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KEGG   PATHWAY: xtr04020
Entry
xtr04020                    Pathway                                
Name
Calcium signaling pathway - Xenopus tropicalis (tropical clawed frog)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
xtr04020  Calcium signaling pathway
xtr04020

Other DBs
GO: 0019722
Organism
Xenopus tropicalis (tropical clawed frog) [GN:xtr]
Gene
100036722  pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
100037840  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
100037857  ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
100038043  prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
100038053  prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
100038089  vegfa; vascular endothelial growth factor A precursor [KO:K05448]
100038110  dnajc27; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100038176  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
100038202  pdgfa; platelet-derived growth factor subunit A precursor [KO:K04359]
100101771  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
100124748  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100124749  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100124855  drd1c; D(1C) dopamine receptor [KO:K05840]
100124862  pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
100124910  fgfr2; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
100125056  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
100125061  orai1; protein orai-2 [KO:K16057]
100125098  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100125191  atp2b3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
100126441  adcy9; LOW QUALITY PROTEIN: adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
100127551  adora2a; adenosine receptor A2a [KO:K04266]
100127567  atp2b1; plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
100127663  egf; pro-epidermal growth factor precursor [KO:K04357]
100127678  tacr1; substance-P receptor [KO:K04222]
100127741  adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
100127763  bdkrb2; B2 bradykinin receptor [KO:K03916]
100135023  camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
100135349  [KO:K06856]
100135711  camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
100144654  adrb2; beta-2 adrenergic receptor [KO:K04142]
100144690  vegfd; vascular endothelial growth factor D [KO:K05449]
100144934  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
100145351  tbxa2r; thromboxane A2 receptor [KO:K04264]
100158591  ptgfr; prostaglandin F receptor [KO:K04262]
100158624  phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
100170161  ngf; beta-nerve growth factor precursor [KO:K02582]
100170183  agtr1; type-1 angiotensin II receptor [KO:K04166]
100170451  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
100196923  fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
100216091  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
100216229  gnal; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
100217324  fgf1; fibroblast growth factor 1 [KO:K18496]
100217325  fgf4; fibroblast growth factor 4 precursor [KO:K04358]
100217326  fgf6; fibroblast growth factor 6 precursor [KO:K04358]
100217327  fgf9; fibroblast growth factor 9 [KO:K04358]
100217329  fgf19; fibroblast growth factor 19 precursor [KO:K22603]
100233215  fgf22; fibroblast growth factor 22 precursor [KO:K04358]
100233218  fgf20; fibroblast growth factor 20 [KO:K04358]
100233219  fgf23.1; fibroblast growth factor 23 [KO:K22428]
100379715  plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
100379739  pln; cardiac phospholamban [KO:K05852]
100379826  mcoln2; mucolipin-2 isoform X1 [KO:K04993]
100380109  orai2; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
100485035  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100485273  grm5; metabotropic glutamate receptor 5 isoform X2 [KO:K04604]
100485434  tgfa; protransforming growth factor alpha [KO:K08774]
100485445  p2rx5; P2X purinoceptor 5 [KO:K05219]
100485463  drd1; D(1A) dopamine receptor [KO:K04144]
100485603  chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
100485618  p2rx1; P2X purinoceptor 1 isoform X2 [KO:K05215]
100485823  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
100485906  cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100486016  nos3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
100486176  fgf5; fibroblast growth factor 5 [KO:K04358]
100486229  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
100486231  htr7l; 5-hydroxytryptamine receptor 7 [KO:K04163]
100486428  grpr; gastrin-releasing peptide receptor [KO:K04169]
100486525  tacr3; neuromedin-K receptor [KO:K04224]
100486849  grin3a; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
100487086  adrb1; beta-4C adrenergic receptor [KO:K04143]
100487267  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
100487444  htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
100487501  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100487508  slc8a3; sodium/calcium exchanger 3 isoform X4 [KO:K05849]
100487523  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100487541  ntrk3; NT-3 growth factor receptor isoform X3 [KO:K05101] [EC:2.7.10.1]
100487606  vegfc; vascular endothelial growth factor C [KO:K05449]
100487776  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
100487782  [KO:K04809]
100487856  avpr1b; vasopressin V1b receptor [KO:K04227]
