KEGG   PATHWAY: mjv05203
Entry
mjv05203                    Pathway                                
Name
Viral carcinogenesis - Manis javanica (Malayan pangolin)
Description
There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers.
Class
Human Diseases; Cancer: overview
Pathway map
mjv05203  Viral carcinogenesis
mjv05203

Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108401592  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
108408627  HRAS; GTPase HRas isoform X1 [KO:K02833]
118967667  GTPase HRas-like isoform X1 [KO:K02833]
108395842  KRAS; GTPase KRas isoform X1 [KO:K07827]
108398047  NRAS; GTPase NRas [KO:K07828]
108398454  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108400663  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108396160  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
108396432  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
108397369  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
108407563  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
108406808  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048]
108408210  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
108401935  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
108385045  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
108405132  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
108393793  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
108392382  DDB1; DNA damage-binding protein 1 [KO:K10610]
108390866  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
108398257  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
108398654  YWHAQ; 14-3-3 protein theta [KO:K16197]
108394547  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
108393303  YWHAG; 14-3-3 protein gamma [KO:K16198]
108394467  14-3-3 protein eta [KO:K16198]
118967462  14-3-3 protein eta-like [KO:K16198]
108405993  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
108386068  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
108388330  signal transducer and activator of transcription 5B [KO:K11224]
108389793  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
108398953  HPN; serine protease hepsin isoform X1 [KO:K08665] [EC:3.4.21.106]
108406544  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108390365  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108400388  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108383561  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108390475  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
108395975  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108397005  RELA; transcription factor p65 isoform X1 [KO:K04735]
108389971  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
108405673  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
108391706  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
108404266  TP53; cellular tumor antigen p53 [KO:K04451]
118974052  cellular tumor antigen p53 [KO:K04451]
108385232  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
108396147  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
108395918  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
108392949  EGR2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
108393202  EGR3; early growth response protein 3 isoform X1 [KO:K12497]
108399800  voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
118968497  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
108387605  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
108409470  SP100; nuclear autoantigen Sp-100 isoform X3 [KO:K15413]
108409292  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
108385913  cyclin-dependent kinase inhibitor 1 [KO:K06625]
118970122  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
108392346  DDX3X; ATP-dependent RNA helicase DDX3X isoform X2 [KO:K11594] [EC:5.6.2.7]
108386756  ATP-dependent RNA helicase DDX3X-like [KO:K11594] [EC:5.6.2.7]
108388574  ATP-dependent RNA helicase DDX3Y-like [KO:K11594] [EC:5.6.2.7]
108392233  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
108408343  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108409966  histone H2B type 2-F isoform X1 [KO:K11252]
108396925  histone H2B type 1-C/E/F/G/I-like [KO:K11252]
108383716  histone H2B type 1-A [KO:K11252]
108384134  histone H2B type 2-E [KO:K11252]
108391851  histone H2B type 2-E1 [KO:K11252]
108400169  histone H2B type 1-M-like [KO:K11252]
108400171  histone H2B-like [KO:K11252]
108400178  histone H2B type 1-K [KO:K11252]
108400184  histone H2B type 1-B-like [KO:K11252]
108400187  histone H2B type 1-M [KO:K11252]
108400704  histone H2B type 1-J [KO:K11252]
108396296  histone H2B type 2-E-like [KO:K11252]
108396300  histone H2B type 1-M-like [KO:K11252]
108387973  histone H2B type 2-E-like [KO:K11252]
118973179  histone H2B type 1-M-like [KO:K11252]
108400179  histone H2B type 1-C/E/F/G/I [KO:K11252]
118969036  histone H2B type 1-B isoform X1 [KO:K11252]
118969037  histone H2B type 3-B [KO:K11252]
108400315  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
118969429  apoptosis regulator BAX [KO:K02159]
108400653  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
108390345  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
108387122  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
108402561  TATA-box-binding protein [KO:K03120]
108386588  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
108394219  TBPL2; TATA box-binding protein-like 2 [KO:K03120]
108398942  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X3 [KO:K11838] [EC:3.4.19.12]
108394490  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
108406893  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
108384934  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
108391164  SNW1; SNW domain-containing protein 1 [KO:K06063]
108405101  GTF2H1; general transcription factor IIH subunit 1 isoform X1 [KO:K03141]
108384354  general transcription factor IIH subunit 2 [KO:K03142]
108401683  GTF2H3; general transcription factor IIH subunit 3 [KO:K03143]
108409887  GTF2H4; general transcription factor IIH subunit 4 isoform X1 [KO:K03144]
108391600  GTF2E1; general transcription factor IIE subunit 1 [KO:K03136]
