KEGG   PATHWAY: pvp05162
Entry
pvp05162                    Pathway                                
Name
Measles - Pteropus vampyrus (large flying fox)
Description
Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. MV infection is characterized by virus-induced immune suppression that can lead to increased susceptibility to secondary bacterial and viral infections. The P, V and C proteins act as virulence factors to suppress innate immune response in host by inhibiting signaling for both type I IFN induction and JAK/STAT-mediated interferon-stimulated gene (ISG) induction. Moreover,  H protein expressed on viral particles and binding to SLAM or CD46,  as well as N protein liberated from infected cells and interacting with Fc-gamma R, causes an inhibition of IL-12 synthesis in dendritic cells. IL-12 is a key cytokine inducing cellular immune responses to protect host from the harm caused by pathogenic infections.
Class
Human Diseases; Infectious disease: viral
Pathway map
pvp05162  Measles
pvp05162

Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105309267  membrane cofactor protein-like [KO:K04007]
111733966  membrane cofactor protein-like [KO:K04007]
105300309  membrane cofactor protein-like [KO:K04007]
105309749  membrane cofactor protein-like isoform X1 [KO:K04007]
105309956  membrane cofactor protein-like [KO:K04007]
105307771  MSN; moesin [KO:K05763]
105300701  SLAMF1; signaling lymphocytic activation molecule isoform X1 [KO:K06536]
105307726  CD209; LOW QUALITY PROTEIN: CD209 antigen [KO:K06563]
105307727  CD209 antigen-like protein C [KO:K06563]
105306475  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
105291001  IFIH1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
105298539  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
105299274  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
105300734  IKBKE; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
105301118  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
105301733  IRF3; interferon regulatory factor 3 [KO:K05411]
105304619  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105301022  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105302532  IKBKG; NF-kappa-B essential modulator [KO:K07210]
105300180  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
105303182  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105293029  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105297999  RELA; transcription factor p65 [KO:K04735]
105293980  TLR7; toll-like receptor 7 [KO:K05404]
105295639  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
105310642  interleukin-1 receptor-associated kinase 1-like [KO:K04730] [EC:2.7.11.1]
105302526  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
105297485  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
105305954  IRF7; interferon regulatory factor 7 [KO:K09447]
105298437  interferon alpha-1-like [KO:K05414]
105309143  interferon alpha-4-like [KO:K05414]
105309144  interferon alpha-4-like [KO:K05414]
105309148  interferon alpha-10-like [KO:K05414]
105309141  IFNB1; interferon beta [KO:K05415]
105291526  TLR2; toll-like receptor 2 [KO:K10159]
105292652  TLR4; toll-like receptor 4 [KO:K10160]
105290063  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105305378  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
105305487  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
105305340  CSNK2B; casein kinase II subunit beta [KO:K03115]
105289467  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
105297002  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
105289440  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
105288933  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105289628  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
105299978  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105303436  JUN; transcription factor AP-1 [KO:K04448]
105299213  FOS; proto-oncogene c-Fos [KO:K04379]
105303981  IL1A; interleukin-1 alpha [KO:K04383]
105303982  IL1B; interleukin-1 beta [KO:K04519]
105293152  IL6; interleukin-6 isoform X2 [KO:K05405]
105305876  IL12A; interleukin-12 subunit alpha [KO:K05406]
105289903  IL12B; interleukin-12 subunit beta [KO:K05425]
105295861  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
105301255  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
105293480  RACK1; receptor of activated protein C kinase 1 [KO:K14753]
105298360  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
105305596  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
105289309  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
105302576  STAT2; signal transducer and activator of transcription 2 isoform X2 [KO:K11221]
105309384  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
105289237  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
105289390  OAS2; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
105296385  ADAR; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
105300586  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
105300587  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
105294625  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
105292967  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
105302307  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
105288779  EIF2AK4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
105293984  RAB9A; ras-related protein Rab-9A [KO:K07899]
105309013  RAB9B; ras-related protein Rab-9B [KO:K07900]
105305304  heat shock 70 kDa protein 1-like [KO:K03283]
105307477  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
105292232  EIF3H; eukaryotic translation initiation factor 3 subunit H isoform X2 [KO:K03247]
105308244  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105292351  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X2 [KO:K10144] [EC:2.3.2.27]
105291226  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
105299201  TP73; tumor protein p73 [KO:K10148]
105297315  BBC3; bcl-2-binding component 3 [KO:K10132]
105299797  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105293104  FAS; tumor necrosis factor receptor superfamily member 6 isoform X5 [KO:K04390]
105305700  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105307475  FADD; FAS-associated death domain protein [KO:K02373]
105298127  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105297238  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
105301762  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
111728746  bcl-2 homologous antagonist/killer-like [KO:K14021]
105301000  bcl-2 homologous antagonist/killer [KO:K14021]
105292717  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
105305503  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
105297848  BAD; bcl2-associated agonist of cell death [KO:K02158]
105293163  cytochrome c [KO:K08738]
105288270  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
105294412  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105294710  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105302792  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
105307128  uncharacterized protein LOC105307128 [KO:K04503]
105293261  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105288434  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
105308799  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
105307393  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
105294446  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
105302600  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105310192  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
105309263  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
105310193  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
105298423  CD28; T-cell-specific surface glycoprotein CD28 isoform X1 [KO:K06470]
105302208  IL2; interleukin-2 [KO:K05429]
105307737  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
105311493  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
105299605  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
105296605  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105297140  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105299371  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
105307215  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105307575  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105308956  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
105309876  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
105303899  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105300159  RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
105298702  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105301304  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105296612  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
105306294  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
105306335  signal transducer and activator of transcription 5A-like [KO:K11223]
105306336  signal transducer and activator of transcription 5B [KO:K11224]
105303406  low affinity immunoglobulin gamma Fc region receptor II-b-like isoform X1 [KO:K12560]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:19203113
  Authors
Schneider-Schaulies S, Schneider-Schaulies J
  Title
Measles virus-induced immunosuppression.