100487899  [KO:K05849]
100488055  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X2 [KO:K04850]
100488106  [KO:K09565] [EC:5.2.1.8]
100488346  [KO:K05850] [EC:7.2.2.10]
100488514  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X2 [KO:K04852]
100488597  [KO:K04345] [EC:2.7.11.11]
100488677  plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
100488806  adra1b; alpha-1B adrenergic receptor [KO:K04136]
100488869  avpr1a; vasopressin V1a receptor [KO:K04226]
100489006  grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
100489059  atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
100489231  cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
100489363  p2rx4; P2X purinoceptor 4 [KO:K05218]
100489466  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
100489565  trhr3; thyrotropin-releasing hormone receptor [KO:K04282]
100489628  ltb4r2; leukotriene B4 receptor 2 [KO:K04297]
100489637  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100489678  mylkl; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
100489755  [KO:K04266]
100490186  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
100490372  [KO:K04150]
100490434  chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
100490580  grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100490598  ptger1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
100490662  p2rx7; P2X purinoceptor 4 [KO:K05220]
100490828  [KO:K05220]
100490912  camk4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
100491392  hrh2; histamine H2 receptor [KO:K04150]
100492057  tpcn2; two pore calcium channel protein 2 [KO:K14077]
100492060  pdgfd; platelet-derived growth factor D [KO:K05450]
100492078  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100492135  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
100492166  slc8a1; sodium/calcium exchanger 1 isoform X2 [KO:K05849]
100492309  fgf16; fibroblast growth factor 16 [KO:K04358]
100492373  adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100492455  cckar; cholecystokinin receptor type A [KO:K04194]
100492507  trhr; thyrotropin-releasing hormone receptor [KO:K04282]
100492723  [KO:K22642]
100492776  adra1a; alpha-1A adrenergic receptor [KO:K04135]
100492782  htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
100492827  pdgfb; platelet-derived growth factor subunit B precursor [KO:K17386]
100492965  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
100492992  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
100493115  camk1d; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
100493234  erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
100493325  f2r; proteinase-activated receptor 1 [KO:K03914]
100493341  itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X10 [KO:K04958]
100493384  erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100493547  chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
100493611  chrna7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
100493801  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100493814  lhcgr; lutropin-choriogonadotropic hormone receptor [KO:K04248]
100493876  oxtr; oxytocin receptor [KO:K04229]
100493899  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
100493952  htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
100493974  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
100494056  mst1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
100494196  [KO:K04322]
100494492  pdgfc; platelet-derived growth factor C [KO:K05450]
100494599  cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
100494644  camk1g; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
100494664  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
100494698  nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
100494876  htr7; 5-hydroxytryptamine receptor 7 [KO:K04163]
100494894  cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
100495074  slc8a2; sodium/calcium exchanger 2 [KO:K05849]
100495109  kdrl; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
100495174  drd5; D(1B) dopamine receptor [KO:K05840]
100495208  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
100495378  ryr1; ryanodine receptor 1 isoform X2 [KO:K04961]
100495383  pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2 [KO:K13755] [EC:3.1.4.17]
100495530  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
100495566  hrh1; histamine H1 receptor [KO:K04149]
100495840  hgf; hepatocyte growth factor isoform X1 [KO:K05460]
100495902  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X2 [KO:K05126] [EC:2.7.10.1]
100495945  grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
100495969  adra1d; alpha-1D adrenergic receptor [KO:K04137]
100496012  htr2c; 5-hydroxytryptamine receptor 2A [KO:K04157]
100496115  [KO:K04160]
100496230  adora2b; adenosine receptor A2b [KO:K04267]
100496298  calm2; calmodulin-2 [KO:K02183]
100496389  [KO:K05869] [EC:2.7.11.17]
100496465  grin2d; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100496529  gna15; guanine nucleotide-binding protein subunit alpha-11 [KO:K04637]
100496569  [KO:K09565] [EC:5.2.1.8]
100496572  [KO:K05100] [EC:2.7.10.1]
100496638  grin2c; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
100496658  [KO:K01116] [EC:3.1.4.11]
100496674  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
100496686  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
100496779  prkcg; protein kinase C gamma type isoform X2 [KO:K19663] [EC:2.7.11.13]
