KEGG   PATHWAY: pcad04072
Entry
pcad04072                   Pathway                                
Name
Phospholipase D signaling pathway - Physeter catodon (sperm whale)
Description
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. PLD activity can be stimulated by a large number of cell surface receptors and is elaborately regulated by intracellular factors, including protein kinase C isoforms, small GTPases of the ARF, Rho and Ras families and the phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2). The PLD-produced PA activates signaling proteins and acts as a node within the membrane to which signaling proteins translocate. Several signaling proteins, including Raf-1 and mTOR, directly bind PA to mediate translocation or activation, respectively.
Class
Environmental Information Processing; Signal transduction
Pathway map
pcad04072  Phospholipase D signaling pathway
pcad04072

Organism
Physeter catodon (sperm whale) [GN:pcad]
Gene
102977431  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102989848  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102982885  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102985889  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102995661  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102973751  KITLG; kit ligand isoform X1 [KO:K05461]
112062628  INS; insulin [KO:K04526]
102975467  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102994349  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102995915  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102985479  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
114483947  growth factor receptor-bound protein 2 [KO:K04364]
102991751  GAB1; GRB2-associated-binding protein 1 isoform X3 [KO:K09593]
102984031  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
102991486  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
102974315  SHC2; SHC-transforming protein 2 [KO:K17447]
102977456  SHC3; SHC-transforming protein 3 [KO:K17448]
102988652  SHC4; SHC-transforming protein 4 isoform X2 [KO:K17449]
102979922  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
102987506  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
102991639  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102981677  LOW QUALITY PROTEIN: son of sevenless homolog 2-like [KO:K03099]
102978925  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
102994715  HRAS; GTPase HRas isoform X2 [KO:K02833]
102977125  KRAS; GTPase KRas isoform X1 [KO:K07827]
102992439  LOW QUALITY PROTEIN: GTPase NRas-like [KO:K07828]
102982641  NRAS; LOW QUALITY PROTEIN: GTPase NRas [KO:K07828]
102974392  MRAS; ras-related protein M-Ras [KO:K07831]
102986000  RRAS; ras-related protein R-Ras [KO:K07829]
102980435  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
102992808  RALGDS; ral guanine nucleotide dissociation stimulator isoform X8 [KO:K08732]
102987577  RALA; ras-related protein Ral-A [KO:K07834]
102979041  RALB; ras-related protein Ral-B [KO:K07835]
102986098  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102978952  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102977108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102975555  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102991779  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102991192  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102981524  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102976971  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
102990087  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102991442  TSC1; hamartin isoform X1 [KO:K07206]
102985473  TSC2; tuberin isoform X9 [KO:K07207]
102994517  RHEB; GTP-binding protein Rheb [KO:K07208]
102991493  MTOR; serine/threonine-protein kinase mTOR isoform X2 [KO:K07203] [EC:2.7.11.1]
102983639  RHOA; transforming protein RhoA [KO:K04513]
102987040  ADP-ribosylation factor 1 [KO:K07937]
102994410  ADP-ribosylation factor 2 [KO:K07937]
102984837  ADP-ribosylation factor 1-like [KO:K07937]
112067148  ADP-ribosylation factor 6 isoform X2 [KO:K07941]
102992700  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102983230  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
102995434  FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha isoform X1 [KO:K08089]
102984169  MS4A2; high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090]
102989924  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
102974010  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
102993186  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
102974888  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102978946  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
102986218  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
102985111  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
102984239  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X2 [KO:K16342] [EC:3.1.1.4]
102983188  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
102983681  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
102976926  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X2 [KO:K13509] [EC:2.3.1.51]
102981564  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
102978078  1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
102974402  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
102979245  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1 [KO:K19007] [EC:2.3.1.51]
102982912  SPHK1; LOW QUALITY PROTEIN: sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
102994529  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
102987866  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
102992191  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102994150  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102984305  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102989074  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102990690  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
102988075  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3 [KO:K00889] [EC:2.7.1.68]
102973790  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
102986835  DGKE; diacylglycerol kinase epsilon isoform X4 [KO:K00901] [EC:2.7.1.107]
102995302  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