108400947  SND1; staphylococcal nuclease domain-containing protein 1 isoform X1 [KO:K15979]
108394315  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
108395362  CREB-binding protein [KO:K04498] [EC:2.3.1.48]
108408869  GTF2B; transcription initiation factor IIB [KO:K03124]
108388480  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108403976  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
108405335  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
108392535  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
108400099  CCNA2; cyclin-A2 isoform X2 [KO:K06627]
108404799  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
108394138  MRPS18B; 28S ribosomal protein S18b, mitochondrial isoform X1 [KO:K16174]
108391145  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
108406827  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
108406584  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
108385436  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
108388002  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
108396202  tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
108384766  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
108390361  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
108403942  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
108387602  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
108408003  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
108397691  PXN; paxillin isoform X1 [KO:K05760]
108402940  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
108400317  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
108404313  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
108384777  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
108405977  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
108388354  RBL2; retinoblastoma-like protein 2 [KO:K16332]
108391616  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
108394566  UBR4; E3 ubiquitin-protein ligase UBR4 [KO:K10691] [EC:2.3.2.27]
108386817  JUN; transcription factor AP-1 [KO:K04448]
108387610  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
108407680  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
108404446  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
108405534  HDAC3; histone deacetylase 3 [KO:K11404] [EC:3.5.1.98]
108410010  HDAC5; histone deacetylase 5 isoform X2 [KO:K11406] [EC:3.5.1.98]
108398708  HDAC4; histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
108404036  HDAC6; histone deacetylase 6 isoform X1 [KO:K11407] [EC:3.5.1.98]
108392457  HDAC7; histone deacetylase 7 isoform X7 [KO:K11408] [EC:3.5.1.98]
108398611  HDAC8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
108393743  HDAC9; histone deacetylase 9 [KO:K11409] [EC:3.5.1.98]
108395595  HDAC10; polyamine deacetylase HDAC10 isoform X1 [KO:K18671] [EC:3.5.1.98]
108392955  HDAC11; histone deacetylase 11 isoform X2 [KO:K11418] [EC:3.5.1.98]
108396911  PKM; pyruvate kinase PKM isoform X2 [KO:K00873] [EC:2.7.1.40]
108391263  IRF9; interferon regulatory factor 9 [KO:K04693]
108406465  DNAJA3; dnaJ homolog subfamily A member 3, mitochondrial isoform X1 [KO:K09504]
108409855  KAT2B; histone acetyltransferase KAT2B isoform X1 [KO:K06062] [EC:2.3.1.48]
108388344  KAT2A; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
108407928  GTF2A1; transcription initiation factor IIA subunit 1 [KO:K03122]
108384954  GTF2A1L; TFIIA-alpha and beta-like factor isoform X1 [KO:K03122]
108402118  GTF2A2; transcription initiation factor IIA subunit 2 [KO:K03123]
108403504  transcription initiation factor IIA subunit 2-like [KO:K03123]
108395068  SRF; serum response factor [KO:K04378]
108400819  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
108402523  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
108410200  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
108391531  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
108407595  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
108383250  transforming protein RhoA [KO:K04513]
108405100  gelsolin isoform X1 [KO:K05768]
108390487  SCIN; adseverin [KO:K05768]
108391826  ACTN1; alpha-actinin-1 isoform X3 [KO:K05699]
108399501  ACTN4; alpha-actinin-4 isoform X3 [KO:K05699]
108387631  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
118972765  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
108386438  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
108401047  CHEK1; serine/threonine-protein kinase Chk1 isoform X2 [KO:K02216] [EC:2.7.11.1]
108407024  CDC20; cell division cycle protein 20 homolog [KO:K03363]
108403423  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
108397081  VAC14; protein VAC14 homolog [KO:K15305]
108406873  RANBP1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
108399798  POLB; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
108408637  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
108393228  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
108400629  LOW QUALITY PROTEIN: C-C chemokine receptor type 5 [KO:K04180]
118970094  C-C chemokine receptor type 5-like [KO:K04180]
108400940  CCR3; C-C chemokine receptor type 3 [KO:K04178]
108406782  CCR4; C-C chemokine receptor type 4 [KO:K04179]
108403019  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
108407571  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
108390232  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
108401780  C3; complement C3 [KO:K03990]
108388563  class I histocompatibility antigen, Gogo-B*0201 alpha chain-like isoform X1 [KO:K06751]
108390694  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
108391351  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X2 [KO:K06751]
108399725  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
Reference
PMID:18201576
  Authors
McLaughlin-Drubin ME, Munger K
  Title
Viruses associated with human cancer.
  Journal
Biochim Biophys Acta 1782:127-50 (2008)
DOI:10.1016/j.bbadis.2007.12.005
Reference
PMID:21102637
  Authors
Moore PS, Chang Y
  Title
Why do viruses cause cancer? Highlights of the first century of human tumour virology.
