KEGG   PATHWAY: xtr04820
Entry
xtr04820                    Pathway                                
Name
Cytoskeleton in muscle cells - Xenopus tropicalis (tropical clawed frog)
Class
Cellular Processes; Cell motility
Pathway map
xtr04820  Cytoskeleton in muscle cells
xtr04820

Organism
Xenopus tropicalis (tropical clawed frog) [GN:xtr]
Gene
496414  col1a1; collagen alpha-1(I) chain precursor [KO:K06236]
780175  col1a2; collagen alpha-2(I) chain precursor [KO:K06236]
100124865  col3a1; collagen alpha-1(III) chain precursor [KO:K19720]
116410519  collagen alpha-1(III) chain-like [KO:K19720]
100497990  collagen alpha-3(V) chain isoform X2 [KO:K19721]
100038277  col5a1; collagen alpha-1(V) chain isoform X1 [KO:K19721]
100492754  col5a2; collagen alpha-2(V) chain [KO:K19721]
733808  col5a3; collagen alpha-1(XI) chain isoform X2 [KO:K19721]
100495290  collagen alpha-1(I) chain isoform X4 [KO:K19721]
100490770  col27a1; collagen alpha-1(XXVII) chain isoform X2 [KO:K19721]
100488265  col11a2; collagen alpha-2(XI) chain isoform X1 [KO:K19721]
780330  col24a1; collagen alpha-1(XXIV) chain precursor [KO:K19721]
100145619  col9a3; collagen alpha-3(IX) chain precursor [KO:K08131]
100036633  col9a2; collagen alpha-2(IX) chain precursor [KO:K08131]
100145133  col9a1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
100101716  dcn; decorin precursor [KO:K04660]
100101672  vcan; versican core protein [KO:K06793]
779443  eln1; elastin precursor [KO:K14211]
100145523  col6a2; collagen alpha-2(VI) chain precursor [KO:K06238]
100486063  col6a5; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
100488707  col6a3; collagen alpha-3(VI) chain isoform X2 [KO:K06238]
100490352  col6a1; collagen alpha-1(VI) chain [KO:K06238]
100487679  col6a6; collagen alpha-6(VI) chain [KO:K06238]
100170153  thbs1; thrombospondin-1 [KO:K16857]
496875  thbs3; thrombospondin-3 precursor [KO:K04659]
780130  thbs4; thrombospondin-4 precursor [KO:K04659]
100494997  thbs2; thrombospondin-2 [KO:K04659]
100494714  comp; cartilage oligomeric matrix protein [KO:K04659]
100490545  fbn1; fibrillin-1 [KO:K06825]
100494368  fbn2; fibrillin-2 [KO:K23342]
100151721  fbn3; fibrillin-3 precursor [KO:K23342]
100124870  col4a1; collagen alpha-1(IV) chain [KO:K06237]
100486079  col4a2; collagen alpha-2(IV) chain [KO:K06237]
100492984  col4a5; collagen alpha-5(IV) chain isoform X2 [KO:K06237]
100493153  col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
100488229  fbln1; fibulin-1 isoform X1 [KO:K17307]
100487324  fbln2; fibulin-2 isoform X1 [KO:K17307]
100494785  hspg2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
100036716  nid2; nidogen-2 precursor [KO:K06826]
100493221  nid1; nidogen-1 isoform X1 [KO:K06826]
595087  fn1; fibronectin precursor [KO:K05717]
100038138  sdc1; syndecan-1 [KO:K06257]
549917  sdc2; syndecan-2 precursor [KO:K16336]
100134998  sdc3; syndecan-3 [KO:K16337]
100144973  sdc4; syndecan 4 precursor [KO:K16338]
100492176  agrn; agrin isoform X4 [KO:K06254]
780007  bgn; biglycan precursor [KO:K08118]
100495580  dsg2; desmoglein-2 isoform X1 [KO:K07597]
100124891  pkp2; plakophilin-2 [KO:K12642]
395011  jup; junction plakoglobin [KO:K10056]
496727  vim; vimentin [KO:K07606]
100495820  vim.2; vimentin [KO:K07606]
394739  des.1; desmin [KO:K07610]
100490404  des.2; vimentin A2 [KO:K07610]
100488009  lama1; laminin subunit alpha-1 isoform X2 [KO:K05637]
