KEGG   PATHWAY: oor04024
Entry
oor04024                    Pathway                                
Name
cAMP signaling pathway - Orcinus orca (killer whale)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
oor04024  cAMP signaling pathway
oor04024

Other DBs
GO: 0019933
Organism
Orcinus orca (killer whale) [GN:oor]
Gene
101278520  VIP; VIP peptides isoform X1 [KO:K05264]
101269969  CRH; corticoliberin [KO:K05256]
101271158  CGA; glycoprotein hormones alpha chain [KO:K08522]
101283991  LHB; lutropin subunit beta [KO:K08521]
101282122  GPHA2; glycoprotein hormone alpha-2 isoform X1 [KO:K25483]
101273661  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
101277384  TSHB; thyrotropin subunit beta [KO:K05251]
101284816  POMC; pro-opiomelanocortin [KO:K05228]
101272149  GCG; pro-glucagon isoform X1 [KO:K05259]
101285489  GIP; gastric inhibitory polypeptide [KO:K05258]
101284624  FSHB; follitropin subunit beta [KO:K05250]
101288321  NPPA; natriuretic peptides A [KO:K12334]
101282085  ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262]
101286166  ADRB1; beta-1 adrenergic receptor [KO:K04141]
101276872  ADRB2; beta-2 adrenergic receptor [KO:K04142]
101281903  DRD1; D(1A) dopamine receptor [KO:K04144]
101270940  DRD5; LOW QUALITY PROTEIN: D(1B) dopamine receptor [KO:K05840]
101278735  ADORA2A; adenosine receptor A2a [KO:K04266]
101277127  HTR4; 5-hydroxytryptamine receptor 4 isoform X3 [KO:K04160]
101285093  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
101282504  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
101275924  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
101272045  VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X1 [KO:K04590]
101278576  CRHR1; corticotropin-releasing factor receptor 1 isoform X4 [KO:K04578]
101277908  CRHR2; corticotropin-releasing factor receptor 2 isoform X3 [KO:K04579]
101290430  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
101276553  TSHR; thyrotropin receptor [KO:K04249]
101281347  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
101283067  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
101272183  GIPR; gastric inhibitory polypeptide receptor [KO:K04580]
101284112  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
101290010  FSHR; follicle-stimulating hormone receptor isoform X1 [KO:K04247]
101288628  NPR1; atrial natriuretic peptide receptor 1 isoform X2 [KO:K12323] [EC:4.6.1.2]
101286834  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X2 [KO:K04632]
101282939  neuroendocrine secretory protein 55-like [KO:K04632]
101277994  EDN1; endothelin-1 [KO:K16366]
101277082  EDN2; endothelin-2 [KO:K16367]
101286477  SST; somatostatin [KO:K05237]
101280462  NPY; pro-neuropeptide Y isoform X2 [KO:K05232]
101273641  GHRL; appetite-regulating hormone [KO:K05254]
101269360  OXT; oxytocin-neurophysin 1 [KO:K05243]
101279054  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
101285522  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
101271652  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
101272099  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
117198714  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
101285827  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101284832  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101290465  DRD2; D(2) dopamine receptor [KO:K04145]
101287054  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 isoform X2 [KO:K04615]
101278543  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
101288190  ADORA1; adenosine receptor A1 isoform X1 [KO:K04265]
101269751  EDNRA; endothelin-1 receptor [KO:K04197]
101273598  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
101272091  SSTR1; somatostatin receptor type 1 [KO:K04217]
101281991  SSTR2; somatostatin receptor type 2 [KO:K04218]
101286363  SSTR5; somatostatin receptor type 5 [KO:K04221]
101274127  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
101274361  LOW QUALITY PROTEIN: hydroxycarboxylic acid receptor 2 [KO:K08402]
101284547  FFAR2; free fatty acid receptor 2 [KO:K04328]
101285907  SUCNR1; succinate receptor 1 [KO:K10042]
101277049  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X2 [KO:K04260]
101285710  OXTR; oxytocin receptor [KO:K04229]
101283330  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
101276500  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
101277471  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
101271719  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101278368  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
101286207  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101283651  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101289858  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
101283178  ADCY5; adenylate cyclase type 5 isoform X2 [KO:K08045] [EC:4.6.1.1]
101273023  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
101273592  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101273171  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101281654  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101282314  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
101281567  adenylate cyclase type 10-like isoform X4 [KO:K11265] [EC:4.6.1.1]
101276081  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
101276902  CNGA2; LOW QUALITY PROTEIN: cyclic nucleotide-gated olfactory channel [KO:K04949]
