KEGG   PATHWAY: sbq05163
Entry
sbq05163                    Pathway                                
Name
Human cytomegalovirus infection - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
sbq05163  Human cytomegalovirus infection
sbq05163

Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN:sbq]
Gene
101040156  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
101029768  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101052779  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101027982  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101032496  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101033359  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101050592  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101034861  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101045714  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101040766  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101028002  TSC1; hamartin isoform X1 [KO:K07206]
101031475  TSC2; tuberin isoform X5 [KO:K07207]
101047083  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101030055  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
101029508  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101033758  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
101038541  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101044006  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101052971  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101043425  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101035787  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101035406  RELA; transcription factor p65 [KO:K04735]
101047461  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101038666  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101036943  SOS1; son of sevenless homolog 1 [KO:K03099]
101046427  SOS2; son of sevenless homolog 2 [KO:K03099]
101047663  HRAS; GTPase HRas isoform X2 [KO:K02833]
101047035  KRAS; GTPase KRas isoform X1 [KO:K07827]
101036877  NRAS; GTPase NRas [KO:K07828]
101054052  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101040361  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101036151  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101038546  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101043202  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101045005  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101048381  SP1; transcription factor Sp1 [KO:K04684]
101032614  ITGAV; integrin alpha-V [KO:K06487]
101049562  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
101051959  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101042808  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101029481  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101046124  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101052068  RHOA; transforming protein RhoA [KO:K04513]
104650592  ras-like GTP-binding protein O-RHO [KO:K04513]
104652261  RHOC; rho-related GTP-binding protein RhoC [KO:K04513]
101052976  MB21D1; cyclic GMP-AMP synthase isoform X2 [KO:K17834] [EC:2.7.7.86]
101032869  TMEM173; stimulator of interferon genes protein isoform X1 [KO:K12654]
101053608  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101033122  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
101032308  interferon alpha-8-like [KO:K05414]
101032622  interferon alpha-2-like [KO:K05414]
101032943  IFNA13; interferon alpha-1/13 [KO:K05414]
104649849  interferon alpha-5-like [KO:K05414]
101034105  interferon alpha-8-like [KO:K05414]
101034416  interferon alpha-5-like [KO:K05414]
101034728  IFNA21; interferon alpha-21 [KO:K05414]
101035681  IFNB1; interferon beta [KO:K05415]
101031357  TNF; tumor necrosis factor isoform X2 [KO:K03156]
104649955  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
101047042  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
101050794  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
101031994  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
101035434  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101033664  IL1B; interleukin-1 beta [KO:K04519]
101031937  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
101048714  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101052050  CCL2; C-C motif chemokine 2 [KO:K14624]
101053219  CCL5; C-C motif chemokine 5 [KO:K12499]
101049298  CXCL8; interleukin-8 [KO:K10030]
101034757  IL6; interleukin-6 [KO:K05405]
101041488  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101050677  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101030203  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101030409  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
101038619  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101041345  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101030348  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101037908  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101030524  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101044875  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101051683  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101046368  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101044114  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101051855  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
101032578  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
101046851  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
101047168  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
101052271  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101029401  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
101029556  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101049881  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101048916  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101036413  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
101031785  calmodulin-alpha-like [KO:K02183]
101041174  CALML6; calmodulin-like protein 6 isoform X2 [KO:K02183]
101029957  CALM3; calmodulin [KO:K02183]
101047982  CALM2; calmodulin [KO:K02183]
101039332  CALML3; calmodulin-like protein 3 [KO:K02183]
101039863  CALML5; calmodulin-like protein 5 [KO:K02183]
101049022  CALM1; LOW QUALITY PROTEIN: calmodulin [KO:K02183]
101045514  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101035788  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101032266  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101039659  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
104650539  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101049490  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
101040060  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101043069  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
101027603  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
101042629  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101041681  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
101032105  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
101049046  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
101027981  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
101043334  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101040601  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101044688  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
101049747  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
101037803  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
101032672  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101034552  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
