KEGG   PATHWAY: pyu05208
Entry
pyu05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Herpailurus yagouaroundi (jaguarundi)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
pyu05208  Chemical carcinogenesis - reactive oxygen species
pyu05208

Organism
Herpailurus yagouaroundi (jaguarundi) [GN:pyu]
Gene
121009727  NQO1; NAD(P)H dehydrogenase [quinone] 1 isoform X1 [KO:K00355] [EC:1.6.5.2]
121009893  [KO:K02263]
121009924  [KO:K08009]
121010113  GSTT2B; LOW QUALITY PROTEIN: glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
121010163  [KO:K00799] [EC:2.5.1.18]
121010164  [KO:K00799] [EC:2.5.1.18]
121010165  [KO:K00799] [EC:2.5.1.18]
121010229  [KO:K02266]
121010320  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
121010516  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121010691  [KO:K00418]
121010701  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
121010824  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
121010927  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
121011002  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121011065  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
121011166  [KO:K00414]
121011416  [KO:K07416] [EC:1.14.14.1]
121011444  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121011523  [KO:K02270]
121011557  [KO:K02267]
121011829  NCF2; neutrophil cytosol factor 2 [KO:K08010]
121011873  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
121012223  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
121012342  [KO:K02263]
121012356  [KO:K02272]
121012552  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
121012848  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
121013230  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
121013412  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
121013560  [KO:K02128]
121013570  [KO:K02272]
121013658  [KO:K03945]
121013887  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
121013900  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
121013911  [KO:K02128]
121013978  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
121014343  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
121014841  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
121014878  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
121014969  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121015111  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121015164  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
121015470  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
121015474  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
121015745  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
121016054  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
121016298  [KO:K02265]
121016389  [KO:K02265]
121016570  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121016847  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
121017018  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
121017559  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
121017757  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
121017835  [KO:K03957]
121017895  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
121017912  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
121017928  GSTM4; glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
121018662  PRKD2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
121018849  [KO:K07293] [EC:3.1.3.48]
121018850  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
121019380  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
121019403  [KO:K00415]
121019463  [KO:K05863]
121019662  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
121019699  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
121019824  [KO:K02267]
121019865  PTPN1; tyrosine-protein phosphatase non-receptor type 1 isoform X1 [KO:K05696] [EC:3.1.3.48]
121019955  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
121020585  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121020936  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
121021044  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
121021303  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
121021313  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
121021430  [KO:K00420]
121021465  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
121021631  SLC26A9; solute carrier family 26 member 9 [KO:K14706]
121021783  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
121021883  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
121022026  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
121022226  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121022524  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
121022686  [KO:K00419]
121022826  HRAS; GTPase HRas isoform X1 [KO:K02833]
121022994  [KO:K02266]
121023018  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121023356  [KO:K02267]
121023724  [KO:K02273]
121023907  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
121023947  BAD; bcl2-associated agonist of cell death [KO:K02158]
121023959  RELA; transcription factor p65 [KO:K04735]
121023971  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
121024325  SLC26A1; sulfate anion transporter 1 isoform X1 [KO:K14700]
121024502  [KO:K05863]
121024508  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
121024689  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
121024703  [KO:K00411] [EC:7.1.1.8]
121024845  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
121024956  NOX1; LOW QUALITY PROTEIN: NADPH oxidase 1 [KO:K08008]
121025049  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
121025331  [KO:K02271]
121025390  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
121025397  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
121025521  [KO:K02267]
121026083  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
121026094  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
121026225  [KO:K02128]
121026601  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
121026604  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
121026606  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
121026608  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
121026610  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
121026766  [KO:K03948]
121026789  [KO:K03948]
121026899  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
121027037  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
121027050  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
121027060  [KO:K00416]
121027103  [KO:K00417]
121027214  JUN; transcription factor AP-1 [KO:K04448]
121027471  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
121027638  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
121027672  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
121027738  NRAS; GTPase NRas [KO:K07828]
121028241  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
121028242  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
121028407  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
121028446  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
121028662  AHR; aryl hydrocarbon receptor isoform X1 [KO:K09093]
121028796  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
121028847  [KO:K02265]
