KEGG   PATHWAY: pcad04020
Entry
pcad04020                   Pathway                                
Name
Calcium signaling pathway - Physeter macrocephalus (sperm whale)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
pcad04020  Calcium signaling pathway
pcad04020

Other DBs
GO: 0019722
Organism
Physeter macrocephalus (sperm whale) [GN:pcad]
Gene
102973173  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
102973279  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
102973335  TPCN2; two pore channel protein 2 isoform X1 [KO:K14077]
102973495  HRH1; histamine H1 receptor [KO:K04149]
102973542  TGFA; protransforming growth factor alpha isoform X4 [KO:K08774]
102973545  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
102973594  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
102973716  CYSLTR1; LOW QUALITY PROTEIN: cysteinyl leukotriene receptor 1 [KO:K04322]
102973747  FGF21; fibroblast growth factor 21 isoform X2 [KO:K22429]
102974068  FGF3; fibroblast growth factor 3 [KO:K04358]
102974165  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102974372  FGF19; fibroblast growth factor 19 [KO:K22603]
102974383  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102974501  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X3 [KO:K23450]
102974552  P2RX7; P2X purinoceptor 7 [KO:K05220]
102974802  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
102974857  [KO:K05862]
102974888  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102974889  RYR2; ryanodine receptor 2 [KO:K04962]
102974970  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
102974975  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
102975098  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
102975151  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X2 [KO:K05857] [EC:3.1.4.11]
102975203  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
102975211  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
102975317  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
102975335  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
102975350  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
102975467  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102975550  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
102975585  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
102975642  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
102975661  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
102975726  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X3 [KO:K05085] [EC:2.7.10.1]
102975818  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
102975937  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
102975963  MST1R; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
102976068  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
102976268  [KO:K04161]
102976450  TACR3; neuromedin-K receptor [KO:K04224]
102976671  CALM1; calmodulin-1 [KO:K02183]
102976725  [KO:K04961]
102976992  FGF10; fibroblast growth factor 10 [KO:K04358]
102977174  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
102977194  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
102977412  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
102977431  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102977492  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
102977506  [KO:K02183]
102977819  BDKRB1; LOW QUALITY PROTEIN: B1 bradykinin receptor [KO:K03915]
102977845  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
102977865  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
102978018  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
102978027  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
102978036  EDNRB; endothelin receptor type B [KO:K04198]
102978084  PHKG2; LOW QUALITY PROTEIN: phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
102978151  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102978329  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
102978526  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
102978580  MST1; LOW QUALITY PROTEIN: hepatocyte growth factor-like protein [KO:K23441]
102978669  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
102978905  CASQ2; calsequestrin-2 [KO:K23445]
102978983  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
102979009  FGF1; fibroblast growth factor 1 isoform X2 [KO:K18496]
102979158  [KO:K04634]
102979394  [KO:K09565] [EC:5.2.1.8]
102979613  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
102979639  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
102979719  EDNRA; endothelin-1 receptor [KO:K04197]
102979753  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
102979968  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
102980147  [KO:K04282]
102980350  ORAI3; protein orai-3 [KO:K16058]
102980523  VEGFD; vascular endothelial growth factor D [KO:K05449]
102980540  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
102980831  AGTR1; type-1 angiotensin II receptor [KO:K04166]
102981091  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102981134  FGF6; fibroblast growth factor 6 [KO:K04358]
102981199  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102981228  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
102981357  ORAI2; protein orai-2 isoform X1 [KO:K16057]
102981418  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
102981739  VEGFA; vascular endothelial growth factor A isoform X7 [KO:K05448]
102981972  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
102982019  [KO:K13755] [EC:3.1.4.17]
102982044  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
102982196  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
102982207  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
102982240  FGFR3; fibroblast growth factor receptor 3 isoform X4 [KO:K05094] [EC:2.7.10.1]
102982293  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102982405  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
102982691  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
102982695  CASQ1; calsequestrin-1 [KO:K23468]
102982885  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102982912  SPHK1; LOW QUALITY PROTEIN: sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
102982984  FGF5; fibroblast growth factor 5 [KO:K04358]
102983013  TACR2; LOW QUALITY PROTEIN: substance-K receptor [KO:K04223]
102983015  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
102983208  SLC8A1; sodium/calcium exchanger 1 isoform X4 [KO:K05849]
102983230  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
102983328  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
102983520  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
102983591  GRPR; gastrin-releasing peptide receptor [KO:K04169]
102983755  PLN; cardiac phospholamban [KO:K05852]
102983841  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102983891  F2R; proteinase-activated receptor 1 [KO:K03914]
102983944  SMIM6; small integral membrane protein 6 [KO:K26468]
102983972  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
102983983  CCKAR; cholecystokinin receptor type A [KO:K04194]
102984161  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102984342  TFEB; transcription factor EB [KO:K15590]
102984346  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
102984374  P2RX5; P2X purinoceptor 5 isoform X2 [KO:K05219]
102984487  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
102984604  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X2 [KO:K05126] [EC:2.7.10.1]
102984774  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
102984842  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
102984905  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
102985075  ADCY7; adenylate cyclase type 7 isoform X4 [KO:K08047] [EC:4.6.1.1]
102985121  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
102985148  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
102985219  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
102985265  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
102985343  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
102985457  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
102985636  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
102985806  NOS3; nitric oxide synthase, endothelial isoform X2 [KO:K13242] [EC:1.14.13.39]
102985820  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