101286138  CNGA3; cyclic nucleotide-gated cation channel alpha-3 isoform X1 [KO:K04950]
101282503  CNGA4; LOW QUALITY PROTEIN: cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
101275567  CNGB1; cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
101287156  CNGB3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
101278649  CALML6; calmodulin-like protein 6 [KO:K02183]
101273078  CALM2; calmodulin-2 [KO:K02183]
101285814  CALM1; calmodulin-1 [KO:K02183]
101279979  CALM3; calmodulin-3 [KO:K02183]
101282017  calmodulin-alpha-like isoform X1 [KO:K02183]
105748632  LOW QUALITY PROTEIN: myosin light chain 1, skeletal muscle isoform-like [KO:K02183]
101284096  calmodulin-1-like [KO:K02183]
125961823  calmodulin-1-like [KO:K02183]
125961824  calmodulin-1-like [KO:K02183]
125961825  calmodulin-1-like [KO:K02183]
125961826  calmodulin-1-like [KO:K02183]
125961827  calmodulin-1-like [KO:K02183]
125961828  calmodulin-1-like [KO:K02183]
101269181  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X16 [KO:K04515] [EC:2.7.11.17]
101287513  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5 [KO:K04515] [EC:2.7.11.17]
101281498  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X8 [KO:K04515] [EC:2.7.11.17]
101271879  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101273696  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
101273429  BVES; blood vessel epicardial substance isoform X2 [KO:K21108]
101281924  POPDC2; popeye domain-containing protein 2 isoform X2 [KO:K26206]
101273166  POPDC3; popeye domain-containing protein 3 [KO:K26207]
101270799  KCNK2; potassium channel subfamily K member 2 isoform X2 [KO:K04913]
101279884  HCN2; LOW QUALITY PROTEIN: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
101280324  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
101272358  ABCC4; ATP-binding cassette sub-family C member 4 isoform X1 [KO:K05673]
101279146  LOW QUALITY PROTEIN: ATP-binding cassette sub-family C member 4-like [KO:K05673]
101278657  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X5 [KO:K08014]
101271995  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
101273601  RRAS; ras-related protein R-Ras [KO:K07829]
101271542  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
101278706  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
101284082  PLD1; phospholipase D1 isoform X6 [KO:K01115] [EC:3.1.4.4]
101280643  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
101287701  MAPK9; mitogen-activated protein kinase 9 isoform X5 [KO:K04440] [EC:2.7.11.24]
101277656  MAPK10; mitogen-activated protein kinase 10 isoform X4 [KO:K04440] [EC:2.7.11.24]
101281228  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
101287340  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
101284281  RAP1B; ras-related protein Rap-1b [KO:K07836]
101280455  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
101290166  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
101269690  VAV2; guanine nucleotide exchange factor VAV2 isoform X11 [KO:K05730]
101282339  VAV1; LOW QUALITY PROTEIN: proto-oncogene vav [KO:K05730]
101274018  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101269741  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101278177  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
101288086  PAK1; serine/threonine-protein kinase PAK 1 isoform X2 [KO:K04409] [EC:2.7.11.1]
101280167  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
101273830  RHOA; transforming protein RhoA [KO:K04513]
101272883  AFDN; afadin isoform X1 [KO:K05702]
101278075  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101278974  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101283011  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101277568  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101285437  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101281352  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
101272095  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101288103  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101273316  AKT1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101277195  BRAF; serine/threonine-protein kinase B-raf isoform X4 [KO:K04365] [EC:2.7.11.1]
101272984  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101286388  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101287162  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101273287  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101289394  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101272376  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101273911  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101282026  PPP1R1B; protein phosphatase 1 regulatory subunit 1B isoform X2 [KO:K15494]
101285623  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101280558  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101286983  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101287685  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
101283835  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
101286338  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3 [KO:K09048]
101272184  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
101284966  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101287411  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2 [KO:K09048]
