KEGG   PATHWAY: umr04510
Entry
umr04510                    Pathway                                
Name
Focal adhesion - Ursus maritimus (polar bear)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
umr04510  Focal adhesion
umr04510

Other DBs
GO: 0005925
Organism
Ursus maritimus (polar bear) [GN:umr]
Gene
103656237  VWF; von Willebrand factor isoform X1 [KO:K03900]
103656511  ITGB1; integrin beta-1 [KO:K05719]
103656863  RAP1B; ras-related protein Rap-1b [KO:K07836]
103656923  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
103657074  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
103657189  [KO:K06274]
103657380  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
103657624  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
103657625  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
103657720  [KO:K12329]
103657721  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
103657827  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
103657856  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
103658054  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
103658181  DOCK1; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 1 [KO:K13708]
103658669  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
103658736  COL1A2; collagen alpha-2(I) chain [KO:K06236]
103658858  ITGB8; integrin beta-8 [KO:K06591]
103659497  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
103659636  ITGA4; integrin alpha-4 [KO:K06483]
103659655  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
103659828  [KO:K07836]
103659892  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
103660044  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103660117  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
103660295  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
103660572  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
103660581  [KO:K06240]
103660792  THBS2; thrombospondin-2 [KO:K04659]
103660945  COL1A1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
103660962  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
103661038  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103661071  ACTN4; alpha-actinin-4 [KO:K05699]
103661079  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
103661277  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
103661279  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
103661560  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
103661742  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
103661921  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103662115  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
103662462  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
103662463  [KO:K16060]
103662543  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
103662651  [KO:K12757]
103662658  [KO:K12757]
103662788  FN1; fibronectin isoform X1 [KO:K05717]
103662830  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
103662842  ROCK1; rho-associated protein kinase 1 isoform X3 [KO:K04514] [EC:2.7.11.1]
103662858  COL4A3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain [KO:K06237]
103662859  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
103663185  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
103663244  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
103663512  LAMA2; laminin subunit alpha-2 [KO:K05637]
103663617  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
103663724  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
103664092  CCND3; G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
103664148  VEGFA; LOW QUALITY PROTEIN: vascular endothelial growth factor A [KO:K05448]
103664242  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
103664410  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
103664600  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
103664633  ITGA2; integrin alpha-2 [KO:K06481]
103664656  LAMA1; laminin subunit alpha-1 [KO:K05637]
103664837  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
103664853  LAMA3; laminin subunit alpha-3 [KO:K06240]
103665161  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
103665409  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
103665592  ITGA2B; integrin alpha-IIb [KO:K06476]
103665736  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
103665746  ITGB4; integrin beta-4 [KO:K06525]
103665813  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103665892  ITGB3; integrin beta-3 [KO:K06493]
103665907  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103666008  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
103666578  CDC42; cell division control protein 42 homolog [KO:K04393]
103666688  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103666874  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103666919  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
103667118  TLN1; talin-1 [KO:K06271]
103667232  VTN; vitronectin [KO:K06251]
103667518  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
103667838  VCL; vinculin isoform X2 [KO:K05700]
103667893  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103668144  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
103668378  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
103668383  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
103668498  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
103668594  EMP2; epithelial membrane protein 2 [KO:K26256]
103668895  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
103668926  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
103668927  [KO:K06237]
103669086  ZYX; zyxin isoform X1 [KO:K06273]
103669103  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
103669131  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
103669173  [KO:K02833]
103669230  CRKL; crk-like protein [KO:K04438]
103669282  TNN; tenascin-N [KO:K06252]
103669286  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103669293  TNR; tenascin-R [KO:K06252]
103669540  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103669585  CAV3; caveolin-3 [KO:K12959]
103669776  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103669791  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
103670054  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103670086  ACTB; actin, cytoplasmic 1 [KO:K05692]
103670095  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103670201  MYL10; myosin regulatory light chain 10 [KO:K12756]
103670406  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
103670411  LAMC3; laminin subunit gamma-3 [KO:K06247]
103670500  TNC; tenascin [KO:K06252]
103670589  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
103670766  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103670861  JUN; transcription factor AP-1 [KO:K04448]
103671035  HRAS; GTPase HRas isoform X3 [KO:K02833]
103671076  PGF; placenta growth factor isoform X1 [KO:K16859]
103671139  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103671891  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
103671909  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103672489  LAMB3; laminin subunit beta-3 [KO:K06244]
103672510  LAMC2; laminin subunit gamma-2 [KO:K06246]
103672511  LAMC1; laminin subunit gamma-1 [KO:K05635]
103672737  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
103672740  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
103672914  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103673473  THBS1; thrombospondin-1 [KO:K16857]
103673553  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
103673818  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
103674040  PARVG; gamma-parvin [KO:K06275]
103674041  PARVB; beta-parvin isoform X3 [KO:K06275]
103674200  FLNB; filamin-B isoform X1 [KO:K27392]
103674291  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
103674343  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
103674429  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
103674619  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
103674660  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103674685  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
103674704  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
103674717  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
103674825  RHOA; transforming protein RhoA [KO:K04513]
103674931  [KO:K04659]
103675043  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
103675103  LAMB2; laminin subunit beta-2 [KO:K06243]
103675162  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103675192  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
103675428  COL2A1; collagen alpha-1(II) chain [KO:K19719]
103675667  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
103675680  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
103675743  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
103676125  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103676164  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
103676407  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
103676495  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103676520  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
103676584  CAV1; caveolin-1 isoform X1 [KO:K06278]
103676585  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103676671  CAV2; caveolin-2 [KO:K12958]
103676722  SHC4; SHC-transforming protein 4 [KO:K17449]
103676817  TLN2; talin-2 [KO:K06271]
103676847  MYL5; myosin light chain 5 [KO:K12753]
103676878  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103676947  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103676964  [KO:K06253]
103676980  LAMA4; laminin subunit alpha-4 [KO:K06241]
103676988  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
103677767  EMP1; epithelial membrane protein 1 [KO:K26255]
103677885  SPP1; osteopontin isoform X1 [KO:K06250]
103678069  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103678355  PXN; paxillin isoform X1 [KO:K05760]
103678405  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
103678592  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103678785  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
103678821  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
103678824  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
103678928  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103679064  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103679149  ITGA11; integrin alpha-11 [KO:K06587]
103679288  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
103679375  VEGFC; vascular endothelial growth factor C [KO:K05449]
103679423  BAD; bcl2-associated agonist of cell death [KO:K02158]
103679547  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
103679611  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
103679686  FLNA; filamin-A isoform X1 [KO:K04437]
103679739  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
103679942  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
103679990  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103680018  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
103680228  [KO:K04725] [EC:2.3.2.27]
103680310  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
103680384  CTNNB1; catenin beta-1 [KO:K02105]
103680680  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
103680734  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
103680775  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
103680852  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
103680903  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
103681403  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
103681497  THBS4; thrombospondin-4 [KO:K04659]
103681714  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
103681753  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
103681822  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
103681825  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
103681833  [KO:K06238]
103682333  TNXB; tenascin-X [KO:K06252]
103682361  PARVA; alpha-parvin isoform X1 [KO:K06275]
103682402  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
121105017  CHAD; chondroadherin [KO:K06248]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
umr04010  MAPK signaling pathway
umr04060  Cytokine-cytokine receptor interaction
umr04070  Phosphatidylinositol signaling system
umr04110  Cell cycle
umr04151  PI3K-Akt signaling pathway
umr04310  Wnt signaling pathway
umr04512  ECM-receptor interaction
umr04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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