KEGG   PATHWAY: shr05207
Entry
shr05207                    Pathway                                
Name
Chemical carcinogenesis - receptor activation - Sarcophilus harrisii (Tasmanian devil)
Description
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stages. Chemicals or environmental factors may act at any of these stages to induce and/or enhance the carcinogenic process. Based on their mode-of-action, carcinogens can be classified as genotoxic or non-genotoxic. Genotoxic agent begins their action at the deoxyribonucleic acid (DNA) level, causing DNA damage through several mechanisms. Non-genotoxic carcinogens are chemicals that cause the development of tumors through multiple non-genotoxic events and epigenetic alterations without direct interaction with DNA. One non-genotoxic mechanism involves receptor activation. Biological mechanisms involving receptor activation fall into two broad categories: (i) those that involve cell surface receptors and some intracellular receptors that activate signal transduction pathways, resulting in biological responses, including gene transcription, and (ii) those that involve intracellular receptors that translocate into the nucleus and act as transcription factors regulating gene expression. Both classes of receptors can be involved in mechanisms of carcinogenesis.
Class
Human Diseases; Cancer: overview
Pathway map
shr05207  Chemical carcinogenesis - receptor activation
shr05207

Organism
Sarcophilus harrisii (Tasmanian devil) [GN:shr]
Gene
100930913  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
100916629  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
100919435  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
100926529  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
100935202  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
100914196  RB1; retinoblastoma-associated protein [KO:K06618]
116421696  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
100934619  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
100928240  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
100935397  CDC6; cell division control protein 6 homolog isoform X2 [KO:K02213]
100924467  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
100927237  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100933581  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100934784  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
100917462  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100916688  CHRNA4; neuronal acetylcholine receptor subunit alpha-4 [KO:K04806]
105750447  CHRNB2; neuronal acetylcholine receptor subunit beta-2 [KO:K04813]
100921280  CHRNA3; neuronal acetylcholine receptor subunit alpha-3 [KO:K04805]
100920846  CHRNB4; neuronal acetylcholine receptor subunit beta-4 [KO:K04815]
100926503  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
100919750  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100927554  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100917433  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100933192  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
100925240  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
100929811  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100932099  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105749979  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100926892  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100924976  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100935230  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100917987  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100913262  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100925440  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100931480  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
100917619  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100932473  RELA; transcription factor p65 [KO:K04735]
100929168  ras-like protein [KO:K02833]
116419913  HRAS; GTPase HRas [KO:K02833]
100915526  KRAS; GTPase KRas isoform X1 [KO:K07827]
100927252  ras-related protein Rab-26-like [KO:K07827]
100929426  ras protein let-60-like [KO:K07827]
100928986  NRAS; GTPase NRas [KO:K07828]
100921899  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100917396  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
100934330  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100913231  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100924435  FOS; proto-oncogene c-Fos [KO:K04379]
116423739  JUN; transcription factor AP-1 [KO:K04448]
100921308  MYC; myc proto-oncogene protein [KO:K04377]
100934666  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100913337  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100924022  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100935225  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100913423  VEGFA; vascular endothelial growth factor A [KO:K05448]
100934542  FGF2; fibroblast growth factor 2 [KO:K18497]
116421895  ADRB1; beta-1 adrenergic receptor [KO:K04141]
100928854  ADRB2; beta-2 adrenergic receptor [KO:K04142]
100935351  ADRB3; beta-3 adrenergic receptor [KO:K04143]
100930666  GNAS; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
100922193  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100922434  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100925657  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100920243  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100932634  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100929278  ADCY7; adenylate cyclase type 7 isoform X3 [KO:K08047] [EC:4.6.1.1]
100923926  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100926025  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
100929360  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100915481  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100934183  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
100913731  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
100913327  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100914193  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X3 [KO:K04450]
100913697  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100926416  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100913890  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