  Journal
Curr Top Microbiol Immunol 330:243-69 (2009)
DOI:10.1007/978-3-540-70617-5_12
Reference
PMID:19203114
  Authors
Hahm B
  Title
Hostile communication of measles virus with host innate immunity and dendritic cells.
  Journal
Curr Top Microbiol Immunol 330:271-87 (2009)
DOI:10.1007/978-3-540-70617-5_13
Reference
PMID:19198566
  Authors
Gerlier D, Valentin H
  Title
Measles virus interaction with host cells and impact on innate immunity.
  Journal
Curr Top Microbiol Immunol 329:163-91 (2009)
DOI:10.1007/978-3-540-70523-9_8
Reference
PMID:16690907
  Authors
Schneider-Schaulies S, Dittmer U
  Title
Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression.
  Journal
J Gen Virol 87:1423-38 (2006)
DOI:10.1099/vir.0.81713-0
Reference
PMID:22049305
  Authors
Avota E, Gassert E, Schneider-Schaulies S
  Title
Cytoskeletal dynamics: concepts in measles virus replication and immunomodulation.
  Journal
Viruses 3:102-17 (2011)
DOI:10.3390/v3020102
Reference
PMID:27854326
  Authors
Jiang Y, Qin Y, Chen M
  Title
Host-Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity.
  Journal
Viruses 8:E308 (2016)
DOI:10.3390/v8110308
Reference
PMID:18922877
  Authors
Pfaller CK, Conzelmann KK
  Title
Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
  Journal
J Virol 82:12365-73 (2008)
DOI:10.1128/JVI.01321-08
Reference
PMID:17720800
  Authors
Yokota S, Okabayashi T, Yokosawa N, Fujii N
  Title
Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.
  Journal
FASEB J 22:74-83 (2008)
DOI:10.1096/fj.07-8976com
Reference
PMID:23146309
  Authors
Delpeut S, Noyce RS, Siu RW, Richardson CD
  Title
Host factors and measles virus replication.
  Journal
Curr Opin Virol 2:773-83 (2012)
DOI:10.1016/j.coviro.2012.10.008
Reference
PMID:26878224
  Authors
Shah M, Anwar MA, Kim JH, Choi S
  Title
Advances in Antiviral Therapies Targeting Toll-like Receptors.
  Journal
Expert Opin Investig Drugs 25:437-53 (2016)
DOI:10.1517/13543784.2016.1154040
Reference
PMID:12620806
  Authors
Yokota S, Saito H, Kubota T, Yokosawa N, Amano K, Fujii N
  Title
Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex.
  Journal
Virology 306:135-46 (2003)
DOI:10.1016/S0042-6822(02)00026-0
Reference
PMID:12804771
  Authors
Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K
  Title
Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.
  Journal
FEBS Lett 545:177-82 (2003)
DOI:10.1016/S0014-5793(03)00528-3
Reference
PMID:12805463
  Authors
Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM
  Title
STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.
  Journal
J Virol 77:7635-44 (2003)
DOI:10.1128/JVI.77.13.7635-7644.2003
Reference
PMID:14585342
  Authors
Shaffer JA, Bellini WJ, Rota PA
  Title
The C protein of measles virus inhibits the type I interferon response.
  Journal
Virology 315:389-97 (2003)
DOI:10.1016/S0042-6822(03)00537-3
Reference
PMID:16971451
  Authors
Carsillo T, Traylor Z, Choi C, Niewiesk S, Oglesbee M
  Title
hsp72, a host determinant of measles virus neurovirulence.
  Journal
J Virol 80:11031-9 (2006)
DOI:10.1128/JVI.01438-06
Reference
PMID:15914229
  Authors
Zhang X, Bourhis JM, Longhi S, Carsillo T, Buccellato M, Morin B, Canard B, Oglesbee M
  Title
Hsp72 recognizes a P binding motif in the measles virus N protein C-terminus.
  Journal
Virology 337:162-74 (2005)
DOI:10.1016/j.virol.2005.03.035
Reference
PMID:29712906
  Authors
Ke Z, Strauss JD, Hampton CM, Brindley MA, Dillard RS, Leon F, Lamb KM, Plemper RK, Wright ER
  Title
Promotion of virus assembly and organization by the measles virus matrix protein.
