KEGG   PATHWAY: pon04062
Entry
pon04062                    Pathway                                
Name
Chemokine signaling pathway - Pongo abelii (Sumatran orangutan)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
pon04062  Chemokine signaling pathway
pon04062

Other DBs
GO: 0070098
Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
100169740  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100171541  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100171605  RHOA; transforming protein RhoA [KO:K04513]
100171710  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100171722  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
100171723  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
100171833  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100171907  RAP1B; ras-related protein Rap-1b [KO:K07836]
100172117  ARRB2; beta-arrestin-2 [KO:K04439]
100172425  CX3CL1; fractalkine precursor [KO:K05508]
100172517  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
100172647  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100172678  ELMO1; engulfment and cell motility protein 1 isoform 1 [KO:K12366]
100172679  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100172740  CCL2; C-C motif chemokine 2 precursor [KO:K14624]
100173039  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100173045  CXCL12; stromal cell-derived factor 1 precursor [KO:K10031]
100173225  SHC1; SHC-transforming protein 1 [KO:K06279]
100173313  PXN; paxillin isoform X2 [KO:K05760]
100173589  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100173664  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100173683  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100173732  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100173972  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100174126  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
100174298  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100174317  NRAS; GTPase NRas [KO:K07828]
100174613  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
100174735  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
100174748  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform 2 [KO:K04345] [EC:2.7.11.11]
100190809  CCR5; C-C chemokine receptor type 5 [KO:K04180]
100190818  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100431221  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
100431483  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100431574  SHC4; SHC-transforming protein 4 [KO:K17449]
100431618  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
100431669  PARD3; partitioning defective 3 homolog isoform X3 [KO:K04237]
100431824  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100431906  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
100432347  CCR7; C-C chemokine receptor type 7 isoform X1 [KO:K04182]
100432571  CXCL16; C-X-C motif chemokine 16 isoform X1 [KO:K10035]
100432582  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
100432846  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100433177  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
100433745  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
100433839  RAP1A; ras-related protein Rap-1A isoform X2 [KO:K04353]
100433988  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100434331  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100434502  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100434737  CCL25; C-C motif chemokine 25 isoform X1 [KO:K13072]
100435461  CCL5; C-C motif chemokine 5 [KO:K12499]
100436498  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100436577  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
100436617  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
100437102  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100437111  CXCL8; interleukin-8 [KO:K10030]
100437239  CCL16; C-C motif chemokine 16 [KO:K21093]
100437605  CCL14; C-C motif chemokine 14 isoform X2 [KO:K21092]
100437617  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100437856  CXCL6; C-X-C motif chemokine 6 [KO:K05506]
100437992  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
100438178  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
100438199  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100438202  CCL22; C-C motif chemokine 22 [KO:K21095]
100438210  CCL15; C-C motif chemokine 15 [KO:K05511]
100438555  CCL17; C-C motif chemokine 17 [KO:K21083]
100438565  CCL23; C-C motif chemokine 23 isoform X1 [KO:K05511]
100438587  PF4V1; platelet factor 4 variant [KO:K05407]
100438959  CXCL1; growth-regulated alpha protein [KO:K05505]
100439163  CCL18; C-C motif chemokine 18 [KO:K21094]
100439475  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 isoform X2 [KO:K04546]
100439532  CCL3; C-C motif chemokine 3 [KO:K05408]
100439688  [KO:K05407]
100439849  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
100439900  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100439906  [KO:K12964]
100440061  PPBP; platelet basic protein [KO:K10029]
100440433  CXCL5; C-X-C motif chemokine 5 [KO:K05506]
100440492  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
100440586  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5 [KO:K07209] [EC:2.7.11.10]
100440799  [KO:K05505]
100441532  CXCL2; C-X-C motif chemokine 2 [KO:K05505]
100442050  NCF1; neutrophil cytosol factor 1 [KO:K08011]
100442100  AKT1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100442141  GRK4; G protein-coupled receptor kinase 4 isoform X20 [KO:K08291] [EC:2.7.11.16]
100442288  BRAF; serine/threonine-protein kinase B-raf isoform X6 [KO:K04365] [EC:2.7.11.1]
100442468  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
100442703  VAV3; guanine nucleotide exchange factor VAV3 isoform X3 [KO:K05730]
100442868  CCR3; C-C chemokine receptor type 3 isoform X1 [KO:K04178]
100443271  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
100443298  CRKL; crk-like protein [KO:K04438]
100444083  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
100445000  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
100445042  SHC2; SHC-transforming protein 2 [KO:K17447]
100445431  ADCY2; adenylate cyclase type 2 isoform X2 [KO:K08042] [EC:4.6.1.1]
100445664  CCR4; C-C chemokine receptor type 4 [KO:K04179]
