Entry
Name
Salmonella infection - Peromyscus leucopus (white-footed mouse)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
BRITE hierarchy
Pathway map
Disease
Organism
Peromyscus leucopus (white-footed mouse) [GN:
pleu ]
Gene
114681076 Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
114682062 Elmo1; LOW QUALITY PROTEIN: engulfment and cell motility protein 1 [KO:K12366 ]
114682503 Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
114682779 Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
114683009 Nlrp3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800 ]
114683624 Ahnak; LOW QUALITY PROTEIN: neuroblast differentiation-associated protein AHNAK [KO:K23934 ]
114684032 Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
114685480 Vps41; vacuolar protein sorting-associated protein 41 homolog isoform X2 [KO:K20184 ]
114685953 Fyco1; LOW QUALITY PROTEIN: FYVE and coiled-coil domain-containing protein 1 [KO:K21954 ]
114686066 Map2k7; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431 ] [EC:2.7.12.2 ]
114686371 Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
114689712 Nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727 ]
114689819 Cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X2 [KO:K05749 ]
114690629 Acbd3; LOW QUALITY PROTEIN: Golgi resident protein GCP60 [KO:K23935 ]
114691172 Vps11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179 ]
114692640 Elmo2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
114693454 Dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415 ]
114693559 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
114694098 Myl7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754 ]
114694280 Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403 ]
114695041 Pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
114695335 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
114695594 Wasl; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612 ]
114696038 Nlrc4; NLR family CARD domain-containing protein 4 isoform X3 [KO:K12805 ]
114697206 Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
114697551 Tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
114698088 Pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
114699493 Vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180 ]
114700864 Plekhm2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348 ]
114701666 Tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793 ]
114702265 Plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282 ]
114703542 Dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416 ]
114703707 Pik3c2a; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923 ] [EC:2.7.1.154 ]
114704363 Mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758 ]
114704487 Dync1i2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415 ]
114704537 Vps33a; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 33A [KO:K20182 ]
114704626 Vps18; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
114705140 Cd14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14 [KO:K04391 ]
114707535 Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
114708008 Dync2h1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414 ]
114708453 Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
114708799 Tnfrsf1a; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
114708874 Gcc2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282 ]
114708976 Dync2li1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417 ]
114708979 Cyfip1; LOW QUALITY PROTEIN: cytoplasmic FMR1-interacting protein 1 [KO:K05749 ]
114709247 Dync1li1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416 ]
114710330 Myl10; LOW QUALITY PROTEIN: myosin regulatory light chain 10 [KO:K12756 ]
Compound
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Bernal-Bayard J, Ramos-Morales F
Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
Journal
Reference
Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
Journal
Reference
Authors
Wemyss MA, Pearson JS
Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
Journal
Reference
Authors
Bierschenk D, Boucher D, Schroder K
Title
Salmonella-induced inflammasome activation in humans.
Journal
Reference
Authors
Pinaud L, Sansonetti PJ, Phalipon A
Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal
Reference
Authors
LaRock DL, Chaudhary A, Miller SI
Title
Salmonellae interactions with host processes.
Journal
Reference
Authors
Ramsden AE, Holden DW, Mota LJ
Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Journal
Reference
Authors
van der Heijden J, Finlay BB
Title
Type III effector-mediated processes in Salmonella infection.
Journal
Reference
Authors
Galan JE
Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
Journal
Reference
Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title
Salmonella takes control: effector-driven manipulation of the host.
Journal
Reference
Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Journal
Reference
Authors
Patel JC, Galan JE
Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Journal
Reference
Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Journal
Reference
Authors
Fu Y, Galan JE
Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
Journal
Related pathway
pleu04621 NOD-like receptor signaling pathway
KO pathway