  Journal
Nat Commun 9:1736 (2018)
DOI:10.1038/s41467-018-04058-2
Reference
PMID:24155404
  Authors
Pfaller CK, Radeke MJ, Cattaneo R, Samuel CE
  Title
Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R.
  Journal
J Virol 88:456-68 (2014)
DOI:10.1128/JVI.02572-13
Reference
PMID:17686838
  Authors
Sato H, Masuda M, Kanai M, Tsukiyama-Kohara K, Yoneda M, Kai C
  Title
Measles virus N protein inhibits host translation by binding to eIF3-p40.
  Journal
J Virol 81:11569-76 (2007)
DOI:10.1128/JVI.00570-07
Reference
PMID:19895323
  Authors
Sion-Vardy N, Lasarov I, Delgado B, Gopas J, Benharroch D, Ariad S
  Title
Measles virus: evidence for association with lung cancer.
  Journal
Exp Lung Res 35:701-12 (2009)
DOI:10.3109/01902140902853176
Reference
PMID:16140759
  Authors
Chen M, Cortay JC, Logan IR, Sapountzi V, Robson CN, Gerlier D
  Title
Inhibition of ubiquitination and stabilization of human ubiquitin E3 ligase PIRH2 by measles virus phosphoprotein.
  Journal
J Virol 79:11824-36 (2005)
DOI:10.1128/JVI.79.18.11824-11836.2005
Reference
PMID:16699046
  Authors
Cruz CD, Palosaari H, Parisien JP, Devaux P, Cattaneo R, Ouchi T, Horvath CM
  Title
Measles virus V protein inhibits p53 family member p73.
  Journal
J Virol 80:5644-50 (2006)
DOI:10.1128/JVI.02400-05
Reference
PMID:10756053
  Authors
Servet-Delprat C, Vidalain PO, Azocar O, Le Deist F, Fischer A, Rabourdin-Combe C
  Title
Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus.
  Journal
J Virol 74:4387-93 (2000)
DOI:10.1128/JVI.74.9.4387-4393.2000
Reference
PMID:20601611
  Authors
Kushwah R, Hu J
  Title
Dendritic cell apoptosis: regulation of tolerance versus immunity.
  Journal
J Immunol 185:795-802 (2010)
DOI:10.4049/jimmunol.1000325
Reference
PMID:10590149
  Authors
Vidalain PO, Azocar O, Lamouille B, Astier A, Rabourdin-Combe C, Servet-Delprat C
  Title
Measles virus induces functional TRAIL production by human dendritic cells.
  Journal
J Virol 74:556-9 (2000)
DOI:10.1128/JVI.74.1.556-559.2000
Reference
PMID:11846228
  Authors
Vidalain PO, Azocar O, Rabourdin-Combe C, Servet-Delprat C
  Title
Measle virus-infected dendritic cells develop immunosuppressive and cytotoxic activities.
  Journal
Immunobiology 204:629-38 (2001)
DOI:10.1078/0171-2985-00102
Reference
PMID:10423127
  Authors
Engelking O, Fedorov LM, Lilischkis R, ter Meulen V, Schneider-Schaulies S
  Title
Measles virus-induced immunosuppression in vitro is associated with deregulation of G1 cell cycle control proteins.
  Journal
J Gen Virol 80 ( Pt 7):1599-608 (1999)
DOI:10.1099/0022-1317-80-7-1599
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:20636817
  Authors
Griffin DE
  Title
Measles virus-induced suppression of immune responses.
  Journal
Immunol Rev 236:176-89 (2010)
DOI:10.1111/j.1600-065X.2010.00925.x
Reference
PMID:11385511
  Authors
Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S
  Title
Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.
  Journal
Nat Med 7:725-31 (2001)
DOI:10.1038/89106
Reference
PMID:15308747
  Authors
Avota E, Muller N, Klett M, Schneider-Schaulies S
  Title
Measles virus interacts with and alters signal transduction in T-cell lipid rafts.
  Journal
J Virol 78:9552-9 (2004)
DOI:10.1128/JVI.78.17.9552-9559.2004
Reference
PMID:16963735
  Authors
Yanagi Y, Takeda M, Ohno S
  Title
Measles virus: cellular receptors, tropism and pathogenesis.
  Journal
J Gen Virol 87:2767-79 (2006)
DOI:10.1099/vir.0.82221-0
Reference
PMID:16237742
  Authors
Kerdiles YM, Sellin CI, Druelle J, Horvat B
  Title
Immunosuppression caused by measles virus: role of viral proteins.
  Journal
Rev Med Virol 16:49-63 (2006)
DOI:10.1002/rmv.486
Related
pathway
pvp04110  Cell cycle
pvp04115  p53 signaling pathway
pvp04120  Ubiquitin mediated proteolysis
pvp04210  Apoptosis
pvp04620  Toll-like receptor signaling pathway
pvp04622  RIG-I-like receptor signaling pathway
pvp04630  JAK-STAT signaling pathway
pvp04658  Th1 and Th2 cell differentiation
pvp04660  T cell receptor signaling pathway
KO pathway
ko05162   
LinkDB

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