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
124989568  adenylate cyclase type 10-like isoform X1 [KO:K11265] [EC:4.6.1.1]
124961065  adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
124994870  cGMP-gated cation channel alpha-1 [KO:K04948]
124971693  LOW QUALITY PROTEIN: cyclic nucleotide-gated olfactory channel-like [KO:K04949]
124963523  cyclic nucleotide-gated cation channel alpha-3-like [KO:K04950]
124959519  cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
124966051  cyclic nucleotide-gated cation channel beta-1-like [KO:K04952]
124967674  cyclic nucleotide-gated cation channel beta-3-like [KO:K04953]
124976834  LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
124967357  calmodulin-1 [KO:K02183]
124967948  calmodulin-like protein 6 [KO:K02183]
124962006  calmodulin-like [KO:K02183]
124962112  calmodulin-A-like [KO:K02183]
124962222  calmodulin-like protein 3 [KO:K02183]
124963056  calmodulin-1 [KO:K02183]
124976085  calmodulin-1 [KO:K02183]
124985817  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
124986742  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
124994412  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
124990768  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
124987181  calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
124989656  blood vessel epicardial substance isoform X1 [KO:K21108]
124993027  popeye domain-containing protein 2 isoform X1 [KO:K26206]
124988663  popeye domain-containing protein 3 [KO:K26207]
124961818  potassium channel subfamily K member 2 isoform X1 [KO:K04913]
124975373  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
124977481  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
124984675  ATP-binding cassette sub-family C member 4 isoform X1 [KO:K05673]
124982354  rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
124978987  rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
124967072  ras-related protein R-Ras [KO:K07829]
124958716  ras-related protein R-Ras2 [KO:K07830]
124966277  ras-related protein R-Ras2-like [KO:K07830]
124992927  phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
124980798  phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
124984889  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
124986765  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
124994121  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
124984745  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
124978224  ras-related protein Rap-1A [KO:K04353]
124982482  ras-related protein Rap-1b [KO:K07836]
124992547  rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
124969345  LOW QUALITY PROTEIN: proto-oncogene vav-like [KO:K05730]
124980429  guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
124964423  guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
124970154  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
124971456  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
124982630  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
124980331  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
124958584  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
124986802  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
124993416  transforming protein RhoA [KO:K04513]
124989136  transforming protein RhoA-like isoform X1 [KO:K04513]
124976920  transforming protein RhoA-like [KO:K04513]
124989634  afadin isoform X1 [KO:K05702]
124993166  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
124993330  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
124963509  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
124986648  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
124968815  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
124962260  LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
124976076  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124966582  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124990234  LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
124971006  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
124977990  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124969568  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
124990635  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124970294  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
124985819  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
124969119  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
124981061  protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
124991738  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
124960013  serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
124963007  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
124979032  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
124991113  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
124958938  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
124984689  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
124969564  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
124964377  cyclic AMP-responsive element-binding protein 3-like isoform X1 [KO:K09048]
124991182  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
124969981  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
124982357  histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
124977967  protein c-Fos [KO:K04379]
124991717  transcription factor Jun [KO:K04448]
124963740  LOW QUALITY PROTEIN: transcription factor Jun-like [KO:K04448]
124991761  transcriptional activator GLI3 [KO:K06230]
124965298  protein patched homolog 1 isoform X1 [KO:K06225]
124994478  hedgehog-interacting protein isoform X1 [KO:K06231]
124978214  NF-kappa-B inhibitor alpha [KO:K04734]
124994613  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
124960546  transcription factor p65 [KO:K04735]
124978854  transcription factor SOX-9 isoform X1 [KO:K18435]
124968799  muellerian-inhibiting factor-like [KO:K04665]
124981928  peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
124994493  peroxisomal acyl-coenzyme A oxidase 3-like isoform X1 [KO:K00232] [EC:1.3.3.6]
124980496  peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
124965416  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
124986986  proteinase-activated receptor 1 [KO:K03914]
124958534  bcl2-associated agonist of cell death-like [KO:K02158]
124966648  hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
124965296  rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
124962770  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
124982345  protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
124977953  myosin regulatory light polypeptide 9 [KO:K12755]
124966930  troponin I, cardiac muscle isoform X1 [KO:K12044]
124988557  cardiac phospholamban [KO:K05852]
124990126  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
124969905  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
124980515  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
124961919  ryanodine receptor 2 isoform X1 [KO:K04962]
124964369  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
124970656  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2A-like [KO:K05209]
124983215  glutamate receptor ionotropic, NMDA 2B [KO:K05210]
124979849  glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
124966828  glutamate receptor ionotropic, NMDA 2D [KO:K05212]
124963937  glutamate receptor ionotropic, NMDA 3A [KO:K05213]
124968675  glutamate receptor ionotropic, NMDA 3B-like [KO:K05214]
124986940  glutamate receptor 1 isoform X1 [KO:K05197]
124994514  glutamate receptor 2 isoform X1 [KO:K05198]
124971795  glutamate receptor 3 isoform X1 [KO:K05199]
124958112  glutamate receptor 4 isoform X1 [KO:K05200]
124991796  cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
124967385  sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
124979517  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
124981180  LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-1-like [KO:K01539] [EC:7.2.2.13]
124992537  sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540]
124961571  sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
124981128  sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
124972490  protein ATP1B4 isoform X1 [KO:K01540]
124960527  sodium/potassium-transporting ATPase subunit gamma-like isoform X1 [KO:K01538]
124966418  phospholemman isoform X1 [KO:K13360]
124990681  sodium/hydrogen exchanger 1 [KO:K05742]
124990787  calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
124962398  plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
124970941  plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
124971750  plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
124983674  plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
124982084  voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
124968359  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
124971751  voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
124961645  voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
124982565  cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
124958301  cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
124961340  LOW QUALITY PROTEIN: uncharacterized protein LOC124961340 [KO:K13296] [EC:3.1.4.17]
124986645  LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4D-like [KO:K13293] [EC:3.1.4.53]
124968763  LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like [KO:K13293] [EC:3.1.4.53]
124968827  cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
124979707  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
124989090  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
DOI:10.1007/s00210-007-0246-7
Reference
PMID:24450633
  Authors
Roberts OL, Dart C
  Title
cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
  Journal
Biochem Soc Trans 42:89-97 (2014)
DOI:10.1042/BST20130253
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:21852968
  Authors
Bozzi Y, Dunleavy M, Henshall DC
  Title
Cell signaling underlying epileptic behavior.
