KEGG   PATHWAY: pon05205
Entry
pon05205                    Pathway                                
Name
Proteoglycans in cancer - Pongo abelii (Sumatran orangutan)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
pon05205  Proteoglycans in cancer
pon05205

Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
100172786  CD44; CD44 antigen precursor [KO:K06256]
100436498  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100174046  CTTN; src substrate cortactin [KO:K06106]
100435468  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
100450307  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100173972  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100442703  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
100171723  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
100447155  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
100459427  HRAS; GTPase HRas [KO:K02833]
100462513  KRAS; GTPase KRas isoform X1 [KO:K07827]
100174317  NRAS; GTPase NRas precursor [KO:K07828]
100440912  RRAS; ras-related protein R-Ras isoform X2 [KO:K07829]
100435791  RRAS2; ras-related protein R-Ras2 [KO:K07830]
100439470  ras-related protein R-Ras2-like [KO:K07830]
100431849  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
100442288  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100173732  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100431871  ARAF; serine/threonine-protein kinase A-Raf isoform X4 [KO:K08845] [EC:2.7.11.1]
100446021  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100450988  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100169740  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100431824  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100443271  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100174194  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
100438199  CDC42; cell division control protein 42 homolog [KO:K04393]
100432611  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100441912  ESR1; estrogen receptor isoform X2 [KO:K08550]
100171625  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100441387  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100173832  ACTB; actin, cytoplasmic 1 [KO:K05692]
100446579  FLNA; filamin-A isoform X1 [KO:K04437]
100449316  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
100431618  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100438951  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
100171605  RHOA; transforming protein RhoA precursor [KO:K04513]
100432582  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100461801  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100444486  ANK1; ankyrin-1 isoform X1 [KO:K10380]
100436372  ANK2; ankyrin-2 isoform X3 [KO:K09255]
100174609  ANK3; ankyrin-3 [KO:K09259]
100458884  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
100432846  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100453779  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103889133  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100174298  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100173589  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100437617  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100454279  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100448114  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100442100  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100450045  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
100173410  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100459799  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100458223  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100172617  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
103890237  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
100444334  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
100457621  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
100444145  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
100445922  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100434318  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100434127  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100433531  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100172212  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
100462386  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100436747  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
100432049  homeobox protein NANOG isoform X1 [KO:K10164]
100453954  homeobox protein NANOG-like [KO:K10164]
100173977  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
100444096  DROSHA; ribonuclease 3 isoform X1 [KO:K03685] [EC:3.1.26.3]
100171541  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100431892  TWIST1; twist-related protein 1 [KO:K09069]
103889786  TWIST2; twist-related protein 2 [KO:K09069]
100174239  HOXD10; homeobox protein Hox-D10 [KO:K09295]
100434577  DCN; decorin [KO:K04660]
100444645  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
100172156  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100456786  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100452403  LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
112129400  LOW QUALITY PROTEIN: putative 3-phosphoinositide-dependent protein kinase 2 [KO:K06276] [EC:2.7.11.1]
100462008  LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
100459428  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
100456988  RPS6KB1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
100432929  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
100444624  RPS6; 40S ribosomal protein S6 [KO:K02991]
100459280  EGFR; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
100137027  CAV1; caveolin-1 [KO:K06278]
100137028  CAV2; caveolin-2 [KO:K12958]
100440174  CAV3; caveolin-3 [KO:K12959]
100438311  CD63; CD63 antigen [KO:K06497]
100453682  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100435491  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100459982  TGFB1; transforming growth factor beta-1 [KO:K13375]
100456464  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
100457237  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
100173014  PDCD4; programmed cell death protein 4 [KO:K16865]
100447558  TNF; tumor necrosis factor [KO:K03156]
100435254  IL12B; interleukin-12 subunit beta [KO:K05425]
100174431  ERBB3; receptor tyrosine-protein kinase erbB-3 precursor [KO:K05084] [EC:2.7.10.1]