  Journal
Nat Rev Cancer 10:878-89 (2010)
DOI:10.1038/nrc2961
Reference
PMID:19400863
  Authors
Kalland KH, Ke XS, Oyan AM
  Title
Tumour virology--history, status and future challenges.
  Journal
APMIS 117:382-99 (2009)
DOI:10.1111/j.1600-0463.2009.02452.x
Reference
PMID:17979705
  Authors
Boccardo E, Villa LL
  Title
Viral origins of human cancer.
  Journal
Curr Med Chem 14:2526-39 (2007)
DOI:10.2174/092986707782023316
Reference
PMID:21084867
  Authors
Saha A, Kaul R, Murakami M, Robertson ES
  Title
Tumor viruses and cancer biology: Modulating signaling pathways for therapeutic intervention.
  Journal
Cancer Biol Ther 10:961-78 (2010)
DOI:10.4161/cbt.10.10.13923
Reference
PMID:21152115
  Authors
Zheng ZM
  Title
Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor viruses.
  Journal
Int J Biol Sci 6:730-55 (2010)
DOI:10.7150/ijbs.6.730
Reference
PMID:19956178
  Authors
Martin D, Gutkind JS
  Title
Human tumor-associated viruses and new insights into the molecular mechanisms of cancer.
  Journal
Oncogene 27 Suppl 2:S31-42 (2008)
DOI:10.1038/onc.2009.351
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:21966251
  Authors
Nishida N, Goel A
  Title
Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review.
  Journal
Curr Genomics 12:130-7 (2011)
DOI:10.2174/138920211795564359
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:9343405
  Authors
Klein NP, Schneider RJ
  Title
Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras.
  Journal
Mol Cell Biol 17:6427-36 (1997)
DOI:10.1128/MCB.17.11.6427
Reference
PMID:16039586
  Authors
Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC
  Title
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
  Journal
Mol Cell 19:159-70 (2005)
DOI:10.1016/j.molcel.2005.06.009
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:10824878
  Authors
Arbuthnot P, Capovilla A, Kew M
  Title
Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways.
  Journal
J Gastroenterol Hepatol 15:357-68 (2000)
DOI:10.1046/j.1440-1746.2000.02069.x
Reference
PMID:9837909
  Authors
Gottlob K, Fulco M, Levrero M, Graessmann A
  Title
The hepatitis B virus HBx protein inhibits caspase 3 activity.
  Journal
J Biol Chem 273:33347-53 (1998)
DOI:10.1074/jbc.273.50.33347
Reference
PMID:15614436
  Authors
Zhang JL, Zhao WG, Wu KL, Wang K, Zhang X, Gu CF, Li Y, Zhu Y, Wu JG
  Title
Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease Hepsin.
  Journal
Arch Virol 150:721-41 (2005)
DOI:10.1007/s00705-004-0446-0
Reference
PMID:15105524
  Authors
Cooray S
  Title
The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival.
  Journal
J Gen Virol 85:1065-76 (2004)
DOI:10.1099/vir.0.19771-0
Reference
PMID:16939421
  Authors
Mukherji A, Janbandhu VC, Kumar V
  Title
HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1.
  Journal
Biochem J 401:247-56 (2007)
DOI:10.1042/BJ20061091
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
  Journal
J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200
Reference
PMID:11604508
  Authors
Waris G, Huh KW, Siddiqui A
  Title
Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress.
  Journal
Mol Cell Biol 21:7721-30 (2001)
DOI:10.1128/MCB.21.22.7721-7730.2001
Reference
PMID:17894800
  Authors
Kasprzak A, Adamek A
  Title
Role of hepatitis C virus proteins (C, NS3, NS5A) in hepatic oncogenesis.
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The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.
  Journal
J Virol 79:7396-401 (2005)
DOI:10.1128/JVI.79.12.7396-7401.2005
Related
pathway
mjv03022  Basal transcription factors
mjv03320  PPAR signaling pathway
mjv04010  MAPK signaling pathway
mjv04062  Chemokine signaling pathway
mjv04064  NF-kappa B signaling pathway
mjv04110  Cell cycle
mjv04115  p53 signaling pathway
mjv04142  Lysosome
mjv04151  PI3K-Akt signaling pathway
mjv04210  Apoptosis
mjv04630  JAK-STAT signaling pathway
mjv04662  B cell receptor signaling pathway
mjv04810  Regulation of actin cytoskeleton
mjv05160  Hepatitis C
mjv05161  Hepatitis B
mjv05165  Human papillomavirus infection
mjv05166  Human T-cell leukemia virus 1 infection
mjv05167  Kaposi sarcoma-associated herpesvirus infection
mjv05169  Epstein-Barr virus infection
KO pathway
ko05203   
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