  Journal
Front Behav Neurosci 5:45 (2011)
DOI:10.3389/fnbeh.2011.00045
Reference
PMID:10880354
  Authors
Lizcano JM, Morrice N, Cohen P
  Title
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
  Journal
Biochem J 349:547-57 (2000)
DOI:10.1042/bj3490547
Reference
PMID:21744067
  Authors
Gerlo S, Kooijman R, Beck IM, Kolmus K, Spooren A, Haegeman G
  Title
Cyclic AMP: a selective modulator of NF-kappaB action.
  Journal
Cell Mol Life Sci 68:3823-41 (2011)
DOI:10.1007/s00018-011-0757-8
Reference
PMID:7688165
  Authors
Lauder JM
  Title
Neurotransmitters as growth regulatory signals: role of receptors and second messengers.
  Journal
Trends Neurosci 16:233-40 (1993)
DOI:10.1016/0166-2236(93)90162-F
Reference
PMID:17077866
  Authors
Voglis G, Tavernarakis N
  Title
The role of synaptic ion channels in synaptic plasticity.
  Journal
EMBO Rep 7:1104-10 (2006)
DOI:10.1038/sj.embor.7400830
Reference
PMID:21346730
  Authors
Altarejos JY, Montminy M
  Title
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.
  Journal
Nat Rev Mol Cell Biol 12:141-51 (2011)
DOI:10.1038/nrm3072
Reference
PMID:24062645
  Authors
Bozzi Y, Borrelli E
  Title
The role of dopamine signaling in epileptogenesis.
  Journal
Front Cell Neurosci 7:157 (2013)
DOI:10.3389/fncel.2013.00157
Reference
PMID:14715909
  Authors
Ceulemans H, Bollen M
  Title
Functional diversity of protein phosphatase-1, a cellular economizer and reset button.
  Journal
Physiol Rev 84:1-39 (2004)
DOI:10.1152/physrev.00013.2003
Reference
PMID:16571352
  Authors
Lipinski RJ, Gipp JJ, Zhang J, Doles JD, Bushman W
  Title
Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.
  Journal
Exp Cell Res 312:1925-38 (2006)
DOI:10.1016/j.yexcr.2006.02.019
Reference
PMID:21693691
  Authors
Lasala C, Schteingart HF, Arouche N, Bedecarras P, Grinspon RP, Picard JY, Josso N, di Clemente N, Rey RA
  Title
SOX9 and SF1 are involved in cyclic AMP-mediated upregulation of anti-Mullerian gene expression in the testicular prepubertal Sertoli cell line SMAT1.
  Journal
Am J Physiol Endocrinol Metab 301:E539-47 (2011)
DOI:10.1152/ajpendo.00187.2011
Reference
PMID:19460777
  Authors
Rosenkranz AC, Rauch BH, Freidel K, Schror K
  Title
Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT.
  Journal
Cardiovasc Res 83:778-84 (2009)
DOI:10.1093/cvr/cvp163
Reference
PMID:11117527
  Authors
Lazennec G, Canaple L, Saugy D, Wahli W
  Title
Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.
  Journal
Mol Endocrinol 14:1962-75 (2000)
DOI:10.1210/mend.14.12.0575
Reference
PMID:16460276
  Authors
Murthy KS
  Title
Signaling for contraction and relaxation in smooth muscle of the gut.
  Journal
Annu Rev Physiol 68:345-74 (2006)
DOI:10.1146/annurev.physiol.68.040504.094707
Reference
PMID:18064650
  Authors
Birukova AA, Zagranichnaya T, Alekseeva E, Bokoch GM, Birukov KG
  Title
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
  Journal
J Cell Physiol 215:715-24 (2008)
DOI:10.1002/jcp.21354
Reference
PMID:9204709
  Authors
Houslay MD, Milligan G
  Title
Tailoring cAMP-signalling responses through isoform multiplicity.
  Journal
Trends Biochem Sci 22:217-24 (1997)
DOI:10.1016/S0968-0004(97)01050-5
Related
pathway
ncar00071  Fatty acid degradation
ncar04015  Rap1 signaling pathway
ncar04020  Calcium signaling pathway
ncar04151  PI3K-Akt signaling pathway
ncar04210  Apoptosis
ncar04260  Cardiac muscle contraction
ncar04340  Hedgehog signaling pathway
ncar04720  Long-term potentiation
ncar04740  Olfactory transduction
ncar04972  Pancreatic secretion
ncar04976  Bile secretion
KO pathway
ko04024   
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