KEGG   PATHWAY: shon05169
Entry
shon05169                   Pathway                                
Name
Epstein-Barr virus infection - Sturnira hondurensis
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
shon05169  Epstein-Barr virus infection
shon05169

Organism
Sturnira hondurensis [GN:shon]
Gene
118982573  CR2; complement receptor type 2 isoform X1 [KO:K04012]
118981330  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
118981732  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
118982809  LOW QUALITY PROTEIN: RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
118999033  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
118999034  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
118999036  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
118999037  boLa class II histocompatibility antigen, DQB*0101 beta chain-like isoform X1 [KO:K06752]
118991469  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
118991472  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
118991540  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
118991542  uncharacterized protein LOC118991542 [KO:K06752]
118999195  H-2 class II histocompatibility antigen, I-E beta chain-like [KO:K06752]
118984928  LOW QUALITY PROTEIN: RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
118995387  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
118997428  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
118994306  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
118983180  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
119002380  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
118978986  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
118982270  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
118999523  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118993207  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118994325  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118993928  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
118979949  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118991736  RELA; transcription factor p65 [KO:K04735]
118987585  TNF; tumor necrosis factor isoform X1 [KO:K03156]
118979610  DDX58; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
118990900  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
118976597  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
118998723  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
119001656  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
118982245  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
118997983  interferon alpha-2-like [KO:K05414]
118984066  interferon alpha-4-like [KO:K05414]
118978917  interferon alpha-2-like [KO:K05414]
118997987  interferon beta-2-like [KO:K05415]
118997988  interferon beta-2-like [KO:K05415]
118997989  interferon beta-2-like [KO:K05415]
118997990  interferon beta-2-like [KO:K05415]
119000288  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
119000285  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
118985040  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
118985299  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
118975851  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
118980890  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
119001265  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
118991120  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
118991332  LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 3-like [KO:K14216] [EC:2.7.7.84]
118977154  2'-5'-oligoadenylate synthase 1-like isoform X1 [KO:K14216] [EC:2.7.7.84]
118990377  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
118985011  C-X-C motif chemokine 10-like [KO:K12671]
118998232  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
118987956  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
118998399  FADD; FAS-associated death domain protein [KO:K02373]
118985238  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
118995133  BID; BH3-interacting domain death agonist [KO:K04726]
118994170  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
118979386  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
118991499  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
118983604  cytochrome c [KO:K08738]
119001286  cytochrome c-like [KO:K08738]
118985954  cytochrome c-like [KO:K08738]
119002556  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
118986319  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
118993073  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
118995118  uncharacterized protein LOC118995118 [KO:K10784]
118994765  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
118994762  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
118994764  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
118979262  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
118994440  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
118976569  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
118988093  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
118992403  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
118974513  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
119003765  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
118974186  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
118999160  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
118978090  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
119003524  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
119003453  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
118983416  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
118983790  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
118974903  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
118985782  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
118976332  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
118996566  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
118987335  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
118991465  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
118991466  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
118991490  tapasin isoform X1 [KO:K08058]
118992559  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
118984114  CALR; calreticulin [KO:K08057]
119004008  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
118980727  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
118980772  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
118996659  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751]
118981397  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
118981398  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
118981399  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
118981513  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
118981536  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
118981733  popy Class I histocompatibility antigen, A-1 alpha chain-like isoform X1 [KO:K06751]
118981759  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
118996962  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
118997317  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
118997319  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
118997469  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
118982113  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
118974354  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118974356  HLA class I histocompatibility antigen, alpha chain E-like [KO:K06751]
118974594  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
118982708  popy class I histocompatibility antigen, alpha chain E-like isoform X1 [KO:K06751]
118974887  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
118982813  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
118982835  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
118982863  class I histocompatibility antigen, Gogo-B*0201 alpha chain-like [KO:K06751]
118999075  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
118999079  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118999080  HLA class I histocompatibility antigen, alpha chain F-like isoform X1 [KO:K06751]
118983746  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
118991392  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
118991570  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like isoform X1 [KO:K06751]
118999324  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
118983999  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
118984161  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
118999599  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
118976536  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
118992170  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like [KO:K06751]
118992194  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
118992220  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
118977201  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
118977214  patr class I histocompatibility antigen, alpha chain E-like [KO:K06751]
118984919  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
118984920  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119000606  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
118977705  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
118993317  popy Class I histocompatibility antigen, A-1 alpha chain-like isoform X1 [KO:K06751]
119001579  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
119001581  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119002099  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
118978534  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
118978541  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
118978542  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118986505  patr class I histocompatibility antigen, B-2 alpha chain-like [KO:K06751]
118986617  patr class I histocompatibility antigen, B-2 alpha chain-like [KO:K06751]
118994399  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
118986866  popy Class I histocompatibility antigen, A-1 alpha chain-like isoform X1 [KO:K06751]
118987037  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
118987155  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
118987156  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
119002841  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like [KO:K06751]
118979575  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
118995180  HLA class I histocompatibility antigen, alpha chain E-like [KO:K06751]
119003007  uncharacterized protein LOC119003007 [KO:K06751]
118992572  B2M; beta-2-microglobulin [KO:K08055]
118976628  SNW1; SNW domain-containing protein 1 [KO:K06063]
118987735  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
118997724  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
119000192  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
118991010  NCOR2; nuclear receptor corepressor 2 isoform X1 [KO:K06065]
118984303  SAP30; histone deacetylase complex subunit SAP30 [KO:K19202]
118986121  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
118985690  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
118985524  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
118985975  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