100496800  fgf23.2; fibroblast growth factor 23 [KO:K22428]
100497172  grin3b; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
100497212  adcy4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100497283  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X4 [KO:K04854]
100497340  itpkb; LOW QUALITY PROTEIN: inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
100497435  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
100497529  tpcn1; two pore calcium channel protein 1 [KO:K16896]
100497595  nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
100497991  mylk4; myosin light chain kinase family member 4 isoform X2 [KO:K00907] [EC:2.7.11.18]
100497993  plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
100498061  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
100498081  xkr7; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100498158  trhr2; thyrotropin-releasing hormone receptor [KO:K04282]
100498243  mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
100498261  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X2 [KO:K07190]
100498518  chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
101730278  p2rx2; P2X purinoceptor 2 [KO:K05216]
101730337  ntsr2; neurotensin receptor type 2 [KO:K04211]
101730384  [KO:K18196]
101730432  mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
101730632  sln; sarcolipin [KO:K22642]
101731179  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
101731188  ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
101731553  [KO:K04345] [EC:2.7.11.11]
101732125  cckbr; gastrin/cholecystokinin type B receptor [KO:K04194]
101733812  [KO:K04166]
101734149  [KO:K06856]
101734935  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105946713  [KO:K04345] [EC:2.7.11.11]
105947943  [KO:K22429]
105948055  p2rx6; P2X purinoceptor 6 isoform X2 [KO:K05221]
108648814  [KO:K04345] [EC:2.7.11.11]
116407821  [KO:K04345] [EC:2.7.11.11]
116407822  [KO:K04345] [EC:2.7.11.11]
116407825  [KO:K04345] [EC:2.7.11.11]
116407985  ntsr1; neurotensin receptor type 1 [KO:K04211]
116411737  [KO:K04345] [EC:2.7.11.11]
116412276  [KO:K04141]
116412424  [KO:K04211]
394489  casq1; calsequestrin-1 precursor [KO:K23468]
394504  slc25a4; ADP/ATP translocase 1 [KO:K05863]
394508  slc25a5; ADP/ATP translocase 2 [KO:K05863]
394554  tnnc2; troponin C, skeletal muscle [KO:K12042]
394741  casq2; calsequestrin-2 precursor [KO:K23445]
394755  gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
395037  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
403095  stim1; stromal interaction molecule 1 precursor [KO:K16059]
407931  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
447990  tnnc1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
448255  phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
493365  ptafr; platelet-activating factor receptor [KO:K04279]
493394  ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
493416  gna14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
493516  fgf3; fibroblast growth factor 3 precursor [KO:K04358]
493522  calm1; calmodulin [KO:K02183]
493525  fgf8; fibroblast growth factor 8 precursor [KO:K04358]
496459  ptk2b; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
496530  calml4; calmodulin-like protein 4 [KO:K02183]
496666  cd38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
496695  vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
496811  mcoln1; mucolipin-1 [KO:K04992]
496833  fgf7; fibroblast growth factor 7 [KO:K04358]
548369  [KO:K06856]
548451  asph; aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
548648  fgfr1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
548923  fgf10; fibroblast growth factor 10 precursor [KO:K04358]
548947  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
549023  camk1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
549077  fgfr4; fibroblast growth factor receptor 4 precursor [KO:K05095] [EC:2.7.10.1]
549157  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
549246  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
549366  [KO:K08048] [EC:4.6.1.1]
549558  mcoln3; mucolipin-3 [KO:K04994]
549672  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
550087  fgf2; fibroblast growth factor 2 [KO:K18497]
613090  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
733728  [KO:K08774]
733739  stim2; stromal interaction molecule 2 [KO:K18196]
733773  gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
779709  itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
779728  ednra; endothelin-1 receptor precursor [KO:K04197]
779740  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
779786  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
779931  ednrb; endothelin B receptor precursor [KO:K04198]
780048  grin1; glutamate receptor ionotropic, NMDA 1 precursor [KO:K05208]
780105  tfeb; transcription factor EB [KO:K15590]
780110  ntrk2; BDNF/NT-3 growth factors receptor precursor [KO:K04360] [EC:2.7.10.1]
780133  ednrb2; endothelin receptor B subtype 2 precursor [KO:K04198]
780197  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
780209  prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
780379  camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
780394  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
xtr04010  MAPK signaling pathway
xtr04070  Phosphatidylinositol signaling system
xtr04210  Apoptosis
KO pathway
ko04020   

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