121029354  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
121029356  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
121029481  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
121029504  VEGFA; vascular endothelial growth factor A [KO:K05448]
121029544  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
121029583  [KO:K00799] [EC:2.5.1.18]
121029585  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
121029586  [KO:K00799] [EC:2.5.1.18]
121029587  [KO:K00799] [EC:2.5.1.18]
121029678  [KO:K02270]
121029870  FOXO3; forkhead box protein O3 [KO:K09408]
121029907  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
121030730  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
121030749  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
121030905  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X1 [KO:K03959]
121030961  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
121031012  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
121031307  [KO:K03947]
121031603  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
121031656  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
121031737  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
121031872  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
121031875  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
121032071  FOS; proto-oncogene c-Fos [KO:K04379]
121032358  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121032405  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
121032976  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
121033019  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121033178  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
121033545  [KO:K03957]
121033733  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121033850  [KO:K02137]
121033993  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
121034018  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121034026  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
121034562  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
121034940  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
121035113  ABL1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
121035386  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
121035824  [KO:K09093]
121035897  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
121035958  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
121035960  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
121035978  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
121036018  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
121036053  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
121036249  [KO:K02271]
121036296  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 isoform X1 [KO:K03960]
121036456  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
121036822  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
121036853  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
121036923  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121037105  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
121037114  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
121037174  AS3MT; arsenite methyltransferase isoform X1 [KO:K07755] [EC:2.1.1.137]
121037198  GSTO1; glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
121037199  GSTO2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
121037436  [KO:K07415] [EC:1.14.14.-]
121037531  [KO:K11352]
121037957  [KO:K02128]
121038261  [KO:K00420]
121038479  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
121038809  KRAS; GTPase KRas isoform X1 [KO:K07827]
121038866  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
121039342  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
121039398  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
121039687  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
121040120  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
121040247  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
121040433  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
121040597  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
121040888  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
121040909  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
121041241  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121041863  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
121041992  [KO:K07408] [EC:1.14.14.1]
121041994  [KO:K07409] [EC:1.14.14.1]
121042004  [KO:K02264]
121042025  [KO:K00237]
121042216  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
121042730  [KO:K00417]
121042768  [KO:K02268]
121042958  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
121043038  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
121043133  [KO:K00413]
121043426  PTPRJ; receptor-type tyrosine-protein phosphatase eta isoform X1 [KO:K05698] [EC:3.1.3.48]
121043437  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
121043560  CAT; catalase [KO:K03781] [EC:1.11.1.6]
121044015  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
121044342  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
121044356  [KO:K07410] [EC:1.14.14.1]
121044367  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
121044392  [KO:K02270]
121044517  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
121044712  [KO:K03955]
121044727  LPO; lactoperoxidase isoform X1 [KO:K12550] [EC:1.11.1.7]
121044831  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
121044948  SLC26A2; sulfate transporter [KO:K14701]
121045129  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
26129851  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
26129852  COX3; cytochrome c oxidase subunit III [KO:K02262]
26129855  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
26129857  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
26129864  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
26129867  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
26129872  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
26129874  COX2; cytochrome c oxidase subunit II [KO:K02261]
26129875  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
26129876  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
26129877  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
26129880  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
26129881  CYTB; cytochrome b [KO:K00412]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
Reference
PMID:24281075
  Authors
Henkler F, Brinkmann J, Luch A
  Title
The role of oxidative stress in carcinogenesis induced by metals and xenobiotics.
  Journal
Cancers (Basel) 2:376-96 (2010)
DOI:10.3390/cancers2020376
Reference
PMID:22705365
  Authors
Lee JC, Son YO, Pratheeshkumar P, Shi X
  Title
Oxidative stress and metal carcinogenesis.
  Journal
Free Radic Biol Med 53:742-57 (2012)
DOI:10.1016/j.freeradbiomed.2012.06.002
Reference
PMID:32033297
  Authors
Hu Y, Li J, Lou B, Wu R, Wang G, Lu C, Wang H, Pi J, Xu Y
  Title
The Role of Reactive Oxygen Species in Arsenic Toxicity.
  Journal
Biomolecules 10:240 (2020)
DOI:10.3390/biom10020240
Reference
PMID:33864199
  Authors
Ozturk M, Metin M, Altay V, Bhat RA, Ejaz M, Gul A, Unal BT, Hasanuzzaman M, Nibir L, Nahar K, Bukhari A, Dervash MA, Kawano T
  Title
Arsenic and Human Health: Genotoxicity, Epigenomic Effects, and Cancer Signaling.
