KEGG   PATHWAY: xtr04010
Entry
xtr04010                    Pathway                                
Name
MAPK signaling pathway - Xenopus tropicalis (tropical clawed frog)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
xtr04010  MAPK signaling pathway
xtr04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Xenopus tropicalis (tropical clawed frog) [GN:xtr]
Gene
100036608  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
100036637  stk3; serine/threonine-protein kinase 3 [KO:K04412]
100036638  rasa2; ras GTPase-activating protein 2 [KO:K08053]
100036643  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
100036671  dusp8; uncharacterized protein LOC100036671 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100036691  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100036724  cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 preproprotein [KO:K04858]
100037840  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
100037849  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
100037853  bdnf; brain-derived neurotrophic factor precursor [KO:K04355]
100037857  ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
100037899  hsp70; heat shock 70kDa protein [KO:K03283]
100038043  prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
100038053  prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
100038089  vegfa; vascular endothelial growth factor A precursor [KO:K05448]
100038126  daxx; death domain-associated protein 6 [KO:K02308]
100038148  cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X2 [KO:K04859]
100038202  pdgfa; platelet-derived growth factor subunit A precursor [KO:K04359]
100101718  ins; insulin precursor [KO:K04526]
100101726  rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
100101741  arrb2; beta-arrestin-2 [KO:K04439]
100101764  map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
100101766  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100101791  rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
100124710  gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100124750  fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
100124789  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100124862  pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
100124910  fgfr2; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
100124947  rap1a; ras-related protein Rap-1A [KO:K04353]
100125024  cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
100125100  ptprr; receptor-type tyrosine-protein phosphatase R precursor [KO:K04458] [EC:3.1.3.48]
100125205  cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
100126216  jund; transcription factor jun-D [KO:K04449]
100127198  mef2c; myocyte-specific enhancer factor 2C [KO:K04454]
100127663  egf; pro-epidermal growth factor precursor [KO:K04357]
100134991  tnf; tumor necrosis factor [KO:K03156]
100134992  igf2; insulin-like growth factor II precursor [KO:K13769]
100135013  map2k4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
100135092  rasa1; ras GTPase-activating protein 1 [KO:K04352]
100135709  rras; ras-related protein R-Ras [KO:K07830]
100135731  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
100144638  nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
100144647  efna2; ephrin-A2 precursor [KO:K05462]
100144684  nlk.2; serine/threonine-protein kinase NLK2 [KO:K04468] [EC:2.7.11.24]
100144690  vegfd; vascular endothelial growth factor D [KO:K05449]
100144704  rps6ka1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
100144709  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100144715  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100144930  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
100144934  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
100145045  [KO:K04441] [EC:2.7.11.24]
100145181  cacnb3; voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
100145251  areg; amphiregulin precursor [KO:K09782]
100145270  ikbkg; NF-kappa-B essential modulator [KO:K07210]
100145427  taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
100145502  igf3; insulin-like growth factor 3 [KO:K13769]
100145659  rapgef2; rap guanine nucleotide exchange factor 2 [KO:K08018]
100145731  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
100151728  casp3.2; caspase-3 [KO:K02187] [EC:3.4.22.56]
100158521  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
100170161  ngf; beta-nerve growth factor precursor [KO:K02582]
100170186  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
100170194  mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
100170570  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
100196923  fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
100216065  il1rap; interleukin-1 receptor accessory protein precursor [KO:K04723]
100216090  kit; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
100216091  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
100216113  lamtor3-like; ragulator complex protein LAMTOR3 [KO:K04370]
100216182  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
100217324  fgf1; fibroblast growth factor 1 [KO:K18496]
100217325  fgf4; fibroblast growth factor 4 precursor [KO:K04358]
100217326  fgf6; fibroblast growth factor 6 precursor [KO:K04358]
100217327  fgf9; fibroblast growth factor 9 [KO:K04358]
100217329  fgf19; fibroblast growth factor 19 precursor [KO:K22603]
100233215  fgf22; fibroblast growth factor 22 precursor [KO:K04358]
100233218  fgf20; fibroblast growth factor 20 [KO:K04358]
100233219  fgf23.1; fibroblast growth factor 23 [KO:K22428]
100329112  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100379980  efna4; ephrin-A4 isoform X1 [KO:K05462]
100485035  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100485272  [KO:K05466]
100485430  jmjd7-pla2g4b; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
100485434  tgfa; protransforming growth factor alpha [KO:K08774]
100485441  hspa1b; LOW QUALITY PROTEIN: heat shock 70 kDa protein [KO:K03283]
100485532  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X2 [KO:K04450]
100485823  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
100485906  cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100485959  krasl; GTPase KRas isoform X2 [KO:K07827]
100486083  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100486176  fgf5; fibroblast growth factor 5 [KO:K04358]