100938677  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
100456735  MYC; myc proto-oncogene protein [KO:K04377]
100173739  CTNNB1; catenin beta-1 [KO:K02105]
100173994  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
100446026  TFAP4; transcription factor AP-4 isoform X1 [KO:K09108]
100448769  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
100462446  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100137030  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100462634  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
100440197  TIMP3; metalloproteinase inhibitor 3 [KO:K16866]
100453386  THBS1; thrombospondin-1 [KO:K16857]
100451667  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
100455867  MMP9; LOW QUALITY PROTEIN: matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
100171487  LUM; lumican precursor [KO:K08122]
100461418  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100171532  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
100435218  TP53; cellular tumor antigen p53 [KO:K04451]
100461291  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
100173357  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
100448281  HPSE; heparanase isoform X1 [KO:K07964] [EC:3.2.1.166]
100437923  HPSE2; inactive heparanase-2 isoform X1 [KO:K07965] [EC:3.2.1.-]
100445155  SDC1; syndecan-1 [KO:K06257]
100171578  PLAU; urokinase-type plasminogen activator precursor [KO:K01348] [EC:3.4.21.73]
100461710  PLAUR; urokinase plasminogen activator surface receptor isoform X1 [KO:K03985]
100438152  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
100439107  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100172223  ITGB1; integrin beta-1 precursor [KO:K05719]
100174092  VTN; vitronectin precursor [KO:K06251]
100451792  ITGAV; integrin alpha-V [KO:K06487]
100445345  ITGB3; integrin beta-3 [KO:K06493]
100449704  FN1; fibronectin isoform X1 [KO:K05717]
100449826  ITGB5; integrin beta-5 [KO:K06588]
100462115  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100441356  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100437467  FZD7; frizzled-7 [KO:K02432]
100444369  FZD1; frizzled-1 [KO:K02432]
100452043  FZD2; frizzled-2 [KO:K02235]
100457942  FZD3; frizzled-3 [KO:K02329]
100447615  FZD4; frizzled-4 [KO:K02354]
100458618  FZD5; frizzled-5 [KO:K02375]
112135184  FZD8; frizzled-8 [KO:K02375]
100172142  FZD6; frizzled-6 precursor [KO:K02376]
100442825  FZD10; frizzled-10 [KO:K02842]
100438736  FZD9; frizzled-9 [KO:K02842]
100453984  ITGA5; integrin alpha-5 [KO:K06484]
100441931  SDC2; syndecan-2 [KO:K16336]
100458178  EZR; ezrin isoform X1 [KO:K08007]
100453730  RDX; radixin isoform X2 [KO:K05762]
100460982  MSN; moesin [KO:K05763]
100454412  LOW QUALITY PROTEIN: syndecan-4-like [KO:K16338]
100174444  SDC4; syndecan-4 precursor [KO:K16338]
100459751  FGF2; fibroblast growth factor 2 [KO:K18497]
100174545  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
100452012  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
100440983  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
100434331  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100458733  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100450941  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
100457650  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100434355  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100439900  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100451563  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100455212  NUDT16L1; tudor-interacting repair regulator protein isoform X1 [KO:K16867]
100173313  PXN; paxillin [KO:K05760]
100447959  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100437870  HBEGF; proheparin-binding EGF-like growth factor [KO:K08523]
100445162  GPC1; glypican-1 [KO:K08107]
100453365  IGF2; insulin-like growth factor II [KO:K13769]
100444952  GPC3; glypican-3 [KO:K08109]
100137034  WNT2; protein Wnt-2 precursor [KO:K00182]
100460815  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
100431449  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100448240  WNT3A; protein Wnt-3a isoform X1 [KO:K00312]
100436330  WNT4; protein Wnt-4 [KO:K00408]
100174132  WNT5B; protein Wnt-5b precursor [KO:K00444]
100447525  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
100440643  WNT6; protein Wnt-6 [KO:K00445]
100451196  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
100441147  WNT7A; protein Wnt-7a [KO:K00572]
100450268  WNT8B; protein Wnt-8b [KO:K00714]
100448766  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
100462535  WNT9B; protein Wnt-9b isoform X1 [KO:K01064]
100452135  WNT9A; protein Wnt-9a [KO:K01064]
100440744  WNT10B; protein Wnt-10b [KO:K01357]
100441013  WNT10A; protein Wnt-10a [KO:K01357]
100443554  WNT11; protein Wnt-11 [KO:K01384]
100452466  WNT16; protein Wnt-16 [KO:K01558]
100461003  SHH; sonic hedgehog protein isoform X1 [KO:K11988]
100443093  IHH; indian hedgehog protein [KO:K11989]
100452966  SMO; smoothened homolog [KO:K06226]
100446648  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
100450374  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
100452609  putative inactive cathepsin L-like protein CTSL3P [KO:K01365] [EC:3.4.22.15]
100440226  LOW QUALITY PROTEIN: cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
100174748  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform 2 [KO:K04345] [EC:2.7.11.11]
100431906  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
100437102  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100449269  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100449853  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100437263  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100438358  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100462273  HSPB2; heat shock protein beta-2 isoform X1 [KO:K09543]
100448471  PTPN6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
pon04010  MAPK signaling pathway
pon04020  Calcium signaling pathway
pon04066  HIF-1 signaling pathway
pon04150  mTOR signaling pathway
pon04151  PI3K-Akt signaling pathway
pon04210  Apoptosis
pon04310  Wnt signaling pathway
pon04340  Hedgehog signaling pathway
pon04350  TGF-beta signaling pathway
pon04370  VEGF signaling pathway
pon04510  Focal adhesion
pon04520  Adherens junction
pon04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
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