  Journal
Biol Trace Elem Res 200:988-1001 (2022)
DOI:10.1007/s12011-021-02719-w
Reference
PMID:23510327
  Authors
Hubaux R, Becker-Santos DD, Enfield KS, Rowbotham D, Lam S, Lam WL, Martinez VD
  Title
Molecular features in arsenic-induced lung tumors.
  Journal
Mol Cancer 12:20 (2013)
DOI:10.1186/1476-4598-12-20
Reference
PMID:21648415
  Authors
Naranmandura H, Xu S, Sawata T, Hao WH, Liu H, Bu N, Ogra Y, Lou YJ, Suzuki N
  Title
Mitochondria are the main target organelle for trivalent monomethylarsonous acid (MMA(III))-induced cytotoxicity.
  Journal
Chem Res Toxicol 24:1094-103 (2011)
DOI:10.1021/tx200156k
Reference
PMID:23583964
  Authors
Faita F, Cori L, Bianchi F, Andreassi MG
  Title
Arsenic-induced genotoxicity and genetic susceptibility to arsenic-related pathologies.
  Journal
Int J Environ Res Public Health 10:1527-46 (2013)
DOI:10.3390/ijerph10041527
Reference
PMID:28179585
  Authors
Sage AP, Minatel BC, Ng KW, Stewart GL, Dummer TJB, Lam WL, Martinez VD
  Title
Oncogenomic disruptions in arsenic-induced carcinogenesis.
  Journal
Oncotarget 8:25736-25755 (2017)
DOI:10.18632/oncotarget.15106
Reference
PMID:21414382
  Authors
Jomova K, Valko M
  Title
Advances in metal-induced oxidative stress and human disease.
  Journal
Toxicology 283:65-87 (2011)
DOI:10.1016/j.tox.2011.03.001
Reference
PMID:16430879
  Authors
Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M
  Title
Free radicals, metals and antioxidants in oxidative stress-induced cancer.
  Journal
Chem Biol Interact 160:1-40 (2006)
DOI:10.1016/j.cbi.2005.12.009
Reference
PMID:32731582
  Authors
Tumolo M, Ancona V, De Paola D, Losacco D, Campanale C, Massarelli C, Uricchio VF
  Title
Chromium Pollution in European Water, Sources, Health Risk, and Remediation Strategies: An Overview.
  Journal
Int J Environ Res Public Health 17:E5438 (2020)
DOI:10.3390/ijerph17155438
Reference
PMID:28860815
  Authors
Wang Y, Su H, Gu Y, Song X, Zhao J
  Title
Carcinogenicity of chromium and chemoprevention: a brief update.
  Journal
Onco Targets Ther 10:4065-4079 (2017)
DOI:10.2147/OTT.S139262
Reference
PMID:24820114
  Authors
Jin X, Chen M, Song L, Li H, Li Z
  Title
The evaluation of p,p'-DDT exposure on cell adhesion of hepatocellular carcinoma.
  Journal
Toxicology 322:99-108 (2014)
DOI:10.1016/j.tox.2014.05.002
Reference
PMID:20370557
  Authors
Liou GY, Storz P
  Title
Reactive oxygen species in cancer.
  Journal
Free Radic Res 44:479-96 (2010)
DOI:10.3109/10715761003667554
Reference
PMID:11275476
  Authors
Murata M, Tamura A, Tada M, Kawanishi S
  Title
Mechanism of oxidative DNA damage induced by carcinogenic 4-aminobiphenyl.
  Journal
Free Radic Biol Med 30:765-73 (2001)
DOI:10.1016/S0891-5849(01)00463-4
Reference
PMID:31283132
  Authors
  Title
  Journal
Pentachlorophenol and Some Related Compounds (2019)
Reference
PMID:19408893
  Authors
Zhu BZ, Shan GQ
  Title
Potential mechanism for pentachlorophenol-induced carcinogenicity: a novel mechanism for metal-independent production of hydroxyl radicals.
  Journal
Chem Res Toxicol 22:969-77 (2009)
DOI:10.1021/tx900030v
Reference
PMID:22166497
  Authors
McHale CM, Zhang L, Smith MT
  Title
Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment.
  Journal
Carcinogenesis 33:240-52 (2012)
DOI:10.1093/carcin/bgr297
Reference
PMID:32977499
  Authors
Scharf P, Broering MF, Oliveira da Rocha GH, Farsky SHP
  Title
Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis.