118982930  HES1; transcription factor HES-1 [KO:K06054]
118987697  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
118977790  RUNX3; runt-related transcription factor 3 [KO:K09279]
118988677  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
118992721  ubiquitin carboxyl-terminal hydrolase 7-like [KO:K11838] [EC:3.4.19.12]
118992723  ubiquitin carboxyl-terminal hydrolase 7 [KO:K11838] [EC:3.4.19.12]
118989366  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
118974748  TP53; cellular tumor antigen p53 [KO:K04451]
118998962  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
118984458  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
118984673  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
118978970  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
118974481  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
118977345  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
119004242  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
118997522  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118986375  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118995662  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118982454  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118975178  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118998595  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118988441  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119003271  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118988089  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119001650  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
118995331  RELB; transcription factor RelB isoform X1 [KO:K09253]
118999475  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
118983883  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
118976327  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
118992175  NFKBIE; NF-kappa-B inhibitor epsilon isoform X1 [KO:K05872]
118974732  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
118994072  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118976281  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118994117  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118995102  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118980132  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
118986453  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
119002731  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
119003578  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
118988883  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118988898  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
118998971  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118998973  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
118984936  JUN; transcription factor AP-1 [KO:K04448]
118980251  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
118990299  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
118976189  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
118985558  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
118983169  CD44; CD44 antigen isoform X1 [KO:K06256]
118997404  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
118981973  CD58; lymphocyte function-associated antigen 3 [KO:K06492]
118997141  VIM; vimentin [KO:K07606]
118986669  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
118975019  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
118978208  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
118974987  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
118983557  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
118992244  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
118995001  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
118996677  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
118990295  BLNK; B-cell linker protein [KO:K07371]
118983037  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
118998776  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
118978371  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
118998396  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
118999952  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
118991404  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
118975891  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
119000945  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
118974983  LOW QUALITY PROTEIN: cyclin-A2-like [KO:K06627]
118994860  CCNA1; cyclin-A1 [KO:K06627]
118995492  CCNA2; cyclin-A2 [KO:K06627]
119001171  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
118995572  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
118975970  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
118983966  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
118985966  E2F1; transcription factor E2F1 [KO:K17454]
118977797  E2F2; transcription factor E2F2 [KO:K09389]
118981164  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
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Nat Rev Cancer 4:757-68 (2004)
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Clin Cancer Res 17:3056-63 (2011)
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Herpesviridae 2:1 (2011)
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Recent advances in understanding Epstein-Barr virus.
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F1000Res 6:386 (2017)
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van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
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Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
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PLoS Pathog 10:e1003960 (2014)
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  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
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Trends Microbiol 21:421-9 (2013)
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  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
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Trends Immunol 36:124-38 (2015)
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  Authors
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  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
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Adv Hematol 2011:829525 (2011)
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  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
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J Zhejiang Univ Sci B 14:8-24 (2013)
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Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
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Nat Rev Immunol 9:503-13 (2009)
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Semin Cancer Biol 18:397-408 (2008)
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Biomolecules 6:E46 (2016)
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Semin Cancer Biol 22:144-53 (2012)
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  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
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Exp Mol Med 47:e133 (2015)
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  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
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Cell Mol Immunol 4:185-96 (2007)
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  Title
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Viruses 5:1587-606 (2013)
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Reference
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Wang LW, Jiang S, Gewurz BE
  Title
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J Virol 91:e01718-16 (2017)
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Mori N, Morishita M, Tsukazaki T, Yamamoto N
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Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
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Int J Cancer 105:661-8 (2003)
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Reference
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Edwards RH, Marquitz AR, Raab-Traub N
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Epstein-Barr virus: exploiting the immune system.
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Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
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Cancers (Basel) 10:E213 (2018)
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Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
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Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
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PLoS Pathog 5:e1000530 (2009)
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Reference
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Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
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Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
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J Virol 83:4652-69 (2009)
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Reference
PMID:19394062
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Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
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Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
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Virology 388:236-47 (2009)
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Reference
PMID:25635182
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Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
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Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
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Future Virol 4:79-91 (2009)
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Reference
PMID:10818681
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Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
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Adv Cancer Res 79:175-200 (2000)
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Reference
PMID:30116721
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El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
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Front Oncol 8:265 (2018)
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Reference
PMID:12811813
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Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
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J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
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PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
shon03050  Proteasome
shon04010  MAPK signaling pathway
shon04020  Calcium signaling pathway
shon04064  NF-kappa B signaling pathway
shon04110  Cell cycle
shon04115  p53 signaling pathway
shon04210  Apoptosis
shon04612  Antigen processing and presentation
shon04620  Toll-like receptor signaling pathway
shon04622  RIG-I-like receptor signaling pathway
shon04630  JAK-STAT signaling pathway
shon04662  B cell receptor signaling pathway
KO pathway
ko05169   
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