102984215  DGKQ; diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
102994216  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
102996943  DGKA; diacylglycerol kinase alpha isoform X2 [KO:K00901] [EC:2.7.1.107]
102991347  DGKD; diacylglycerol kinase delta isoform X2 [KO:K00901] [EC:2.7.1.107]
102979328  DGKH; diacylglycerol kinase eta isoform X4 [KO:K00901] [EC:2.7.1.107]
102987733  DGKI; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
102987759  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
102992298  DGKB; diacylglycerol kinase beta isoform X3 [KO:K00901] [EC:2.7.1.107]
102994205  PLPP2; LOW QUALITY PROTEIN: phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
102975027  PLPP1; phospholipid phosphatase 1 isoform X3 [KO:K01080] [EC:3.1.3.4]
102994990  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
102991729  phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
102991552  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
102991481  AGT; angiotensinogen [KO:K09821]
112062522  AVP; vasopressin-neurophysin 2-copeptin [KO:K05242]
102979960  CXCL8; interleukin-8 [KO:K10030]
102980831  AGTR1; type-1 angiotensin II receptor [KO:K04166]
102983891  F2R; proteinase-activated receptor 1 [KO:K03914]
102978027  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
102986485  GRM2; metabotropic glutamate receptor 2 isoform X1 [KO:K04605]
102982821  GRM3; metabotropic glutamate receptor 3 isoform X1 [KO:K04606]
102993906  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
102990345  GRM6; metabotropic glutamate receptor 6 [KO:K04608]
102987044  GRM7; metabotropic glutamate receptor 7 isoform X1 [KO:K04609]
102987895  GRM8; metabotropic glutamate receptor 8 isoform X2 [KO:K04610]
102987364  AVPR1A; vasopressin V1a receptor [KO:K04226]
102993909  AVPR1B; vasopressin V1b receptor isoform X1 [KO:K04227]
102977461  AVPR2; vasopressin V2 receptor [KO:K04228]
102992144  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
102986483  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102995933  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
102976773  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102981443  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102994918  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
102991051  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
102995584  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
102995856  LOW QUALITY PROTEIN: C-X-C chemokine receptor type 2 [KO:K05050]
102995357  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
102985636  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
102974165  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102983015  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
102995810  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
102989616  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X2 [KO:K04639]
102983371  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
102976409  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
102979209  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
102990707  CYTH1; cytohesin-1 isoform X2 [KO:K18441]
102991011  CYTH3; cytohesin-3 isoform X2 [KO:K18441]
102992963  CYTH2; cytohesin-2 [KO:K18441]
102990288  CYTH4; cytohesin-4 [KO:K18441]
102993267  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X2 [KO:K04632]
102987258  neuroendocrine secretory protein 55-like [KO:K04632]
102988341  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
102981199  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102991224  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102989136  ADCY3; adenylate cyclase type 3 isoform X3 [KO:K08043] [EC:4.6.1.1]
102985820  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
102983319  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102986152  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
102985075  ADCY7; adenylate cyclase type 7 isoform X4 [KO:K08047] [EC:4.6.1.1]
102975211  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
102995803  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102987186  rap guanine nucleotide exchange factor 3 isoform X2 [KO:K08014]
102985646  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X2 [KO:K04351]
102977482  dynamin-3 [KO:K01528] [EC:3.6.5.5]
114483869  dynamin-1-like [KO:K01528] [EC:3.6.5.5]
102989343  DNM1; dynamin-1 [KO:K01528] [EC:3.6.5.5]
102991476  DNM2; dynamin-2 [KO:K23484] [EC:3.6.5.5]
114484958  dynamin-2-like [KO:K23484] [EC:3.6.5.5]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C00639  Prostaglandin F2alpha
C00681  1-Acyl-sn-glycerol 3-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:17245604
  Authors
Oude Weernink PA, Lopez de Jesus M, Schmidt M
  Title
Phospholipase D signaling: orchestration by PIP2 and small GTPases.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 374:399-411 (2007)
DOI:10.1007/s00210-007-0131-4
Reference
PMID:21936578
  Authors
Selvy PE, Lavieri RR, Lindsley CW, Brown HA
  Title
Phospholipase D: enzymology, functionality, and chemical modulation.
  Journal
Chem Rev 111:6064-119 (2011)
DOI:10.1021/cr200296t
Reference
PMID:24995811
  Authors
Brandenburg LO, Pufe T, Koch T
  Title
Role of phospholipase d in g-protein coupled receptor function.
  Journal
Membranes (Basel) 4:302-18 (2014)
DOI:10.3390/membranes4030302
Reference
PMID:17054901
  Authors
Oude Weernink PA, Han L, Jakobs KH, Schmidt M
  Title
Dynamic phospholipid signaling by G protein-coupled receptors.
  Journal
Biochim Biophys Acta 1768:888-900 (2007)
DOI:10.1016/j.bbamem.2006.09.012
Reference
PMID:24990952
  Authors
Foster DA, Salloum D, Menon D, Frias MA
  Title
Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).
  Journal
J Biol Chem 289:22583-8 (2014)
DOI:10.1074/jbc.R114.566091
Reference
PMID:16143829
  Authors
Jenkins GM, Frohman MA
  Title
Phospholipase D: a lipid centric review.
  Journal
Cell Mol Life Sci 62:2305-16 (2005)
DOI:10.1007/s00018-005-5195-z
Reference
PMID:19815110
  Authors
Metcalfe DD, Peavy RD, Gilfillan AM
  Title
Mechanisms of mast cell signaling in anaphylaxis.
  Journal
J Allergy Clin Immunol 124:639-46; quiz 647-8 (2009)
DOI:10.1016/j.jaci.2009.08.035
Reference
PMID:18936782
  Authors
Kalesnikoff J, Galli SJ
  Title
New developments in mast cell biology.