  Journal
Int J Mol Sci 21:E6996 (2020)
DOI:10.3390/ijms21196996
Reference
PMID:23066403
  Authors
Snyder R
  Title
Leukemia and benzene.
  Journal
Int J Environ Res Public Health 9:2875-93 (2012)
DOI:10.3390/ijerph9082875
Reference
PMID:9118888
  Authors
Snyder R, Hedli CC
  Title
An overview of benzene metabolism.
  Journal
Environ Health Perspect 104 Suppl 6:1165-71 (1996)
DOI:10.1289/ehp.961041165
Reference
PMID:11978484
  Authors
Kawanishi S, Hiraku Y, Murata M, Oikawa S
  Title
The role of metals in site-specific DNA damage with reference to carcinogenesis.
  Journal
Free Radic Biol Med 32:822-32 (2002)
DOI:10.1016/S0891-5849(02)00779-7
Reference
PMID:27919191
  Authors
Das DN, Panda PK, Naik PP, Mukhopadhyay S, Sinha N, Bhutia SK
  Title
Phytotherapeutic approach: a new hope for polycyclic aromatic hydrocarbons induced cellular disorders, autophagic and apoptotic cell death.
  Journal
Toxicol Mech Methods 27:1-17 (2017)
DOI:10.1080/15376516.2016.1268228
Reference
PMID:21910479
  Authors
Shultz CA, Quinn AM, Park JH, Harvey RG, Bolton JL, Maser E, Penning TM.
  Title
Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone.
  Journal
Chem Res Toxicol 24:2153-66 (2011)
DOI:10.1021/tx200294c
Reference
PMID:25279998
  Authors
Penning TM
  Title
Human aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons.
  Journal
Chem Res Toxicol 27:1901-17 (2014)
DOI:10.1021/tx500298n
Reference
PMID:10706104
  Authors
Burczynski ME, Penning TM
  Title
Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor.
  Journal
Cancer Res 60:908-15 (2000)
Reference
PMID:15963346
  Authors
Xue W, Warshawsky D
  Title
Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review.
  Journal
Toxicol Appl Pharmacol 206:73-93 (2005)
DOI:10.1016/j.taap.2004.11.006
Reference
PMID:15142886
  Authors
Chen ZH, Hurh YJ, Na HK, Kim JH, Chun YJ, Kim DH, Kang KS, Cho MH, Surh YJ
  Title
Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells.
  Journal
Carcinogenesis 25:2005-13 (2004)
DOI:10.1093/carcin/bgh183
Reference
PMID:16684662
  Authors
Rifkind AB
  Title
CYP1A in TCDD toxicity and in physiology-with particular reference to CYP dependent arachidonic acid metabolism and other endogenous substrates.
  Journal
Drug Metab Rev 38:291-335 (2006)
DOI:10.1080/03602530600570107
Reference
PMID:9380738
  Authors
Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, Johansson SL, Patil KD, Gross ML, Gooden JK, Ramanathan R, Cerny RL, Rogan EG
  Title
Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators.
  Journal
Proc Natl Acad Sci U S A 94:10937-42 (1997)
DOI:10.1073/pnas.94.20.10937
Reference
PMID:9472688
  Authors
Zhu BT, Conney AH
  Title
Functional role of estrogen metabolism in target cells: review and perspectives.
  Journal
Carcinogenesis 19:1-27 (1998)
DOI:10.1093/carcin/19.1.1
Reference
PMID:19387921
  Authors
McKillop IH, Schrum LW
  Title
Role of alcohol in liver carcinogenesis.
  Journal
Semin Liver Dis 29:222-32 (2009)
DOI:10.1055/s-0029-1214377
Reference
PMID:15603755
  Authors
Gonzalez FJ
  Title
Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1.
  Journal
Mutat Res 569:101-10 (2005)
DOI:10.1016/j.mrfmmm.2004.04.021
Reference
PMID:31864052
  Authors
Montalbano AM, Albano GD, Anzalone G, Moscato M, Gagliardo R, Di Sano C, Bonanno A, Ruggieri S, Cibella F, Profita M
  Title
Cytotoxic and genotoxic effects of the flame retardants (PBDE-47, PBDE-99 and PBDE-209) in human bronchial epithelial cells.