101289047  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X4 [KO:K09047]
101281894  CREBBP; CREB-binding protein isoform X2 [KO:K04498] [EC:2.3.1.48]
101287751  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
101281702  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
101286650  FOS; protein c-Fos [KO:K04379]
101288913  JUN; transcription factor Jun [KO:K04448]
101272809  GLI3; transcriptional activator GLI3 isoform X1 [KO:K06230]
101277029  GLI1; zinc finger protein GLI1 [KO:K16797]
101284461  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
101287512  HHIP; hedgehog-interacting protein isoform X1 [KO:K06231]
101289477  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101279857  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101270342  RELA; transcription factor p65 isoform X1 [KO:K04735]
101281345  SOX9; transcription factor SOX-9 [KO:K18435]
101280977  AMH; muellerian-inhibiting factor [KO:K04665]
101283267  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
101275698  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
101287447  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X4 [KO:K00232] [EC:1.3.3.6]
101283533  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
101278325  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
101274967  BAD; bcl2-associated agonist of cell death [KO:K02158]
101277193  LIPE; LOW QUALITY PROTEIN: hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
101278979  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
101289250  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
101279306  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X5 [KO:K06270]
125962845  protein phosphatase 1 regulatory subunit 12A-like [KO:K06270]
101270950  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
101276056  TNNI3; troponin I, cardiac muscle isoform X2 [KO:K12044]
101270843  PLN; cardiac phospholamban [KO:K05852]
101283250  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
101284310  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
101283653  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
101289369  RYR2; ryanodine receptor 2 [KO:K04962]
101278622  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X4 [KO:K05208]
101270526  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101285554  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101286467  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X4 [KO:K05211]
101270626  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101271675  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
101271001  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
101289103  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
101277565  GRIA2; glutamate receptor 2 isoform X4 [KO:K05198]
101289535  GRIA3; glutamate receptor 3 isoform X2 [KO:K05199]
101274079  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
101278319  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
101279507  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
101288540  ATP1A4; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
101288792  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
101280223  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X2 [KO:K01539] [EC:7.2.2.13]
101286190  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
101286264  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
101286948  ATP1B4; protein ATP1B4 isoform X2 [KO:K01540]
101277459  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
101285757  FXYD1; phospholemman isoform X1 [KO:K13360]
101272326  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
101279655  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
101274437  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X6 [KO:K05850] [EC:7.2.2.10]
101279530  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X2 [KO:K05850] [EC:7.2.2.10]
101273845  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X3 [KO:K05850] [EC:7.2.2.10]
101286148  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X4 [KO:K05850] [EC:7.2.2.10]
101272740  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X7 [KO:K04850]
101276749  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101281199  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X11 [KO:K04853]
101275416  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
101289640  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
101270317  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1 [KO:K13296] [EC:3.1.4.17]
101280331  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
101270463  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2 [KO:K13293] [EC:3.1.4.53]
101286059  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
101278828  cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
101275290  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X2 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
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Related
pathway
oor00071  Fatty acid degradation
oor04015  Rap1 signaling pathway
oor04020  Calcium signaling pathway
oor04151  PI3K-Akt signaling pathway
oor04210  Apoptosis
oor04260  Cardiac muscle contraction
oor04340  Hedgehog signaling pathway
oor04720  Long-term potentiation
oor04740  Olfactory transduction
oor04972  Pancreatic secretion
oor04976  Bile secretion
KO pathway
ko04024   
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