  Journal
Nat Immunol 9:1215-23 (2008)
DOI:10.1038/ni.f.216
Reference
PMID:12217395
  Authors
Cockcroft S, Way G, O'Luanaigh N, Pardo R, Sarri E, Fensome A
  Title
Signalling role for ARF and phospholipase D in mast cell exocytosis stimulated by crosslinking of the high affinity FcepsilonR1 receptor.
  Journal
Mol Immunol 38:1277-82 (2002)
DOI:10.1016/S0161-5890(02)00075-5
Reference
PMID:19410013
  Authors
Lee CS, Kim KL, Jang JH, Choi YS, Suh PG, Ryu SH
  Title
The roles of phospholipase D in EGFR signaling.
  Journal
Biochim Biophys Acta 1791:862-8 (2009)
DOI:10.1016/j.bbalip.2009.04.007
Reference
PMID:16622417
  Authors
Lee CS, Kim IS, Park JB, Lee MN, Lee HY, Suh PG, Ryu SH
  Title
The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.
  Journal
Nat Cell Biol 8:477-84 (2006)
DOI:10.1038/ncb1401
Reference
PMID:14769825
  Authors
Kam Y, Exton JH
  Title
Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid.
  Journal
FASEB J 18:311-9 (2004)
DOI:10.1096/fj.03-0731com
Reference
PMID:9310372
  Authors
Kozawa O, Blume-Jensen P, Heldin CH, Ronnstrand L
  Title
Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.
  Journal
Eur J Biochem 248:149-55 (1997)
DOI:10.1111/j.1432-1033.1997.00149.x
Reference
PMID:11042115
  Authors
Slaaby R, Du G, Altshuller YM, Frohman MA, Seedorf K
  Title
Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade.
  Journal
Biochem J 351 Pt 3:613-9 (2000)
DOI:10.1042/bj3510613
Reference
PMID:11991733
  Authors
Fahimi-Vahid M, Gosau N, Michalek C, Han L, Jakobs KH, Schmidt M, Roberts N, Avkiran M, Wieland T
  Title
Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.
  Journal
J Mol Cell Cardiol 34:441-53 (2002)
DOI:10.1006/jmcc.2002.1525
Reference
PMID:10666319
  Authors
Freeman EJ
  Title
The Ang II-induced growth of vascular smooth muscle cells involves a phospholipase D-mediated signaling mechanism.
  Journal
Arch Biochem Biophys 374:363-70 (2000)
DOI:10.1006/abbi.1999.1608
Reference
PMID:9119890
  Authors
Naro F, Donchenko V, Minotti S, Zolla L, Molinaro M, Adamo S
  Title
Role of phospholipase C and D signalling pathways in vasopressin-dependent myogenic differentiation.
  Journal
J Cell Physiol 171:34-42 (1997)
DOI:10.1002/(SICI)1097-4652(199704)171:1<34::AID-JCP5>3.0.CO;2-I
Reference
PMID:10807766
  Authors
Murdoch C, Finn A
  Title
Chemokine receptors and their role in inflammation and infectious diseases.
  Journal
Blood 95:3032-43 (2000)
Reference
PMID:8135758
  Authors
Sugiyama T, Sakai T, Nozawa Y, Oka N
  Title
Prostaglandin F2 alpha-stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: involvement in sustained 1,2-diacylglycerol production.
  Journal
Biochem J 298 ( Pt 2):479-84 (1994)
DOI:10.1042/bj2980479
Reference
PMID:17210675
  Authors
Foster DA
  Title
Regulation of mTOR by phosphatidic acid?
  Journal
Cancer Res 67:1-4 (2007)
DOI:10.1158/0008-5472.CAN-06-3016
Reference
PMID:15310762
  Authors
Delon C, Manifava M, Wood E, Thompson D, Krugmann S, Pyne S, Ktistakis NT
  Title
Sphingosine kinase 1 is an intracellular effector of phosphatidic acid.
  Journal
J Biol Chem 279:44763-74 (2004)
DOI:10.1074/jbc.M405771200
Reference
PMID:23076158
  Authors
Park JB, Lee CS, Jang JH, Ghim J, Kim YJ, You S, Hwang D, Suh PG, Ryu SH
  Title
Phospholipase signalling networks in cancer.
  Journal
Nat Rev Cancer 12:782-92 (2012)
DOI:10.1038/nrc3379
Reference
PMID:19264150
  Authors
Foster DA
  Title
Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.
  Journal
Biochim Biophys Acta 1791:949-55 (2009)
DOI:10.1016/j.bbalip.2009.02.009
Related
pathway
pcad00561  Glycerolipid metabolism
pcad04010  MAPK signaling pathway
pcad04014  Ras signaling pathway
pcad04020  Calcium signaling pathway
pcad04024  cAMP signaling pathway
pcad04071  Sphingolipid signaling pathway
pcad04144  Endocytosis
pcad04150  mTOR signaling pathway
pcad04151  PI3K-Akt signaling pathway
pcad04664  Fc epsilon RI signaling pathway
KO pathway
ko04072   
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