100486222  casp3.1; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
100486334  igf1; insulin-like growth factor I [KO:K05459]
100486349  arrb1; beta-arrestin-1 isoform X2 [KO:K04439]
100486410  relb; transcription factor RelB isoform X1 [KO:K09253]
100486469  nrk; nik-related protein kinase isoform X2 [KO:K04407] [EC:2.7.11.1]
100486502  rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
100486554  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
100486973  rps6ka4; ribosomal protein S6 kinase alpha-5 [KO:K16510] [EC:2.7.11.1]
100487013  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100487038  il1b; interleukin-1 beta [KO:K04519]
100487430  tgfbr2.2; TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
100487452  rasgrp3; ras guanyl-releasing protein 3 isoform X2 [KO:K12362]
100487501  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100487523  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100487606  vegfc; vascular endothelial growth factor C [KO:K05449]
100488052  hspa1a; heat shock cognate 71 kDa protein [KO:K03283]
100488055  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X2 [KO:K04850]
100488058  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
100488289  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
100488307  map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X2 [KO:K04423] [EC:2.7.11.25]
100488360  map3k22; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
100488361  cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
100488417  rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
100488514  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X2 [KO:K04852]
100488582  tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
100488597  [KO:K04345] [EC:2.7.11.11]
100488949  map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
100489041  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
100489201  map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100489231  cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
100489637  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100489680  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
100489960  sos1; son of sevenless homolog 1 [KO:K03099]
100490021  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
100490038  akt1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100490504  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
100490781  ntf4; neurotrophin-4 [KO:K12457]
100491321  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
100491546  il1r1; interleukin-1 receptor type 1 [KO:K04386]
100491719  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
100492060  pdgfd; platelet-derived growth factor D [KO:K05450]
100492078  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100492135  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
100492267  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
100492309  fgf16; fibroblast growth factor 16 [KO:K04358]
100492432  tek; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
100492672  angpt1; angiopoietin-1 isoform X1 [KO:K05465]
100492718  insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100492827  pdgfb; platelet-derived growth factor subunit B precursor [KO:K17386]
100492965  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
100492992  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
100493069  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
100493077  dusp10.2; dual specificity protein phosphatase 5 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
100493234  erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
100493384  erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100493570  map3k2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
100493801  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100493878  map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
100493879  nf1; neurofibromin isoform X1 [KO:K08052]
100493911  jun; transcription factor AP-1 [KO:K04448]
100493992  ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100494283  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100494415  traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100494492  pdgfc; platelet-derived growth factor C [KO:K05450]
100494599  cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
100494894  cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
100495109  kdrl; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
100495479  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100495539  map4k1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
100495717  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
100495797  map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
100495840  hgf; hepatocyte growth factor isoform X1 [KO:K05460]
100495884  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X5 [KO:K04863]
100495890  artn; artemin isoform X2 [KO:K25415]
100495902  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X2 [KO:K05126] [EC:2.7.10.1]
100496161  rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
100496320  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
100496373  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X2 [KO:K04434]
100496432  rasgrp4; RAS guanyl-releasing protein 4 [KO:K04350]
100496446  mras; ras-related protein M-Ras [KO:K07831]
100496511  mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
100496779  prkcg; protein kinase C gamma type isoform X2 [KO:K19663] [EC:2.7.11.13]
100496800  fgf23.2; fibroblast growth factor 23 [KO:K22428]
100497015  sos2; son of sevenless homolog 2 [KO:K03099]
100497117  flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
100497217  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
100497283  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X4 [KO:K04854]
100497353  srf; serum response factor isoform X1 [KO:K04378]
100497525  pla2g4f; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
100497609  elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
100497692  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
100498061  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
100498430  tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
100498529  dusp3; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
101731553  [KO:K04345] [EC:2.7.11.11]
101731563  angpt2; angiopoietin-2 [KO:K05466]
101731867  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
