KEGG   PATHWAY: pkl05169
Entry
pkl05169                    Pathway                                
Name
Epstein-Barr virus infection - Pipistrellus kuhlii (Kuhl's pipistrelle)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
pkl05169  Epstein-Barr virus infection
pkl05169

Organism
Pipistrellus kuhlii (Kuhl's pipistrelle) [GN:pkl]
Gene
118721264  CR2; complement receptor type 2 [KO:K04012]
118704917  CD19; B-lymphocyte antigen CD19 [KO:K06465]
118705668  SLA class II histocompatibility antigen, DQ haplotype D alpha chain isoform X1 [KO:K06752]
118705669  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752]
118705670  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
118705671  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
118705672  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
118705673  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
118705674  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
118705675  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
118705676  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
118706033  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
118706034  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
118711134  TLR2; toll-like receptor 2 [KO:K10159]
118715489  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
118728234  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
118706455  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
118712509  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
118728922  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
118705059  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
118705284  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
118719404  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118728482  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118706407  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118726764  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
118703354  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118706879  RELA; transcription factor p65 isoform X1 [KO:K04735]
118716986  TNF; tumor necrosis factor [KO:K03156]
118714203  IL6; interleukin-6 [KO:K05405]
118716422  DDX58; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
118707494  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
118714100  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
118730716  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
118721500  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
118717964  IRF7; LOW QUALITY PROTEIN: interferon regulatory factor 7 [KO:K09447]
118712200  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
118716770  IFNB1; interferon beta [KO:K05415]
118716063  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
118716053  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
118724308  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
118731195  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
118709492  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
118729130  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
118725866  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
118717741  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
118719718  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
118719719  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
118725488  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
118703083  2'-5'-oligoadenylate synthase 1-like isoform X1 [KO:K14216] [EC:2.7.7.84]
118705071  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
118718077  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
118719270  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
118713371  FADD; FAS-associated death domain protein [KO:K02373]
118709494  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
118728790  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
118717677  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
118707440  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
118712174  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
118705679  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
118727795  cytochrome c [KO:K08738]
118717745  cytochrome c-like [KO:K08738]
118729137  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
118724633  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
118729116  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
118710580  CD3E; T-cell surface glycoprotein CD3 epsilon chain isoform X1 [KO:K06451]
118710561  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
118710562  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
118721444  CD247; T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
118714388  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
118714173  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
118702221  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
118729512  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 10B-like [KO:K03064]
118718118  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
118713066  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
118726623  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
118722595  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 isoform X1 [KO:K03028]
118709389  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
118702162  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
118726511  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
118728059  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
118715048  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
118720905  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 isoform X1 [KO:K03038]
118713656  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
118727284  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
118709078  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
118702405  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
118708638  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
118714268  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
118705649  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
118705652  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
118722450  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
118710375  CALR; calreticulin [KO:K08057]
118705707  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
118715990  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751]
118716976  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like isoform X1 [KO:K06751]
118718034  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118718036  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X1 [KO:K06751]
118726079  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
118722313  B2M; beta-2-microglobulin [KO:K08055]
118714773  SNW1; SNW domain-containing protein 1 [KO:K06063]
118728514  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
118705602  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
118723755  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
118710411  NCOR2; nuclear receptor corepressor 2 isoform X1 [KO:K06065]
118711571  SAP30L; histone deacetylase complex subunit SAP30L isoform X1 [KO:K19202]
118711213  SAP30; histone deacetylase complex subunit SAP30 isoform X1 [KO:K19202]
118709695  CIR1; corepressor interacting with RBPJ 1 isoform X1 [KO:K06066]
118707481  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
118708083  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
118723388  HES1; transcription factor HES-1 [KO:K06054]
118726153  FCER2; low affinity immunoglobulin epsilon Fc receptor [KO:K06468]
118724096  RUNX3; runt-related transcription factor 3 isoform X1 [KO:K09279]
118718671  MYC; myc proto-oncogene protein [KO:K04377]
118702775  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
118729242  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
118726809  TP53; cellular tumor antigen p53 [KO:K04451]
118705573  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
118731305  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
118723504  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
118708686  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
118713534  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
118703506  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
118721522  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
118722506  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118715291  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118731984  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118703803  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118722550  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
118725879  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
118727672  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118714856  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118702383  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118726383  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
118719699  RELB; transcription factor RelB isoform X1 [KO:K09253]
118718901  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
118702448  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
118706189  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
118726732  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
118725973  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118728660  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118732117  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118725940  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118707045  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
118724462  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
118721075  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
118702109  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
118705126  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118705127  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
118714740  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118714741  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
118722794  JUN; transcription factor AP-1 [KO:K04448]
118719330  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
118707030  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
118715516  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
118707886  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
118713637  CD44; CD44 antigen isoform X1 [KO:K06256]
118704833  ITGAL; integrin alpha-L [KO:K05718]
118727464  CD58; lymphocyte function-associated antigen 3 [KO:K06492]
118731218  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
118730837  VIM; vimentin [KO:K07606]
118705217  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
118725867  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
118726602  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
118718271  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
118708680  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
118720792  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
118710908  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
118720037  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
118719337  BLNK; B-cell linker protein isoform X1 [KO:K07371]
118720533  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
118703716  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
118729119  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
118712764  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
118728810  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
118705228  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
118730275  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
118714298  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
118728720  CCNA1; cyclin-A1 [KO:K06627]
118725924  CCNA2; cyclin-A2 isoform X1 [KO:K06627]
118716047  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
118718119  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
118728263  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
118728588  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
118707945  E2F1; transcription factor E2F1 [KO:K17454]
118722322  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
118724618  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
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  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
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Reference
PMID:12740915
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Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
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Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
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Nat Rev Immunol 1:75-82 (2001)
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PMID:11669605
  Authors
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  Title
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Semin Cancer Biol 11:435-44 (2001)
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Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
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J Biol Chem 278:47753-61 (2003)
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Nat Rev Clin Oncol 12:11-26 (2015)
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Cancers (Basel) 10:E213 (2018)
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PLoS Pathog 5:e1000530 (2009)
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Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
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J Virol 83:4652-69 (2009)
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Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
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Virology 388:236-47 (2009)
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Future Virol 4:79-91 (2009)
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Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
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Front Oncol 8:265 (2018)
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Epstein-Barr virus: induction and control of cell transformation.
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J Cell Physiol 196:207-18 (2003)
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PMID:21347341
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Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
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Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
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PLoS Pathog 7:e1001275 (2011)
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Related
pathway
pkl03050  Proteasome
pkl04010  MAPK signaling pathway
pkl04020  Calcium signaling pathway
pkl04064  NF-kappa B signaling pathway
pkl04110  Cell cycle
pkl04115  p53 signaling pathway
pkl04210  Apoptosis
pkl04612  Antigen processing and presentation
pkl04620  Toll-like receptor signaling pathway
pkl04622  RIG-I-like receptor signaling pathway
pkl04630  JAK-STAT signaling pathway
pkl04662  B cell receptor signaling pathway
KO pathway
ko05169   
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