101052034  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
101034152  cAMP-dependent protein kinase catalytic subunit gamma-like [KO:K04345] [EC:2.7.11.11]
101036705  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101043989  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
101047300  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101028834  C-C motif chemokine 3-like 1 [KO:K05408]
104651567  C-C motif chemokine 3-like [KO:K05408]
101028297  CCL4; C-C motif chemokine 4 isoform X2 [KO:K12964]
101044920  CX3CL1; fractalkine [KO:K05508]
101042405  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
101034540  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
101043419  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
101038799  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X8 [KO:K12331]
101040423  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
101049632  AKAP13; A-kinase anchor protein 13 isoform X1 [KO:K16529]
101051787  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
101028677  LOW QUALITY PROTEIN: rho-associated protein kinase 1-like [KO:K04514] [EC:2.7.11.1]
101039371  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101043327  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
101043873  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
104649855  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
101032719  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
101043452  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
104652116  neuroendocrine secretory protein 55 [KO:K04632]
101051107  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
101047858  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
101047066  MYC; myc proto-oncogene protein isoform X2 [KO:K04377]
101037958  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
101031615  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101049662  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
101032691  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
101030219  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
101037444  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101044137  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101040899  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101052690  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101034085  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101035834  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101034435  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101042795  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
101044974  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101036473  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
101052885  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101041199  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X4 [KO:K09048]
101054090  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
101047355  ATF6B; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
101050663  CXCL12; stromal cell-derived factor 1 isoform X3 [KO:K10031]
101042221  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101046010  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101039384  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101032613  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101032561  PTK2B; protein-tyrosine kinase 2-beta isoform X2 [KO:K05871] [EC:2.7.10.2]
101052217  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
101041293  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
101051048  CRKL; crk-like protein [KO:K04438]
101029260  CRK; adapter molecule crk [KO:K04438]
101054286  PXN; paxillin isoform X1 [KO:K05760]
101032801  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
101035361  interleukin-10 receptor subunit beta isoform X4 [KO:K05135]
101038106  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
101037693  CCR1; C-C chemokine receptor type 1 [KO:K04176]
101054252  CCR3; C-C chemokine receptor type 3 [KO:K04178]
101029550  CCR5; C-C chemokine receptor type 5 [KO:K04180]
101050206  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
101052015  TAP2; LOW QUALITY PROTEIN: antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
101044016  TAPBP; tapasin [KO:K08058]
101042173  PDIA3; LOW QUALITY PROTEIN: protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
101043082  CALR; calreticulin [KO:K08057]
101042893  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101043856  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101046108  HLA class I histocompatibility antigen, B-27 alpha chain-like [KO:K06751]
104650390  class I histocompatibility antigen, B alpha chain-like [KO:K06751]
104650398  putative HLA class I histocompatibility antigen, alpha chain H [KO:K06751]
101032412  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
101040674  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101041111  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101033054  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
101040568  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
101040877  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like isoform X1 [KO:K06751]
101044935  LOW QUALITY PROTEIN: popy class I histocompatibility antigen, alpha chain E [KO:K06751]
101050220  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101050865  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101047890  B2M; beta-2-microglobulin isoform X2 [KO:K08055]
101038444  cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 [KO:K06621]
101036938  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
101043647  TP53; cellular tumor antigen p53 [KO:K04451]
101041919  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
101040767  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101040507  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101038309  RB1; retinoblastoma-associated protein [KO:K06618]
101029045  E2F1; transcription factor E2F1 [KO:K17454]
101042612  E2F2; transcription factor E2F2 [KO:K09389]
101034207  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
101035660  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
101035635  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101046905  FADD; FAS-associated death domain protein [KO:K02373]
101053601  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101040331  BID; BH3-interacting domain death agonist [KO:K04726]
101050177  BAX; apoptosis regulator BAX [KO:K02159]
101041291  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101033270  cytochrome c [KO:K08738]
101034412  cytochrome c-like [KO:K08738]
101051525  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101029697  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:19107226
  Authors
Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
PMID:24839861
  Authors
Roy S, Arav-Boger R
  Title
New cell-signaling pathways for controlling cytomegalovirus replication.
  Journal
Am J Transplant 14:1249-58 (2014)
DOI:10.1111/ajt.12725
Reference
PMID:14720582
  Authors
Cinatl J, Scholz M, Kotchetkov R, Vogel JU, Doerr HW
  Title
Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology.
  Journal
Trends Mol Med 10:19-23 (2004)
DOI:10.1016/j.molmed.2003.11.002
Reference
PMID:15380778
  Authors
Evers DL, Wang X, Huang ES
  Title
Cellular stress and signal transduction responses to human cytomegalovirus infection.
  Journal
Microbes Infect 6:1084-93 (2004)
DOI:10.1016/j.micinf.2004.05.026
Reference
PMID:29547547
  Authors
Murray MJ, Peters NE, Reeves MB
  Title
Navigating the Host Cell Response during Entry into Sites of Latent Cytomegalovirus Infection.