101732520  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
101733150  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101733706  rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
101733715  nrtn; neurturin [KO:K25414]
105945458  pspn; persephin [KO:K25416]
105946713  [KO:K04345] [EC:2.7.11.11]
105947943  [KO:K22429]
105948093  pla2g4d; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
108648814  [KO:K04345] [EC:2.7.11.11]
116407821  [KO:K04345] [EC:2.7.11.11]
116407822  [KO:K04345] [EC:2.7.11.11]
116407825  [KO:K04345] [EC:2.7.11.11]
116408028  cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
116409784  [KO:K04519]
116410221  ptpn5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
116410232  rras2; ras-related protein R-Ras2 [KO:K07830]
116411737  [KO:K04345] [EC:2.7.11.11]
394657  crkl; crk-like protein [KO:K04438]
394860  stk4; serine/threonine-protein kinase 4 [KO:K04411]
395024  myc; myc proto-oncogene protein [KO:K04377]
395037  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
407869  rela; transcription factor p65 [KO:K04735]
431679  tp53; cellular tumor antigen p53 [KO:K04451]
448005  atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
448023  crk; adapter molecule crk [KO:K04438]
448043  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
448118  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
448125  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
448132  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
448296  mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
448357  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
448442  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
448450  epha2; ephrin type-A receptor 2 precursor [KO:K05103] [EC:2.7.10.1]
448550  nfkb2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
448643  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
493275  ppp5c; protein PPP5D1 [KO:K04460] [EC:3.1.3.16]
493340  stmn1; stathmin [KO:K04381]
493361  nradd; neurotrophin receptor associated death domain precursor [KO:K02583]
493389  cdc42; cell division control protein 42 homolog isoform 1 [KO:K04393]
493392  ppm1b; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
493396  kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
493413  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
493420  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
493492  grb2; growth factor receptor-bound protein 2 [KO:K04364]
493516  fgf3; fibroblast growth factor 3 precursor [KO:K04358]
493524  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
493525  fgf8; fibroblast growth factor 8 precursor [KO:K04358]
493543  csf1r; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
493557  rap1b; ras-related protein Rap-1b precursor [KO:K07836]
493570  max; protein max [KO:K04453]
496444  cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
496637  efna1; ephrin-A1 precursor [KO:K05462]
496738  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
496827  efna3; ephrin A3 precursor [KO:K05462]
496833  fgf7; fibroblast growth factor 7 [KO:K04358]
548573  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
548648  fgfr1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
548715  tgfbr1; TGF-beta receptor type-1 precursor [KO:K04674] [EC:2.7.11.30]
548863  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
548905  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
548912  ppm1a; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
548923  fgf10; fibroblast growth factor 10 precursor [KO:K04358]
548954  fos; proto-oncogene c-Fos [KO:K04379]
549042  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
549077  fgfr4; fibroblast growth factor receptor 4 precursor [KO:K05095] [EC:2.7.10.1]
549124  ntf3; neurotrophin-3 precursor [KO:K04356]
549157  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
549176  efna5; ephrin-A5 precursor [KO:K05462]
549217  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
549517  nras; GTPase NRas [KO:K07828]
549591  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
549654  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
549757  hras; GTPase HRas [KO:K02833]
549834  mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
549871  raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
549881  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
550087  fgf2; fibroblast growth factor 2 [KO:K18497]
550101  mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
613115  map2k7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
733718  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
733728  [KO:K08774]
733738  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
733788  taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
733814  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
733815  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
733816  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
733847  kitlg; kit ligand precursor [KO:K05461]
733987  ereg; proepiregulin precursor [KO:K09784]
779515  mapk10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
779570  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
779664  cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
779756  nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
779785  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
779840  flna; filamin-A [KO:K04437]
779865  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor [KO:K04405]
779883  hspa1l; heat shock protein family A (Hsp70) member 1 like [KO:K03283]
779920  mapt; microtubule-associated protein tau [KO:K04380]
780110  ntrk2; BDNF/NT-3 growth factors receptor precursor [KO:K04360] [EC:2.7.10.1]
780186  taok2; serine/threonine-protein kinase TAO2 [KO:K04429] [EC:2.7.11.1]
780197  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
780206  cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
780209  prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
780232  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
780278  hspb1; heat shock protein beta-1 [KO:K04455]
780323  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
xtr04070  Phosphatidylinositol signaling system
xtr04110  Cell cycle
xtr04115  p53 signaling pathway
xtr04210  Apoptosis
xtr04310  Wnt signaling pathway
KO pathway
ko04010   

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