100497008  lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
100492880  itga1; integrin alpha-1 [KO:K06480]
100492714  itga2; integrin alpha-2 [KO:K06481]
100158580  itga2b.1; integrin alpha-IIb [KO:K06476]
100495138  itga2b.2; integrin alpha-IIb isoform X1 [KO:K06476]
100494331  itga3; integrin alpha-3 [KO:K06482]
100487924  itga4; integrin alpha-4 [KO:K06483]
100492002  itga5; integrin alpha-5 [KO:K06484]
100497992  itga6; integrin alpha-6 isoform X1 [KO:K06485]
100494050  itga7; integrin alpha-7 isoform X2 [KO:K06583]
100487624  itga8; integrin alpha-8 [KO:K06584]
100494771  itga9; integrin alpha-9 [KO:K06585]
101734246  itga10; integrin alpha-10 [KO:K06586]
100489152  itga11; integrin alpha-11 [KO:K06587]
100144691  itgav; integrin alpha-V [KO:K06487]
394767  itgb1; integrin beta-1 precursor [KO:K05719]
100498495  itgb3; integrin beta-3 [KO:K06493]
100485847  itgb4; integrin beta-4 isoform X1 [KO:K06525]
100216279  itgb5; integrin beta-5 precursor [KO:K06588]
100037861  itgb6; integrin beta-6 [KO:K06589]
100486332  itgb7; integrin beta-7 [KO:K06590]
100494899  itgb8; integrin beta-8 [KO:K06591]
733752  tln1; talin-1 isoform X1 [KO:K06271]
100144637  tln2; talin-2 isoform X1 [KO:K06271]
100036705  vcl; vinculin [KO:K05700]
100216053  actn3; alpha-actinin-3 [KO:K21073]
448602  actn2; alpha-actinin-2 [KO:K21073]
394957  actg1; actin, cytoplasmic 2 [KO:K05692]
407952  actb; actin, cytoplasmic 1 [KO:K05692]
549272  dag1; dystroglycan precursor [KO:K06265]
100488410  sgca; alpha-sarcoglycan [KO:K12565]
100496492  sgce; epsilon-sarcoglycan isoform X7 [KO:K27061]
100216021  sgcb; beta-sarcoglycan [KO:K12566]
100495350  sgcd; delta-sarcoglycan [KO:K12563]
780370  sgcg; gamma-sarcoglycan [KO:K12564]
100486888  sgcz; zeta-sarcoglycan isoform X1 [KO:K27062]
116409667  sspn; sarcospan [KO:K22194]
105946662  dmd.3; dystrophin isoform X1 [KO:K10366]
780141  snta1; alpha-1-syntrophin [KO:K24063]
100493340  sntb1; beta-1-syntrophin [KO:K24064]
100145613  sntb2; beta-2-syntrophin [KO:K24064]
779813  dtna; dystrobrevin alpha [KO:K26998]
100329116  flnc; filamin-C isoform X3 [KO:K27393]
100145440  atp1a3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
395044  atp1a1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
100125050  atp1a2; ATPase, Na+/K+ transporting, alpha 2 polypeptide [KO:K01539] [EC:7.2.2.13]
394667  atp1b2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
548592  atp1b1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
394687  atp1b3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
100490400  atp1b4; protein ATP1B4 isoform X1 [KO:K01540]
100216211  ank3; ankyrin-3 isoform X22 [KO:K09259]
100036647  sptan1; spectrin alpha chain, non-erythrocytic 1 [KO:K06114]
100488521  sptbn4; spectrin beta chain, non-erythrocytic 4 [KO:K06115]
100485263  sptbn5; spectrin beta chain, non-erythrocytic 5 [KO:K06115]
100145120  sptbn1; spectrin, beta, non-erythrocytic 1 [KO:K06115]
100486199  sptbn2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
448578  csrp3; cysteine and glycine-rich protein 3 [KO:K09377]
448688  csrp1; cysteine and glycine-rich protein 1 [KO:K09377]
549369  csrp2; cysteine and glycine-rich protein 2 [KO:K09377]
100216111  myh7; myosin, heavy chain 7, cardiac muscle, beta [KO:K24220]
100379877  myh8; myosin-4 [KO:K24220]
100492956  myh13; myosin-4 [KO:K24220]
100493121  myosin-4 [KO:K24220]
100495212  myosin-4-like [KO:K24220]