  Journal
Pathogens 7:E30 (2018)
DOI:10.3390/pathogens7010030
Reference
PMID:27501260
  Authors
Campadelli-Fiume G, Collins-McMillen D, Gianni T, Yurochko AD
  Title
Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome.
  Journal
Annu Rev Virol 3:215-236 (2016)
DOI:10.1146/annurev-virology-110615-035618
Reference
PMID:28132838
  Authors
Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB
  Title
Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity.
  Journal
Cell Host Microbe 21:231-243 (2017)
DOI:10.1016/j.chom.2017.01.001
Reference
PMID:29082387
  Authors
Hancock MH, Nelson JA
  Title
Modulation of the NFkappab Signalling Pathway by Human Cytomegalovirus.
  Journal
Virology (Hyderabad) 1:104 (2017)
Reference
PMID:21383764
  Authors
Rahman MM, McFadden G
  Title
Modulation of NF-kappaB signalling by microbial pathogens.
  Journal
Nat Rev Microbiol 9:291-306 (2011)
DOI:10.1038/nrmicro2539
Reference
PMID:27060663
  Authors
Zhang J, Feng H, Xu S, Feng P
  Title
Hijacking GPCRs by viral pathogens and tumor.
  Journal
Biochem Pharmacol 114:69-81 (2016)
DOI:10.1016/j.bcp.2016.03.021
Reference
PMID:28035083
  Authors
Lee S, Chung YH, Lee C
  Title
US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection.
  Journal
Biomol Ther (Seoul) 25:69-79 (2017)
DOI:10.4062/biomolther.2016.208
Reference
PMID:23145028
  Authors
Langemeijer EV, Slinger E, de Munnik S, Schreiber A, Maussang D, Vischer H, Verkaar F, Leurs R, Siderius M, Smit MJ
  Title
Constitutive beta-catenin signaling by the viral chemokine receptor US28.
  Journal
PLoS One 7:e48935 (2012)
DOI:10.1371/journal.pone.0048935
Reference
PMID:15990176
  Authors
Couty JP, Gershengorn MC
  Title
G-protein-coupled receptors encoded by human herpesviruses.
  Journal
Trends Pharmacol Sci 26:405-11 (2005)
DOI:10.1016/j.tips.2005.06.004
Reference
PMID:25549333
  Authors
Fiallos E, Judkins J, Matlaf L, Prichard M, Dittmer D, Cobbs C, Soroceanu L
  Title
Human cytomegalovirus gene expression in long-term infected glioma stem cells.
  Journal
PLoS One 9:e116178 (2014)
DOI:10.1371/journal.pone.0116178
Reference
PMID:24445563
  Authors
Vischer HF, Siderius M, Leurs R, Smit MJ
  Title
Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
  Journal
Nat Rev Drug Discov 13:123-39 (2014)
DOI:10.1038/nrd4189
Reference
PMID:20398729
  Authors
Slinger E, Langemeijer E, Siderius M, Vischer HF, Smit MJ
  Title
Herpesvirus-encoded GPCRs rewire cellular signaling.
  Journal
Mol Cell Endocrinol 331:179-84 (2011)
DOI:10.1016/j.mce.2010.04.007
Reference
PMID:11175803
  Authors
Murphy PM
  Title
Viral exploitation and subversion of the immune system through chemokine mimicry.
  Journal
Nat Immunol 2:116-22 (2001)
DOI:10.1038/84214
Reference
PMID:16352349
  Authors
Vischer HF, Leurs R, Smit MJ
  Title
HCMV-encoded G-protein-coupled receptors as constitutively active modulators of cellular signaling networks.
  Journal
Trends Pharmacol Sci 27:56-63 (2006)
DOI:10.1016/j.tips.2005.11.006
Reference
PMID:25805993
  Authors
de Munnik SM, Smit MJ, Leurs R, Vischer HF
  Title
Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.
  Journal
Front Pharmacol 6:40 (2015)
DOI:10.3389/fphar.2015.00040
Reference
PMID:15172446
  Authors
Michelson S
  Title
Consequences of human cytomegalovirus mimicry.