100445790  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
100446021  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100446181  XCR1; chemokine XC receptor 1 [KO:K04193]
100446305  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
100447155  VAV1; proto-oncogene vav [KO:K05730]
100447283  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
100447326  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
100447772  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100447844  RASGRP2; RAS guanyl-releasing protein 2 isoform X2 [KO:K12361]
100447959  PTK2; focal adhesion kinase 1 isoform X4 [KO:K05725] [EC:2.7.10.2]
100448114  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100448517  CCR9; C-C chemokine receptor type 9 [KO:K04184]
100449316  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100449496  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100449504  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100450032  XCL1; lymphotactin [KO:K05507]
100450406  [KO:K05507]
100450941  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3 [KO:K01116] [EC:3.1.4.11]
100451032  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
100451077  FOXO3; forkhead box protein O3 isoform X1 [KO:K09408]
100452011  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
100452216  CCR6; C-C chemokine receptor type 6 [KO:K04181]
100452237  CCL21; C-C motif chemokine 21 [KO:K16062]
100452304  CXCL9; C-X-C motif chemokine 9 isoform X2 [KO:K05416]
100452410  CRK; adapter molecule crk isoform X1 [KO:K04438]
100452415  CCR10; C-C chemokine receptor type 10 [KO:K04185]
100452449  WAS; actin nucleation-promoting factor WAS [KO:K05747]
100452603  CCL19; C-C motif chemokine 19 [KO:K05512]
100452668  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
100452673  CCR8; C-C chemokine receptor type 8 [KO:K04183]
100452681  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
100452739  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100453042  CX3CR1; CX3C chemokine receptor 1 isoform X1 [KO:K04192]
100453050  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
100453085  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
100453366  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100453407  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
100453483  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X2 [KO:K07825]
100453525  CCL7; C-C motif chemokine 7 [KO:K05509]
100453779  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100453830  [KO:K16598]
100454097  BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
100454138  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100454207  CCL27; C-C motif chemokine 27 [KO:K16598]
100454265  CCL1; C-C motif chemokine 1 [KO:K05514]
100454279  AKT2; RAC-beta serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
100454308  CCL26; C-C motif chemokine 26 [KO:K21096]
100454648  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
100454669  GRK3; G protein-coupled receptor kinase 3 isoform X1 [KO:K00910] [EC:2.7.11.15]
100455593  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X3 [KO:K21290]
100455620  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
100455858  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100455956  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
100456049  RELA; transcription factor p65 isoform X1 [KO:K04735]
100456074  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
100456474  DOCK2; dedicator of cytokinesis protein 2 isoform X1 [KO:K12367]
100457650  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
100458137  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
100458183  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100458686  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100458716  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100458733  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100458754  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
100459427  HRAS; GTPase HRas isoform X1 [KO:K02833]
100459445  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100459500  CCL28; C-C motif chemokine 28 [KO:K05513]
100459632  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
100459971  [KO:K04175]
100460060  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100460370  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
100460558  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
100460653  [KO:K05408]
100460754  CCR2; C-C chemokine receptor type 2 [KO:K04177]
100460806  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
100461018  [KO:K12964]
100461066  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
100461383  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100461595  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
100461801  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
100461893  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
100461947  [KO:K04175]
100461961  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5 [KO:K05858] [EC:3.1.4.11]
100462011  SHC3; SHC-transforming protein 3 isoform X2 [KO:K17448]
100462513  KRAS; GTPase KRas isoform X1 [KO:K07827]
100462537  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
100938049  CCL8; C-C motif chemokine 8 [KO:K16596]
100938458  CCL24; C-C motif chemokine 24 [KO:K21097]
103889133  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103889518  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
103889530  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
112128563  [KO:K04542]
112129369  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
112129584  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
112130221  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
112130240  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
112132689  CCR1; C-C chemokine receptor type 1 [KO:K04176]
112135444  [KO:K04542]
129052407  [KO:K04634]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
pon04010  MAPK signaling pathway
pon04060  Cytokine-cytokine receptor interaction
pon04120  Ubiquitin mediated proteolysis
pon04630  JAK-STAT signaling pathway
pon04670  Leukocyte transendothelial migration
pon04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

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