100495638  myosin-4 [KO:K24220]
100495802  myosin-4-like [KO:K24220]
100495968  myosin-4 isoform X1 [KO:K24220]
101730386  myosin-4-like [KO:K24220]
407946  myh4; myosin, heavy chain 4, skeletal muscle [KO:K24220]
448514  myh2; myosin, heavy chain 2, skeletal muscle, adult [KO:K24220]
448762  myh3; myosin heavy chain IIa [KO:K24220]
100495065  myosin-3 [KO:K24220]
100486122  myh7b; myosin-7B [KO:K24220]
100487082  myh15; myosin-15 [KO:K24220]
100485637  myosin-7 [KO:K17751]
100216059  myh6; myosin-6 isoform X1 [KO:K17751]
100487997  myh9; myosin-9 isoform X1 [KO:K10352]
100490639  myh11; myosin-11 isoform X2 [KO:K10352]
100493774  myosin-10 isoform X1 [KO:K10352]
394551  myl1; myosin light chain 1/3, skeletal muscle isoform [KO:K05738]
394608  myl3; myosin light chain 3 [KO:K12749]
100124786  myl4; myosin light chain 4 [KO:K12750]
100135705  myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100135145  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
100124811  myl9; myosin regulatory light polypeptide 9 [KO:K12755]
394763  mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
100487880  mybpc1; myosin-binding protein C, slow-type isoform X2 [KO:K12557]
100127192  mybpc2; myosin-binding protein C, fast-type isoform X1 [KO:K12558]
100127177  mybpc3; myosin-binding protein C, cardiac-type [KO:K12568]
734124  mybph; myosin binding protein H [KO:K24494]
394698  actc1; actin, alpha cardiac muscle 1 [KO:K12314]
394673  acta4; actin, striated muscle 3 [KO:K12314]
448346  acta1; actin, alpha skeletal muscle [KO:K12314]
394982  MGC75582; actin, alpha cardiac muscle 2 [KO:K12314]
447990  tnnc1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
394556  tnni1.2; troponin I type 1 (skeletal, slow) [KO:K10371]
100125108  tnni1; troponin I, slow skeletal muscle [KO:K10371]
100493291  tnnt1; troponin T, slow skeletal muscle isoform X10 [KO:K10372]
394554  tnnc2; troponin C, skeletal muscle [KO:K12042]
496523  tnni2; troponin I, fast skeletal muscle [KO:K12043]
394748  tnnt3; troponin T, fast skeletal muscle [KO:K12046]
496889  tnni3; troponin I, cardiac muscle [KO:K12044]
100493699  tnnt2; troponin T, cardiac muscle isoform X2 [KO:K12045]
448541  tpm1; tropomyosin alpha-1 chain [KO:K10373]
594975  tpm2; tropomyosin 2 [KO:K10374]
394917  MGC76092; uncharacterized protein LOC394917 [KO:K09290]
116406865  tropomyosin alpha-3 chain-like [KO:K09290]
549841  tpm4; tropomyosin alpha-4 chain [KO:K10375]
105948415  muscle M-line assembly protein unc-89 [KO:K12567] [EC:2.7.11.1]
733882  ttn; titin isoform X1 [KO:K12567] [EC:2.7.11.1]
549913  myot; myotilin [KO:K19875]
100380097  tcap; telethonin [KO:K19879]
101733716  synpo2; synaptopodin-2 [KO:K24066]
100491666  neb; nebulin isoform X32 [KO:K18267]
100496676  nebl; nebulette isoform X1 [KO:K25865]
448363  myoz1; myozenin-1 [KO:K26050]
496895  myoz2; myozenin-2 [KO:K26050]
496725  myoz3; myozenin-3 [KO:K26050]
394527  pdlim1; PDZ and LIM domain protein 1 [KO:K23353]
394862  pdlim4; PDZ and LIM domain protein 4 [KO:K23353]
448291  pdlim3; PDZ and LIM domain protein 3 [KO:K23353]
100488396  pdlim2; PDZ and LIM domain protein 2 [KO:K23353]
550008  capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
550078  capza1; F-actin-capping protein subunit alpha-1 [KO:K10364]
100494073  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
100484998  xirp1; xin actin-binding repeat-containing protein 1 isoform X1 [KO:K27381]