  Journal
Chemosphere 245:125600 (2020)
DOI:10.1016/j.chemosphere.2019.125600
Reference
PMID:33907575
  Authors
Sun HN, Ren CX, Gong YX, Xie DP, Kwon T
  Title
Regulatory function of peroxiredoxin I on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung cancer development.
  Journal
Oncol Lett 21:465 (2021)
DOI:10.3892/ol.2021.12726
Reference
PMID:25372613
  Authors
Pluchino LA, Wang HC
  Title
Chronic exposure to combined carcinogens enhances breast cell carcinogenesis with mesenchymal and stem-like cell properties.
  Journal
PLoS One 9:e108698 (2014)
DOI:10.1371/journal.pone.0108698
Reference
PMID:25535943
  Authors
Pluchino LA, Liu AK, Wang HC
  Title
Reactive oxygen species-mediated breast cell carcinogenesis enhanced by multiple carcinogens and intervened by dietary ergosterol and mimosine.
  Journal
Free Radic Biol Med 80:12-26 (2015)
DOI:10.1016/j.freeradbiomed.2014.12.015
Reference
PMID:30327380
  Authors
Moldogazieva NT, Lutsenko SV, Terentiev AA
  Title
Reactive Oxygen and Nitrogen Species-Induced Protein Modifications: Implication in Carcinogenesis and Anticancer Therapy.
  Journal
Cancer Res 78:6040-6047 (2018)
DOI:10.1158/0008-5472.CAN-18-0980
Reference
PMID:32358622
  Authors
Kirtonia A, Sethi G, Garg M
  Title
The multifaceted role of reactive oxygen species in tumorigenesis.
  Journal
Cell Mol Life Sci 77:4459-4483 (2020)
DOI:10.1007/s00018-020-03536-5
Reference
PMID:29449774
  Authors
Kumari S, Badana AK, G MM, G S, Malla R
  Title
Reactive Oxygen Species: A Key Constituent in Cancer Survival.
  Journal
Biomark Insights 13:1177271918755391 (2018)
DOI:10.1177/1177271918755391
Reference
PMID:28881698
  Authors
Gao X, Schottker B
  Title
Reduction-oxidation pathways involved in cancer development: a systematic review of literature reviews.
  Journal
Oncotarget 8:51888-51906 (2017)
DOI:10.18632/oncotarget.17128
Reference
PMID:15769673
  Authors
Storz P
  Title
Reactive oxygen species in tumor progression.
  Journal
Front Biosci 10:1881-96 (2005)
DOI:10.2741/1667
Reference
PMID:28835450
  Authors
Assi M
  Title
The differential role of reactive oxygen species in early and late stages of cancer.
  Journal
Am J Physiol Regul Integr Comp Physiol 313:R646-R653 (2017)
DOI:10.1152/ajpregu.00247.2017
Reference
PMID:15024053
  Authors
Storz P, Doppler H, Toker A
  Title
Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling.
  Journal
Mol Cell Biol 24:2614-26 (2004)
DOI:10.1128/MCB.24.7.2614-2626.2004
Reference
PMID:24998536
  Authors
Nourazarian AR, Kangari P, Salmaninejad A
  Title
Roles of oxidative stress in the development and progression of breast cancer.
  Journal
Asian Pac J Cancer Prev 15:4745-51 (2014)
DOI:10.7314/apjcp.2014.15.12.4745
Reference
PMID:32336668
  Authors
Zheng F, Goncalves FM, Abiko Y, Li H, Kumagai Y, Aschner M
  Title
Redox toxicology of environmental chemicals causing oxidative stress.
  Journal
Redox Biol 34:101475 (2020)
DOI:10.1016/j.redox.2020.101475
Related
pathway
pyu00190  Oxidative phosphorylation
pyu00980  Metabolism of xenobiotics by cytochrome P450
pyu04010  MAPK signaling pathway
pyu04064  NF-kappa B signaling pathway
pyu04066  HIF-1 signaling pathway
pyu04151  PI3K-Akt signaling pathway
pyu04370  VEGF signaling pathway
pyu05207  Chemical carcinogenesis - receptor activation
pyu05211  Renal cell carcinoma
pyu05215  Prostate cancer
pyu05219  Bladder cancer
pyu05221  Acute myeloid leukemia
pyu05222  Small cell lung cancer
pyu05223  Non-small cell lung cancer
pyu05224  Breast cancer
pyu05225  Hepatocellular carcinoma
KO pathway
ko05208   

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