102985851  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X2 [KO:K08794] [EC:2.7.11.17]
102985889  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102985937  FGF16; fibroblast growth factor 16 [KO:K04358]
102985977  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
102986621  ADORA2B; adenosine receptor A2b isoform X1 [KO:K04267]
102986670  GDNF; glial cell line-derived neurotrophic factor isoform X3 [KO:K05452]
102986785  KDR; vascular endothelial growth factor receptor 2 isoform X5 [KO:K05098] [EC:2.7.10.1]
102986791  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
102986921  P2RX1; P2X purinoceptor 1 isoform X5 [KO:K05215]
102986927  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102987010  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
102987032  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102987099  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X10 [KO:K04857]
102987140  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X7 [KO:K00476] [EC:1.14.11.16]
102987197  [KO:K05853] [EC:7.2.2.10]
102987258  [KO:K04632]
102987292  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X6 [KO:K07190]
102987364  AVPR1A; vasopressin V1a receptor [KO:K04226]
102987404  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
102987446  PTAFR; platelet-activating factor receptor isoform X1 [KO:K04279]
102987522  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
102987558  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
102987672  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
102988232  [KO:K02183]
102988237  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
102988309  CALM3; calmodulin-3 [KO:K02183]
102988341  [KO:K04632]
102988344  [KO:K04446]
102988490  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
102988669  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
102988868  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
102988954  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X25 [KO:K04515] [EC:2.7.11.17]
102989017  FGF2; fibroblast growth factor 2 [KO:K18497]
102989081  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2 [KO:K05860] [EC:3.1.4.11]
102989136  ADCY3; adenylate cyclase type 3 isoform X3 [KO:K08043] [EC:4.6.1.1]
102989311  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
102989391  DRD1; D(1A) dopamine receptor [KO:K04144]
102989459  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
102989551  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102989559  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102989661  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
102989784  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
102989848  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102989984  VEGFC; vascular endothelial growth factor C isoform X2 [KO:K05449]
102990012  FGF9; fibroblast growth factor 9 [KO:K04358]
102990192  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
102990275  NTRK1; high affinity nerve growth factor receptor isoform X2 [KO:K03176] [EC:2.7.10.1]
102990403  [KO:K04809]
102990815  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X8 [KO:K04348] [EC:3.1.3.16]
102990817  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
102990905  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
102991051  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
102991055  PHKB; phosphorylase b kinase regulatory subunit beta [KO:K07190]
102991224  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102991454  TBXA2R; thromboxane A2 receptor [KO:K04264]
102991603  TACR1; substance-P receptor [KO:K04222]
102991654  [KO:K22642]
102991688  PDE1C; LOW QUALITY PROTEIN: dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
102991891  OXTR; LOW QUALITY PROTEIN: oxytocin receptor [KO:K04229]
102991951  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X2 [KO:K05862]
102991966  FGF23; fibroblast growth factor 23 [KO:K22428]
102991967  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
102992015  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
102992034  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
102992196  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
102992259  NTRK3; NT-3 growth factor receptor isoform X3 [KO:K05101] [EC:2.7.10.1]
102992313  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
102992414  [KO:K05862]
102992556  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102992700  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102992726  FGF20; fibroblast growth factor 20 [KO:K04358]
102992796  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
102993267  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X2 [KO:K04632]
102993285  C7H4orf3; LOW QUALITY PROTEIN: uncharacterized protein C4orf3 homolog [KO:K26467]
102993417  FGF18; fibroblast growth factor 18 [KO:K04358]
102993502  [KO:K08794] [EC:2.7.11.17]
102993731  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
102993777  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X5 [KO:K17332]
102993901  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X2 [KO:K05850] [EC:7.2.2.10]
102993906  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
102993909  AVPR1B; vasopressin V1b receptor isoform X1 [KO:K04227]
102993945  ADRB2; beta-2 adrenergic receptor isoform X1 [KO:K04142]
102994154  FGF7; fibroblast growth factor 7 [KO:K04358]
102994349  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102994529  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
102994758  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
102994764  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
102994784  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
102994812  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
102994869  [KO:K16896]
102995074  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X5 [KO:K04260]
102995187  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
102995231  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
102995267  ADORA2A; adenosine receptor A2a [KO:K04266]
102995353  ADRB3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143]
102995357  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
102995361  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
102995503  DRD5; LOW QUALITY PROTEIN: D(1B) dopamine receptor [KO:K05840]
102995611  GNA15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
102995656  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
102995661  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102995725  RYR3; ryanodine receptor 3 isoform X6 [KO:K04963]
102995803  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102995810  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
102995826  P2RX6; P2X purinoceptor 6 isoform X3 [KO:K05221]
102995847  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
102995860  NTSR1; neurotensin receptor type 1 [KO:K04211]
102995871  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
102995887  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
102995915  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102996031  P2RX3; P2X purinoceptor 3 [KO:K05217]
102996114  TNNC2; troponin C, skeletal muscle [KO:K12042]
102996437  [KO:K05863]
102996772  STIM1; stromal interaction molecule 1 isoform X3 [KO:K16059]
102996804  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
102996886  [KO:K02183]
102997025  [KO:K04633]
112062129  MRLN; myoregulin isoform X1 [KO:K22643]
112064233  ADRB1; beta-1 adrenergic receptor [KO:K04141]
112065112  [KO:K22642]
112065477  PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268]
112066461  [KO:K15041]
112067418  FGF4; fibroblast growth factor 4 [KO:K04358]
112067521  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
114483863  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
114483879  [KO:K04633]
114483958  [KO:K05849]
114484403  [KO:K16896]
114484431  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
114486038  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
114486997  TRDN; triadin [KO:K23449]
129392645  [KO:K02183]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
pcad04010  MAPK signaling pathway
pcad04070  Phosphatidylinositol signaling system
pcad04210  Apoptosis
pcad04720  Long-term potentiation
pcad04730  Long-term depression
KO pathway
ko04020   

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