100916355  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100917654  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100923082  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
100922067  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100932966  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
100914706  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100928725  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
100916740  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
100923199  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
100916057  CHRNA9; neuronal acetylcholine receptor subunit alpha-9 [KO:K04810]
100923157  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
100928498  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
100931854  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X2 [KO:K04373] [EC:2.7.11.1]
100931566  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X4 [KO:K04373] [EC:2.7.11.1]
116422810  RPS6KA1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
100935401  ESR1; estrogen receptor isoform X1 [KO:K08550]
100915121  ESR2; estrogen receptor beta [KO:K08551]
100921806  VDR; vitamin D3 receptor [KO:K08539]
100921166  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100914017  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100928380  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100931009  SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099]
100932999  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100918487  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
111718631  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100935081  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100930707  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X2 [KO:K04688] [EC:2.7.11.1]
100918719  PAQR7; membrane progestin receptor alpha isoform X2 [KO:K25039]
100925526  PAQR8; membrane progestin receptor beta [KO:K25040]
100926083  PAQR5; membrane progestin receptor gamma isoform X1 [KO:K25041]
100932349  PGR; progesterone receptor isoform X1 [KO:K08556]
105750026  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
100920045  LOW QUALITY PROTEIN: signal transducer and activator of transcription 5A [KO:K11223]
100920307  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
100928451  BCL6; LOW QUALITY PROTEIN: B-cell lymphoma 6 protein [KO:K15618]
111720025  KLF5; Krueppel-like factor 5 isoform X1 [KO:K09206]
100919226  KLF4; Krueppel-like factor 4 isoform X1 [KO:K17846]
100928059  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100919958  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
100931367  JAG1; protein jagged-1 [KO:K06052]
102465943  MIR141; sha-miR-141 [KO:K17018]
100933955  AR; androgen receptor [KO:K08557]
102464790  MIRLET7G; sha-let-7g [KO:K16980]
102466098  MIRLET7A; sha-let-7a [KO:K16980]
102464809  MIRLET7I; sha-let-7i [KO:K16980]
100933169  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100923118  FGF18; fibroblast growth factor 18 [KO:K04358]
100925286  FGF20; fibroblast growth factor 20 [KO:K04358]
100928224  FGF5; fibroblast growth factor 5 [KO:K04358]
100934722  FGF6; fibroblast growth factor 6 [KO:K04358]
100921812  FGF4; fibroblast growth factor 4 [KO:K04358]
100922075  FGF3; fibroblast growth factor 3 [KO:K04358]
100925381  FGF8; fibroblast growth factor 8 isoform X3 [KO:K04358]
100925383  FGF7; fibroblast growth factor 7 [KO:K04358]
100932059  FGF17; fibroblast growth factor 17 [KO:K04358]
100934743  FGF16; fibroblast growth factor 16 [KO:K04358]
100915656  FGF22; fibroblast growth factor 22 [KO:K04358]
100920456  FGF9; fibroblast growth factor 9 [KO:K04358]
116423189  FGF10; fibroblast growth factor 10 [KO:K04358]
100919868  DLL1; delta-like protein 1 [KO:K06051]
100933691  DLL4; delta-like protein 4 isoform X1 [KO:K06051]
100922238  PTGES3; prostaglandin E synthase 3 isoform X3 [KO:K15730] [EC:5.3.99.3]
100919416  AIPL1; aryl-hydrocarbon-interacting protein-like 1 [KO:K17767]
100928585  AIP; AH receptor-interacting protein isoform X1 [KO:K17767]
100933338  AHR; aryl hydrocarbon receptor [KO:K09093]
100916736  uncharacterized protein LOC100916736 [KO:K09093]
116423505  aryl hydrocarbon receptor-like [KO:K09093]
100928900  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100929957  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100917881  HSP90B1; endoplasmin [KO:K09487]
100924029  KPNA1; importin subunit alpha-5 isoform X2 [KO:K23940]
100915610  LOW QUALITY PROTEIN: importin subunit alpha-1 [KO:K15043]
100924288  KPNA7; LOW QUALITY PROTEIN: importin subunit alpha-8 [KO:K15043]
100933039  KPNA3; importin subunit alpha-4 [KO:K23583]
100934091  KPNA4; importin subunit alpha-3 [KO:K23583]
100921858  KPNA6; importin subunit alpha-7 isoform X3 [KO:K15042]
100932452  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
100932704  KPNB1; importin subunit beta-1 [KO:K14293]
100917700  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
100927711  cytochrome P450 1A1 isoform X1 [KO:K07408] [EC:1.14.14.1]
100935353  cytochrome P450 1B1 isoform X2 [KO:K07410] [EC:1.14.14.1]
100925093  EPHX1; epoxide hydrolase 1 isoform X2 [KO:K01253] [EC:3.3.2.9]
100931196  bifunctional epoxide hydrolase 2 isoform X1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
100931720  LOW QUALITY PROTEIN: bifunctional epoxide hydrolase 2-like [KO:K08726] [EC:3.3.2.10 3.1.3.76]
100931457  LOW QUALITY PROTEIN: bifunctional epoxide hydrolase 2-like [KO:K08726] [EC:3.3.2.10 3.1.3.76]
100927232  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
100925348  EPHX4; epoxide hydrolase 4 isoform X1 [KO:K22369] [EC:3.3.-.-]
100928482  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
100929215  GSTT2B; glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
100924507  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
100926836  LOW QUALITY PROTEIN: glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
100935165  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
100913363  glutathione S-transferase omega-1-like isoform X2 [KO:K00799] [EC:2.5.1.18]
100927430  glutathione S-transferase Mu 2 isoform X2 [KO:K00799] [EC:2.5.1.18]
100927692  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
100927944  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
100929408  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