100488785  xirp2; xin actin-binding repeat-containing protein 2 isoform X1 [KO:K27381]
100487160  nrap; nebulin-related-anchoring protein [KO:K24421]
100495211  mypn; myopalladin isoform X2 [KO:K22028]
394699  ldb3; LIM domain-binding protein 3 [KO:K19867]
548530  pdlim5; PDZ and LIM domain protein 5 [KO:K19867]
549491  tmod4; tropomodulin-4 [KO:K10370]
549678  tmod3; tropomodulin-3 [KO:K10370]
100127704  tmod2; tropomodulin-2 [KO:K10370]
100486576  tmod1; tropomodulin-1 isoform X2 [KO:K10370]
779718  zyx; zyxin [KO:K06273]
448334  fhl1; four and a half LIM domains protein 1 [KO:K14365]
100145283  fhl2; four and a half LIM domains protein 2 [KO:K14380]
493527  fhl3; four and a half LIM domains protein 3 [KO:K24414]
100145340  lmod2; leiomodin-2 [KO:K22030]
100379914  lmod1; leiomodin-1 [KO:K22030]
780137  lmod3; leiomodin-3 [KO:K22030]
594995  ankrd1; ankyrin repeat domain-containing protein 1 [KO:K21433]
100037897  ankrd2; ankyrin repeat domain-containing protein 2 [KO:K21434]
100491499  fmnl2; formin-like protein 2 isoform X5 [KO:K23957]
100493601  fmnl3; formin-like protein 3 isoform X3 [KO:K23957]
493573  fmnl1; formin-like protein 1 [KO:K23957]
780046  inf2; inverted formin-2 [KO:K23958]
100125016  daam1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
101731433  daam2; disheveled-associated activator of morphogenesis 2 [KO:K04512]
733754  diaph1; protein diaphanous homolog 1 isoform X2 [KO:K05740]
100485481  diaph2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
100145568  diaph3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
779576  fmn2; formin-2 [KO:K02184]
100101675  myom1; myomesin-1 isoform X1 [KO:K24495]
100216300  myom2; myomesin-2 isoform X3 [KO:K24495]
101734332  myom3; myomesin-3 [KO:K24495]
394749  eno1; enolase 1 [KO:K01689] [EC:4.2.1.11]
613089  eno3; enolase 3 (beta, muscle) [KO:K01689] [EC:4.2.1.11]
100494806  ank2; ankyrin-2 isoform X8 [KO:K09255]
395005  ckm; creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
116410817  trim54; tripartite motif-containing protein 54 [KO:K10653]
100485287  trim55; tripartite motif-containing protein 55 isoform X1 [KO:K10654]
780012  trim63; E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
595079  ampd3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
100488507  ampd1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
100490248  ampd2; AMP deaminase 2 isoform X3 [KO:K01490] [EC:3.5.4.6]
101730564  obscn; obscurin isoform X1 [KO:K17531] [EC:2.7.11.1]
100497532  capn3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
100145182  plec; plectin isoform X1 [KO:K10388]
100488509  syne3; nesprin-3 isoform X1 [KO:K21761]
100145637  syne1; nesprin-1 [KO:K19326]
100216251  syne2; nesprin-2 isoform X3 [KO:K19346]
100137098  sun1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
100494901  sun2; SUN domain-containing protein 2 [KO:K19347]
100495534  tmem43; transmembrane protein 43 [KO:K27488]
100127712  emd; emerin [KO:K12569]
100145693  lbr; lamin-B receptor [KO:K19532] [EC:1.3.1.70]
733973  lmna; lamin [KO:K12641]
394806  lmnb1; lamin-B1 [KO:K07611]
733537  lmnb3; lamin B3 [KO:K07611]
100038111  lmnb2; lamin-B2 [KO:K07611]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
xtr04512  ECM-receptor interaction
xtr04814  Motor proteins
KO pathway
ko04820   
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