  Journal
Hum Immunol 65:465-75 (2004)
DOI:10.1016/j.humimm.2004.02.002
Reference
PMID:29237840
  Authors
Tu CC, Arnolds KL, O'Connor CM, Spencer JV
  Title
Human Cytomegalovirus UL111A and US27 Gene Products Enhance the CXCL12/CXCR4 Signaling Axis via Distinct Mechanisms.
  Journal
J Virol 92:e01981-17 (2018)
DOI:10.1128/JVI.01981-17
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:22454101
  Authors
Noriega V, Redmann V, Gardner T, Tortorella D
  Title
Diverse immune evasion strategies by human cytomegalovirus.
  Journal
Immunol Res 54:140-51 (2012)
DOI:10.1007/s12026-012-8304-8
Reference
PMID:17145306
  Authors
Loureiro J, Ploegh HL
  Title
Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions.
  Journal
Adv Immunol 92:225-305 (2006)
DOI:10.1016/S0065-2776(06)92006-9
Reference
PMID:10707064
  Authors
Fortunato EA, McElroy AK, Sanchez I, Spector DH
  Title
Exploitation of cellular signaling and regulatory pathways by human cytomegalovirus.
  Journal
Trends Microbiol 8:111-9 (2000)
DOI:10.1016/S0966-842X(00)01699-1
Reference
PMID:15389728
  Authors
Cinatl J Jr, Scholz M, Doerr HW
  Title
Role of tumor cell immune escape mechanisms in cytomegalovirus-mediated oncomodulation.
  Journal
Med Res Rev 25:167-85 (2005)
DOI:10.1002/med.20018
Reference
PMID:14975530
  Authors
Cinatl J Jr, Vogel JU, Kotchetkov R, Wilhelm Doerr H
  Title
Oncomodulatory signals by regulatory proteins encoded by human cytomegalovirus: a novel role for viral infection in tumor progression.
  Journal
FEMS Microbiol Rev 28:59-77 (2004)
DOI:10.1016/j.femsre.2003.07.005
Reference
PMID:12062798
  Authors
Castillo JP, Kowalik TF
  Title
Human cytomegalovirus immediate early proteins and cell growth control.
  Journal
Gene 290:19-34 (2002)
DOI:10.1016/S0378-1119(02)00566-8
Reference
PMID:15352160
  Authors
Kalejta RF
  Title
Human cytomegalovirus pp71: a new viral tool to probe the mechanisms of cell cycle progression and oncogenesis controlled by the retinoblastoma family of tumor suppressors.
  Journal
J Cell Biochem 93:37-45 (2004)
DOI:10.1002/jcb.20177
Reference
PMID:20969904
  Authors
Brune W
  Title
Inhibition of programmed cell death by cytomegaloviruses.
  Journal
Virus Res 157:144-50 (2011)
DOI:10.1016/j.virusres.2010.10.012
Reference
PMID:28869497
  Authors
Brune W, Andoniou CE
  Title
Die Another Day: Inhibition of Cell Death Pathways by Cytomegalovirus.
  Journal
Viruses 9:E249 (2017)
DOI:10.3390/v9090249
Reference
PMID:27160907
  Authors
Yamin R, Lecker LSM, Weisblum Y, Vitenshtein A, Le-Trilling VTK, Wolf DG, Mandelboim O
  Title
HCMV vCXCL1 Binds Several Chemokine Receptors and Preferentially Attracts Neutrophils over NK Cells by Interacting with CXCR2.
  Journal
Cell Rep 15:1542-1553 (2016)
DOI:10.1016/j.celrep.2016.04.042
Reference
PMID:28488292
  Authors
Wang X, Sanchez J, Stone MJ, Payne RJ
  Title
Sulfation of the Human Cytomegalovirus Protein UL22A Enhances Binding to the Chemokine RANTES.
  Journal
Angew Chem Int Ed Engl 56:8490-8494 (2017)
DOI:10.1002/anie.201703059
Related
pathway
sbq00590  Arachidonic acid metabolism
sbq03050  Proteasome
sbq04010  MAPK signaling pathway
sbq04064  NF-kappa B signaling pathway
sbq04110  Cell cycle
sbq04150  mTOR signaling pathway
sbq04151  PI3K-Akt signaling pathway
sbq04210  Apoptosis
sbq04612  Antigen processing and presentation
sbq04623  Cytosolic DNA-sensing pathway
sbq04630  JAK-STAT signaling pathway
sbq04668  TNF signaling pathway
sbq04810  Regulation of actin cytoskeleton
KO pathway
ko05163   
LinkDB

DBGET integrated database retrieval system