100926310  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
100926572  GSTA1; glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
100927091  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
100919527  UDP-glucuronosyltransferase 1-1 isoform X6 [KO:K00699] [EC:2.4.1.17]
100914496  uncharacterized protein LOC100914496 [KO:K00699] [EC:2.4.1.17]
100916465  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
100931571  cytochrome P450 2B4-like [KO:K07412] [EC:1.14.14.1]
105749943  cytochrome P450 2B4-like [KO:K07412] [EC:1.14.14.1]
100923785  NR1I3; nuclear receptor subfamily 1 group I member 3 [KO:K08541]
100926708  RXRA; retinoic acid receptor RXR-alpha isoform X3 [KO:K08524]
100914649  RXRB; retinoic acid receptor RXR-beta isoform X2 [KO:K08525]
100932014  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
100918011  cytochrome P450 3A4-like [KO:K07424] [EC:1.14.14.1]
100930770  cytochrome P450 3A24 [KO:K07424] [EC:1.14.14.1]
116421952  cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
100917093  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
Compound
C00076  Calcium cation
C00410  Progesterone
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00780  Serotonin
C00788  L-Adrenaline
C00951  Estradiol-17beta
C03690  Bis(2-ethylhexyl)phthalate
C04623  DDT
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06697  Arsenite
C06790  Trichloroethene
C06916  Clofibrate
C07020  Gemfibrozil
C07434  Phenobarbital
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C08150  Medroxyprogesterone acetate
C11042  Hexachlorobenzene
C11150  Trichloroacetate
C11371  Nafenopin
C11906  Sodium arsenite
C13624  Bisphenol A
C14240  Di(2-ethylhexyl) adipate
C14573  3,3',4,4',5-Pentachlorobiphenyl
C15995  Bombesin
C16452  N'-Nitrosonornicotine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Reference
PMID:15660110
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
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Reference
PMID:19631282
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Mutat Res 682:94-109 (2009)
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Reference
PMID:21444681
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Wu CH, Lee CH, Ho YS
  Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
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Clin Cancer Res 17:3533-41 (2011)
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Reference
PMID:19194381
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  Title
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
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Nat Rev Cancer 9:195-205 (2009)
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Reference
PMID:21541211
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Singh S, Pillai S, Chellappan S
  Title
Nicotinic acetylcholine receptor signaling in tumor growth and metastasis.
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J Oncol 2011:456743 (2011)
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Reference
PMID:31956359
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Cheng WL, Chen KY, Lee KY, Feng PH, Wu SM
  Title
Nicotinic-nAChR signaling mediates drug resistance in lung cancer.
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J Cancer 11:1125-1140 (2020)
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Reference
PMID:24827506
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Grando SA
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Connections of nicotine to cancer.
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Nat Rev Cancer 14:419-29 (2014)
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Reference
PMID:24398389
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Schaal C, Chellappan SP
  Title
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.
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Mol Cancer Res 12:14-23 (2014)
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Reference
PMID:21640716
  Authors
Improgo MR, Tapper AR, Gardner PD
  Title
Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer.
  Journal
Biochem Pharmacol 82:1015-21 (2011)
DOI:10.1016/j.bcp.2011.05.020
Reference
PMID:18262664
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Egleton RD, Brown KC, Dasgupta P
  Title
Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis.
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Trends Pharmacol Sci 29:151-8 (2008)
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Reference
PMID:24830349
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Xue J, Yang S, Seng S
  Title
Mechanisms of Cancer Induction by Tobacco-Specific NNK and NNN.
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Cancers (Basel) 6:1138-56 (2014)
DOI:10.3390/cancers6021138
Reference
PMID:21801603
  Authors
Wen J, Fu JH, Zhang W, Guo M
  Title
Lung carcinoma signaling pathways activated by smoking.
  Journal
Chin J Cancer 30:551-8 (2011)
DOI:10.5732/cjc.011.10059
Reference
PMID:28664511
  Authors
Gankhuyag N, Lee KH, Cho JY
  Title
The Role of Nitrosamine (NNK) in Breast Cancer Carcinogenesis.
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J Mammary Gland Biol Neoplasia 22:159-170 (2017)
DOI:10.1007/s10911-017-9381-z
Reference
PMID:22330135
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Guo J, Kim D, Gao J, Kurtyka C, Chen H, Yu C, Wu D, Mittal A, Beg AA, Chellappan SP, Haura EB, Cheng JQ
  Title
IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer.
  Journal
Oncogene 32:151-9 (2013)
DOI:10.1038/onc.2012.39
Reference
PMID:20106947
  Authors
Chen RJ, Ho YS, Guo HR, Wang YJ
  Title
Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells.
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Toxicol Sci 115:118-30 (2010)
DOI:10.1093/toxsci/kfq028
Reference
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Related
pathway
shr00980  Metabolism of xenobiotics by cytochrome P450
shr03320  PPAR signaling pathway
shr04010  MAPK signaling pathway
shr04024  cAMP signaling pathway
shr04150  mTOR signaling pathway
shr04151  PI3K-Akt signaling pathway
shr04370  VEGF signaling pathway
shr04915  Estrogen signaling pathway
shr05204  Chemical carcinogenesis - DNA adducts
shr05206  MicroRNAs in cancer
shr05208  Chemical carcinogenesis - reactive oxygen species
KO pathway
ko05207   
LinkDB

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